Unique clinical and imaging findings in a first ever documented PCR positive rabies survival patient: A case report

Journal of Clinical Virology

Volumn 70, Issue , 2015, Pages 83-88

  Netravathia, M ^a   Udani, V ^b   Manic, R S ^a   Gadada, V ^a   Ashwinic, M A ^a   Bhatd, M ^a   Mehtae, S ^c   Chowdharye, A ^c   Pala, P K ^a   Madhusudanac, S N ^a   Satishchandraa, P ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

^b P D HINDUJA NATIONAL HOSPITAL   (India)

^c Haffkine Institute for Training Research and Testing India   (India)

Author keywords

PCR positive rabies survivor; Rabies encephalopathy

Indexed keywords

ANTICONVULSIVE AGENT; ANTIGEN; IMMUNOGLOBULIN; NEUTRALIZING ANTIBODY; RABIES IMMUNOGLOBULIN; RABIES NUCLEOPROTEIN ANTIGEN; RABIES VACCINE; STEROID; UNCLASSIFIED DRUG; VALPROIC ACID; VIRUS RNA;

ACUTE DEMYELINATING ENCEPHALOMYELITIS; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID; CHILD; COMPUTER ASSISTED TOMOGRAPHY; DOG BITE; ELECTROENCEPHALOGRAM; ENCEPHALOMYELITIS; FLUORESCENT ANTIBODY TECHNIQUE; GENE; HOSPITALIZATION; HUMAN; HUMAN TISSUE; HYDROCEPHALUS; IMAGING; MALE; NEUROLOGIC EXAMINATION; NUCHAL SKIN BIOPSY; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSIOTHERAPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROPHYLAXIS; RABIES; RABIES NUCLEOPROTEIN GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; SKIN BIOPSY; STEROID THERAPY; SURVIVAL; SURVIVOR; TONIC CLONIC SEIZURE; ANIMAL; BITES AND STINGS; BRAIN; CAT; DOG; ELECTROENCEPHALOGRAPHY; EVOKED RESPONSE; GENETICS; PATHOLOGY; PROCEDURES; RABIES VIRUS; TREATMENT OUTCOME; VIROLOGY;

ANIMALS; BITES AND STINGS; BRAIN; CATS; CHILD; DOGS; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; POLYMERASE CHAIN REACTION; RABIES; RABIES VIRUS; TREATMENT OUTCOME;

EID: 84939619142     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2015.07.003     Document Type: Article

References (26)

