Phage display and synthetic peptides as promising biotechnological tools for the serological diagnosis of leprosy

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Alban, Silvana Maria ^a   De Moura, Juliana Ferreira ^a   Thomaz Soccol, Vanete ^a   Sékula, Samira Bührer ^b   Alvarenga, Larissa Magalhães ^b   Mira, Marcelo Távora ^c   Olortegui, Carlos Chávez ^d   Minozzo, João Carlos ^e  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^e Department of Biochemistry and Immunology Federal University of Minas Gerais ^*  (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; MYCOBACTERIUM ANTIGEN; PEPTIDE ANTIBODY; PEPTIDE MIMOTOPE; POLYCLONAL ANTISERUM; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; BACTERIUM ANTIBODY; PEPTIDE LIBRARY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY PRODUCTION; ANTIGEN BINDING; ANTIGEN RECOGNITION; AREA UNDER THE CURVE; ARTICLE; BIOTECHNOLOGY; CLINICAL ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOREACTIVITY; IN VITRO STUDY; LEPROSY; MOLECULAR CLONING; MOUSE; MULTIBACILLARY LEPROSY; MYCOBACTERIUM LEPRAE; NONHUMAN; PAUCIBACILLARY LEPROSY; PEPTIDE LIBRARY; PEPTIDE SYNTHESIS; PHAGE DISPLAY; PROTEIN ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; SEQUENCE ALIGNMENT; SERODIAGNOSIS; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING; YOUDEN INDEX; ANIMAL; BLOOD; BOVINE; CHEMISTRY; RABBIT;

ANIMALS; ANTIBODIES, BACTERIAL; CATTLE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LEPROSY; MICE; MYCOBACTERIUM LEPRAE; PEPTIDE LIBRARY; RABBITS;

EID: 84940319081     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0106222     Document Type: Article

References (27)

1. Britton WJ, Lockwood DNJ (2004) Leprosy. Lancet 363: 1209-1219. (Pubitemid 38481849)
2. World Health Organization (2012) Global leprosy situation, 2012. Available: http://www.who.int/wer/2012/wer8734/en/index.html. Accessed 21 September 2012.
3. Geluk A, van der Ploeg J, Teles ROB, Franken KLMC, Prins C, et al. (2008) Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection. Clin Vaccine Immunol 15: 522-533. (Pubitemid 351967078)
4. Alban SM, Sella SR, Miranda RN, Mira MT, Thomaz-Soccol V (2009) PCR-restriction fragment length polymorphism analysis as a tool for Mycobacterium species identification in lepromas for lepromin production. Lepr Rev 80: 129-142.
5. Lockwood DNJ (2005) Leprosy. Medicine 33: 26-29.
6. World Health Organization (1997) WHO Seventh Expert Committee Report, June 1997. Available: http://www.who.int/lep/resources/Expert.pdf. Accessed1 July 2010.
7. Bührer-Sékula S, Visschedijk J, Grossi MA, Dhakal KP, Namadi AU, et al. (2007) The ML flow test as a point of care test for leprosy control programmes: potential effects on classification of leprosy patients. Lepr Rev 78: 70-79. (Pubitemid 47105482)
8. Duthie MS, Goto W, Ireton GC, Reece ST, Cardoso LPV, et al. (2007) Use of protein antigens for early serological diagnosis of leprosy. Clin Vaccine Immunol 14: 1400-1408. (Pubitemid 350304031)
9. Stefani MM (2008) Challenges in the post genomic era for the development of tests for leprosy diagnosis. Rev Soc Bras Med Trop (Suppl 2): 89-94.
10. Duthie MS, Ireton GC, Kanaujia GV, Goto W, Liang H, et al. (2008) Selection of antigens and development of prototype tests for point-of-care leprosy diagnosis. Clin Vaccine Immunol 15: 1590-1597.
11. Geluk A, Spencer JS, Bobosha K, Pessolani MC, Pereira GM, et al. (2009) From genome-based in silico predictions to ex vivo verification of leprosy diagnosis. Clin Vaccine Immunol 16: 352-359.
12. Alban SM, de Moura JF, Minozzo JC, Mira MT, Thomaz Soccol V (2013) Identification of mimotopes of Mycobacterium leprae as potential diagnostic reagents. BMC Infect Dis 13: 42.
13. Thomaz Soccol V, Alban SM, de Moura JF (2011) Uso de peptídeos miméticos de Mycobacterium leprae para diagnóstico e vacinas. Brazilian Patent PI015110000997.
14. Frank R (1992) Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron 48: 9217-9232.
15. Harlow E, Lane D (1988)Antibodies: A laboratory manual. Cold Spring Harbor Laboratory Press. 726 p.
16. Pessolani MC, Brennan PJ (1992) Mycobacterium leprae produces extracellular homologs of the antigen 85 complex. Infect Immun 60: 4452-4459.
17. Metz CE (1978) Basic principles of ROC analysis. Semin Nucl Med 8: 283-289.
18. Zweig MH, Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39: 561-577. (Pubitemid 23118304)
19. Youden WJ (1950) Index for rating diagnostic tests. Cancer 3: 32-35.
20. Meyer CG, May J, Stark K (1998) Human leukocyte antigens in tuberculosis and leprosy. Trends Microbiol 6: 148-154. (Pubitemid 28197804)
21. Lyashchenko K, Colangeli R, Houde M, Al Jahdali H, Menzies D, et al. (1998) Heterogeneous antibody responses in tuberculosis. Infect Immun 66: 3936-3940. (Pubitemid 28347858)
22. Monot M, Honoré N, Garnier T, Zidane N, Sherafi D, et al. (2009) Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat Genet 41: 1282-1289.
23. Aráoz R, Honoré N, Banu S, Demangel C, Cissoko Y, et al. (2006) Towards an immunodiagnostic test for leprosy. Microbes Infect 8: 2270-2276. (Pubitemid 44322057)
24. Aseffa A, Brennan P, Dockrell H, Gillis T, Hussain R, et al. (2005) Report on the first meeting of the IDEAL (Initiative for Diagnostic and Epidemiological Assays for Leprosy) consortium held at Armauer Hansen Research Institute, ALERT, Addis Ababa, Ethiopia on 24-27 October 2004. Lepr Rev 76: 147-159. (Pubitemid 41039744)
25. Van Regenmortel MH (2001) Antigenicity and immunogenicity of synthetic peptides. Biologicals 29: 209-213.
26. Thole JE, Schöningh R, Janson AA, Garbe T, Cornelisse YE, et al. (1992) Molecular and immunological analysis of a fibronectin-binding protein antigen secreted by Mycobacterium leprae. Mol Microbiol 6: 153-163.
27. Filley E, Thole JE, Rook GA, Nagai S, Waters M, et al. (1994) Identification of an antigenic domain on Mycobacterium leprae protein antigen 85B, which is specifically recognized by antibodies from patients with leprosy. J Infect Dis 169: 162-169. Tecnológico Inovação Nível Superior