Do we need a new definition of sepsis?

Intensive Care Medicine

Volumn 41, Issue 5, 2015, Pages 909-911

  Shankar Hari, Manu ^a,b   Deutschman, Clifford S ^c,d   Singer, Mervyn ^e  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c LONG ISLAND JEWISH MEDICAL CENTER   (United States)

^d FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLASSIFICATION; HUMAN; NOMENCLATURE; PATHOPHYSIOLOGY; SEPSIS;

HUMANS; SEPSIS; TERMINOLOGY AS TOPIC;

EID: 84939969644     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-015-3680-x     Document Type: Article

References (15)

1. Bone RC, Sibbald WJ, Sprung CL (1992) The ACCP-SCCM consensus conference on sepsis and organ failure. Chest 101:1481–1483
2. Levy MM, Fink MP, Marshall JC, for the International Sepsis Committee et al (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Intensive Care Med 29:530–538
3. Rhee C, Gohil S, Klompas M (2014) Regulatory mandates for sepsis care—reasons for caution. N Engl J Med 370:1673–1676
4. Adhikari NK, Fowler RA, Bhagwanjee S, Rubenfeld GD (2010) Critical care and the global burden of critical illness in adults. Lancet 376:1339–1346
5. ProCESS Investigators, Yealy DM, JA Kellum, Huang DT et al (2014) A randomized trial of protocol-based care for early septic shock. N Engl J Med 370:1683–1693
6. ARISE Investigators, Peake SL, Delaney A, Bailey M et al (2014) Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371:1496–1506
7. Gaieski DF, Edwards JM, Kallan MJ, Carr BG (2013) Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med 41:1167–1174
8. Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R (2014) Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA 311:1308–1316
9. Xiao W, Mindrinos MN, Seok J, for the Inflammation and Host Response to Injury Large-Scale Collaborative Research Progam et al (2011) A genomic storm in critically injured humans. J Exp Med 208:2581–2590
10. Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862–874
11. Czura CJ (2011) “Merinoff symposium 2010: sepsis”—speaking with one voice. Mol Med 17:2–3
12. Nathan C, Cars O (2014) Antibiotic resistance—problems, progress, and prospects. N Engl J Med 371:1761–1763
13. Ferrer R, Martin-Loeches I, Phillips G et al (2014) Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med 42:1749–1755
14. Kumar A, Roberts D, Wood K et al (2006) Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34:1589–1596
15. Clermont G, Angus DC, Linde-Zwirble WT, Griffin MF, Fine MJ, Pinsky MR (2002) Does acute organ dysfunction predict patient-centered outcomes? Chest 121:1963–1971