The Safety of Yoga: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

American Journal of Epidemiology

Volumn 182, Issue 4, 2015, Pages 281-293

  Cramer, Holger ^a,b   Ward, Lesley ^b,c   Saper, Robert ^d   Fishbein, Daniel ^e   Dobos, Gustav ^a   Lauche, Romy ^a,b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Myanmar Research International   (United States)

Author keywords

adverse events; complementary therapies; meta analysis; review; safety; yoga

Indexed keywords

COMPLEMENTARITY; DISEASE CONTROL; DISEASE TREATMENT; FREQUENCY ANALYSIS; HEALTH CARE; LITERATURE REVIEW; META-ANALYSIS;

ATTRIBUTABLE RISK; COMPARATIVE STUDY; EXERCISE; FOLLOW UP; HEALTH EDUCATION; HUMAN; KINESIOTHERAPY; META ANALYSIS; OUTCOME ASSESSMENT; PATIENT SAFETY; PHYSIOTHERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; SYSTEMATIC REVIEW; YOGA; ADOLESCENT; ADULT; ADVERSE EFFECTS; AGED; ALTERNATIVE MEDICINE; BIBLIOGRAPHIC DATABASE; CHILD; FEMALE; MALE; MIDDLE AGED; SAFETY; STATISTICS AND NUMERICAL DATA; VERY ELDERLY; WOUNDS AND INJURIES; YOUNG ADULT;

SCOPUS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; DATABASES, BIBLIOGRAPHIC; FEMALE; HUMANS; MALE; MIDDLE AGED; MIND-BODY THERAPIES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SAFETY; WOUNDS AND INJURIES; YOGA; YOUNG ADULT;

EID: 84940183928     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwv071     Document Type: Review

References (149)

1. Iyengar BKS. Light on Yoga. New York, NY: Schocken Books; 1966.
2. Feuerstein G. The Yoga Tradition. Prescott, AZ: Hohm Press; 1998.
3. De Michaelis E. A History of Modern Yoga: Patanjali and Western Esotericism. London, UK: Continuum International Publishing Group; 2005.
4. Macy D. Yoga journal releases 2008 "Yoga in America" market study. http://www3.yogajournal.com/advertise/press-releases/10. Accessed November 3, 2014.
5. Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Rep. 2008;12:1-23.
6. Krucoff C. Insight from injury. If the practice of hatha yoga was meant to heal, why are so many yogis getting hurt? Yoga J. 2003;203:120-124.
7. McCall T. Working with students who have yoga injuries, part 1. http://www.yogajournal.com/for-teachers/2634. Published August 27, 2008. Accessed November 3, 2014.
8. Broad WJ. How yoga can wreck your body. http://www.nytimes.com/2012/01/08/magazine/how-yoga-can-wreckyour-body.html?pagewanted=all&-r=0. Published January 5, 2012. Accessed November 3, 2014.
9. Grant D. The 10 best responses to New York Times magazine's yoga article. http://observer.com/2012/01/the-10-best-responses-to-new-york-times-magazine-yoga-article/. Published December 12, 2012. Accessed November 3, 2014.
10. Fishbein D, Barrett L, Teranishi R, et al. Is yoga really dangerous? A systematic review of adverse events reported in the medical literature. J Altern Complement Med. 2014;20(5):A21.
11. Cramer H, Krucoff C, Dobos G. Adverse events associated with yoga: a systematic review of published case reports and case series. PLoS One. 2013;8(10):e75515.
12. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.
13. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions. West Sussex, UK: John Wiley & Sons, Ltd; 2008.
14. US Food and Drug Administration. Safety. http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm. Updated October 1, 2014. Accessed November 3, 2014.
15. Bradburn MJ, Deeks JJ, Berlin JA, et al. Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events. Stat Med. 2007;26(1):53-77.
16. Sweeting MJ, Sutton AJ, Lambert PC. What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data. Stat Med. 2004;23(9):1351-1375.
17. nd ed. London, UK: BMJ Publication Group; 2001:313-335.
18. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-560.
19. Afonso RF, Hachul H, Kozasa EH, et al. Yoga decreases insomnia in postmenopausal women: a randomized clinical trial. Menopause. 2012;19(2):186-193.
20. Bali Y, Ebnezar J. Efficacy of mind sound resonance technique in common neck pain. Int J Res Ayurveda Pharm. 2012;3(2):227-232.
