Relationship between elevated triglyceride levels with the increase of HOMA-IR and HOMA-β in healthy children and adolescents with normal weight

European Journal of Pediatrics

Volumn 174, Issue 5, 2015, Pages 597-605

  Simental Mendía, Luis E ^a   Castañeda Chacón, Argelia ^a   Rodriguez Morán, Martha ^a   Aradillas García, Celia ^b   Guerrero Romero, Fernando ^a  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

Author keywords

Insulin action; Insulin secretion; Prepubertal children; Puberty; Triglycerides

Indexed keywords

TRIACYLGLYCEROL;

ADOLESCENT; BLOOD; BODY MASS; BODY WEIGHT; CHILD; CROSS-SECTIONAL STUDY; FEMALE; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; MALE; METABOLISM; PANCREAS ISLET BETA CELL; PHYSIOLOGY; PUBERTY; STATISTICAL MODEL;

ADOLESCENT; BODY MASS INDEX; BODY WEIGHT; CHILD; CROSS-SECTIONAL STUDIES; FEMALE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LINEAR MODELS; MALE; PUBERTY; TRIGLYCERIDES;

EID: 84939998972     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-014-2426-z     Document Type: Article

References (51)

1. Amiel SA, Sherwin RS, Simonson DC, Lauritano AA, Tamborlane WV (1986) Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes. N Engl J Med 315:215–219
2. Arslanian S, Suprasongsin C (1997) Glucose-fatty acid interactions in prepubertal and pubertal children: effects of lipid infusion. Am J Physiol 272:E523–4299
3. Boden G (1997) Role of fatty acids in the pathogenesis of IR in NIDDM. Diabetes 46:3–10
4. Brufani C, Tozzi A, Fintini D, Ciampalini P, Grossi A, Fiori R, Kiepe D, Manco M, Schiaffini R, Porzio O, Cappa M, Barbetti F (2009) Sexual dimorphism of body composition and insulin sensitivity across pubertal development in obese Caucasian subjects. Eur J Endocrinol 160:769–775
5. Butte NF, Cai G, Cole SA, Wilson TA, Fisher JO, Zakeri IF, Ellis KJ, Comuzzie AG (2007) Metabolic and behavioral predictors of weight gain in Hispanic children: the Viva la Familia Study. Am J Clin Nutr 85:1478–1485
6. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ, Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, National High Blood Pressure Education Program Coordinating Committee (2003) Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42:1206–1252
7. Cigolini M, Seidell JC, Targher G, Deslypere JP, Ellsinger BM, Charzewska J, Cruz A, Björntorp P (1995) Fasting serum insulin in relation to components of metabolic syndrome in European healthy men: the European Fat Distribution Study. Metabolism 44:35–40.8
8. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH (2003) Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988–1994. Arch Pediatr Adolesc Med 157:821–827
9. Derakhshan A, Tohidi M, Arshi B, Khalili D, Azizi F, Hadaegh F (2014) Relationship of hyperinsulinaemia, insulin resistance and β-cell dysfunction with incident diabetes and pre-diabetes: the Tehran Lipid and Glucose Study. Diabet Med doi: 10.1111/dme.12560
10. Duncan GE, Li SM, Zhuo XH (2004) Prevalence and trends of a metabolic syndrome phenotype among U.S. adolescents, 1999–2000. Diabetes Care 27:2438–2443
11. Dwyer T, Blizzard L, Venn A, Stankovich JM, Ponsonby AL, Morley R (2002) Syndrome X in 8-y-old Australian children: stronger associations with current body fatness than with infant size or growth. Int J Obes Relat Metab Disord 26:1301–1309
12. Eisenmann JC (2005) Waist circumference percentiles for 7- to 15-year-old Australian children. Acta Paediatr 94:1182–1185
13. Freedman DS, Mei Z, Srinivasan SR, Berenson GS, Dietz WH (2007) Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study. J Pediatr 150:12–17, e2
14. Gasevic D, Frohlich J, Mancini GB, Lear SA (2012) The association between triglyceride to high-density-lipoprotein cholesterol ratio and insulin resistance in a multiethnic primary prevention cohort. Metabolism 61:583–589
