Impact of patient-selected care buddies on adherence to HIV care, disease progression, and conduct of daily life among pre-antiretroviral HIV-infected patients in Rakai, Uganda: A randomized controlled trial

Journal of Acquired Immune Deficiency Syndromes

Volumn 70, Issue 1, 2015, Pages 75-82

  Nakigozi, Gertrude ^a   Makumbi, Fredrick E ^b   Bwanika, John B ^a   Atuyambe, Lynn ^b   Reynolds, Steven J ^c,d,e   Kigozi, Godfrey ^a   Nalugoda, Fred ^a   Chang, Larry W ^d,e   Kiggundu, Valerian ^a   Serwadda, David ^b   Wawer, Maria J ^e   Gray, Ronald H ^e   Kamya, Moses R ^f  

^a RAKAI HEALTH SCIENCES PROGRAM   (Uganda)

^b MAKERERE UNIVERSITY SCHOOL OF PUBLIC HEALTH   (Uganda)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^f MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

Author keywords

HIV; patient selected care buddy; pre ART; randomized controlled trial; Uganda

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD4 ANTIGEN; COTRIMOXAZOLE;

ADOLESCENT; ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DAILY LIFE ACTIVITY; DISEASE COURSE; FEMALE; FOLLOW UP; HEALTH CARE QUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; MIDDLE AGED; PATIENT CARE; PATIENT SELECTED CARE BUDDY; PATIENT SELECTION; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; UGANDA; HEALTH SERVICE; HIGH RISK BEHAVIOR; PATHOLOGY; PATIENT COMPLIANCE; PSYCHOLOGY; SOCIAL SUPPORT; YOUNG ADULT;

ADOLESCENT; ADULT; DISEASE PROGRESSION; FEMALE; HEALTH SERVICES ADMINISTRATION; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; PATIENT COMPLIANCE; RISK-TAKING; SOCIAL SUPPORT; UGANDA; YOUNG ADULT;

EID: 84939789783     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000710     Document Type: Article

References (31)