21. Bilderbeck AC, Farias M, Brazil IA, et al. Participation in a 10-week course of yoga improves behavioural control and decreases psychological distress in a prison population. J Psychiatr Res. 2013;47(10):1438-1445.
22. Blank SE, Kittel J, Haberman MR. Active practice of Iyengar yoga as an intervention for breast cancer survivors. Int J Yoga Ther. 2003;15(1):51-59.
23. Bower JE, Garet D, Sternlieb B, et al. Yoga for persistent fatigue in breast cancer survivors: a randomized controlled trial. Cancer. 2012;118(15):3766-3775.
24. Cade WT, Reeds DN, Mondy KE, et al. Yoga lifestyle intervention reduces blood pressure in HIV-infected adults with cardiovascular disease risk factors. HIV Med. 2010;11(6):379-388.
25. Carson JW, Carson KM, Porter LS, et al. Yoga of Awareness program for menopausal symptoms in breast cancer survivors: results from a randomized trial. Support Care Cancer. 2009;17(10):1301-1309.
26. Carter JJ, Gerbarg PL, Brown RP, et al. Multi-component yoga breath program for Vietnam veteran post traumatic stress disorder: randomized controlled trial. J Trauma Stress Disord Treat. 2013;2:3.
27. Cebrià i Iranzo MD, Arnall DA, Igual Camacho C, et al. Effects of inspiratory muscle training and yoga breathing exercises on respiratory muscle function in institutionalized frail older adults: a randomized controlled trial. J Geriatr Phys Ther. 2014;37(2):65-75.
28. Chan W, Immink MA, Hillier S. Yoga and exercise for symptoms of depression and anxiety in people with poststroke disability: a randomized, controlled pilot trial. Altern Ther Health Med. 2012;18(3):34-43.
29. Chattha R, Nagarathna R, Padmalatha V, et al. Effect of yoga on cognitive functions in climacteric syndrome: a randomised control study. BJOG. 2008;115(8):991-1000.
30. Chattha R, Raghuram N, Venkatram P, et al. Treating the climacteric symptoms in Indian women with an integrated approach to yoga therapy: a randomized control study. Menopause. 2008;15(5):862-870.
31. Cheema BS, Houridis A, Busch L, et al. Effect of an office worksite-based yoga program on heart rate variability: outcomes of a randomized controlled trial. BMC Complement Altern Med. 2013;13:82.
32. Chen KM, Chen MH, Chao HC, et al. Sleep quality, depression state, and health status of older adults after silver yoga exercises: cluster randomized trial. Int J Nurs Stud. 2009;46(2):154-163.
33. Chen KM, Chen MH, Lin MH, et al. Effects of yoga on sleep quality and depression in elders in assisted living facilities. J Nurs Res. 2010;18(1):53-61.
34. Chen KM, Fan JT, Wang HH, et al. Silver yoga exercises improved physical fitness of transitional frail elders. Nurs Res. 2010;59(5):364-370.
35. Cohen BE, Chang AA, Grady D, et al. Restorative yoga in adults with metabolic syndrome: a randomized, controlled pilot trial. Metab Syndr Relat Disord. 2008;6(3):223-229.
36. Cohen DL, Bloedon LT, Rothman RL, et al. Iyengar yoga versus enhanced usual care on blood pressure in patients with prehypertension to stage I hypertension: a randomized controlled trial. Evid Based Complement Alternat Med. 2011;2011:546428.
37. Colgrove YS, Sharma N, Kluding P, et al. Effect of yoga on motor function in people with Parkinson's disease: a randomized, controlled pilot study. J Yoga Phys Ther. 2012;2(2):112.
38. Cramer H, Lauche R, Hohmann C, et al. Randomized-controlled trial comparing yoga and home-based exercise for chronic neck pain. Clin J Pain. 2013;29(3):216-223.
39. Culos-Reed SN, Carlson LE, Daroux LM, et al. A pilot study of yoga for breast cancer survivors: physical and psychological benefits. Psychooncology. 2006;15(10):891-897.
40. Culos-Reed SN, Carlson LE, Daroux LM, et al. Discovering the physical and psychological benefits of yoga for cancer survivors. Int J Yoga Ther. 2004;14(1):45-52.
41. Deshpande S, Nagendra HR, Raghuram N. A randomized control trial of the effect of yoga on gunas (personality) and health in normal healthy volunteers. Int J Yoga. 2008;1(1):2-10.
