Antioxidant therapies for ulcerative dermatitis: A potential model for skin picking disorder

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  George, Nneka M ^a   Whitaker, Julia ^a   Vieira, Giovana ^b   Geronimo, Jerome T ^c   Bellinger, Dwight A ^a   Fletcher, Craig A ^a   Garner, Joseph P ^c   Bader, Michael ^d  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c STANFORD UNIVERSITY   (United States)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; ANTIOXIDANT;

ALOPECIA; ANIMAL HEALTH; ANIMAL HOUSING; ANIMAL HUSBANDRY; ANTIOXIDANT ACTIVITY; ARTICLE; COMORBIDITY; CONTROLLED STUDY; CORNEA OPACITY; DISEASE SEVERITY; DRUG RESPONSE; GLUTATHIONE METABOLISM; GRANULATION TISSUE; GROOMING; HEALTH STATUS; IMMUNE COMPLEX DISEASE; LIPID PEROXIDATION; MALOCCLUSION; MORTALITY; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATIVE STRESS; PALLIATIVE THERAPY; PSYCHOCUTANEOUS DISEASE; PYODERMA GANGRENOSUM; QUALITY OF LIFE; SCORING SYSTEM; SKIN PICKING DISORDER; TREATMENT CONTRAINDICATION; TRICHOTILLOMANIA; ANIMAL; C57BL MOUSE; COMPLICATION; DERMATITIS; DISEASE MODEL; FEMALE; HUMAN; MALE; SELF-INJURIOUS BEHAVIOR; SKIN ULCER;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; DERMATITIS; DISEASE MODELS, ANIMAL; FEMALE; GLUTATHIONE; HUMANS; MALE; MICE; MICE, INBRED C57BL; SELF-INJURIOUS BEHAVIOR; SKIN ULCER;

EID: 84940486619     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132092     Document Type: Article

References (39)

