Serum S100B protein is increased and correlates with interleukin 6, hypoperfusion indices, and outcome in patients admitted for surgical control of hemorrhage

Shock

Volumn 40, Issue 4, 2013, Pages 274-280

  Stamataki, Elisavet ^a   Stathopoulos, Anastasios ^a   Garini, Eleanna ^a   Kokkoris, Stelios ^a   Glynos, Constantinos ^a   Psachoulia, Christina ^b   Pantziou, Harikleia ^b   Nanas, Serafeim ^a   Routsi, Christina ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b EVANGELISMOS HOSPITAL   (Greece)

Author keywords

brain damage; control of bleeding; Hemorrhagic shock; inflammation; interleukin 6; lactate; S100B protein

Indexed keywords

BICARBONATE; INTERLEUKIN 6; LACTIC ACID; PROTEIN S100B;

ABDOMINAL AORTA ANEURYSM; ADULT; ARTICLE; BLEEDING; CONTROLLED STUDY; DISEASE SEVERITY; ELECTIVE SURGERY; FEMALE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PERFUSION; PH; PREOPERATIVE PERIOD; PROGNOSIS; PROTEIN BLOOD LEVEL; TISSUE PERFUSION; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; AORTIC ANEURYSM, ABDOMINAL; BICARBONATES; BIOLOGICAL MARKERS; FEMALE; HEMORRHAGE; HUMANS; INTERLEUKIN-6; LACTIC ACID; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; TREATMENT OUTCOME;

EID: 84885675951     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3182a35de5     Document Type: Article

References (35)

