In vivo profiling reveals a competent heat shock response in adult neurons: Implications for neurodegenerative disorders

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Carnemolla, Alisia ^a   Lazell, Hayley ^a   Moussaoui, Saliha ^b,c   Bates, Gillian P ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Rhenovia Pharma ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; MESSENGER RNA; NVP HSP 990; UNCLASSIFIED DRUG; 2-AMINO-7-(4-FLUORO-2-(6-METHOXYPYRIDIN-2-YL)PHENYL)-4-METHYL-7,8-DIHYDROPYRIDO(4,3-D)PYRIMIDIN-5(6H)-ONE; PYRIDONE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BACTERIAL ARTIFICIAL CHROMOSOME; BRAIN NERVE CELL; CELL SIZE; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS STRIATUM; DEGENERATIVE DISEASE; DNAJB1 GENE; DRD1A GENE; DRD2 GENE; GENE; GENE EXPRESSION REGULATION; GFAP GENE; HEAT SHOCK RESPONSE; HSF GENE; HSP90AA1 GENE; HSP90AB1 GENE; HSPA1A GENE; HSPA1B GENE; IN VIVO STUDY; MBP GENE; MOUSE; NERVE CELL DIFFERENTIATION; NERVE PROJECTION; NONHUMAN; OLIGODENDROGLIA; SIRT1 GENE; TRANSGENIC MOUSE; ANIMAL; BRAIN; CHEMISTRY; CYTOLOGY; FEMALE; FLOW CYTOMETRY; HIPPOCAMPUS; MALE; METABOLISM; NERVE CELL; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHYSIOLOGY;

MUS MUSCULUS;

ADMINISTRATION, ORAL; ANIMALS; ASTROCYTES; BRAIN; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CORPUS STRIATUM; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HEAT-SHOCK RESPONSE; HIPPOCAMPUS; HSP90 HEAT-SHOCK PROTEINS; MALE; MICE; MICE, TRANSGENIC; NEURODEGENERATIVE DISEASES; NEURONS; OLIGODENDROGLIA; PYRIDONES; PYRIMIDINES; RNA, MESSENGER;

EID: 84940069341     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0131985     Document Type: Article

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