42. Deshpande S, Nagendra HR, Raghuram N. A randomized control trial of the effect of yoga on verbal aggressiveness in normal healthy volunteers. Int J Yoga. 2008;1(2):76-82.
43. Deshpande S, Nagendra HR, Nagarathna R. A randomized control trial of the effect of yoga on gunas (personality) and self esteem in normal healthy volunteers. Int J Yoga. 2009;2(1):13-21.
44. Dhruva A, Miaskowski C, Abrams D, et al. Yoga breathing for cancer chemotherapy-associated symptoms and quality of life: results of a pilot randomized controlled trial. J Altern Complement Med. 2012;18(5):473-479.
45. Donesky-Cuenco D, Nguyen HQ, Paul S, et al. Yoga therapy decreases dyspnea-related distress and improves functional performance in people with chronic obstructive pulmonary disease: a pilot study. J Altern Complement Med. 2009;15(3):225-234.
46. Duraiswamy G, Thirthalli J, Nagendra HR, et al. Yoga therapy as an add-on treatment in the management of patients with schizophrenia - a randomized controlled trial. Acta Psychiatr Scand. 2007;116(3):226-232.
47. Ebnezar J, Nagarathna R, Bali Y, et al. Effect of an integrated approach of yoga therapy on quality of life in osteoarthritis of the knee joint: a randomized control study. Int J Yoga. 2011;4(2):55-63.
48. Ebnezar J, Nagarathna R, Yogitha B, et al. Effects of an integrated approach of hatha yoga therapy on functional disability, pain, and flexibility in osteoarthritis of the knee joint: a randomized controlled study. J Altern Complement Med. 2012;18(5):463-472.
49. Ebnezar J, Nagarathna R, Yogitha B, et al. Effect of integrated yoga therapy on pain, morning stiffness and anxiety in osteoarthritis of the knee joint: a randomized control study. Int J Yoga. 2012;5(1):28-36.
50. Ebnezar J, Yogitha B. Effectiveness of yoga therapy with the therapeutic exercises on walking pain, tenderness, early morning stiffness and disability in osteoarthritis of the knee joint - a comparative study. J Yoga Phys Ther. 2012;2(3):114.
51. Elavsky S, McAuley E. Exercise and self-esteem in menopausal women: a randomized controlled trial involving walking and yoga. Am J Health Promot. 2007;22(2):83-92.
52. Elavsky S, McAuley E. Physical activity and mental health outcomes during menopause: a randomized controlled trial. Ann Behav Med. 2007;33(2):132-142.
53. Evans S, Moieni M, Lung K, et al. Impact of Iyengar yoga on quality of life in young women with rheumatoid arthritis. Clin J Pain. 2013;29(11):988-997.
54. Field T, Diego M, Delgado J, et al. Yoga and social support reduce prenatal depression, anxiety and cortisol. J Yoga Phys Ther. 2012;2:124.
55. Field T, Diego M, Delgado J, et al. Yoga and social support reduce prenatal depression, anxiety and cortisol. J Bodyw Mov Ther. 2013;17(4):397-403.
56. Field T, Diego M, Delgado J, et al. Tai chi/yoga reduces prenatal depression, anxiety and sleep disturbances. Complement Ther Clin Pract. 2013;19(1):6-10.
57. Franzblau SH, Echevarria S, Smith M, et al. A preliminary investigation of the effects of giving testimony and learning yogic breathing techniques on battered women's feelings of depression. J Interpers Violence. 2008;23(12):1800-1808.
58. Franzblau SH, Smith M, Echevarria S, et al. Take a breath, break the silence: the effects of yogic breathing and testimony about battering on feelings of self-efficacy in battered women. Int J Yoga Ther. 2006;16(1):49-57.
59. Garrett M, Hogan N, Larkin A, et al. Exercise in the community for people with minimal gait impairment due to MS: an assessor-blind randomized controlled trial. Mult Scler. 2013;19(6):782-789.
60. Ghoncheh S, Smith JC. Progressive muscle relaxation, yoga stretching, and ABC relaxation theory. J Clin Psychol. 2004;60(1):131-136.
61. Gould LF, Dariotis JK, Mendelson T, et al. A school-based mindfulness intervention for urban youth: exploring moderators of intervention effects. J Commun Psychol. 2012;40(8):968-982.