1. World Health Organization, WHO Expert Consultation on Rabies. Second report, World Health Organization Technical Report Series 982, 2013.
2. Sudarshan M.K., Madhusudana S.N., Mahendra B.J., Rao N.S., Ashwath Narayana D.H., Abdul Rahman S., Meslin F.X., Lobo D., Ravikumar K., Gangaboraiah B. Assessing the burden of human rabies in India: Results of a national multi-center epidemiological survey. Int. J. Infect. Dis. 2007, 11:29-35.
3. Emmons R.W., Leonard L.L., DeGenaro F., Protas E.S., Bazeley P.L., Giammona S.T., Sturckow K. A case of human rabies with prolonged survival. Intervirology 1973, 1(1):60-72.
4. Hattwick M.A., Thomas T.W., Stechschulte J., George M.B., Michael B.G. Recovery from rabies: a case report. Ann. Intern. Med. 1972, 76(6):931-942.
5. Porras C., Barboza J.J., Fuenzalida E., Adaros H.L., Oviedo A.M., Furst J. Recovery from Rabies in man. Ann. Intern. Med. 1976, 85(1):44-48.
6. Tillotson D., Axelrod J.R., Lyman D.O. Rabies in a laboratory worker-New York. MMWR Morb. Mortal. Wkly. Rep. 1977, 26:183-184.
7. Alvarez L., Fajardo R., Lopez E. Partial recovery from rabies in a nine-year old boy. Pediatr. Infect. Dis. J. 1994, 13:1154-1155.
8. Madhusudana S.N., Nagaraj D., Uday M., Ratnavalli E., Kumar M.V. Partial recovery from rabies in a six-year old girl. Int. J. Infect. Dis. 2002, 6:85-86.
9. Karahocagil M.K., Akdeniz H., Aylan O., Sunnetcioglu M., Un H., Yapici K., et al. Complete recovery from clinical rabies: Case report. Turkiye Klinikleri J. Med. Sci. 2013, 33(2):547-552.
10. De Souza A., Madhusudana S.N. Survival from rabies encephalitis. J. Neurol. Sci. 2014, 339(1-2):8-14.
11. Centers for disease control, Prevention (CDS) Recovery of a patient from clinical rabies-California, 2011. MMWR Morb. Mortal. Wkly. Rep. 2012, 61:61-65.
12. Centers for disease control, Prevention (CDC) Presumptive abortive human rabies-Texas, 2009. MMWR Morb. Mortal. Wkly. Rep. 2010, 59:185-190.
13. Willoughby R.E., Tieves K.S., Hoffman G.M., Ghaneyam N.S., Amlie-Lefond C.M., Schwabe M.J., Chusid M.J., Ruppreccht C.E. Survival after treatment of rabies with induction of Coma. N. Engl. J. Med. 2005, 352:2508-2514.
14. ProMED-mail (14 November 2008) Rabies, human survival, bat-Brazil: (Pernambuco) [Archive number 20,081,114.3599]; August 16 2013 [Available: accessed]. http://www.promedmail.org,
15. Consales C.A., Bolzan V.L. Rabies review: immunopathology, clinical aspects and treatment. J. Venomous Anim. Toxins Incl. Trop. Dis. 2007, 13(1):5-38.
16. Mani J., Reddy B.C., Borgohain R., Sitajaylakshmi S., Sundaram C., Mohandas S. Magnetic resonance imaging in Rabies. Postgrad. Med. J. 2003, 79:3532-3554.
17. Madhusudana S.N., Tripathi K.K. Oral infectivity of street and fixed rabies virus strains in laboratory animals. Indian J. Exp. Biol. 1990, 28:497-499.
18. Burton E.C., Burns D.K., Opatowsky M.J., El-Feky W.H., Fischbach B., Melton L., et al. Rabies encephalomyelitis. Arch. Neurol. 2005, 62:873-882.
19. Laothamatas J., Hemachudha T., Mitrabhakdi E., Wannakrairot P., Tulayadaechanont S. MR Imaging in Human rabies. AJNR Am. J. Neuroradiol. 2003, 24:1102-1109.
20. Nagaraj T., Vasanth J.P., Desai A., Kamat A., Madhusudana S.N., Ravi V. Ante mortem diagnosis of human rabies using saliva samples: comparison of real time and conventional RT-PCR techniques. J. Clin. Virol. 2006, 36(1):17-23.
21. Mani R.S., Madhusudana S.N., Mahadevan A., Reddy V., Belludi A.Y., Shankar S.K. Utility of real-time Taqman PCR for antemortem and postmortem diagnosis of human rabies. J. Med. Virol. 2014, 86(10):1804-1812.
22. Fekadu M., Endeshaw T., Alemu W., Bogale Y., Teshager T., Olson J.G. Possible human-to-human transmission of rabies in Ethiopia. Ethiop. Med. J. 1996, 34(2):123-127.
23. Houff S.A., Burton R.C., Wilson R.W., Henson T.E., London W.T., Baer G.M., Anderson L.J., Winkler W.G., Madden D.L., Sever J.L. Human-to-human transmission of rabies virus bycorneal transplant. N. Engl. J. Med. 1979, 300(March (11)):603-604.
24. Srinivasan A., Burton E.C., Kuehnert M.J., Rupprecht C., Sutker W.L., Ksiazek T.G., et al. Rabies in transplant recipients investigation team: transmission of rabies virus from an organ donor to fourtransplant recipients. N. Engl. J. Med. 2005, 352(March (11)):1103-1111.
25. Yadav R., Ramdas M., Karthik N., Kulkarni G.B., Dawn R., Kumar M.V., Nagaraja D. "Hot cross bun sign" in HIV-related PML. Neurol. India 2011, 59(2):293-294.
26. Jain R.S., Nagpal K., Tejwani S. Hot cross bun and Inverse Trident sign in PML with HIV seropositivity. Neurol. India 2014, 62(3):341-342.