The importance of analysis of long-range rearrangement of BRCA1 and BRCA2 in genetic diagnosis of familial breast cancer

Cancer Genetics

Volumn 208, Issue 9, 2015, Pages 448-454

  Kwong, Ava ^a,b,c   Chen, Jiawei ^a   Shin, Vivian Y ^a   Ho, John C W ^a,b   Law, Fian B F ^b   Au, Chun Hang ^b   Chan, Tsun Leung ^b   Ma, Edmond S K ^b   Ford, James M ^c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b HONG KONG SANATORIUM AND HOSPITAL   (Hong Kong)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BRCA; Hereditary breast and ovarian cancers; Large genmic rearrangements; Multiplex ligation dependent probe amplification

Indexed keywords

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FALSE NEGATIVE RESULT; FAMILIAL CANCER; FAMILY HISTORY; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC SCREENING; GENETIC VARIABILITY; GERMLINE MUTATION; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; PRIORITY JOURNAL; SMALL NUCLEOTIDE VARIATION; TRIPLE NEGATIVE BREAST CANCER; TUMOR SUPPRESSOR GENE; BREAST TUMOR; GENETICS; HIGH THROUGHPUT SEQUENCING; MIDDLE AGED; MULTIPLEX POLYMERASE CHAIN REACTION; NUCLEOTIDE SEQUENCE; OVARY TUMOR; PROCEDURES; VERY ELDERLY; YOUNG ADULT;

BRCA1 PROTEIN; BRCA1 PROTEIN, HUMAN; BRCA2 PROTEIN; BRCA2 PROTEIN, HUMAN;

ADULT; AGED; AGED, 80 AND OVER; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC TESTING; GERM-LINE MUTATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MIDDLE AGED; MULTIPLEX POLYMERASE CHAIN REACTION; OVARIAN NEOPLASMS; YOUNG ADULT;

EID: 84940451201     PISSN: 22107762     EISSN: 22107770     Source Type: Journal    
DOI: 10.1016/j.cancergen.2015.05.031     Document Type: Article

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