Implementing Mass Cytometry at the Bedside to Study the Immunological Basis of Human Diseases: Distinctive Immune Features in Patients with a History of Term or Preterm Birth

Cytometry Part A

Volumn 87, Issue 9, 2015, Pages 817-829

  Gaudillière, Brice ^a   Ganio, Edward A ^a   Tingle, Martha ^a   Lancero, Hope L ^a   Fragiadakis, Gabriela K ^a,b   Baca, Quentin J ^a   Aghaeepour, Nima ^a   Wong, Ronald J ^a   Quaintance, Cele ^a   El Sayed, Yasser Y ^a   Shaw, Gary M ^a   Lewis, David B ^a   Stevenson, David K ^a   Nolan, Garry P ^a,b   Angst, Martin S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Clinical applications; CyTOF; Innate immunity; Mass cytometry; Monocytes; Preterm birth; Single cell; TLR4

Indexed keywords

ADULT; CROSS-SECTIONAL STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOLOGY; MONONUCLEAR CELL; NEWBORN; POINT OF CARE TESTING; PREGNANCY; PREMATURE BIRTH; PROCEDURES; TERM BIRTH;

ADULT; CROSS-SECTIONAL STUDIES; FEMALE; FLOW CYTOMETRY; HUMANS; INFANT, NEWBORN; LEUKOCYTES, MONONUCLEAR; POINT-OF-CARE TESTING; PREGNANCY; PREMATURE BIRTH; TERM BIRTH;

EID: 84940447814     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.22720     Document Type: Article

References (37)

