Effects of restoration of the euthyroid state on epicardial adipose tissue and carotid intima media thickness in subclinical hypothyroid patients

Endocrine

Volumn 48, Issue 3, 2015, Pages 909-915

  Yazıcı, Dilek ^a   Özben, Beste ^a   Toprak, Ahmet ^b   Yavuz, Dilek ^a   Aydın, Hasan ^c   Tarçın, Özlem ^d   Deyneli, Oğuzhan ^a   Akalın, Sema ^a  

^a MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b UNIVERSITY OF MISSOURI   (United States)

^c YEDITEPE UNIVERSITY   (Turkey)

^d BASKENT UNIVERSITY   (Turkey)

Author keywords

Carotid intima media thickness; Epicardial adipose tissue thickness; Subclinical hypothyroidism

Indexed keywords

THYROXINE;

ADIPOSE TISSUE; ADULT; ARTERIAL WALL THICKNESS; CARDIOVASCULAR DISEASE; ECHOGRAPHY; FEMALE; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; MALE; MIDDLE AGED; PERICARDIUM; PROSPECTIVE STUDY; RISK FACTOR; TREATMENT OUTCOME; YOUNG ADULT;

ADIPOSE TISSUE; ADULT; CARDIOVASCULAR DISEASES; CAROTID INTIMA-MEDIA THICKNESS; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOTHYROIDISM; MALE; MIDDLE AGED; PERICARDIUM; PROSPECTIVE STUDIES; RISK FACTORS; THYROXINE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84939873409     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-014-0372-1     Document Type: Article

References (46)

