Thyroid function is intrinsically linked to insulin sensitivity and endothelium-dependent vasodilation in healthy euthyroid subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 9, 2006, Pages 3337-3343

  Fernández Real, Jose Manuel ^a   López Bermejo, Abel ^a   Castro, Antoni ^a   Casamitjana, Roser ^a   Ricart, Wifredo ^a  

^a HOSPITAL JOSEP TRUETA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN; INSULIN; LIPID; THYROTROPIN; TRIACYLGLYCEROL;

ADULT; ANTHROPOMETRY; ARTICLE; BODY MASS; CONTROLLED STUDY; ECHOGRAPHY; ENDOTHELIAL DYSFUNCTION; FREE THYROXINE INDEX; HUMAN; HUMAN EXPERIMENT; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; MALE; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; THYROID FUNCTION TEST; THYROTROPIN BLOOD LEVEL; VASODILATATION;

EID: 33748749271     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-0841     Document Type: Article

References (45)

1. 4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87:489-499
2. Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT 2004 American Association of Clinical Endocrinologists/American Thyroid Association/Endocrine Society subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. Endocr Pract 10:497-501
3. Stathatos N, Wartofsky L 2002 Managing subclinical hypothyroidism in women. Womens Health Primary Care 5:239-246
4. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, Hershman JM, Burman KD, Denke MA, Gorman C, Cooper RS, Weissman NJ 2004 Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 291:228-238
5. Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT 2005 Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society. J Clin Endocrinol Metab 90:581-585
6. Surks MI 2005 Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society. J Clin Endocrinol Metab 90:586-587
7. Bruckert E, Giral P, Chadarevian R, Turpin G 1999 Low free-thyroxine levels are a risk factor for subclinical atherosclerosis in euthyroid hyperlipidemic patients. J Cardiovasc Risk 6:327-331
8. Pallas D, Koutras DA, Adamopoulos P, Marafelia P, Souvatzoglou A, Piperingos G, Moulopoulos SD 1991 Increased mean serum thyrotropin in apparently euthyroid hypercholesterolemic patients: does it mean occult hypothyroidism? J Endocrinol Invest 14:743-746
9. Michalopoulou G, Alevizaki M, Piperingos G, Mitsibounas D, Mantzos E, Adamopoulos P, Koutras DA 1998 High serum cholesterol levels in persons with "high-normal" TSH levels: should one extend the definition of subclinical hypothyroidism? Eur J Endocrinol 138:141-145
10. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC 2000 The Colorado thyroid disease prevalence study. Arch Intern Med 160:526-534
11. Tunbridge WMG, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Evans JG, Young E, Bird T, Smith PA 1977 The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 7:481-493
12. Geul KW, van Sluisveld IL, Grobbee DE, Docter R, de Bruyn AM, Hooykaas H, van der Merwe JP, van Hemert AM, Krenning EP, Hennemann G 1993 The importance of thyroid microsomal antibodies in the development of elevated serum TSH in middle-aged women: association with serum lipids. Clin Endocrinol (Oxf) 39:275-280
13. Parle JV, Franklin JA, Cross KW, Jones SR, Sheppard MC 1992 Circulating lipids and minor abnormalities of thyroid function. Clin Endocrinol (Oxf) 37:411-414
14. Danese MD, Ladenson PW, Meinert CL, Powe NR 2000 Effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. J Clin Endocrinol Metab 85:2993-3001
15. Caraccio N, Ferrannini E, Monzani F 2002 Lipoprotein profile in subclinical hypothyroidism: effect of levothyroxine replacement therapy. A randomized, placebo-controlled study. J Clin Endocrinol Metab 87:1533-1538
16. Prinz PN, Scanlan JM, Vitaliano PP, Moe KE, Borson S, Toivola B, Merriam GR, Larsen LH, Reed HL 1999 Thyroid hormones: positive relationships with cognition in healthy, euthyroid older men. J Gerontol A Biol Sci Med Sci 54:M111-M116
17. Auer J, Berent R, Weber T, Lassnig E, Eber B 2003 Thyroid function is associated with presence and severity of coronary atherosclerosis. Clin Cardiol 26:569-573
18. Lekakis J, Papamichael C, Alevizaki M, Piperingos G, Marafelia P, Mantzos J, Stamatelopoulos S, Koutras DA 1997 Flow-mediated, endothelium-dependent vasodilation is impaired in subjects with hypothyroidism, borderline hypothyroidism, and high-normal serum thyrotropin (TSH) values. Thyroid 7:411-414
19. Taddei S, Caraccio N, Virdis A, Dardano A, Versari D, Ghiadoni L, Salvetti A, Ferrannini E, Monzani F 2003 Impaired endothelium-dependent vasodilation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J Clin Endocrinol Metab 88:3731-3737
20. Park KW, Dai HB, Ojamaa K, Lowenstein E, Klein I, Sellke FW 1997 The direct vasomotor effect of thyroid hormones on rat skeletal muscle resistance arteries. Anesth Analg 85:734-738