62. Hagins M, Rundle A, Consedine NS, et al. A randomized controlled trial comparing the effects of yoga with an active control on ambulatory blood pressure in individuals with prehypertension and stage 1 hypertension. J Clin Hypertens. 2014;16(1):54-62.
63. Harbans S, Anjali S, Smita J. Comparative clinical evaluation of the antidyslipidaemic effects of lashunadi compound and yogic exercises in patients of metabolic syndrome. Indian J Trad Know. 2011;10(4):651-656.
64. Hariprasad VR, Koparde V, Sivakumar PT, et al. Randomized clinical trial of yoga-based intervention in residents from elderly homes: effects on cognitive function. Indian J Psychiatry. 2013;55(suppl 3):S357-S363.
65. Hariprasad VR, Sivakumar PT, Koparde V, et al. Effects of yoga intervention on sleep and quality-of-life in elderly: a randomized controlled trial. Indian J Psychiatry. 2013;55(suppl 3):S364-S368.
66. Hegde SV, Adhikari P, Shetty S, et al. Effect of community-based yoga intervention on oxidative stress and glycemic parameters in prediabetes: a randomized controlled trial. Complement Ther Med. 2013;21(6):571-576.
67. Hogan N, Kehoe M, Larkin A, et al. The effect of community exercise interventions for people with MS who use bilateral support for gait. Mult Scler Int. 2014;2014:109142.
68. Huang AJ, Jenny HE, Chesney MA, et al. A group-based yoga therapy intervention for urinary incontinence in women: a pilot randomized trial. Female Pelvic Med Reconstr Surg. 2014;20(3):147-154.
69. Ikai S, Uchida H, Suzuki T, et al. Effects of yoga therapy on postural stability in patients with schizophrenia-spectrum disorders: a single-blind randomized controlled trial. J Psychiatr Res. 2013;47(11):1744-1750.
70. Innes KE, Selfe TK. The effects of a gentle yoga program on sleep, mood, and blood pressure in older women with restless legs syndrome (RLS): a preliminary randomized controlled trial. Evid Based Complement Alternat Med. 2012;2012:294058.
71. Jensen PS, Kenny DT. The effects of yoga on the attention and behavior of boys with attention-deficit/hyperactivity disorder (ADHD). J Atten Disord. 2004;7(4):205-216.
72. John PJ, Sharma N, Sharma CM, et al. Effectiveness of yoga therapy in the treatment of migraine without aura: a randomized controlled trial. Headache. 2007;47(5):654-661.
73. Kiecolt-Glaser JK, Bennett JM, Andridge R, et al. Yoga's impact on inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial. J Clin Oncol. 2014;32(10):1040-1049.
74. Kim S, Bemben MG, Bemben DA. Effects of an 8-month yoga intervention on arterial compliance and muscle strength in premenopausal women. J Sports Sci Med. 2012;11(2):322-330.
75. Köhn M, Persson Lundholm U, Bryngelsson IL, et al. Medical yoga for patients with stress-related symptoms and diagnoses in primary health care: a randomized controlled trial. Evid Based Complement Alternat Med. 2013;2013:215348.
76. Littman AJ, Bertram LC, Ceballos R, et al. Randomized controlled pilot trial of yoga in overweight and obese breast cancer survivors: effects on quality of life and anthropometric measures. Support Care Cancer. 2012;20(2):267-277.
77. Manchanda SC, Narang R, Reddy KS, et al. Retardation of coronary atherosclerosis with yoga lifestyle intervention. J Assoc Physicians India. 2000;48(7):687-694.
78. Manocha R, Marks GB, Kenchington P, et al. Sahaja yoga in the management of moderate to severe asthma: a randomised controlled trial. Thorax. 2002;57(2):110-115.
79. Martins RF, Pinto e Silva JL. Treatment of pregnancy-related lumbar and pelvic girdle pain by the yoga method: a randomized controlled study. J Altern Complement Med. 2014;20(1):24-31.
80. McIver S, O'Halloran P, McGartland M. Yoga as a treatment for binge eating disorder: a preliminary study. Complement Ther Med. 2009;17(4):196-202.
81. Michalsen A, Jeitler M, Brunnhuber S, et al. Iyengar yoga for distressed women: a 3-armed randomized controlled trial. Evid Based Complement Alternat Med. 2012;2012:408727.
82. Michalsen A, Traitteur H, Lüdtke R, et al. Yoga for chronic neck pain: a pilot randomized controlled clinical trial. J Pain. 2012;13(11):1122-1130.