1. Rosen S, Fox MP. Retention in HIV care between testing and treatment in sub-Saharan Africa: a systematic review. PLoS Med. 2011: 8: e1001056
2. Mermin J, Ekwaru JP, Liechty CA. Effect of co-Trimoxazole prophylaxis, antiretroviral therapy, and insecticide-Treated bednets on the frequency of malaria in HIV-1-infected adults in Uganda: a prospective cohort study. Lancet. 2006; 367: 1256-1261
3. Burtle D, Welfare W, Elden S, et al. Introduction and evaluation of a pre-ART care service in Swaziland: an operational research study. BMJ Open. 2012; 2: e000195
4. Larson BA, Brennan A, McNamara L, et al. Early loss to follow up after enrolment in pre-ART care at a large public clinic in Johannesburg, South Africa. Trop Med Int Health. 2010; 15(suppl 1): 43-47
5. Mulissa A, Jerene D, Bindtjorn B. Patients present earlier and survival has improved, but pre-ART attrition is high in a six-year HIV cohort data from Ethiopia. PLoS One. 2010; 5: e13268
6. Clouse K, Pettifor AE, Maskew M, et al. Patient retention from HIV diagnosis through one year on antiretroviral therapy at a primary healthcare clinic in Johannesburg, South Africa. J Acquir Immune Defic Syndr. 2013; 62: e39-e46
7. Amuron B, Namara G, Birungi J, et al. Mortality and loss to-follow-up during the pre-Treatment period in an antiretroviral therapy programme under normal health service conditions in Uganda. BMC Public Health. 2009; 9: 290
8. Bassett IV, Wang B, Chetty S, et al. Loss to care and death before antiretroviral therapy in Durban South Africa. J Acquir Immune Defic Syndr. 2009; 5: 135-139
9. Tayler-Smith K, Zachariah R, Massaquoi M, et al. Unacceptable attrition among WHO stages 1 and 2 patients in a hospital based setting in rural Malawi: can we retain such patients within the general health system? Trans R Soc Trop Med Hyg. 2010; 104: 313-319
10. Lessells RU, Mutevedzi PC, Cooke GS, et al. Retention in HIV care for individuals not yet eligible for antiretroviral therapy: rural KwaZulu-Natal, South Africa. J Acquir Immune Defic Syndr. 2011; 56: e79-e86
11. Kranzer K, Govindasamy D, Ford N, et al. Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic review. J Int AIDS Soc. 2012; 15: 17383
12. Mugglin C, Estill J, Wandeler G, et al. Loss to programme between HIV diagnosis and initiation of antiretroviral therapy in sub-Saharan Africa: systematic review and meta-Analysis. Trop Med Int Health. 2012; 17: 1509-1520
13. Losina E, Basset IV, Giddy J, et al. The ART of linkage: pre-Treatment loss to care after HIV diagnosis at two PEPFAR Sites in Durban, South Africa. PLoS One. 2010; 5: e9538
14. Van der Paal L, Shafer LA, Todd J, et al. HIV-1 disease progression and mortality before the introduction of highly active antiretroviral therapy in rural Uganda. AIDS. 2007; 21: (suppl 6): S21-S29
15. Nachega JB, Chaisson RE, Goliath R, et al. Randomized controlled trial of trained patient-nominated treatment supporters providing partial directly observed antiretroviral therapy. AIDS. 2010; 24: 1273-1280
16. Taiwo BO, Idoko JA, Welty LJ, et al. Assessing the viorologic and adherence benefits of patient-selected HIV treatment partners in a resourcelimited setting. J Acquir Immune Defic Syndr. 2010; 54: 85-92
17. Simoni JM, Pearson CR, Pantalone DW, et al. Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load A meta-Analytic review of randomized controlled trials. J Acquir Immune Defic Syndr. 2006; 43(suppl 1): S23-S35
18. Rueda S, Park-Wyllie LY, Bayoumi AM, et al. Patient support and education for promoting adherence to highly active antiretroviral therapy for HIV/AIDS. Cochrane Database Syst Rev. 2006: CD001442
19. Foster SD, Nakamanya S, Kyomuhangi R, et al. The experience of medicine companions to support adherence to antiretroviral therapy: quantitative and qualitative data from a trial population in Uganda. AIDS Care. 2010; 22(suppl 1): 35-43
20. Farmer P, Léandre F, Mukherjee J, et al. Community-based treatment of advanced HIV disease: introducing DOT-HAART (directly observed therapy with highly active antiretroviral therapy). Bull World Health Organ. 2001; 79: 1145-1151
21. AVERT. 2012. HIV & AIDS in Uganda j AVERT. Avaialble at: www. avert.org/hiv-Aids-uganda.htm
22. Donald G, McNeil Jr. At front lines, AIDS war is falling apart. The New York Times. May 9, 2010. Available at: http://www.nytimes.com/2010/05/10/world/africa/10aids.html?-r=0
23. Zwillich T. Obama administration may flat-line funding for PEPFAR. Lancet. 2009; 373: 1325
24. Guangyong Z A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol. 2004; 159: 702-706
25. Altman DG, Schulz KF, Moher D, et al. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med. 2001; 134: 663-694
26. Amuron B, Coutinho A, Grosskurth H, et al A cluster randomized trial to compare home-based with health facility-based antiretroviral treatment in Uganda: study design and baseline findings. Open AIDS J. 2007; 1: 21-27
27. Ferrari JR, Mccown W, Pantano J. Experiencing satisfaction and stress as an AIDS care provider: the AIDS caregiver scale. Eval Health Prof. 1993; 16: 295-310
28. Van Tam V, Larsson M, Pharris A, et al. Peer support and improved conduct of daily life among persons living with HIV on antiretroviral treatment: a randomised controlled trial from north-eastern Vietnam. Health Qual Life Outcomes. 2012; 10: 53
29. Karamagi CAS, Tumwine JK, Tylleskar T, et al. Intimate partner violence against women in eastern Uganda: implications for HIV prevention. BMC Public Health. 2006; 6: 284
30. Koenig MA, Lutalo T, Zhao F, et al. Domestic violence in rural Uganda: evidence from a community-based study. Bull World Health Organ. 2003; 81: 53-60
31. Mills E, Nachega J, Bangsberg D, et al. Adherence to ART: a systematic review of developed and developing nation patient-reported barriers and facilitators. PLoS Med. 2006; 3: e438