1. Angele MK, Schneider CP, Chaudry IH: Bench-to-bedside review: latest results in hemorrhagic shock. Crit Care 12(4):218, 2008.
2. Molina PE. Noradrenergic inhibition of TNF upregulation in hemorrhagic shock. Neuroimmunomodulation 9:125-133, 2001. (Pubitemid 34042864)
3. Roumen RM, Hendriks T, van der Ven-Jongekrijg J, Nieuwenhuijzen GA, Sauerwein EW, van der Meer JW, Goris RJ: Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma. Ann Surg 218:769-776, 1993.
4. Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL: Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 25:1813-1819, 1997. (Pubitemid 27483960)
5. Cai B, Deitch EA, Ulloa L: Novel insights for systemic inflammation in sepsis and hemorrhage. Mediators Inflamm 2010;2010:642462. doi: 10.1155/2010/642462. Epub 2010 Jun 8.
6. Lee CC, Chang IJ, Yen ZS, Hsu CY, Chen SY, Su CP, Chiang WC, Chen SC, Chen WJ: Delayed fluid resuscitation in hemorrhagic shock induces pro-inflammatory cytokine response. Ann Emerg Med 49:37-44, 2007.
7. Donato R: S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 33:637-668, 2001. (Pubitemid 32520962)
8. Michetti F, Corvino V, Geloso MC, Lattanzi W, Bernardini C, Serpeto L, Gazzolo D: The S100B protein in biological fluids: more than a lifelong bio-marker of brain distress. J Neurochem 120:644-659, 2012.
9. Anderson RA, Hansson LO, Nilsson O, Dijlai-Merzoug R, Settergren G: High serum S100B levels for trauma patients without head injuries. Neurosurgery 48:1255-1258, 2001.
10. Pelinka LE, Szalay L, Jafarmadar M, Schmidhammer R, Redl H, Bahrami S: Circulated S100B is increased after bilateral femur fracture without brain injury in the rat. Br J Anaesth 91:595-597, 2003. (Pubitemid 37258608)
11. Brin T, Borucki K, Ambrosch A: The influence of experimental alcohol load and alcohol intoxication on S100B concentrations. Shock 36:356-360, 2011.
12. Pelinka LE, Bahrami S, Szalay L, Umar F, Redl H: Hemorrhagic shock induces an S100B increase associated with shock severity. Shock 19:422-426, 2003. (Pubitemid 44305167)
13. Meybohm P, Cavus E, Dörges V, Weber B, Stadlbauer KH, Wenzel V, Scholz J, Steffen M, Bein B: Release of protein S100B in haemorrhagic shock: effects of small volume resuscitation combined with arginine vasopressin. Resuscitation 76:449-456, 2008. (Pubitemid 351192214)
14. Pelinka LE, Harada N, Szalay L, Jafarmadar M, Redl H, Bahrami S: Release of S100B differs during ischemia and reperfusion of the liver, the gut, and the kidney in rats. Shock 21:72-76, 2004.
15. Routsi C, Stamataki E, Nanas S, Psachoulia C, Stathopoulos A, Koroneos A, Zervou M, Jullien G, Roussos C: Increased levels of serum S100B protein in critically ill patients without brain injury. Shock 26:20-24, 2006. (Pubitemid 44297001)
16. Zhao P, Gao S, Lin B: Elevated levels of serum S100B is associated with the presence and outcome of hemorrhagic shock. Clin Lab 58:1051-1055, 2012.
17. Chen RY, Fan FC, Schuessler GB, Simchon S, Kim S, Chien S: Regional cerebral blood flow and oxygen consumption of the canine brain during hemor-rhagic hypotension. Stroke 15:343-350, 1984. (Pubitemid 14171273)
18. Cruickshank AM, Fraser WD, Burns HJG, Van Dame J, Shenkin A: Response of serum interleukin-6 in patients undergoing elective surgery of varying severity. Clin Science 79:161-165, 1990. (Pubitemid 20218956)
19. Cata JP, Abdelmalak B, Farag E: Neurological biomarkers in the perioperative period. Br J Anaesth 107:844-858, 2011.
20. Rasmussen LS, Christiansen M, Rasmussen H, Kristensen PA, Moller JT, and the ISPOCD Group: Do blood concentrations of neurone specific enolase and S100" protein reflect cognitive dysfunction after abdominal surgery? Br J Anaesh 84:242-244, 2000. (Pubitemid 30060311)
21. McDonach DL, Mathew JP, White WD, Phillips-Bute B, Laskowitz DT, Podgoreanu MV, Newman MF, and the Neurologic Outcome Research Group: Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. Anesthesiology 112:852-859, 2010.
22. Anderson RE, Winnerkvist A, Hansson L-O, Nilson O, Rosengren L, Settergren G, Vaage J: Biochemical markers of cerebrospinal ischemia after repair of aneu-rysms of the descending and the thoracoabdominal aorta. J Cardiothorac Vasc Anesth 17:598-603, 2003. (Pubitemid 37296624)
23. Wellborn MB, Oldenburg HS, Hess PJ, Huber TS, Martin TD, Rauwerda JA, Wesdorp RI, Espat NJ, Copeland EM 3rd, Moldawer LL, et al.: The relationship between visceral ischemia, proinflammatory cytokines, and organ injury in patients undergoing thoracoabdominal aortic aneurysm repair. Crit Care Med 28:3191-3197, 2000.
24. Ashraf S, Bhattacharya K, Tian Y, Watterson K: Cytokine and S100B levels in paediatric patients undergoing corrective cardiac surgery with or without total circulatory arrest. Eur J Cardiothorac Surg 16:32-37, 1999. (Pubitemid 29336429)
25. Beer C, Blacker D, Bynevelt M, Hankey GJ, Puddey IB: Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke. J Neuroinflamm 7:71, 2010.
26. Tracey KJ: The inflammatory reflex. Nature 420:853-859, 2002. (Pubitemid 36019638)
27. Guerra MC, Tortorelli LS, Galland F, Da Re C, Negri E, Engelke DS, Rodrigues L, Leite MC, Gonçalves C-A: Lipopolysaccharide modulates astrocytic S100B secretion: a study in cerebrospinal fluid and astrocyte cultures from rats. J Neuroinflamm 8:128-138, 2011.
28. Li Y, Barger SW, Liu L, Mrak RE, Griffin WS: S100B induction of the pro-inflammatory cytokine interleukin-6 in neurons. J Neurochem 74:143-150, 2000. (Pubitemid 30012764)
29. Ponath G, Schettler C, Kaestner F, Voigt B, Wentker D, Arolt V, Rothermurndt M: Autocrine S100B effects on astrocytes are mediated via RAGE. J Neuroimmunol 184:214-222, 2007. (Pubitemid 46366005)
30. Foell D, Wittkowski H, Vogl T, Roth J: S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biolol 81:28-37, 2007. (Pubitemid 46021248)
31. Nylen K, Ost M, Csajbok LZ, Nilsson I, Hall C, Blennow K, Nellgard B, Rosengren L: Serum levels of S100B, S100A1Band S100BB are related to outcome after severe traumatic brain injury. Acta Neurochir (Wien) 150:221-227, 2008.
32. Hu YY, Dong XQ, Yu WH, Zhang ZY: Change in plasma S100B level after acute spontaneous basal ganglia haemorrhage. Shock 33:134-140, 2010.
33. Nguyen DN, Spapen H, Fuhong S, Schiettecatte J, Shi L, Hachimi-Idrissi S, Huyghens L: Elevated serum levels of S100B protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock. Crit Care Med 34:1967-1974, 2006. (Pubitemid 43982475)
34. Johnsson P, Backstrom M, Bergh C, Jonsson H, Luhrs C, Alling C: Increase S100B in blood after cardiac surgery is a powerful predictor of late mortality. Ann Thorac Surg 75:162-168, 2003. (Pubitemid 36099041)
35. Herrman M: High serum S100B levels for trauma patients without head injuries. Neurosurgery 49:1272-1273, 2001.