83. Moadel AB, Shah C, Wylie-Rosett J, et al. Randomized controlled trial of yoga among a multiethnic sample of breast cancer patients: effects on quality of life. J Clin Oncol. 2007;25(28):4387-4395.
84. Mustian KM, Sprod LK, Janelsins M, et al. Multicenter, randomized controlled trial of yoga for sleep quality among cancer survivors. J Clin Oncol. 2013;31(26):3233-3241.
85. Nagarathna R, Usharani MR, Rao AR, et al. Efficacy of yoga based life style modification program on medication score and lipid profile in type 2 diabetes - a randomized control study. Int J Diabetes Dev Countries. 2012;32(3):122-130.
86. Newham JJ, Wittkowski A, Hurley J, et al. Effects of antenatal yoga on maternal anxiety and depression: a randomized controlled trial. Depress Anxiety. 2014;31(8):631-640.
87. Newton KM, Reed SD, Guthrie KA, et al. Efficacy of yoga for vasomotor symptoms: a randomized controlled trial. Menopause. 2014;21(4):339-346.
88. Noggle JJ, Steiner NJ, Minami T, et al. Benefits of yoga for psychosocial well-being in a US high school curriculum: a preliminary randomized controlled trial. J Dev Behav Pediatr. 2012;33(3):193-201.
89. Oken BS, Kishiyama S, Zajdel D, et al. Randomized controlled trial of yoga and exercise in multiple sclerosis. Neurology. 2004;62(11):2058-2064.
90. Oken BS, Zajdel D, Kishiyama S, et al. Randomized, controlled, six-month trial of yoga in healthy seniors: effects on cognition and quality of life. Altern Ther Health Med. 2006;12(1):40-47.
91. Pal A, Srivastava N, Narain VS, et al. Effect of yogic intervention on the autonomic nervous system in the patients with coronary artery disease: a randomized controlled trial. East Mediterr Health J. 2013;19(5):452-458.
92. Pal A, Srivastava N, Tiwari S, et al. Effect of yogic practices on lipid profile and body fat composition in patients of coronary artery disease. Complement Ther Med. 2011;19(3):122-127.
93. Park J, McCaffrey R, Dunn D, et al. Managing osteoarthritis: comparisons of chair yoga, Reiki, and education (pilot study). Holist Nurs Pract. 2011;25(6):316-326.
94. Patel C, North WR. Randomised controlled trial of yoga and bio-feedback in management of hypertension. Lancet. 1975;2(7925):93-95.
95. Pullen PR, Nagamia SH, Mehta PK, et al. Effects of yoga on inflammation and exercise capacity in patients with chronic heart failure. J Card Fail. 2008;14(5):407-413.
96. Rakhshani A, Nagarathna R, Mhaskar R, et al. The effects of yoga in prevention of pregnancy complications in high-risk pregnancies: a randomized controlled trial. Prev Med. 2012;55(4):333-340.
97. Rani M, Singh U, Agrawal GG, et al. Impact of Yoga Nidra on menstrual abnormalities in females of reproductive age. J Altern Complement Med. 2013;19(12):925-929.
98. Rao MR, Raghuram N, Nagendra HR, et al. Anxiolytic effects of a yoga program in early breast cancer patients undergoing conventional treatment: a randomized controlled trial. Complement Ther Med. 2009;17(1):1-8.
99. Sabina AB, Williams AL, Wall HK, et al. Yoga intervention for adults with mild-to-moderate asthma: a pilot study. Ann Allergy Asthma Immunol. 2005;94(5):543-548.
100. Sakuma Y, Sasaki-Otomaru A, Ishida S, et al. Effect of a home-based simple yoga program in child-care workers: a randomized controlled trial. J Altern Complement Med. 2012;18(8):769-776.
101. Saper RB, Sherman KJ, Cullum-Dugan D, et al. Yoga for chronic low back pain in a predominantly minority population: a pilot randomized controlled trial. Altern Ther Health Med. 2009;15(6):18-27.
102. Satyapriya M, Nagarathna R, Padmalatha V, et al. Effect of integrated yoga on anxiety, depression & well being in normal pregnancy. Complement Ther Clin Pract. 2013;19(4):230-236.
103. Satyapriya M, Nagendra HR, Nagarathna R, et al. Effect of integrated yoga on stress and heart rate variability in pregnant women. Int J Gynaecol Obstet. 2009;104(3):218-222.