1. Andrews AG, Dysko RC, Spilman S.C., Kunkel RG, Brammer DW, Johnson KJ. Immune complex vasculitis with secondary ulcerative dermatitis in aged C57BL/6NNia mice. Vet Pathol. 1994; 31: 293-300. PMID: 8053123
2. Kastenmayer RJ, Fain MA, Perdue KA A retrospective study of idiopathic ulcerative dermatitis in mice with aC57BL/6 background. J Am Assoc Lab AnimSci. 2006; 45: 8-12.
3. Sundberg JP, Brown KS, McMahon WM Chronic ulcerative dermatitis in black mice. Handbook of Mouse Mutations With Skin and Hair Abnormalities. 1994: 485-492.
4. Sundberg JP, Sundberg BA, King LE Cutaneous changes in commonly used inbred mouse strains and mutant stocks. Pathobiology of the Aging Mouse. 1996; 2:325-337.
5. Dufour BD, Adeola O, Cheng H.W., Donkin SS, Klein JD, Pajor EA, et al Nutritional up-regulation of serotonin paradoxically induces compulsive behavior. Nutr Neurosci. 2010; 13: 256-264. PMID: 21040623
6. Grant JE, Odlaug BL, Chamberlain S.R., Keuthen NJ, Lochner C, Stein DJ. Skin picking disorder. Am J Psychiatry. 2012; 169:1143-1149. doi: 10.1176/appi.ajp.2012.12040508 PMID: 23128921
7. Odlaug BL, Grant JE Clinical characteristics and medical complications of pathologic skin picking. Gen Hosp Psychiatry. 2008; 30: 61-66. doi: 10.1016/j.genhosppsych.2007.07.009 [doi]. PMID: 18164942
8. Garner JP, Thogerson CM, Dufour B.D., Wurbel H., Murray JD, Mench JA. Reverse-translational biomarker validation of abnormal repetitive behaviors in mice: An illustration of the 4P's modeling approach. Behav Brain Res. 2011; 219:189-196. doi: 10.1016/j.bbr.2011.01.002 [doi]. PMID: 21219937
9. Odlaug BL, Lust K, Schreiber L.R., Christenson G., Derbyshire K, Grant JE. Skin picking disorder in university students: Health correlates and gender differences. Gen Hosp Psychiatry. 2013; 35:168-173. doi: 10.1016/j.genhosppsych.2012.08.006 [doi]. PMID: 23123103
10. Grant JE, Odlaug BL, Kim SW N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: A double-blind, placebo-controlled study. Arch Gen Psychiatry. 2009; 66: 756-763. doi: 10.1001/archgenpsychiatry.2009.60 [doi]. PMID: 19581567
11. Odlaug BL, Grant JE N-acetyl cysteine in the treatment of grooming disorders. J Clin Psychopharmacol. 2007; 27: 227-229. PMID: 17414258
12. L. T. Vieira G. Preventing, treating and predictiing barbering behavior in C57BL/6 mice. Ph.D., Purdue University. 2014. Available: http://search.proquest.com/docview/1649219463?accountid=14244.
13. Williams LK, Csaki LS, Cantor R.M., Reue K., Lawson GW. Ulcerative dermatitis in C57BL/6 mice exhibits an oxidative stress response consistent with normal wound healing. Comp Med. 2012; 62:166-171. PMID: 22776048
14. Perkins SN, Hursting SD, Phang J.M., Haines DC. Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice. J Invest Dermatol. 1998; 111: 292-296. doi: 10.1046/j.1523-1747.1998.00270.x PMID: 9699732
15. Dufour BD, Garner JP An ethological analysis of barbering behavior. In: Bergner CL, Kalueff AV, La Porte JL, editors. Neurobiology of grooming behavior. Cambridge; New York: Cambridge University Press; 2010.
16. Garner JP, Weisker SM, Dufour B, Mench JA Barbering (fur and whisker trimming) by laboratory mice as a model of human trichotillomania and obsessive-compulsive spectrum disorders. Comp Med. 2004; 54:216-224. PMID: 15134369
17. Neuhaus B, Niessen CM, Mesaros A, Withers D.J., Krieg T., Partridge L. Experimental analysis of risk factors for ulcerative dermatitis in mice. Exp Dermatol. 2012; 21: 712-713. doi: 10.1111/j.1600-0625.2012.01558.x PMID: 22897579
18. Kassed CA, Herkenham M. NF-kappaB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety. Behav Brain Res. 2004; 154: 577-584. doi: 10.1016/j.bbr.2004. 03.026 [doi]. PMID: 15313047
19. Mader JR, Mason MA, Bale L.K., Gades NM, Conover CA. The association of early dietary supplementation with vitamin E with the incidence of ulcerative dermatitis in mice on a C57BL/6 background: Diet and ulcerative dermatitis in mice. Scand J LabAnim Sci. 2010; 37: 253-259. PMID: 23180906