1. Bendall SC, Simonds EF, Qiu P, Amir el AD, Krutzik PO, Finck R, Bruggner RV, Melamed R, Trejo A, Ornatsky OI, Balderas RS, Plevritis SK, Sachs K, Pe'er D, Tanner SD, Nolan GP. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 2011;332:687-696.
2. Bjornson ZB, Nolan GP, Fantl WJ. Single-cell mass cytometry for analysis of immune system functional states. Curr Opin Immunol 2013;25:484-494.
3. Bendall SC, Nolan GP. From single cells to deep phenotypes in cancer. Nat Biotechnol 2012;30:639-647.
4. Gaudilliere B, Fragiadakis GK, Bruggner RV, Nicolau M, Finck R, Tingle M, Silva J, Ganio EA, Yeh CG, Maloney WJ, Huddleston JI, Goodman SB, Davis MM, Bendall SC, Fantl WJ, Angst MS, Nolan GP. Clinical recovery from surgery correlates with single-cell immune signatures. Sci Transl Med 2014;6:255ra131.
5. Tarnok A. Revisiting the crystal ball-high content single cells analysis as predictor of recovery. Cytometry A 2015;87A:97-98.
6. Leipold MD. Another step on the path to mass cytometry standardization. Cytometry A J Int Soc Anal Cytol 2015;87:380-382.
7. Yao Y, Liu R, Shin MS, Trentalange M, Allore H, Nassar A, Kang I, Pober JS, Montgomery RR. CyTOF supports efficient detection of immune cell subsets from small samples. J Immunol Methods 2014;415:1-5.
8. Finck R, Simonds EF, Jager A, Krishnaswamy S, Sachs K, Fantl W, Pe'er D, Nolan GP, Bendall SC. Normalization of mass cytometry data with bead standards. Cytometry A 2013;83A:483-494.
9. Leipold MD, Maecker HT. Mass cytometry: Protocol for daily tuning and running cell samples on a CyTOF mass cytometer. J Vis Exp 2012;e439869.
10. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008;371:75-84.
11. Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, Cousens S, Mathers C, Black RE. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: An updated systematic analysis. Lancet 2015;385:430-440.
12. Romero R, Dey SK, Fisher SJ. Preterm labor: One syndrome, many causes. Science 2014;345:760-765.
13. Zhao H, Kalish F, Schulz S, Yang Y, Wong RJ, Stevenson DK. Unique roles of infiltrating myeloid cells in the murine uterus during early to midpregnancy. J Immunol 2015;194:3713-3722.
14. Harper M, Li L, Zhao Y, Klebanoff MA, Thorp JM Jr., Sorokin Y, Varner MW, Wapner RJ, Caritis SN, Iams JD, Carpenter MW, Peaceman AM, Mercer BM, Sciscione A, Rouse DJ, Ramin SM, Anderson GD, Eunice Kennedy Shriver National Institute of Child H. and Human Development Maternal-Fetal Medicine Units, N. Change in mononuclear leukocyte responsiveness in midpregnancy and subsequent preterm birth. Obstet Gynecol 2013;121:805-811.
15. Macey MG, McCarthy DA, Vordermeier S, Newland AC, Brown KA. Effects of cell purification methods on CD11b and L-selectin expression as well as the adherence and activation of leucocytes. J Immunol Methods 1995;181:211-219.
16. Souques F, Duperray C, Pene J, Bousquet J, Arnoux B. Modification of surface marker expression on CD14 monocytes of allergic patients after lysis or Ficoll purification. J Immunol Methods 1997;204:153-160.
17. Lundahl J, Hallden G, Hallgren M, Skold CM, Hed J. Altered expression of CD11b/CD18 and CD62L on human monocytes after cell preparation procedures. J Immunol Methods 1995;180:93-100.
18. Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Moser K, Ortmann WA, Espe KJ, Balasubramanian S, Hughes KM, Chan JP, Begovich A, Chang SY, Gregersen PK, Behrens TW. Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation. Genes Immun 2004;5:347-353.
19. Appay V, Reynard S, Voelter V, Romero P, Speiser DE, Leyvraz S. Immuno-monitoring of CD8+ T cells in whole blood versus PBMC samples. J Immunol Methods 2006;309:192-199.
20. Lu Y, Ahmed S, Harari F, Vahter M. Impact of Ficoll density gradient centrifugation on major and trace element concentrations in erythrocytes and blood plasma. J Trace Elements Med Biol Organ Soc Miner Trace Elements 2015;29:249-254.
21. Schulz KR, Danna EA, Krutzik PO, Nolan GP. Single-cell phospho-protein analysis by flow cytometry. Curr Protocols Immunol (edited by John E. Coligan, et al.) 2012;17:11-20.
22. Kay AW, Fukuyama J, Aziz N, Dekker CL, Mackey S, Swan GE, Davis MM, Holmes S, Blish CA. Enhanced natural killer-cell and T-cell responses to influenza A virus during pregnancy. Proc Natl Acad Sci USA 2014;111:14506-14511.
23. Bastek JA, Gomez LM, Elovitz MA. The role of inflammation and infection in preterm birth. Clin Perinatol 2011;38:385-406.
24. Erlebacher A. Immunology of the maternal-fetal interface. Annu Rev Immunol 2013;31:387-411.
25. Elovitz MA, Wang Z, Chien EK, Rychlik DF, Phillippe M. A new model for inflammation-induced preterm birth: The role of platelet-activating factor and Toll-like receptor-4. Am J Pathol 2003;163:2103-2111.
26. Tricot S, Meyrand M, Sammicheli C, Elhmouzi-Younes J, Corneau A, Bertholet S, Malissen M, Le Grand R, Nuti S, Luche H, Cosma A. Evaluating the efficiency of isotope transmission for improved panel design and a comparison of the detection sensitivities of mass cytometer instruments. Cytometry A 2015;87A:357-368.
27. Kraus TA, Sperling RS, Engel SM, Lo Y, Kellerman L, Singh T, Loubeau M, Ge Y, Garrido JL, Rodriguez-Garcia M, Moran TM. Peripheral blood cytokine profiling during pregnancy and post-partum periods. Am J Reprod Immunol 2010;64:411-426.
28. Bodenmiller B, Zunder ER, Finck R, Chen TJ, Savig ES, Bruggner RV, Simonds EF, Bendall SC, Sachs K, Krutzik PO, Nolan GP. Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nat Biotechnol 2012;30:858-867.
29. Zunder ER, Finck R, Behbehani GK, Amir el AD, Krishnaswamy S, Gonzalez VD, Lorang CG, Bjornson Z, Spitzer MH, Bodenmiller B, Fantl WJ, Pe'er D, Nolan GP. Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm. Nat Protocols 2015;10:316-333.
30. Maecker HT, McCoy JP, Nussenblatt R. Standardizing immunophenotyping for the human immunology project. Nat Rev Immunol 2012;12:191-200.
31. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 2004;430:257-263.
32. Bruggner RV, Bodenmiller B, Dill DL, Tibshirani RJ, Nolan GP. Automated identification of stratifying signatures in cellular subpopulations. Proc Natl Acad Sci USA 2014;111:E2770-E2777.
33. Aghaeepour N, Finak G, Flow CAPC, Consortium D, Hoos H, Mosmann TR, Brinkman R, Gottardo R, Scheuermann RH. Critical assessment of automated flow cytometry data analysis techniques. Nat Methods 2013;10:228-238.
34. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl AcadSci USA 2001;98:5116-5121.
35. Tibshirani R, Hastie T, Narasimhan B, Chu G. Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc Natl Acad Sci USA 2002;99:6567-6572.
36. Bardou M, Hadi T, Mace G, Pesant M, Debermont J, Barrichon M, Wendremaire M, Laurent N, Sagot P, Lirussi F. Systemic increase in human maternal circulating CD14+CD16- MCP-1+ monocytes as a marker of labor. Am J Obstet Gynecol 2014;210:70 e71-e79.
37. Gonzalez JM, Franzke CW, Yang F, Romero R, Girardi G. Complement activation triggers metalloproteinases release inducing cervical remodeling and preterm birth in mice. Am J Pathol 2011;179:838-849.