104. Schmid AA, Van Puymbroeck M, Altenburger PA, et al. Poststroke balance improves with yoga: a pilot study. Stroke. 2012;43(9):2402-2407.
105. Shantakumari N, Sequeira S, El deeb R. Effects of a yoga intervention on lipid profiles of diabetes patients with dyslipidemia. Indian Heart J. 2013;65(2):127-131.
106. Sherman KJ, Cherkin DC, Erro J, et al. Comparing yoga, exercise, and a self-care book for chronic low back pain: a randomized, controlled trial. Ann Intern Med. 2005;143(12):849-856.
107. Sherman KJ, Cherkin DC, Wellman RD, et al. A randomized trial comparing yoga, stretching, and a self-care book for chronic low back pain. Arch Intern Med. 2011;171(22):2019-2026.
108. Singh V, Wisniewski A, Britton J, et al. Effect of yoga breathing exercises (pranayama) on airway reactivity in subjects with asthma. Lancet. 1990;335(8702):1381-1383.
109. Smith C, Hancock H, Blake-Mortimer J, et al. A randomised comparative trial of yoga and relaxation to reduce stress and anxiety. Complement Ther Med. 2007;15(2):77-83.
110. Sobana R, Parthasarathy S, Duraisamy, et al. The effect of yoga therapy on selected psychological variables among male patients with insomnia. J Clin Diagn Res. 2013;7(1):55-57.
111. Subramanian H, Soudarssanane MB, Jayalakshmy R, et al. Non-pharmacological interventions in hypertension: a community-based cross-over randomized controlled trial. Indian J Community Med. 2011;36(3):191-196.
112. Telles S, Singh N, Bhardwaj AK, et al. Effect of yoga or physical exercise on physical, cognitive and emotional measures in children: a randomized controlled trial. Child Adolesc Psychiatry Ment Health. 2013;7(1):37.
113. Telles S, Singh N, Joshi M, et al. Post traumatic stress symptoms and heart rate variability in Bihar flood survivors following yoga: a randomized controlled study. BMC Psychiatry. 2010;10:18.
114. Telles S, Yadav A, Kumar N, et al. Blood pressure and Purdue pegboard scores in individuals with hypertension after alternate nostril breathing, breath awareness, and no intervention. Med Sci Monit. 2013;19:61-66.
115. Tiedemann A, O'Rourke S, Sesto R, et al. A 12-week Iyengar yoga program improved balance and mobility in older community-dwelling people: a pilot randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2013;68(9):1068-1075.
116. Tilbrook HE, Cox H, Hewitt CE, et al. Yoga for chronic low back pain: a randomized trial. Ann Intern Med. 2011;155(9):569-578.
117. Vadiraja HS, Raghavendra RM, Nagarathna R, et al. Effects of a yoga program on cortisol rhythm and mood states in early breast cancer patients undergoing adjuvant radiotherapy: a randomized controlled trial. Integr Cancer Ther. 2009;8(1):37-46.
118. Vadiraja HS, Rao MR, Nagarathna R, et al. Effects of yoga program on quality of life and affect in early breast cancer patients undergoing adjuvant radiotherapy: a randomized controlled trial. Complement Ther Med. 2009;17(5-6):274-280.
119. Vadiraja HS, Rao MR, Nagendra RH, et al. Effects of yoga on symptom management in breast cancer patients: a randomized controlled trial. Int J Yoga. 2009;2(2):73-79.
120. Vaishali K, Kumar KV, Adhikari P, et al. Effects of yoga-based program on glycosylated hemoglobin level serum lipid profile in community dwelling elderly subjects with chronic type 2 diabetes mellitus - a randomized controlled trial. Phys Occup Ther Geriatr. 2012;30(1):22-30.
121. Van Puymbroeck M, Payne LL, Hsieh PC. A phase I feasibility study of yoga on the physical health and coping of informal caregivers. Evid Based Complement Alternat Med. 2007;4(4):519-529.
122. Visceglia E, Lewis S. Yoga therapy as an adjunctive treatment for schizophrenia: a randomized, controlled pilot study. J Altern Complement Med. 2011;17(7):601-607.
123. Vogler J, O'Hara L, Gregg J, et al. The impact of a short-term Iyengar yoga program on the health and well-being of physically inactive older adults. Int J Yoga Ther. 2011;21:61-72.
124. Williams K, Abildso C, Steinberg L, et al. Evaluation of the effectiveness and efficacy of Iyengar yoga therapy on chronic low back pain. Spine. 2009;34(19):2066-2076.