15. Giannini C, Santoro N, Caprio S, Kim G, Lartaud D, Shaw M, Pierpont B, Weiss R (2011) The triglyceride-to-HDL cholesterol ratio: association with insulin resistance in obese youths of different ethnic backgrounds. Diabetes Care 34(8):1869–74. doi:10.2337/dc10-2234
16. Goran MI, Gower BA (2001) Longitudinal study on pubertal insulin resistance. Diabetes 50:2444–2450
17. Gower BA, Nagy TR, Goran MI (1999) Visceral fat, insulin sensitivity, and lipids in prepubertal children. Diabetes 48:1515–1521
18. Guerrero-Romero F, Aradillas-García C, Simental-Mendía LE, Torres-Rodríguez ML, Mendoza Ede L, Rosales-Cervantes J, Rodríguez-Ramírez G, Rodríguez-Moran M (2013) Biochemical characteristics and risk factors for insulin resistance at different levels of obesity. Pediatrics 131:e1211–e1217
19. Gungor NI, Saad R, Janosky J, Arslanian S (2004) Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr 144:47–55
20. Guzzaloni G, Grugni G, Mazzilli G, Moro D, Morabito F (2002) Comparison between beta-cell function and insulin resistance indexes in prepubertal and pubertal obese children. Metabolism 51:1011–1016
21. Haney EM, Huffman LH, Bougatsos C, Freeman M, Steiner RD, Nelson HD (2007) Screening and treatment for lipid disorders in children and adolescents: systematic evidence review for the US Preventive Services Task Force. Pediatrics 120:e189–e214
22. Hannon TS, Bacha F, Lee SJ, Janosky J, Arslanian SA (2006) Use of markers of dyslipidemia to identify overweight youth with insulin resistance. Pediatr Diabetes 7:260–266
23. Henderson M, Rabasa­Lhoret R, Bastard JP, Chiasson JL, Baillargeon JP, Hanley JA, Lambert M (2011) Measuring insulin sensitivity in youth: How do the different indices compare with the gold­standard method. Diabetes Metab 37:72–78
24. Herd SL, Gower BA, Dashti N, Goran MI (2001) Body fat, fat distribution and serum lipids, lipoproteins and apolipoproteins in African-American and Caucasian-American prepubertal children. Int J Obes Relat Metab Disord 25:198–204
25. Hirschler V, Aranda C, Calcagno Mde L, Maccalini G, Jadzinsky M (2005) Can waist circumference identify children with the metabolic syndrome? Arch Pediatr Adolesc Med 159:740–744
26. Hoffman RP (2006) Increased fasting triglyceride levels are associated with hepatic insulin resistance in Caucasian but not African-American adolescents. Diabetes Care 29:1402–1404
27. Kaiser N, Leibowitz G, Nesher R (2003) Glucotoxicity and b-cell failure in T2DM. J Pediatr Endocrinol Metab 16:5–22
28. Katsuki A, Sumida Y, Urakawa H, Gabazza EC, Murashima S, Maruyama N, Morioka K, Nakatani K, Yano Y, Adachi Y (2003) Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance. Diabetes Care 26:2341–2344
29. Kelishadi R, Cook SR, Motlagh ME, Gouya MM, Ardalan G, Motaghian M, Majdzadeh R, Ramezani MA (2008) Metabolically obese normal weight and phenotypically obese metabolically normal youths: the CASPIAN Study. J Am Diet Assoc 108:82–90
30. Li C, Ford ES, Mokdad AH, Cook S (2006) Recent trends in waist circumference and waist-height ratio among US children and adolescents. Pediatrics 118:e1390–e1398
31. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419
32. McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G (2003) Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med 139:802–809
33. Medina-Urrutia A, Juarez-Rojas JG, Martínez-Alvarado R, Jorge-Galarza E, Posadas-Sánchez R, Cardoso-Saldaña G, Caracas-Portilla N, Mendoza-Perez E, Posadas-Romero C (2008) High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and C-reactive protein. Atherosclerosis 201:392–7. doi:10.1016/j.atherosclerosis.2008.02.029
