In vivo optical imaging of human retinal capillary networks using speckle variance optical coherence tomography with quantitative clinico-histological correlation

Microvascular Research

Volumn 100, Issue , 2015, Pages 32-39

  Chan, Geoffrey ^a,b   Balaratnasingam, Chandrakumar ^a,b,c   Xu, Jing ^d   Mammo, Zaid ^c   Han, Sherry ^d   Mackenzie, Paul ^c,d   Merkur, Andrew ^c   Kirker, Andrew ^c   Albiani, David ^c   Sarunic, Marinko V ^d   Yu, Dao Yi ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Capillary; Confocal microscopy; Perifovea; Retina; Speckle variance OCT; Vasculature

Indexed keywords

ADULT; AGED; BLOOD FLOW; CAPILLARY; COMPARATIVE STUDY; COMPUTER ASSISTED DIAGNOSIS; CONFOCAL MICROSCOPY; FEMALE; FLUORESCENCE ANGIOGRAPHY; FLUORESCENCE IMAGING; HUMAN; MALE; MICROCIRCULATION; MIDDLE AGED; OPTICAL COHERENCE TOMOGRAPHY; PATHOLOGY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROCEDURES; REPRODUCIBILITY; RETINA BLOOD VESSEL; YOUNG ADULT;

ADULT; AGED; CAPILLARIES; FEMALE; FLUORESCEIN ANGIOGRAPHY; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MICROCIRCULATION; MICROSCOPY, CONFOCAL; MIDDLE AGED; OPTICAL IMAGING; PREDICTIVE VALUE OF TESTS; REGIONAL BLOOD FLOW; REPRODUCIBILITY OF RESULTS; RETINAL VESSELS; TOMOGRAPHY, OPTICAL COHERENCE; YOUNG ADULT;

EID: 84939779027     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2015.04.006     Document Type: Article

References (38)