1. A.R. Cappola, P.W. Ladenson, Hypothyroidism and atherosclerosis. J. Clin. Endocrinol. Metab. 88, 2438–2444 (2003)
2. A.E. Hak, H.A. Pols, T.J. Visser, H.A. Drexhage, A. Hofman, J.C. Witteman, Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann. Int. Med. 132, 270–278 (2000)
3. P.B. Fowler, J. Swale, H. Andrews, Hypercholesterolaemia in borderline hypothyroidism. Stage of premyxoedema. Lancet 2, 488–491 (1970)
4. B.U. Althaus, J.J. Staub, A. Ryff-De Lèche, A. Oberhänsli, H.B. Stähelin, LDL/HDL-changes in subclinical hypothyroidism: possible risk factors for coronary heart disease. Clin. Endocrinol. (Oxf) 28, 157–163 (1988)
5. B. Müller, D.A. Tsakiris, C.B. Roth, M. Guglielmetti, J.J. Staub, G.A. Marbet, Haemostatic profile in hypothyroidism as potential risk factor for vascular or thrombotic disease. Eur. J. Clin. Invest. 31, 131–137 (2001)
6. K. Ojamaa, J.D. Klemperer, I. Klein, Acute effects of thyroid hormone on vascular smooth muscle. Thyroid 6, 505–512 (1996)
7. J. Földes, M. Istvánfy, M. Halmágyi, A. Váradi, A. Gara, O. Pártos, Hypothyroidism and the heart. Examination of left ventricular function in subclinical hypothyroidism. Acta. Med. Hung. 44, 337–347 (1987)
8. J.M. Fernández-Real, A. López-Bermejo, A. Castro, R. Casamitjana, W. Ricart, Thyroid function is intrinsically linked to insulin sensitivity and endothelium-dependent vasodilation in healthy euthyroid subjects. J. Clin. Endocrinol. Metab. 91, 3337–3343 (2006)
9. N. Knudsen, P. Laurberg, L.B. Rasmussen, I. Bülow, H. Perrild, L. Ovesen, T. Jørgensen, Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J. Clin. Endocrinol. Metab. 90, 4019–4024 (2005)
10. T. Reinehr, Obesity and thyroid function. Mol. Cell. Endocrinol. 316, 165–171 (2010)
11. M. Alevizaki, K. Saltiki, P. Voidonikola, E. Mantzou, C. Papamichael, K. Stamatelopoulos, Free thyroxine is an independent predictor of subcutaneous fat in euthyroid individuals. Eur. J. Endocrinol. 161, 459–465 (2009)
12. O. Tarcin, G.B. Abanonu, D. Yazici, O. Tarcin, Association of metabolic syndrome parameters with TT3 and FT3/FT4 ratio in obese Turkish population. Metab. Syndr. Relat. Disord. 10, 137–142 (2012)
13. A. Roos, S.J. Bakker, T.P. Links, R.O. Gans, B.H. Wolffenbuttel, Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects. J. Clin. Endocrinol. Metab. 92, 491–496 (2007)
14. S. Mamiya, M. Hagiwara, S. Inoue, H. Hidaka, Thyroid hormones inhibit platelet function and myosin light chain kinase. J. Biol. Chem. 264, 8575–8579 (1989)
15. K.M. Rexrode, V.J. Carey, C.H. Hennekens, E.E. Walters, G.A. Colditz, M.J. Stampfer, W.C. Willett, J.E. Manson, Abdominal adiposity and coronary heart disease in women. JAMA 280, 1843–1848 (1998)
16. J. Shirani, K. Berezowski, W.C. Roberts, Quantitative measurement of normal and excessive (cor adiposum) subepicardial adipose tissue, its clinical significance, and its effect on electrocardiographic QRS voltage. Am. J. Cardiol. 76, 414–418 (1995)
17. A.R. Baker, N.F. Silva, D.W. Quinn, A.L. Harte, D. Pagano, R.S. Bonser, S. Kumar, P.G. McTernan, Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc. Diabetol. 5, 1 (2006)
18. G. Iacobellis, D. Pistilli, M. Gucciardo, F. Leonetti, F. Miraldi, G. Brancaccio, P. Gallo, C.R. di Gioia, Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine 29, 251–255 (2005)
19. G. Iacobellis, F. Assael, M.C. Ribaudo, A. Zappaterreno, G. Alessi, U. Di Mario, F. Leonetti, Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes. Res. 11, 304–310 (2003)
20. G. Iacobellis, A.M. Sharma, Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome. Curr. Pharm. Des. 13, 2180–2184 (2007)
21. J.W. Jeong, M.H. Jeong, K.H. Yun, S.K. Oh, E.M. Park, Y.K. Kim, S.J. Rhee, E.M. Lee, J. Lee, N.J. Yoo, N.H. Kim, J.C. Park, Echocardiographic epicardial fat thickness and coronary artery disease. Circ. J. 71, 536–539 (2007)
22. R. Taguchi, J. Takasu, Y. Itani, R. Yamamoto, K. Yokoyama, S. Watanabe, Y. Masuda, Pericardial fat accumulation in men as a risk factor for coronary artery disease. Atherosclerosis 157, 203–209 (2001)
23. L. Korkmaz, S. Sahin, A.R. Akyuz, M. Ziyrek, I. Anaforoglu, M. Kose, H. Erkan, M.T. Ağaç, Z. Acar, Epicardial adipose tissue increased in patients with newly diagnosed subclinical hypothyroidism Med. Princ. Pract. 22, 42–46 (2013)
24. M. Asik, S. Sahin, F. Ozkul, I. Anaforoglu, S. Ayhan, S. Karagol, F. Gunes, E. Algun, Evaluation of epicardial fat tissue thickness in patients with Hashimoto thyroiditis. Clin. Endocrinol. (Oxf) 79, 571–576 (2013)
25. M.D. Cabral, P.F. Teixeira, N.A. Silva, F.F. Morais, D.V. Soares, E. Salles, J.M. Henriques, S.P. Leite, C.A. Montenegro, M. Vaisman, Normal flow-mediated vasodilatation of the brachial artery and carotid artery intima-media thickness in subclinical hypothyroidism. Braz. J. Med. Biol. Res. 42, 426–432 (2009)
26. V.N. Valentina, B. Marijan, D. Chedo, K. Branka, Subclinical hypothyroidism and risk to carotid atherosclerosis. Arq. Bras. Endocrinol. Metabol. 55, 475–480 (2011)
