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Volumn 43, Issue 2, 2015, Pages 145-151

Novel antibiotics: Are we still in the pre–post-antibiotic era?

Author keywords

Avibactam; Cadazolid; Ceftolozane; Omadacycline; Tedizolid

Indexed keywords

ANTIINFECTIVE AGENT;

EID: 84939974943     PISSN: 03008126     EISSN: 14390973     Source Type: Journal    
DOI: 10.1007/s15010-015-0749-y     Document Type: Review
Times cited : (43)

References (51)
  • 1
    • 84864276755 scopus 로고    scopus 로고
    • Resistance surveillance studies: a multifaceted problem—the fluoroquinolone example
    • COI: 1:CAS:528:DC%2BC38Xpsl2qur8%3D, PID: 22460782
    • Dalhoff A. Resistance surveillance studies: a multifaceted problem—the fluoroquinolone example. Infection. 2012;40:239–62.
    • (2012) Infection , vol.40 , pp. 239-262
    • Dalhoff, A.1
  • 2
    • 84897473243 scopus 로고    scopus 로고
    • Colonization of liver transplant recipients with KPC-producing Klebsiella pneumoniae is associated with high infection rates and excess mortality: a case–control analysis
    • COI: 1:STN:280:DC%2BC2c7lt1SnsA%3D%3D, PID: 24217959
    • Lubbert C, et al. Colonization of liver transplant recipients with KPC-producing Klebsiella pneumoniae is associated with high infection rates and excess mortality: a case–control analysis. Infection. 2014;42:309–16.
    • (2014) Infection , vol.42 , pp. 309-316
    • Lubbert, C.1
  • 3
    • 84859038949 scopus 로고    scopus 로고
    • Oritavancin: mechanism of action
    • COI: 1:CAS:528:DC%2BC38Xksl2rsr4%3D, PID: 22431851
    • Zhanel GG, Schweizer F, Karlowsky JA. Oritavancin: mechanism of action. Clin Infect Dis. 2012;54:S214–9.
    • (2012) Clin Infect Dis , vol.54 , pp. 214-219
    • Zhanel, G.G.1    Schweizer, F.2    Karlowsky, J.A.3
  • 4
    • 70349307402 scopus 로고    scopus 로고
    • Oritavancin population pharmacokinetics in healthy subjects and patients with complicated skin and skin structure infections or bacteremia
    • COI: 1:CAS:528:DC%2BD1MXht1KkurjN, PID: 19635952
    • Rubino CM, et al. Oritavancin population pharmacokinetics in healthy subjects and patients with complicated skin and skin structure infections or bacteremia. Antimicrob Agents Chemother. 2009;53:4422–8.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 4422-4428
    • Rubino, C.M.1
  • 5
    • 84872029377 scopus 로고    scopus 로고
    • Pharmacodynamics of a simulated single 1,200-milligram dose of oritavancin in an in vitro pharmacokinetic/pharmacodynamic model of methicillin-resistant Staphylococcus aureus infection
    • COI: 1:CAS:528:DC%2BC3sXlt1SrsLg%3D, PID: 23089749
    • Belley A, et al. Pharmacodynamics of a simulated single 1,200-milligram dose of oritavancin in an in vitro pharmacokinetic/pharmacodynamic model of methicillin-resistant Staphylococcus aureus infection. Antimicrob Agents Chemother. 2013;57:205–11.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 205-211
    • Belley, A.1
  • 6
    • 79959197607 scopus 로고    scopus 로고
    • Comparison of the efficacy and safety of oritavancin front-loaded dosing regimens to daily dosing: an analysis of the SIMPLIFI trial
    • COI: 1:CAS:528:DC%2BC3MXos1OrtLc%3D, PID: 21537018
    • Dunbar LM, et al. Comparison of the efficacy and safety of oritavancin front-loaded dosing regimens to daily dosing: an analysis of the SIMPLIFI trial. Antimicrob Agents Chemother. 2011;55:3476–84.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 3476-3484
    • Dunbar, L.M.1
  • 7
    • 84907392537 scopus 로고    scopus 로고
    • Dalbavancin or oritavancin for skin infections
    • PID: 25243251
    • Corey GR, Jiang H, Moeck G. Dalbavancin or oritavancin for skin infections. N Engl J Med. 2014;371:1162–3.
