Cortical and subcortical glutathione levels in adults with autism spectrum disorder

Autism Research

Volumn 9, Issue 4, 2016, Pages 429-435

  Durieux, Alice M S ^a   Horder, Jamie ^a   Mendez, M Andreina ^a   Egerton, Alice ^a   Williams, Steven C R ^a   Wilson, C Ellie ^a   Spain, Debbie ^a   Murphy, Clodagh ^a   Robertson, Dene ^b   Barker, Gareth J ^a   Murphy, Declan G ^a   Mcalonan, Grainne M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Autism; Glutathione; Magnetic resonance spectroscopy; Oxidative stress; Redox

Indexed keywords

BIOLOGICAL MARKER; CREATININE; GLUTATHIONE; PROTON;

ADULT; AGE DISTRIBUTION; ARTICLE; AUTISM; BASAL GANGLION; BRAIN LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DORSOMEDIAL PREFRONTAL CORTEX; FEMALE; GRAY MATTER; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; MALE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; WHITE MATTER; ADOLESCENT; BRAIN MAPPING; DIAGNOSTIC IMAGING; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PREFRONTAL CORTEX; PROCEDURES; YOUNG ADULT;

ADOLESCENT; ADULT; AUTISM SPECTRUM DISORDER; BASAL GANGLIA; BRAIN MAPPING; GLUTATHIONE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; PREFRONTAL CORTEX; PROTONS; YOUNG ADULT;

EID: 84939601584     PISSN: 19393792     EISSN: 19393806     Source Type: Journal    
DOI: 10.1002/aur.1522     Document Type: Article

References (41)