34. Milburn JL Jr, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, BeltrandelRio H, Newgard CB, Johnson JH, Unger RH (1995) Pancreatic b-cells in obesity: evidence for induction of functional, morphologic and metabolic abnormalities by increased long-chain fatty acids. J Biol Chem 270:1295–1299
35. Moran A, Jacobs DR Jr, Steinberger J, Hong CP, Prineas R, Luepker R, Sinaiko AR (1999) Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 48:2039–44
36. Mo-Suwan L, Lebel L (1996) Risk factors for cardiovascular disease in obese and normal school children: association of insulin with other cardiovascular risk factors. Biomed Environ Sci 9(2–3):269–75
37. Ogden CL, Kuczmarski RJ, Flegal KM, Mei Z, Guo S, Wei R, Grummer-Strawn LM, Curtin LR, Roche AF, Johnson CL (2002) Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics 109:45–60
38. Pinhas-Hamiel O, Lerner-Geva L, Copperman NM, Jacobson MS (2007) Lipid and insulin levels in obese children: changes with age and puberty. Obesity (Silver Spring) 15:2825–2831
39. Quijada Z, Paoli M, Zerpa Y, Camacho N, Cichetti R, Villarroel V, Arata-Bellabarba G, Lanes R (2008) The triglyceride/HDL-cholesterol ratio as a marker of cardiovascular risk in obese children; association with traditional and emergent risk factors. Pediatr Diabetes 9(5):464–71. doi:10.1111/j.1399-5448.2008.00406.x
40. Ram J, Snehalatha C, Nanditha A, Selvam S, A Shetty S, Godsland IF, Johnston DG, Ramachandran A (2014) Hypertriglyceridaemic waist phenotype as a simple predictive marker of incident diabetes in Asian-Indian men with prediabetes. Diabet Med doi: 10.1111/dme.12517
41. Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI (1996) Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97:2859–2865
42. Rodríguez-Moran M, Aradillas-García C, Simental-Mendia LE, Monreal-Escalante E, de la Cruz ME, Dávila Esqueda ME, Guerrero-Romero F (2010) Family history of hypertension and cardiovascular risk factors in prepubertal children. Am J Hypertens 23(3):299–304. doi:10.1038/ajh.2009.257
43. Schwartz B, Jacobs DR Jr, Moran A, Steinberger J, Hong CP, Sinaiko AR (2008) Measurement of insulin sensitivity in children: comparison between the euglycemic­hyperinsulinemic clamp and surrogate measures. Diabetes Care 31:783–788
44. Simental-Mendía LE, Rodríguez-Morán M, Simental-Saucedo L, Guerrero-Romero F (2013) Insulin secretion is increased in non-diabetic subjects with fasting hypertriglyceridaemia. Diabetes Metab Res Rev 29(3):214–9. doi:10.1002/dmrr.2379
45. Sinaiko AR, Donahue RP, Jacobs DR Jr, Prineas RJ (1999) Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults. The Minneapolis Children’s Blood Pressure Study. Circulation 99(11):1471–1476
46. Sinaiko AR, Steinberger J, Moran A, Prineas RJ, Vessby B, Basu S, Tracy R, Jacobs DR Jr (2005) Relation of body mass index and insulin resistance to cardiovascular risk factors, inflammatory factors, and oxidative stress during adolescence. Circulation 111:1985–1991
47. Steinberger J, Moorehead C, Katch V, Rocchini AP (1995) Relationship between insulin resistance and abnormal lipid profile in obese adolescents. J Pediatr 126:690–695
48. Tanner JM, Whitehouse RH, Takaishi M (1996) Standards from birth to maturity for height, weight, height and weight velocity: British children. Arch Dis Child 41:454–495
49. Unger RH, Zhou YT (2001) Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes 50(Suppl 1):S118–S121
50. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S (2004) Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 350:2362–2374
51. Zimmet PZ, Collins VR, Dowse GK, Knight LT (1992) Hyperinsulinemia in youth is a predictor of type 2 (non-insulin-dependent) diabetes. Diabetologia 35(6):534–41