20. Ezell PC, Papa L, Lawson GW Palatability and treatment efficacy of various ibuprofen formulations in C57BL/6 mice with ulcerative dermatitis. J Am Assoc Lab AnimSci. 2012; 51: 609-615. PMID: 23312090
21. Williams-Fritze M.J., Carlson Scholz JA, Zeiss C, Deng Y, Wilson S.R., Franklin R., et al. Maropitant citrate for treatment of ulcerative dermatitis in mice with a C57BL/6 background. J Am Assoc Lab Anim Sci. 2011; 50: 221-226. PMID: 21439216
22. Ohmura T, Hayashi T, Satoh Y., Konomi A, Jung B, Satoh H. Involvement of substance P in scratching behaviour in an atopic dermatitis model. Eur J Pharmacol. 2004; 491:191-194. http://dx.doi.org/10.1016/j.ejphar.2004.03.047. PMID: 15140636
23. Inagaki N, Shiraishi N, Igeta K., Nagao M, Kim JF, Chikumoto T, et al Depletion of substance P, a mechanism for inhibition of mouse scratching behavior by tacrolimus. Eur J Pharmacol. 2010; 626: 283-289. doi: 10.1016/j.ejphar.2009.09.043 PMID: 19818345
24. Camfield DA, Sarris J, Berk M. Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): A review of mechanistic and clinical evidence. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 35: 887-895. doi: 10.1016/j.pnpbp.2011.02.011 PMID: 21352883
25. Ng F, Berk M, Dean O., Bush AI. Oxidative stress in psychiatric disorders: Evidence base and therapeutic implications. Int J Neuropsychopharmacol. 2008; 11: 851-876. doi: 10.1017/S1461145707008401 [doi]. PMID: 18205981
26. Berman AE, Chan WY, Brennan A.M., Reyes RC, Adler BL, Suh SW, et al N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1-/- mouse. Ann Neurol. 2011; 69: 509-520. doi: 10.1002/ ana.22162 PMID: 21446024
27. Ullman-Cullere MH, Foltz CJ. Body condition scoring: A rapid and accurate method for assessing health status in mice. Lab Anim Sci. 1999; 49: 319-323. PMID: 10403450
28. Mischley LK. Glutathione deficiency in parkinson's disease: Intranasal administration as a method of augmentation. J Orthomol Med. 2011; 26:1; 1-5; 5.
29. Afshar H, Roohafza H, Mohammad-Beigi H, Haghighi M., Jahangard L, Shokouh P, et al N-acetylcysteine add-on treatment in refractory obsessive-compulsive disorder: A randomized, double-blind, placebo-controlled trial. J Clin Psychopharmacol. 2012; 32: 797-803. PMID: 23131885
30. Bachmanov AA, Reed DR, Beauchamp G.K., Tordoff MG. Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet. 2002; 32: 435-443. PMID: 12467341
31. Schindelin J, Arganda-Carreras I, Frise E., Kaynig V, Longair M, Pietzsch T., et al. Fiji: An open-source platform for biological-image analysis. Nat Methods. 2012; 9: 676-682. doi: 10.1038/nmeth.2019 [doi]. PMID: 22743772
32. Miller JL, Angulo M. An open-label pilotstudy of N-acetylcysteine for skin-picking in prader-willi syndrome. Am J Med Genet A. 2014; 164A: 421-424. doi: 10.1002/ajmg.a.36306 PMID: 24311388
33. Sims NR, Nilsson M, Muyderman H. Mitochondrial glutathione: A modulator of brain cell death. J Bioenerg Biomembr. 2004; 36: 329-333. PMID: 15377867
34. Tayebati SK, Nwankwo IE, Amenta F. Intranasal drug delivery to the central nervous system: Present status and future outlook. Curr Pharm Des. 2013; 19: 510-526. CPD-EPUB-20121025-1 [pii]. PMID: 23116337
35. Gaskill BN. Thermal comfort in mice: Effects of behavioral thermoregulation on physiology. Ph.D., Purdue University. 2011. Available: http://search.proquest.com.libproxy.lib.unc.edu/docview/904416143?accountid=14244.
36. Bechard A, Meagher R, Mason G. Environmental enrichment reduces the likelihood of alopecia in adult C57BL/6J mice. J Am Assoc Lab AnimSci. 2011; 50:171-174. PMID: 21439209
37. Odlaug BL, Grant JE Pathologic skin picking. Am J Drug Alcohol Abuse. 2010; 36: 296-303. doi: 10.3109/00952991003747543 [doi]. PMID: 20575652
38. Mischley LK, Vespignani MF, Finnell JS Safety survey of intranasal glutathione. Journal of Alternative and Complementary Medicine. 2013; 19: 459-463.
39. Richter SH, Garner JP, Zipser B, Lewejohann L., Sachser N, Touma C, et al Effect of population heterogenization on the reproducibility of mouse behavior: A multi-laboratory study. PLoS One. 2011; 6: e16461. doi: 10.1371/journal.pone.0016461 [doi]. PMID: 21305027