    • (2014) N Engl J Med , vol.371 , pp. 1162-1163
    • Corey, G.R.1    Jiang, H.2    Moeck, G.3
  • 8
    • 0242468561 scopus 로고    scopus 로고
    • Once-weekly dalbavancin versus standard-of-care antimicrobial regimens for treatment of skin and soft-tissue infections
    • COI: 1:CAS:528:DC%2BD3sXpvFyktrk%3D, PID: 14583862
    • Seltzer E, et al. Once-weekly dalbavancin versus standard-of-care antimicrobial regimens for treatment of skin and soft-tissue infections. Clin Infect Dis. 2003;37:1298–303.
    • (2003) Clin Infect Dis , vol.37 , pp. 1298-1303
    • Seltzer, E.1
  • 9
    • 27644549908 scopus 로고    scopus 로고
    • Randomized, double-blind comparison of once-weekly dalbavancin versus twice-daily linezolid therapy for the treatment of complicated skin and skin structure infections
    • COI: 1:CAS:528:DC%2BD2MXht1emsbjJ, PID: 16231250
    • Jauregui LE, et al. Randomized, double-blind comparison of once-weekly dalbavancin versus twice-daily linezolid therapy for the treatment of complicated skin and skin structure infections. Clin Infect Dis. 2005;41:1407–15.
    • (2005) Clin Infect Dis , vol.41 , pp. 1407-1415
    • Jauregui, L.E.1
  • 10
    • 13444257356 scopus 로고    scopus 로고
    • Efficacy and safety of weekly dalbavancin therapy for catheter-related bloodstream infection caused by gram-positive pathogens
    • COI: 1:CAS:528:DC%2BD2MXhs12gtbs%3D, PID: 15668859
    • Raad I, et al. Efficacy and safety of weekly dalbavancin therapy for catheter-related bloodstream infection caused by gram-positive pathogens. Clin Infect Dis. 2005;40:374–80.
    • (2005) Clin Infect Dis , vol.40 , pp. 374-380
    • Raad, I.1
  • 11
    • 33747892962 scopus 로고    scopus 로고
    • Effect of dalbavancin on the normal intestinal microflora
    • COI: 1:CAS:528:DC%2BD28Xotl2lurw%3D, PID: 16840427
    • Nord CE, Rasmanis G, Wahlund E. Effect of dalbavancin on the normal intestinal microflora. J Antimicrob Chemother. 2006;58:627–31.
    • (2006) J Antimicrob Chemother , vol.58 , pp. 627-631
    • Nord, C.E.1    Rasmanis, G.2    Wahlund, E.3
  • 12
    • 15844407157 scopus 로고    scopus 로고
    • Human pharmacokinetics and rationale for once-weekly dosing of dalbavancin, a semi-synthetic glycopeptide
    • COI: 1:CAS:528:DC%2BD2MXitV2jsLk%3D, PID: 15750034
    • Dorr MB, et al. Human pharmacokinetics and rationale for once-weekly dosing of dalbavancin, a semi-synthetic glycopeptide. J Antimicrob Chemother. 2005;55:ii25–30.
    • (2005) J Antimicrob Chemother , vol.55 , pp. 25-30
    • Dorr, M.B.1
  • 13
    • 84901794881 scopus 로고    scopus 로고
    • Once-weekly dalbavancin versus daily conventional therapy for skin infection
    • PID: 24897082
    • Boucher HW, et al. Once-weekly dalbavancin versus daily conventional therapy for skin infection. N Engl J Med. 2014;370:2169–79.
    • (2014) N Engl J Med , vol.370 , pp. 2169-2179
    • Boucher, H.W.1
  • 14
    • 84908266611 scopus 로고    scopus 로고
    • Tedizolid population pharmacokinetics, exposure–response, and target attainment
    • COI: 1:CAS:528:DC%2BC2cXhvVKisrjN, PID: 25136028
    • Flanagan S, Passarell J, Lu Q. Tedizolid population pharmacokinetics, exposure–response, and target attainment. Antimicrob Agents Chemother. 2014;58:6462–70.
    • (2014) Antimicrob Agents Chemother. , vol.58 , pp. 6462-6470
    • Flanagan, S.1    Passarell, J.2    Lu, Q.3
  • 16
    • 84904718296 scopus 로고    scopus 로고
    • Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial
    • COI: 1:CAS:528:DC%2BC2cXhtVWrs7bK, PID: 24909499
    • Moran GJ, et al. Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial. Lancet Infect Dis. 2014;14:696–705.