125. Williams KA, Petronis J, Smith D, et al. Effect of Iyengar yoga therapy for chronic low back pain. Pain. 2005;115(1-2):107-117.
126. Yang K, Bernardo LM, Sereika SM, et al. Utilization of 3-month yoga program for adults at high risk for type 2 diabetes: a pilot study. Evid Based Complement Alternat Med. 2011;2011:257891.
127. Yogitha B, Ebnezar J. Effect of yoga therapy and conventional treatment in the management of common neck pain - a comparative study. J Yoga Phys Ther. 2012;2:108.
128. Yogitha B, Nagarathna R, John E, et al. Complimentary effect of yogic sound resonance relaxation technique in patients with common neck pain. Int J Yoga. 2010;3(1):18-25.
129. Yurtkuran M, Alp A, Yurtkuran M, et al. A modified yoga-based exercise program in hemodialysis patients: a randomized controlled study. Complement Ther Med. 2007;15(3):164-171.
130. Cramer H, Lauche R, Haller H, et al. A systematic review and meta-analysis of yoga for low back pain. Clin J Pain. 2013;29(5):450-460.
131. Ward L, Stebbings S, Cherkin D, et al. Yoga for functional ability, pain and psychosocial outcomes in musculoskeletal conditions: a systematic review and meta-analysis. Musculoskeletal Care. 2013;11(4):203-217.
132. Cramer H, Haller H, Lauche R, et al. A systematic review and meta-analysis of yoga for hypertension. Am J Hypertens. 2014;27(9):1146-1151.
133. Cramer H, Lauche R, Haller H, et al. A systematic review of yoga for heart disease. Eur J Prev Cardiol. 2015;22(3):284-295.
134. Cramer H, Lauche R, Haller H, et al. Effects of yoga on cardiovascular disease risk factors: a systematic review and meta-analysis. Int J Cardiol. 2014;173(2):170-183.
135. Cramer H, Posadzki P, Dobos G, et al. Yoga for asthma: a systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2014;112(6):503-510.e5.
136. Buffart LM, van Uffelen JG, Riphagen II, et al. Physical and psychosocial benefits of yoga in cancer patients and survivors, a systematic review and meta-analysis of randomized controlled trials. BMC Cancer. 2012;12:559.
137. Cramer H, Lange S, Klose P, et al. Yoga for breast cancer patients and survivors: a systematic review and meta-analysis. BMC Cancer. 2012;12:412.
138. Cramer H, Lauche R, Klose P, et al. Yoga for schizophrenia: a systematic review and meta-analysis. BMC Psychiatry. 2013;13:32.
139. Cramer H, Lauche R, Langhorst J, et al. Yoga for rheumatic diseases: a systematic review. Rheumatology. 2013;52(11):2025-2030.
140. Cramer H, Lauche R, Langhorst J, et al. Yoga for depression: a systematic review and meta-analysis. Depress Anxiety. 2013;30(11):1068-1083.
141. Mikkonen J, Pedersen P, McCarthy PW. A survey of musculoskeletal injury among Ashtanga Vinyasa yoga practitioners. Int J Yoga Ther. 2008;18(1):59-64.
142. Penman S, Cohen M, Stevens P, et al. Yoga in Australia: results of a national survey. Int J Yoga. 2012;5(2):92-101.
143. Holton MK, Barry AE. Do side-effects/injuries from yoga practice result in discontinued use? Results of a national survey. Int J Yoga. 2014;7(2):152-154.
144. Cramer H, Lauche R, Langhorst J, et al. Predictors of yoga use among internal medicine patients. BMC Complement Altern Med. 2013;13:172.
145. Schulz KF, Chalmers I, Hayes RJ, et al. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273(5):408-412.
146. Fønnebø V, Grimsgaard S, Walach H, et al. Researching complementary and alternative treatments - the gatekeepers are not at home. BMC Med Res Methodol. 2007;7:7.
147. Schulz KF, Altman DG, Moher D, et al. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med. 2010;152(11):726-732.
148. Fishman L, Saltonstall E, Genis S. Understanding and preventing yoga injuries. Int J Yoga Ther. 2009;19(1):47-53.
149. Emerson D, Sharma R, Chaudhry S, et al. Trauma sensitive yoga: principles, practice, and research. Int J Yoga Ther. 2009;19(1):13-128.