21. Ojamaa K, Klemperer JD, Klein I 1996 Acute effects of thyroid hormone on vascular smooth muscle. Thyroid 6:505-512
22. Mizuma H, Murakami M, Mori M 2001 Thyroid hormone activation in human vascular smooth muscle cells. Expression of type II iodothyronine deiodinase. Circ Res 88:313-318
23. Klein I, Ojamaa K 2000 The cardiovascular system in hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner, Ingbar's the thyroid: a fundamental and clinical text. 8th ed. Philadelphia: Lippincott Williams, Wilkins; 777-782
24. Bakker SJ, ter Maaten JC, Popp-Snijders C, Slaets JP, Heine RJ, Gans RO 2001 The relationship between thyrotropin and low-density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects. J Clin Endocrinol Metab 86:1206-1211
25. Chubb SA, Davis WA, Davis TM 2005 Interactions among thyroid function, insulin sensitivity, and serum lipid concentrations: the Fremantle diabetes study. J Clin Endocrinol Metab 90:5317-5320
26. 3 in normal subjects: a clue to the understanding of subclinical thyroid disease. J Clin Endocrinol Metab 87:1068-1072
27. Meikle AW, Stringham JD, Woodward MG, Nelson JC 1988 Hereditary and environmental influences on the variation of thyroid hormones in normal male twins. J Clin Endocrinol Metab 66:588-592
28. Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, LiVosli VA, Niccoli-Sire P, John R, Ruf J, Smyth PP, Spencer CA, Stockigt JR 2003 Guidelines Committee, National Academy of Clinical Biochemistry Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 13:3-126
29. Yagi H, Pohlenz J, Hayashi Y, Sakurai A, Refetoff S 1997 Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3′-triiodothyroinine binding affinity. J Clin Endocrinol Metab 82:1608-1614
30. Jameson JL 2001 Mechanisms of thyroid hormone action. In: DeGroot LJ, Jameson JL, eds. Endocrinology. 4th ed, vol 2. Philadelphia: WB Saunders; 1327-1344
31. Michalaki MA, Vagenakis AG, Leonardou AS, Argentou MN, Habeos IG, Makri MG, Psyrogiannis AI, Kalfarentzos FE, Kyriazopoulou VE 2006 Thyroid function in humans with morbid obesity. Thyroid 16:73-78
32. Knudsen N, Laurberg P, Rasmussen LB, Bulow I, Perrild H, Ovesen L, Jorgensen T 2005 Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab 90:4019-4024
33. Iacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F 2005 Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clin Endocrinol (Oxf) 62:487-491
34. Nyrnes A, Jorde R, Sundsfjord J 2006 Serum TSH is positively associated with BMI. Int J Obes 30:100-105
35. Astrup A, Buemann B, Christensen NJ, Madsen J, Gluud C, Bennett P, Svenstrup B 1992 The contribution of body composition, substrates, and hormones to the variability in energy expenditure and substrate utilization in premenopausal women. J Clin Endocrinol Metab 74:279-286
36. Liu YY, Schultz JJ, Brent GA 2003 A thyroid hormone receptor α gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. J Biol Chem 278:38913-38920
37. Moore R, Grant AM, Howard AN, Mills IH 1980 Treatment of obesity with triiodothyronine and a very-low-calorie liquid formula diet. Lancet 1:223-226
38. Gelvin EP, Kenigsberg S, Boyd LJ 1959 Results of addition of liothyronine to a weight-reducing regimen. JAMA 170:1507-1512
39. Danowski TS, Narduzzi JV, Amidi M, Cohn R, Limaye NR, Grimes BJ, Weir TF 1967 Hydrocortisone and/or desiccated thyroid in physiologic dosage. XIX. Desiccated thyroid in the therapy of obesity. Metabolism 16:102-110
40. Hollingsworth DR, Amatruda Jr TT, Scheig R 1970 Quantitative and qualitative effects of l-triiodothyronine in massive obesity. Metabolism 19:934-945
41. Mentuccia D, Proietti-Pannunzi L, Tanner K, Bacci V, Pollin TI, Poehlman ET, Shuldiner AR, Celi FS 2002 Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance. Diabetes 51:880-883
42. Canani LH, Capp C, Dora JM, Souza Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL 2005 The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 90:3472-3478
43. Ness GC, Lopez D, Chambers CM, Newsome WP, Cornelius P, Long CA, Harwood Jr HJ 1998 Effects of L-triiodothyronine and the thyromimetic L-94901 on serum lipoprotein levels and hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo A-I gene expression. Biochem Pharmacol 56:121-129
44. Gumieniak O, Hurwitz S, Perlstein TS, Ngumezi UC, Hopkins PN, Jeunemaitre X, Williams GH 2005 Aggregation of high-normal thyroid-stimulating hormone in hypertensive families. J Clin Endocrinol Metab 90:5985-5990
45. Gumieniak O, Perlstein TS, Hopkins PN, Brown NJ, Murphey LJ, Jeunemaitre X, Hollenberg NK, Williams GH 2004 Thyroid function and blood pressure homeostasis in euthyroid subjects. J Clin Endocrinol Metab 89:3455-3461