    • (2014) Lancet Infect Dis , vol.14 , pp. 696-705
    • Moran, G.J.1
  • 17
    • 84909956314 scopus 로고    scopus 로고
    • Early experience with tedizolid: clinical efficacy, pharmacodynamics, and resistance
    • COI: 1:CAS:528:DC%2BC2cXhvFSiu7fJ, PID: 25266820
    • Rybak JM, Marx K, Martin CA. Early experience with tedizolid: clinical efficacy, pharmacodynamics, and resistance. Pharmacotherapy. 2014;34:1198–208.
    • (2014) Pharmacotherapy , vol.34 , pp. 1198-1208
    • Rybak, J.M.1    Marx, K.2    Martin, C.A.3
  • 18
    • 84907977684 scopus 로고    scopus 로고
    • Single- and multiple-dose pharmacokinetics and absolute bioavailability of tedizolid
    • COI: 1:CAS:528:DC%2BC2cXhsV2qt73N, PID: 24989138
    • Flanagan S, et al. Single- and multiple-dose pharmacokinetics and absolute bioavailability of tedizolid. Pharmacotherapy. 2014;34:891–900.
    • (2014) Pharmacotherapy , vol.34 , pp. 891-900
    • Flanagan, S.1
  • 19
    • 84908297834 scopus 로고    scopus 로고
    • Pharmacokinetics of tedizolid in subjects with renal or hepatic impairment
    • COI: 1:CAS:528:DC%2BC2cXhvVKju7vO, PID: 25136024
    • Flanagan S, Minassian SL, Morris D. Pharmacokinetics of tedizolid in subjects with renal or hepatic impairment. Antimicrob Agents Chemother. 2014;58:6471–6.
    • (2014) Antimicrob Agents Chemother. , vol.58 , pp. 6471-6476
    • Flanagan, S.1    Minassian, S.L.2    Morris, D.3
  • 20
    • 24144434959 scopus 로고    scopus 로고
    • Absolute bioavailability and pharmacokinetics of linezolid in hospitalized patients given enteral feedings
    • COI: 1:CAS:528:DC%2BD2MXpvFKltLs%3D, PID: 16127039
    • Beringer P, et al. Absolute bioavailability and pharmacokinetics of linezolid in hospitalized patients given enteral feedings. Antimicrob Agents Chemother. 2005;49:3676–81.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3676-3681
    • Beringer, P.1
  • 21
    • 84921933187 scopus 로고    scopus 로고
    • Analysis of the phase 3 ESTABLISH trials: tedizolid versus linezolid in acute bacterial skin and skin structure infection
    • COI: 1:CAS:528:DC%2BC2MXit1Kkur8%3D, PID: 25421472
    • Shorr AF, et al. Analysis of the phase 3 ESTABLISH trials: tedizolid versus linezolid in acute bacterial skin and skin structure infection. Antimicrob Agents Chemother. 2015;59:864–71.
    • (2015) Antimicrob Agents Chemother. , vol.59 , pp. 864-871
    • Shorr, A.F.1
  • 22
    • 84927574043 scopus 로고    scopus 로고
    • Ceftazidime–avibactam and comparator agents tested against urinary tract isolates from a global surveillance program (2011)
    • COI: 1:CAS:528:DC%2BC2cXhtlCjtLzE
    • Flamm RK, et al. Ceftazidime–avibactam and comparator agents tested against urinary tract isolates from a global surveillance program (2011). Diagn Microb Infect Dis. 2014;80:233–8.
    • (2014) Diagn Microb Infect Dis , vol.80 , pp. 233-238
    • Flamm, R.K.1
  • 23
    • 84859602519 scopus 로고    scopus 로고
    • In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii
    • COI: 1:CAS:528:DC%2BC38Xlt1GntL4%3D, PID: 22294643
    • Higgins PG, et al. In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii. J Antimicrob Chemother. 2012;67:1167–9.
    • (2012) J Antimicrob Chemother , vol.67 , pp. 1167-1169
    • Higgins, P.G.1
  • 24
    • 79959735594 scopus 로고    scopus 로고
    • In vitro activity of BAL30072 against Burkholderia pseudomallei
    • COI: 1:CAS:528:DC%2BC3MXotVegsLg%3D, PID: 21596528
    • Mima T, et al. In vitro activity of BAL30072 against Burkholderia pseudomallei. Int J Antimicrob Agents. 2011;38:157–9.
