Undetermined stroke with an embolic pattern-a common phenotype with high early recurrence risk

Annals of Medicine

Volumn 47, Issue 5, 2015, Pages 406-413

  Putaala, Jukka ^a   Nieminen, Tuomo ^a   Haapaniemi, Elena ^a   Meretoja, Atte ^a,b   Rantanen, Kirsi ^a   Heikkinen, Noora ^a   Kinnunen, Janne ^a   Strbian, Daniel ^a   Mustanoja, Satu ^a   Curtze, Sami ^a   Pakarinen, Sami ^a   Lehto, Mika ^a   Tatlisumak, Turgut ^a,c,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d Institute of Internal Medicine   (Sweden)

Author keywords

Atrial fibrillation; mortality; recurrence; stroke

Indexed keywords

ADULT; AGED; ANTICOAGULATION; ARTICLE; BRAIN ISCHEMIA; BRAIN SCINTISCANNING; CARDIOEMBOLIC STROKE; CEREBROVASCULAR ACCIDENT; CHADS2 SCORE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COMORBIDITY; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RECURRENCE RISK; RECURRENT DISEASE; RISK ASSESSMENT; RISK FACTOR; TRANSIENT ISCHEMIC ATTACK; UNDETERMINED STROKE WITH AN EMBOLIC PATTERN; AGE; COHORT ANALYSIS; COMPLICATION; COMPUTER ASSISTED TOMOGRAPHY; HEART DISEASES; INTRACRANIAL EMBOLISM; ISCHEMIC ATTACK, TRANSIENT; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; RETROSPECTIVE STUDY; STROKE; SWEDEN; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HEART DISEASES; HUMANS; INTRACRANIAL EMBOLISM; ISCHEMIC ATTACK, TRANSIENT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; RECURRENCE; RETROSPECTIVE STUDIES; STROKE; SWEDEN; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84940453638     PISSN: 07853890     EISSN: 13652060     Source Type: Journal    
DOI: 10.3109/07853890.2015.1057612     Document Type: Article

References (29)

1. Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, ODonnell MJ, et al. Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol. 2014; 1: 429-38.
2. Sacco RL, Prabhakaran S, Thompson JL, Murphy A, Sciacca RR, Levin B, et al. Comparison of warfarin versus aspirin for the prevention of recurrent stroke or death: subgroup analyses from the Warfarin-Aspirin Recurrent Stroke Study. Cerebrovasc Dis. 2006; 2: 4-12.
3. Palomeras Soler E, Fossas Felip P, Cano Orgaz AT, Sanz Cartagena P. Cryptogenic infarct. A follow-up period of 1 year study. Neurologia. 2009; 24: 304-8.
4. Soda T, Nakayasu H, Maeda M, Kusumi M, Kowa H, Awaki E, et al. Stroke recurrence within the first year following cerebral infarction-Tottori University Lacunar Infarction Prognosis Study (TULIPS). Acta Neurol Scand. 2004; 110: 343-9.
5. Mas JL, Arquizan C, Lamy C, Zuber M, Cabanes L, Derumeaux G, et al. Recurrent cerebrovascular events associated with patent foramen ovale, atrial septal aneurysm, or both. N Engl J Med. 2001; 345: 1740-6.
6. Putaala J, Haapaniemi E, Metso AJ, Metso TM, Artto V, Kaste M, et al. Recurrent ischemic events in young adults after first-ever ischemic stroke. Ann Neurol. 2010; 68: 661-71.
7. Furlan AJ, Reisman M, Massaro J, Mauri L, Adams H, Albers GW, et al. Closure or medical therapy for cryptogenic stroke with patent foramen ovale. N Engl J Med. 2012; 366: 991-9.
8. Homma S, DiTullio MR, Sacco RL, Sciacca RR, Mohr JP,; PICSS Investigators. Age as a determinant of adverse events in medically treated cryptogenic stroke patients with patent foramen ovale. Stroke. 2004; 3: 2145-9.
9. Arauz A, Murillo L, Marquez JM, Tamayo A, Cantu C, Roldan FJ, et al. Long-term risk of recurrent stroke in young cryptogenic stroke patients with and without patent foramen ovale. Int J Stroke. 2012; 7: 631-4.
10. Almekhlafi MA, Wilton SB, Rabi DM, Ghali WA, Lorenzetti DL, Hill MD. Recurrent cerebral ischemia in medically treated patent foramen ovale: a meta-analysis. Neurology. 2009; 73: 89-97.
11. De Castro S, Cartoni D, Fiorelli M, Rasura M, Anzini A, Zanette EM, et al. Morphological and functional characteristics of patent foramen ovale and their embolic implications. Stroke. 2000; 31: 2407-13.
12. Vallejos J, Jaramillo A, Reyes A, Illanes S, Orellana P, Manterola J, et al. Prognosis of cryptogenic ischemic stroke: a prospective single-center study in Chile. J Stroke Cerebrovasc Dis. 2012; 21: 621-8.
13. Weber R, Goertler M, Benemann J, Diener HC, Weimar C,;. German Stroke Study Collaboration. Prognosis after cryptogenic cerebral ischemia in patients with coagulopathies. Cerebrovasc Dis. 2009; 28: 611-17.
14. Petty GW, Brown RD Jr, Whisnant JP, Sicks JD, OFallon WM, Wiebers DO. Ischemic stroke subtypes: a population-based study of functional outcome, survival, and recurrence. Stroke. 2000; 31: 1062-8.
15. Kolominsky-Rabas PL, Weber M, Gefeller O, Neundoerfer B, Heuschmann PU. Epidemiology of ischemic stroke subtypes according to TOAST criteria: incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke. 2001; 32: 2735-40.
16. Gladstone DJ, Spring M, Dorian P, Panzov V, Thorpe KE, Hall J, et al. Atrial fibrillation in patients with cryptogenic stroke. N Engl J Med. 2014; 370: 2467-77.
17. Sanna T, Diener HC, Passman RS, Di Lazzaro V, Bernstein RA, Morillo CA, et al. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med. 2014; 370: 2478-86.
18. Ntaios G, Papavasileiou V, Milionis H, Makaritsis K, Manios E, Spengos K, et al. Embolic strokes of undetermined source in the athens stroke registry: a descriptive analysis. Stroke. 2015; 46: 176-81.
19. Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest. 2010; 137: 263-72.
20. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993; 24: 35-41.
21. Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005; 58: 688-97.
22. Mitchell LB, Southern DA, Galbraith D, Ghali WA, Knudtson M, Wilton SB, et al. Prediction of stroke or TIA in patients without atrial fibrillation using CHADS2 and CHA2DS2-VASc scores. Heart. 2014; 100: 1524-30.
23. Ntaios G, Vemmou A, Koroboki E, Savvari P, Makaritsis K, Saliaris M, et al. The type of atrial fibrillation is associated with long-term outcome in patients with acute ischemic stroke. Int J Cardiol. 2013; 167: 1519-23.
24. Bang OY, Lee PH, Joo SY, Lee JS, Joo IS, Huh K. Frequency and mechanisms of stroke recurrence after cryptogenic stroke. Ann Neurol. 2003; 54: 227-34.
25. Mohr JP, Thompson JL, Lazar RM, Levin B, Sacco RL, Furie KL, et al. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med. 2001; 345: 1444-51.
26. Grau AJ, Weimar C, Buggle F, Heinrich A, Goertler M, Neumaier S, et al. Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank. Stroke. 2001; 32: 2559-66.
27. Bang OY, Ovbiagele B, Kim JS. Evaluation of cryptogenic stroke with advanced diagnostic techniques. Stroke. 2014; 45: 1186-94.
28. Pajunen P, Koukkunen H, Ketonen M, Jerkkola T, Immonen-Raiha P, Karja-Koskenkari P, et al. The validity of the Finnish Hospital Discharge Register and Causes of Death Register data on coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2005; 12: 132-7.
29. Beigel R, Wunderlich NC, Ho SY, Arsanjani R, Siegel RJ. The left atrial appendage: anatomy, function, and noninvasive evaluation. JACC Cardiovasc Imaging. 2014; 7: 1251-65.