A Smart Capsule with GI-Tract-Location-Specific Payload Release

IEEE Transactions on Biomedical Engineering

Volumn 62, Issue 9, 2015, Pages 2289-2295

  Yu, Wuyang ^a   Rahimi, Rahim ^a   Ochoa, Manuel ^a   Pinal, Rodolfo ^a   Ziaie, Babak ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Drug absorption study; drug delivery; magnetic actuation; smart capsule

Indexed keywords

CAPACITORS; DRUG DELIVERY; MAGNETISM; MAGNETS; PERMANENT MAGNETS; POLYAMIDES; RAYON; REED RELAYS; WIRE;

DISCHARGING THE CAPACITOR; DRUG ABSORPTION; DRUG RESERVOIR; GASTROINTESTINAL TRACT; MAGNETIC ACTUATION; MAGNETIC MARKER; MAGNETIC PROXIMITY; SMART CAPSULE;

LOCATION;

GELATIN; NYLON; RUBBER;

ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; COLON CANCER; CROHN DISEASE; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG INDUSTRY; DRUG RELEASE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL ABSORPTION; INFLAMMATORY BOWEL DISEASE; LARGE INTESTINE DISEASE; MAGNETIC FIELD; MELTING POINT; SMALL INTESTINE; TARGETED DELIVERY CAPSULE; WATER FLOW; CAPSULE ENDOSCOPY; DEVICES; EQUIPMENT DESIGN; MAGNETISM; TEMPERATURE;

CAPSULE ENDOSCOPY; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; MAGNETICS; TEMPERATURE;

EID: 84940093640     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2015.2418340     Document Type: Article

References (19)

1. G. Iddan et al., "Wireless capsule endoscopy," Nature, vol. 405, pp. 417-417, 2000.
2. A. Moglia et al., "Capsule endoscopy: Progress update and challenges ahead," Nature Rev. Gastroenterol. Hepatol., vol. 6, pp. 353-362, 2009.
3. I. R.Wilding and D. V Prior, "Remote controlled capsules in human drug absorption (HDA) studies," Crit. Rev. Ther. Drug Carrier Syst., vol. 20, pp. 405-431, 2003.
4. P. J. Houzego et al., "Ingestible device for the release of substances at distinct locations in alimentary canal," U.S. Patent 6 884 239 B2, Apr. 26, 2005.
5. I. Wilding et al., "Development of a new engineering-based capsule for human drug absorption studies," Pharm. Sci. Technol. Today, vol. 3, no. 11, pp. 385-392, Nov. 2000.
6. I. R. Wilding et al., "Assessment of lumiracoxib bioavailability from targeted sites in the human intestine using remotely activated capsules and gamma scintigraphy," Pharm. Res., vol. 21, no. 3, pp. 443-446, Mar. 2004.
7. M. McGirr et al., "The use of the InteliSite companion device to deliver mucoadhesive polymers to the dog colon," Eur. J. Pharm. Sci., vol. 36, no. 4/5, pp. 386-391, Mar. 2009.
8. R. Gröning et al., "Control of drug release from capsules using high frequency energy transmission systems," Int. J. Pharm., vol. 364, no. 1, pp. 9-13, Nov. 2008.
9. X. Pi et al., "A novel micro-fabricated thruster for drug release in remote controlled capsule," Sens. Actuators A, Phys., vol. 159, no. 2, pp. 227-232, May 2010.
10. S. Yim et al., "Magnetically actuated soft capsule with the multimodal drug release function," IEEE/ASME Trans. Mechatron., vol. 18, no. 4, pp. 1413-1418, Aug. 2013.
11. C. T. Dietzel et al., "Magnetic active agent release system: Evaluation of a new way for a reproducible, externally controlled drug release into the small intestine," J. Control. Release, vol. 161, pp. 722-727, 2012.
12. S. P.Woods and T. G. Constandinou, "Wireless capsule endoscope for targeted drug delivery: Mechanics and design considerations," IEEE Trans. Biomed. Eng., vol. 60, no. 4, pp. 945-953, Apr. 2013.
13. B. Hugemann and O. Schuster, "Device for the release of substances at defined locations in the alimentary tract," U.S. Patent 4 425 117 A, Jan. 10, 1984.
14. A. Lambert et al., "Autonomous telemetric capsule to explore the small bowel," Med. Biol. Eng. Comput., vol. 29, no. 2, pp. 191-196, 1991.
15. R. Ganz et al., "Esophageal sphincter device for gastroesophageal reflux disease," N. Engl. J. Med., vol. 368, pp. 719-727, 2013.
16. J. J. Powell et al., "Concentrations of metals in gastric juice in health and peptic ulcer disease," Gut, vol. 33, no. 12, pp. 1617-1620, Dec. 1992.
17. L. P. Degen and S. F. Phillips, "Variability of gastrointestinal transit in healthy women and men," Gut, vol. 39, no. 2, pp. 299-305, 1996.
18. J. Fallingborg et al., "Intraluminal pH of the human gastrointestinal tract," Dan. Med. Bull., vol. 46, pp. 183-196, 1999.
19. WebMD, LLC., "Digestive Disorders Health Center," (2014). [Online]. Available: http://www.webmd.com/digestive-disorders/picture-ofthe-intestines.