    • (2011) Int J Antimicrob Agents , vol.38 , pp. 157-159
    • Mima, T.1
  • 25
    • 84879488177 scopus 로고    scopus 로고
    • Activity of BAL30072 alone or combined with beta-lactamase inhibitors or with meropenem against carbapenem-resistant Enterobacteriaceae and non-fermenters
    • COI: 1:CAS:528:DC%2BC3sXpsFCiu7k%3D, PID: 23449829
    • Mushtaq S, et al. Activity of BAL30072 alone or combined with beta-lactamase inhibitors or with meropenem against carbapenem-resistant Enterobacteriaceae and non-fermenters. J Antimicrob Chemother. 2013;68:1601–8.
    • (2013) J Antimicrob Chemother , vol.68 , pp. 1601-1608
    • Mushtaq, S.1
  • 27
    • 84940002136 scopus 로고    scopus 로고
    • OnVista. Präsentation umfangreicher Daten zu Basileas Anti-Infektiva Isavuconazol, Ceftobiprol und BAL30072 auf ICAAC
    • OnVista. Präsentation umfangreicher Daten zu Basileas Anti-Infektiva Isavuconazol, Ceftobiprol und BAL30072 auf ICAAC. http://www.onvista.de/news/praesentation-umfangreicher-daten-zu-basileas-anti-infektiva-isavuconazol-ceftobiprol-und-bal30072-auf-icaac-1127929.
  • 28
    • 84887449664 scopus 로고    scopus 로고
    • Antimicrobial activity of ceftolozane–tazobactam tested against Enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in U.S. Hospitals (2011–2012)
    • COI: 1:CAS:528:DC%2BC3sXhvVCjurzM, PID: 24100499
    • Farrell DJ, et al. Antimicrobial activity of ceftolozane–tazobactam tested against Enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in U.S. Hospitals (2011–2012). Antimicrob Agents Chemother. 2013;57:6305–10.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 6305-6310
    • Farrell, D.J.1
  • 29
    • 84902087476 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam activity tested against Gram-negative bacterial isolates from hospitalised patients with pneumonia in US and European medical centres (2012)
    • COI: 1:CAS:528:DC%2BC2cXotlyhsLg%3D, PID: 24856078
    • Farrell DJ, et al. Ceftolozane/tazobactam activity tested against Gram-negative bacterial isolates from hospitalised patients with pneumonia in US and European medical centres (2012). Int J Antimicrob Agents. 2014;43:533–9.
    • (2014) Int J Antimicrob Agents , vol.43 , pp. 533-539
    • Farrell, D.J.1
  • 30
    • 84921029928 scopus 로고    scopus 로고
    • Antimicrobial activity of ceftolozane/tazobactam tested against Pseudomonas aeruginosa and Enterobacteriaceae with various resistance patterns isolated in European hospitals (2011–12)
    • COI: 1:CAS:528:DC%2BC2MXis1Ciu7Y%3D, PID: 24917579
    • Sader HS, et al. Antimicrobial activity of ceftolozane/tazobactam tested against Pseudomonas aeruginosa and Enterobacteriaceae with various resistance patterns isolated in European hospitals (2011–12). J Antimicrob Chemother. 2014;69:2713–22.
    • (2014) J Antimicrob Chemother , vol.69 , pp. 2713-2722
    • Sader, H.S.1
  • 31
    • 84939945733 scopus 로고    scopus 로고
    • Personal communication of CUBIST Pharmaceuticals, December 17th 2014
    • Personal communication of CUBIST Pharmaceuticals, December 17th 2014.
  • 32
    • 84939969104 scopus 로고    scopus 로고
    • FDA. FDA approves new antibacterial drug Zerbaxa. 2014
    • FDA. FDA approves new antibacterial drug Zerbaxa. 2014. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427534.htm.
  • 33
    • 84906085321 scopus 로고    scopus 로고
    • Multicenter, double-blind, randomized, phase II trial to assess the safety and efficacy of ceftolozane–tazobactam plus metronidazole compared with meropenem in adult patients with complicated intra-abdominal infections
    • PID: 24982069
    • Lucasti C, et al. Multicenter, double-blind, randomized, phase II trial to assess the safety and efficacy of ceftolozane–tazobactam plus metronidazole compared with meropenem in adult patients with complicated intra-abdominal infections. Antimicrob Agents Chemother. 2014;58:5350–7.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 5350-5357
    • Lucasti, C.1
  • 34
    • 84911483559 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam (CXA 201) for the treatment of intra-abdominal infections
    • Maseda E, et al. Ceftolozane/tazobactam (CXA 201) for the treatment of intra-abdominal infections. Expert Rev Anti Infect Ther. 2014;12:1–15.