1. Bearelly S., Rao S., Fekrat S. Anaphylaxis following intravenous fluorescein angiography in a vitreoretinal clinic: report of 4 cases. Can. J. Ophthalmol. 2009, 44:444-445.
2. Bek T. Inner retinal ischaemia: current understanding and needs for further investigations. Acta Ophthalmol. 2009, 87:362-367.
3. Braaf B., Vienola K.V., Sheehy C.K., Yang Q., Vermeer K.A., Tiruveedhula P., Arathorn D.W., Roorda A., de Boer J.F. Real-time eye motion correction in phase-resolved OCT angiography with tracking SLO. Biomed. Opt. Express 2013, 4:51-65.
4. Chan G., Balaratnasingam C., Yu P.K., Morgan W.H., McAllister I.L., Cringle S.J., Yu D.Y. Quantitative morphometry of perifoveal capillary networks in the human retina. Invest. Ophthalmol. Vis. Sci. 2012, 53:5502-5514.
5. Chan G., Balaratnasingam C., Yu P.K., Morgan W.H., McAllister I.L., Cringle S.J., Yu D.Y. Quantitative changes in perifoveal capillary networks in patients with vascular comorbidities. Invest. Ophthalmol. Vis. Sci. 2013, 54:5175-5185.
6. Ellabban A.A., Tsujikawa A., Matsumoto A., Ogino K., Hangai M., Ooto S., Yamashiro K., Akiba M., Yoshimura N. Macular choroidal thickness and volume in eyes with angioid streaks measured by swept source optical coherence tomography. Am J. Ophthalmol. 2012, 153:1133-1143.
7. Fingler J., Zawadzki R.J., Werner J.S., Schwartz D., Fraser S.E. Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique. Opt. Express 2009, 17:22190-22200.
8. Hamilton N.B., Attwell D., Hall C.N. Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease. Front. Neuroenerg. 2010, 2.
9. Hayreh S.S., Weingeist T.A. Experimental occlusion of the central artery of the retina. IV: Retinal tolerance time to acute ischaemia. Br. J. Ophthalmol. 1980, 64:818-825.
10. Jia Y., Tan O., Tokayer J., Potsaid B., Wang Y., Liu J.J., Kraus M.F., Subhash H., Fujimoto J.G., Hornegger J., Huang D. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt. Express 2012, 20:4710-4725.
11. Jian Y., Wong K., Sarunic M.V. Graphics processing unit accelerated optical coherence tomography processing at megahertz axial scan rate and high resolution video rate volumetric rendering. J. Biomed. Opt. 2013, 18:26002.
12. Kaur C., Foulds W.S., Ling E.A. Hypoxia-ischemia and retinal ganglion cell damage. Clin. Ophthalmol. 2008, 2:879-889.
13. Larina I.V., Larin K.V., Justice M.J., Dickinson M.E. Optical coherence tomography for live imaging of mammalian development. Curr. Opin. Genet. Dev. 2011, 21:579-584.
14. Lee K.K., Mariampillai A., Yu J.X., Cadotte D.W., Wilson B.C., Standish B.A., Yang V.X. Real-time speckle variance swept-source optical coherence tomography using a graphics processing unit. Biomed. Opt. Express 2012, 3:1557-1564.
15. Less J.R., Skalak T.C., Sevick E.M., Jain R.K. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res. 1991, 51:265-273.
16. Mahmud M.S., Cadotte D.W., Vuong B., Sun C., Luk T.W., Mariampillai A., Yang V.X. Review of speckle and phase variance optical coherence tomography to visualize microvascular networks. J. Biomed. Opt. 2013, 18:50901.
17. Mariampillai A., Standish B.A., Moriyama E.H., Khurana M., Munce N.R., Leung M.K., Jiang J., Cable A., Wilson B.C., Vitkin I.A., Yang V.X. Speckle variance detection of microvasculature using swept-source optical coherence tomography. Opt. Lett. 2008, 33:1530-1532.
18. Mariampillai A., et al. Optimized speckle variance OCT imaging of microvasculature. Opt. Lett. 2010, 35(8):1257-1259.
19. Mendis K.R., Balaratnasingam C., Yu P., Barry C.J., McAllister I.L., Cringle S.J., Yu D.Y. Correlation of histologic and clinical images to determine the diagnostic value of fluorescein angiography for studying retinal capillary detail. Invest. Ophthalmol. Vis. Sci. 2010, 51:5864-5869.
20. Mintun M.A., Lundstrom B.N., Snyder A.Z., Vlassenko A.G., Shulman G.L., Raichle M.E. Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:6859-6864.
21. Motaghiannezam R., Fraser S. Logarithmic intensity and speckle-based motion contrast methods for human retinal vasculature visualization using swept source optical coherence tomography. Biomed. Opt. Express 2012, 3:503-521.
22. Nelson D.A., Burgansky-Eliash Z., Barash H., Loewenstein A., Barak A., Bartov E., Rock T., Grinvald A. High-resolution wide-field imaging of perfused capillaries without the use of contrast agent. Clin. Ophthalmol. 2011, 5:1095-1106.
23. Novotny H.R., Alvis D.L. A method of photographing fluorescence in circulating blood in the human retina. Circulation 1961, 24:82-86.
24. Rastogi V., Puri N., Arora S., Kaur G., Yadav L., Sharma R. Artefacts: a diagnostic dilemma - a review. J. Clin. Diagn. Res. 2013, 7:2408-2413.
25. Richard E., van Gool W.A., Hoozemans J.J., van Haastert E.S., Eikelenboom P., Rozemuller A.J., van de Berg W.D. Morphometric changes in the cortical microvascular network in Alzheimer's disease. J. Alzheimers Dis. 2010, 22:811-818.
26. Schwartz D.M., Fingler J., Kim D.Y., Zawadzki R.J., Morse L.S., Park S.S., Fraser S.E., Werner J.S. Phase-variance optical coherence tomography: a technique for noninvasive angiography. Ophthalmology 2014, 121:180-187.
27. Snodderly D.M., Weinhaus R.S., Choi J.C. Neural-vascular relationships in central retina of macaque monkeys (Macaca fascicularis). J. Neurosci. 1992, 12:1169-1193.
28. Tan P.E., Yu P.K., Balaratnasingam C., Cringle S.J., Morgan W.H., McAllister I.L., Yu D.Y. Quantitative confocal imaging of the retinal microvasculature in the human retina. Invest. Ophthalmol. Vis. Sci. 2012, 53:5728-5736.
29. Tawia S.A., Rogers P.A. In vivo microscopy of the subepithelial capillary plexus of the endometrium of rats during embryo implantation. J. Reprod. Fertil. 1992, 96:673-680.
30. Van Velthoven M.E., Faber D.J., Verbraak F.D., van Leeuwen T.G., de Smet M.D. Recent developments in optical coherence tomography for imaging the retina. Prog. Retin. Eye Res. 2007, 26:57-77.
31. Vienola K.V., Braaf B., Sheehy C.K., Yang Q., Tiruveedhula P., Arathorn D.W., de Boer J.F., Roorda A. Real-time eye motion compensation for OCT imaging with tracking SLO. Biomed. Opt. Express 2012, 3:2950-2963.
32. Wang R.K., An L., Francis P., Wilson D.J. Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography. Opt. Lett. 2010, 35:1467-1469.
33. Xu J., Wong K., Jian Y., Sarunic M.V. Real-time acquisition and display of flow contrast using speckle variance optical coherence tomography in a graphics processing unit. J. Biomed. Opt. 2014, 19:026001.
34. Xu J., Han S., Balaratnasingam C., Mammo Z., Wong K.S., Lee S., Cua M., Young M., Kirker A., Albiani D., Forooghian F., Mackenzie P., Merkur A., Yu D.Y., Sarunic M.V. Retinal angiography with real-time speckle variance optical coherence tomography. Br. J. Ophthalmol. 2015, [Epub ahead of print]. 10.1136/bjophthalmol-2014-306010.
35. Yannuzzi L.A., Rohrer K.T., Tindel L.J., Sobel R.S., Costanza M.A., Shields W., Zang E. Fluorescein angiography complication survey. Ophthalmology 1986, 93:611-617.
36. Yoshii Y., Sugiyama K. Intercapillary distance in the proliferating area of human glioma. Cancer Res. 1988, 48:2938-2941.
37. Young M., Lebed E., Jian Y., Mackenzie P.J., Beg M.F., Sarunic M.V. Real-time high-speed volumetric imaging using compressive sampling optical coherence tomography. Biomed. Opt. Express 2011, 2:2690-2697.
38. Yu P.K., Balaratnasingam C., Morgan W.H., Cringle S.J., McAllister I.L., Yu D.Y. The structural relationship between the microvasculature, neurons, and glia in the human retina. Invest. Ophthalmol. Vis. Sci. 2010, 51:447-458.