27. F. Monzani, N. Caraccio, M. Kozàkowà, A. Dardano, F. Vittone, A. Virdis, S. Taddei, C. Palombo, E. Ferrannini, Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo-controlled study. J. Clin. Endocrinol. Metab. 89, 2099–2106 (2004)
28. A. Poli, E. Tremoli, A. Colombo, M. Sirtori, P. Pignoli, R. Paoletti, Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients. A new model for the quantitation and follow-up of preclinical atherosclerosis in living human subjects. Atherosclerosis 70, 253–261 (1988)
29. L. Tian, J. Ni, T. Guo, J. Liu, Y. Dang, Q. Guo, L. Zhang, TSH stimulates the proliferation of vascular smooth muscle cells. Endocrine 46, 651–658 (2014)
30. A. Haribabu, V.S. Reddy, Ch. Pallavi, A.R. Bitla, A. Sachan, P. Pullaiah, V. Suresh, P.V. Rao, M.M. Suchitra, Evaluation of protein oxidation and its association with lipid peroxidation and thyrotropin levels in overt and subclinical hypothyroidism. Endocrine 44, 152–157 (2013)
31. Y.T. Yu, C.T. Ho, H.S. Hsu, C.I. Li, L.E. Davidson, C.S. Liu, T.C. Li, C.M. Shih, C.C. Lin, W.Y. Lin, Subclinical hypothyroidism is associated with elevated high-sensitive C-reactive protein among adult Taiwanese. Endocrine 44, 716–722 (2013)
32. G. Vitale, M. Galderisi, G.A. Lupoli, A. Celentano, I. Pietropaolo, N. Parenti, O. De Divitiis, G. Lupoli, Left ventricular myocardial impairment in subclinical hypothyroidism assessed by a new ultrasound tool: pulsed tissue Doppler. J. Clin. Endocrinol. Metab. 87, 4350–4355 (2002)
33. J. Westerink, Y. van der Graaf, D.R. Faber, F.L. Visseren, SMART study group.: The relation between thyroid-stimulating hormone and measures of adiposity in patients with manifest vascular disease. Eur. J. Clin. Invest. 41, 159–166 (2011)
34. G. Iacobellis, M.C. Ribaudo, F. Assael, E. Vecci, C. Tiberti, A. Zappaterreno, U. Di Mario, F. Leonetti, Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J. Clin. Endocrinol. Metab. 88, 5163–5168 (2003)
35. H. Aydın, A. Toprak, O. Deyneli, D. Yazici, O. Tarcın, S. Sancak, D. Yavuz, S. Akalin, Epicardial fat tissue thickness correlates with endothelial dysfunction and other cardiovascular risk factors in patients with metabolic syndrome. Metab. Syndr. Relat. Disorders 8, 229–234 (2010)
36. G. Iacobellis, F. Leonetti, N. Singh, A. Sharma, Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects. Int. J. Cardiol. 115, 272–273 (2007)
37. N. Bettencourt, A.M. Toschke, D. Leite, J. Rocha, M. Carvalho, F. Sampaio, S. Xará, A. Leite-Moreira, E. Nagel, V. Gama, Epicardial adipose tissue is an independent predictor of coronary atherosclerotic burden. Int. J. Cardiol. 158, 26–32 (2012)
38. G. Iacobellis, D. Corradi, A.M. Sharma, Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat. Clin. Pract. Cardiovasc. Med. 2, 536–543 (2005)
39. S. Sarin, C. Wenger, A. Marwaha, A. Qureshi, B.D. Go, C.A. Woomert, K. Clark, L.A. Nassef, J. Shirani, Clinical significance of epicardial fat measured using cardiac multislice computed tomography. Am. J. Cardiol. 102, 767–771 (2008)
40. T. Mazurek, L. Zhang, A. Zalewski, J.D. Mannion, J.T. Diehl, H. Arafat, L. Sarov-Blat, S. O’Brien, E.A. Keiper, A.G. Johnson, J. Martin, B.J. Goldstein, Y. Shi, Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 108, 2460–2466 (2003)
41. P. Maurovich-Horvat, K. Kallianos, L.C. Engel, J. Szymonifka, C.S. Fox, U. Hofmann, Q.A. Truong, Influence of pericoronary adipose tissue on local coronary atherosclerosis as assessed by a novel MDCT volumetric method. Atherosclerosis 219, 151–157 (2011)
42. R.P. Dullaart, R. de Vries, C. Roozendaal, A.C. Kobold, W.J. Sluiter, Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects. Clin. Endocrinol. (Oxf) 67, 668–673 (2007)
43. M.M. Ciccone, E. Bilianou, A. Balbarini, M. Gesualdo, L. Ghiadoni, M. Metra, P. Palmiero, R. Pedrinelli, M. Salvetti, P. Scicchitano, A. Zito, S. Novo, A.V. Mattioli, Task force on: ‘Early markers of atherosclerosis: influence of age and sex. J. Cardiovasc. Med. (Hagerstown) 14, 757–766 (2013)
44. P.J. Touboul, M.G. Hennerici, S. Meairs, H. Adams, P. Amarenco, N. Bornstein, L. Csiba, M. Desvarieux, S. Ebrahim, R. Hernandez Hernandez, M. Jaff, S. Kownator, T. Naqvi, P. Prati, T. Rundek, M. Sitzer, U. Schminke, J.C. Tardif, A. Taylor, E. Vicaut, K.S. Woo, Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim,Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc. Dis. 34, 290–296 (2012)
45. T. Nagasaki, M. Inaba, Y. Henmi, Y. Kumeda, M. Ueda, H. Tahara, S. Sugiguchi, S. Fujiwara, M. Emoto, E. Ishimura, N. Onoda, T. Ishikawa, Y. Nishizawa, Decrease in carotid intima-media thickness in hypothyroid patients after normalization of thyroid function. Clin. Endocrinol. (Oxf) 59, 607–612 (2003)
46. M. Adrees, J. Gibney, N. El-Saeity, G. Boran, Effects of 18 months of L-T4 replacement in women with subclinical hypothyroidism. Clin. Endocrinol. (Oxf) 71, 298–303 (2009)