    • (2014) Expert Rev Anti Infect Ther. , vol.12 , pp. 1-15
    • Maseda, E.1
  • 35
    • 85027943613 scopus 로고    scopus 로고
    • In vivo efficacy of ceftolozane against Pseudomonas aeruginosa in a rabbit experimental model of pneumonia: comparison with ceftazidime, piperacillin/tazobactam and imipenem
    • COI: 1:CAS:528:DC%2BC2cXht12mt7bP, PID: 25108877
    • Bretonniere C, et al. In vivo efficacy of ceftolozane against Pseudomonas aeruginosa in a rabbit experimental model of pneumonia: comparison with ceftazidime, piperacillin/tazobactam and imipenem. Int J Antimicrob Agents. 2014;44:218–21.
    • (2014) Int J Antimicrob Agents , vol.44 , pp. 218-221
    • Bretonniere, C.1
  • 36
    • 78751688377 scopus 로고    scopus 로고
    • Contrasting effects of acidic pH on the extracellular and intracellular activities of the anti-gram-positive fluoroquinolones moxifloxacin and delafloxacin against Staphylococcus aureus
    • COI: 1:CAS:528:DC%2BC3MXisVyjsbs%3D, PID: 21135179
    • Lemaire S, Tulkens PM, Van Bambeke F. Contrasting effects of acidic pH on the extracellular and intracellular activities of the anti-gram-positive fluoroquinolones moxifloxacin and delafloxacin against Staphylococcus aureus. Antimicrob Agents Chemother. 2011;55:649–58.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 649-658
    • Lemaire, S.1    Tulkens, P.M.2    Van Bambeke, F.3
  • 37
    • 84908638643 scopus 로고    scopus 로고
    • Antibiotic activity against biofilms from Staphylococcus aureus clinical isolates: factors determining the activity of the investigational fluoroquinolone delafloxacin in comparison with daptomycin and vancomycin
    • COI: 1:CAS:528:DC%2BC2cXhvVGjsr%2FO, PID: 25114142
    • Siala W, et al. Antibiotic activity against biofilms from Staphylococcus aureus clinical isolates: factors determining the activity of the investigational fluoroquinolone delafloxacin in comparison with daptomycin and vancomycin. Antimicrob Agents Chemother. 2014;58:6385–97.
    • (2014) Antimicrob Agents Chemother. , vol.58 , pp. 6385-6397
    • Siala, W.1
  • 39
    • 84877846455 scopus 로고    scopus 로고
    • Randomized, double-blind, multicenter phase 2 study comparing the efficacy and safety of oral solithromycin (CEM-101) to those of oral levofloxacin in the treatment of patients with community-acquired bacterial pneumonia
    • COI: 1:CAS:528:DC%2BC3sXoslyrs7w%3D, PID: 23507282
    • Oldach D, et al. Randomized, double-blind, multicenter phase 2 study comparing the efficacy and safety of oral solithromycin (CEM-101) to those of oral levofloxacin in the treatment of patients with community-acquired bacterial pneumonia. Antimicrob Agents Chemother. 2013;57:2526–34.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 2526-2534
    • Oldach, D.1
  • 40
    • 84910004816 scopus 로고    scopus 로고
    • Renaissance of antibiotics against difficult infections: focus on oritavancin and new ketolides and quinolones
    • PID: 25058176
    • Van Bambeke F. Renaissance of antibiotics against difficult infections: focus on oritavancin and new ketolides and quinolones. Ann Med. 2014;46:512–29.
