Maternal Serum S100-B, PAPP-A and IL-6 levels in severe preeclampsia

Archives of Gynecology and Obstetrics

Volumn 292, Issue 1, 2015, Pages 97-102

  Artunc Ulkumen, Burcu ^a   Guvenc, Yesim ^a   Goker, Asli ^a   Gozukara, Ceyhun ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Cerebral hypoperfusion; HELLP syndrome; IL 6; PAPP A; S100B; Severe preeclampsia

Indexed keywords

BIOLOGICAL MARKER; INTERLEUKIN 6; PREGNANCY ASSOCIATED PLASMA PROTEIN A; PROTEIN S100B; S100B PROTEIN, HUMAN;

ADULT; BLOOD; CASE CONTROL STUDY; FEMALE; HELLP SYNDROME; HUMAN; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PLACENTA; PREECLAMPSIA; PREGNANCY; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; HELLP SYNDROME; HUMANS; INTERLEUKIN-6; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROSPECTIVE STUDIES; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84939996017     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-014-3610-0     Document Type: Article

References (25)

1. Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM (2011) Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag 7:467–474
2. Deen ME, Ruurda LG, Wang J, Dekker GA (2006) Risk factors for preeclampsia in multiparous women: primipaternity versus the birth interval hypothesis. J Matern Fetal Neonatal Med. 19(2):79–84
3. Al-Jameila N, Khana FA, Khana MF, Tabassuma HT (2014) A Brief overview of preeclampsia. J Clin Med Res. 6(1):1–7
4. Spencer K, Cowans NJ, Nicholaides KH (2008) Low levels of maternal serum PAPP-A in the first trimester and the risk of preeclampsia. Prenat Diagn 28:7–10
5. Donato R (2001) S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 33:637–668
6. Schmidt AP, Tort ABL, Amaral OB et al (2004) Serum S100B in pregnancy-related hypertensive disorders: a case-control study. Clin Chem 50(2):435–438
7. Petzold A, Green AJ, Keir G et al (2002) Role of Serum S100B as an early predictor of high intracranial pressure and mortality in brain injury: a pilot study. Crit Care Med 30:2705–2710
8. Farina A, Rapacchia G, Sterrantino FA, Pula G et al (2011) Prospective Evaluation of ultrasound and biochemical-based multivariable models for the prediction of late pre-eclampsia. Prenat Diagn 12:1147–1152
9. Montanari L, Alfei A, Albonico G et al (2009) The impact of first-trimester serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A on the diagnosis of fetal growth restriction and small for gestational age infant. Fetal Diagn Ther 1:130–135
10. Smith GC, Stenhouse EJ, Crossley JA et al (2002) Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J Clin Endocrinol Metab 4:1762–1767
11. Dugoff L, Hobbins JC, Malone FD et al (2004) First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial). Am J Obstet Gynecol 4:1446–1451
12. Lovati E, Beneventi F, Simonetta M, Laneri M et al (2013) Gestational diabetes mellitus: including serum pregnancy-associated plasma protein-A testing in the clinical management of primiparous women? A case–control study. Diabetes Res Clin Pract 100(3):340–347
13. Marchi N, Angelov L, Masaryk T et al (2007) Seizure-promoting effect of blood–brain barrier disruption. Epilepsia. 48(4):732–742. doi:10.1111/j.1528-1167.2007.00988.x
14. Scott WK, Wang Y, Scott WW (1995) Preeclampsia is associated with decreased placental IL-6 production. Repr Sci. 2(4):614–617. doi:10.1177/107155769500200406
15. Tosun M, Celik H, Avci B et al (2010) Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia. J Matern Fetal Neonatal Med. 23(8):880–886. doi:10.3109/14767051003774942
16. Guven MA, Coskun A, Ertas IE et al (2009) Association of maternal serum CRP, IL-6, TNF-α Homocysteine, Folic Acid and Vitamin B12 levels with the severity of preeclampsia and fetal birth weight. Hypertens Pregnancy 28(2):190–200. doi:10.1080/10641950802601179
17. Borekci B, Aksoy H, Al RA et al (2007) Maternal serum interleukin-10, interleukin-2 and interleukin-6 in pre-eclampsia and eclampsia. Am J Reprod Immunol 58(1):56–64
18. Hayashi M, Ueda Y, Ohkura T et al (2005) IL-6 concentrations in the placenta and blood in normal pregnancies and preeclampsia. Horm Metab Res 37(7):419–424. doi:10.1055/s-2005-870231
19. Hypertension in Pregnancy (Report of the ACOG Task Force on Hypertension in Pregnancy) (2013). Obstetrics and Gynecology, Vol. 122, No. 5
20. PTskitishvilli E, Sharentuya N, Temma-Asona K, Mimura K, Kinugasa-Taniguchi Y, Kanagawa T, et al. (2010). Oxidative stress-induced S100B protein from placenta and amnion affects soluble endoglin release from endothelial cells. Mol Hum Reprod 16:188–199
21. Vettorazzi J, Torres FV, Avila TT, Martins-Costa SH, et al. (2012). Serum S100B in pregnancy complicated by preeclampsia: a case control study. Pregn Hypertens (2):101–105
22. Atis A, Aydin Y, Basol E, Kaleli S, Turgay F, Goker N (2012) PAPP-A levels of late pregnancy in preeclampsia and HELLP Syndrome. Arch Gynecol Obstet 285:45–49
23. Elisavet S, Anastasios S, Eleanna G, Stelios K, Constantinos G, Christina P (2013) Serum s100B protein is increased and correlates with interleukin 6, hypoperfusion indices, and outcome in patients admitted for surgical control of hemorrhage. Shock. 40(4):274–280
24. Steiner J, Schiltz K, Walter M, Wunderlich MT, Keilhoff G, Brisch R et al (2010) S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric research. Psychoneuroendocrinology. 35(2):321–324
25. Tskitishvili E, Komoto Y, Kinugasa Y, Kanagawa T, Song M, Mimura K et al (2007) Level of S100B protein expression in the amnion at various gestational ages in the third trimester of normal pregnancies. Acta Obstet Gynecol Scand 86(8):915–920