1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, 5th ed. Washington, DC: Author.
2. Barkley, R.A., & Murphy, K.R. (1998). Attention-deficit hyperactivity disorder: A Handbook for Diagnosis and Treatment (2nd ed.). New York: Guilford Press.
3. Baron-Cohen, S., Scott, F.J., Allison, C., Williams, J., Bolton, P., Matthews, F.E., et al. (2009). Prevalence of autism-spectrum conditions: UK school-based population study. British Journal of Psychiatry, 194, 500-509.
4. Beck, A.T., Ward, C.H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571.
5. Bernhardt, B.C., Valk, S.L., Silani, G., Bird, G., Frith, U., & Singer, T. (2014). Selective disruption of sociocognitive structural brain networks in autism and alexithymia. Cerebral Cortex, 24, 3258-3267.
6. Bottomley, P.A. (1987). Spatial localization in NMR spectroscopy in vivo. Annals of the New York Academy of Sciences, 508, 333-348.
7. Brooks, J.C., Roberts, N., Kemp, G.J., Gosney, M.A., Lye, M., & Whitehouse, G.H. (2001). A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations. Cerebral Cortex, 11, 598-605.
8. Chauhan, A., Audhya, T., & Chauhan, V. (2012). Brain region-specific glutathione redox imbalance in autism. Neurochemical Research, 37, 1681-1689.
9. Chauhan, A., & Chauhan, V. (2006). Oxidative stress in autism. Pathophysiology, 13, 171-181.
10. Chauhan, A., Chauhan, V., Brown, W.T., & Cohen, I. (2004). Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin-the antioxidant proteins. Life Science, 75, 2539-2549.
11. Currais, A., & Maher, P. (2013). Functional consequences of age-dependent changes in glutathione status in the brain. Antioxidants and Redox Signaling, 19, 813-822.
12. Deth, R., Muratore, C., Benzecry, J., Power-Charnitsky, V.A., & Waly, M. (2008). How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. Neurotoxicology, 29, 190-201.
13. Deth, R.C. (2013). Autism: A redox/methylation disorder. Global Advances in Health and Medicine, 2, 68-73.
14. Fayed, N., Modrego, P.J., & Medrano, J. (2009). Comparative test-retest reliability of metabolite values assessed with magnetic resonance spectroscopy of the brain. The LCModel versus the manufacturer software. Neurological Research, 31, 472-477.
15. Ferreira, R., & Murray, J. (1983). Spielberger's State-Trait Anxiety Inventory: Measuring anxiety with and without an audience during performance on a stabilometer. Perceptual and Motor Skills, 57, 15-18.
16. Ferrer, I., Martinez, A., Boluda, S., Parchi, P., & Barrachina, M. (2008). Brain banks: Benefits, limitations and cautions concerning the use of post-mortem brain tissue for molecular studies. Cell and Tissue Banking, 9, 181-194.
17. Frustaci, A., Neri, M., Cesario, A., Adams, J.B., Domenici, E., Dalla Bernardina, B., et al. (2012). Oxidative stress-related biomarkers in autism: systematic review and meta-analyses. Free Radical Biology and Med, 52, 2128-2141.
18. Geier, D.A., Kern, J.K., Garver, C.R., Adams, J.B., Audhya, T., Nataf, R., et al. (2009). Biomarkers of environmental toxicity and susceptibility in autism. Journal of Neurological Science, 280, 101-108.
19. Godlewska, B.R., Yip, S.W., Near, J., Goodwin, G.M., & Cowen, P.J. (2014). Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy. Psychopharmacology (Berl), 231, 327-332.
20. Gussew, A., Erdtel, M., Hiepe, P., Rzanny, R., & Reichenbach, J.R. (2012). Absolute quantitation of brain metabolites with respect to heterogeneous tissue compositions in (1)H-MR spectroscopic volumes. MAGMA, 25, 321-333.
21. Haznedar, M.M., Buchsbaum, M.S., Hazlett, E.A., LiCalzi, E.M., Cartwright, C., & Hollander, E. (2006). Volumetric analysis and three-dimensional glucose metabolic mapping of the striatum and thalamus in patients with autism spectrum disorders. American Journal of Psychiatry, 163, 1252-1263.
22. Hollander, E., Anagnostou, E., Chaplin, W., Esposito, K., Haznedar, M.M., Licalzi, E., et al. (2005). Striatal volume on magnetic resonance imaging and repetitive behaviors in autism. Biological Psychiatry, 58, 226-232.
23. Horder, J., Lavender, T., Mendez, M.A., O'Gorman, R., Daly, E., Craig, M.C., et al. (2013). Reduced subcortical glutamate/glutamine in adults with autism spectrum disorders: A [(1)H]MRS study. Translational Psychiatry, 3, e279.
24. James, S.J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D.W., et al. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American Journal of Clinical Nutrition, 80, 1611-1617.
25. Kern, J.K., & Jones, A.M. (2006). Evidence of toxicity, oxidative stress, and neuronal insult in autism. Journal of Toxicology and Environmental Health Part B Critical Reviews, 9, 485-499.
26. Lagopoulos, J., Hermens, D.F., Tobias-Webb, J., Duffy, S., Naismith, S.L., White, D., et al. (2013). In vivo glutathione levels in young persons with bipolar disorder: A magnetic resonance spectroscopy study. Journal of Psychiatric Research, 47, 412-417.
27. Lord, C., Rutter, M., DiLavore, P., & Risi, S. (1999). Autism Diagnostic Observation Schedule. Los Angeles, California: Western Psychological Services.
28. Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659-685.
29. Main, P.A., Angley, M.T., O'Doherty, C.E., Thomas, P., & Fenech, M. (2012). The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: A systematic review and meta-analysis. Nutrition and Metabolism (London), 9, 35.
30. Matson, J.L., & Cervantes, P.E. (2014). Commonly studied comorbid psychopathologies among persons with autism spectrum disorder. Research in Developmental Disabilities, 35, 952-962.
31. Maurya, P.K., & Rizvi, S.I. (2010). Age-dependent changes in glutathione-s-transferase: Correlation with total plasma antioxidant potential and red cell intracellular glutathione. Indian Journal of Clinical Biochemistry, 25, 398-400.
32. Mazzone, L., Ruta, L., & Reale, L. (2012). Psychiatric comorbidities in asperger syndrome and high functioning autism: diagnostic challenges. Annals of General Psychiatry, 11, 16.
33. Naaijen, J., Lythgoe, D.J., Amiri, H., Buitelaar, J.K., & Glennon, J.C. (2015). Fronto-striatal glutamatergic compounds in compulsive and impulsive syndromes: A review of magnetic resonance spectroscopy studies. Neuroscience and Biobehavioral Reviews, 52, 74-88.
34. Provencher, S.W. (1993). Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic Resonance in Medicine, 30, 672-679.
35. Rudie, J.D., Brown, J.A., Beck-Pancer, D., Hernandez, L.M., Dennis, E.L., Thompson, P.M., et al. (2013) Altered functional and structural brain network organization in autism. Neuroimage Clinical, 2, 79-94.
36. Schmitz, N., Daly, E., & Murphy, D. (2007). Frontal anatomy and reaction time in Autism. Neuroscience Letters, 412, 12-17.
37. Shimizu, T., Iwanaga, M., Yasunaga, A., Urata, Y., Goto, S., Shibata, S., et al. (1998). Protective role of glutathione synthesis on radiation-induced DNA damage in rabbit brain. Cellular and Molecular Neurobiology, 18, 299-310.
38. Theoharides, T.C., Kempuraj, D., & Redwood, L. (2009). Autism: An emerging 'neuroimmune disorder' in search of therapy. Expert Opinion on Pharmacotherapy, 10, 2127-2143.
39. Watanabe, T., Yahata, N., Abe, O., Kuwabara, H., Inoue, H., Takano, Y., et al. (2012). Diminished medial prefrontal activity behind autistic social judgments of incongruent information. PLoS One, 7, e39561.
40. Wicker, B., Fonlupt, P., Hubert, B., Tardif, C., Gepner, B., & Deruelle, C. (2008). Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder. Social Cognitive and Affectve Neuroscience, 3, 135-143.
41. Wood, S.J., Berger, G.E., Wellard, R.M., Proffitt, T.M., McConchie, M., Berk, M., et al. (2009). Medial temporal lobe glutathione concentration in first episode psychosis: A 1H-MRS investigation. Neurobiology of Disease, 33, 354-357.