    • (2014) Ann Med , vol.46 , pp. 512-529
    • Van Bambeke, F.1
  • 41
    • 84875140013 scopus 로고    scopus 로고
    • Antimicrobial activity of ceftaroline–avibactam tested against clinical isolates collected from U.S. Medical Centers in 2010–2011
    • COI: 1:CAS:528:DC%2BC3sXltVKrtL4%3D, PID: 23380730
    • Sader HS, Flamm RK, Jones RN. Antimicrobial activity of ceftaroline–avibactam tested against clinical isolates collected from U.S. Medical Centers in 2010–2011. Antimicrob Agents Chemother. 2013;57:1982–8.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 1982-1988
    • Sader, H.S.1    Flamm, R.K.2    Jones, R.N.3
  • 42
    • 78650636489 scopus 로고    scopus 로고
    • Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae
    • COI: 1:CAS:528:DC%2BC3MXisVegsL8%3D, PID: 21041502
    • Livermore DM, et al. Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae. Antimicrob Agents Chemother. 2011;55:390–4.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 390-394
    • Livermore, D.M.1
  • 44
    • 84862573378 scopus 로고    scopus 로고
    • In vitro activity of MK-7655, a novel beta-lactamase inhibitor, in combination with imipenem against carbapenem-resistant Gram-negative bacteria
    • COI: 1:CAS:528:DC%2BC38XpsV2isLs%3D, PID: 22526311
    • Hirsch EB, et al. In vitro activity of MK-7655, a novel beta-lactamase inhibitor, in combination with imipenem against carbapenem-resistant Gram-negative bacteria. Antimicrob Agents Chemother. 2012;56:3753–7.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 3753-3757
    • Hirsch, E.B.1
  • 45
    • 84939984960 scopus 로고    scopus 로고
    • Griffith DC, et al. A phase 1 study of the safety, tolerability, and pharmacokinetics of the beta-lactamase inhibitor RPX7009 in health adult subjects, in 24th European congress of clinical microbiology an infectious diseases ECCMID 20142014: Barcelona
    • Griffith DC, et al. A phase 1 study of the safety, tolerability, and pharmacokinetics of the beta-lactamase inhibitor RPX7009 in health adult subjects, in 24th European congress of clinical microbiology an infectious diseases ECCMID 20142014: Barcelona.
  • 46
    • 84939966876 scopus 로고    scopus 로고
    • Nordmann P, et al. Characterisation of beta-lactamase inhibition by AAI101, an extended-spectrum beta-lactamase inhibitor, in 24th European congress of clinical microbiology an infectious diseases ECCMID 20142014: Barcelona
    • Nordmann P, et al. Characterisation of beta-lactamase inhibition by AAI101, an extended-spectrum beta-lactamase inhibitor, in 24th European congress of clinical microbiology an infectious diseases ECCMID 20142014: Barcelona.
  • 47
    • 84893466318 scopus 로고    scopus 로고
    • In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections
    • PID: 24277020
    • Locher HH, et al. In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections. Antimicrob Agents Chemother. 2014;58:892–900.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 892-900
    • Locher, H.H.1
  • 48
    • 84894042563 scopus 로고    scopus 로고
    • In vitro activity of cadazolid against clinically relevant Clostridium difficile isolates and in an in vitro gut model of C. difficile infection
    • COI: 1:CAS:528:DC%2BC2cXisF2ltrg%3D, PID: 24128668
    • Chilton CH, et al. In vitro activity of cadazolid against clinically relevant Clostridium difficile isolates and in an in vitro gut model of C. difficile infection. J Antimicrob Chemother. 2014;69:697–705.
    • (2014) J Antimicrob Chemother , vol.69 , pp. 697-705
    • Chilton, C.H.1
  • 49
    • 84894045611 scopus 로고    scopus 로고
    • Cadazolid, a novel antibiotic with potent activity against Clostridium difficile: safety, tolerability and pharmacokinetics in healthy subjects following single and multiple oral doses
    • COI: 1:CAS:528:DC%2BC2cXisF2ltrc%3D, PID: 24106141
    • Baldoni D, et al. Cadazolid, a novel antibiotic with potent activity against Clostridium difficile: safety, tolerability and pharmacokinetics in healthy subjects following single and multiple oral doses. J Antimicrob Chemother. 2014;69:706–14.
    • (2014) J Antimicrob Chemother , vol.69 , pp. 706-714
    • Baldoni, D.1
  • 50
    • 84973232244 scopus 로고    scopus 로고
    • Multicentre, double-blind, randomised, phase 2 study evaluating the novel antibiotic, cadazolid, in subjects with Clostridium difficile-associated diarrhoea. Abstract LB 2956, 22nd European congress of clinical microbiology and infectious disease, Berlin
    • Louie T, et al. Multicentre, double-blind, randomised, phase 2 study evaluating the novel antibiotic, cadazolid, in subjects with Clostridium difficile-associated diarrhoea. Abstract LB 2956, 22nd European congress of clinical microbiology and infectious disease, Berlin, April 27–30, 2013.
    • (2013) April , pp. 27-30
    • Louie, T.1


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