Testing for High-Risk APOL1 Alleles in Potential Living Kidney Donors

American Journal of Kidney Diseases

Volumn 66, Issue 3, 2015, Pages 396-401

  Riella, Leonardo V ^a   Sheridan, Alice M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

African American; APOL1 gene; apolipoprotein L1; contraindication; donor screening; end stage renal disease (ESRD); genetic susceptibility; high risk allele; Index Words Living kidney donation; kidney donor evaluation; kidney failure; medical ethics; racial difference; renal transplantation; risk stratification

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN L1; UNCLASSIFIED DRUG; APOL1 PROTEIN, HUMAN; HIGH DENSITY LIPOPROTEIN;

AFRICAN AMERICAN; ALLELE; APOL1 GENE; END STAGE RENAL DISEASE; ENVIRONMENTAL EXPOSURE; GENE; GENETIC RISK; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HIGH RISK PATIENT; HUMAN; KIDNEY DONOR; KIDNEY TRANSPLANTATION; LIVING DONOR; NEPHROLOGIST; OUTCOME ASSESSMENT; RACE DIFFERENCE; REVIEW; RISK ASSESSMENT; UNITED STATES; CHRONIC KIDNEY FAILURE; DONOR SELECTION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; GENOTYPE; KIDNEY FAILURE, CHRONIC; PROCEDURES;

AFRICAN AMERICANS; APOLIPOPROTEINS; DONOR SELECTION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; LIPOPROTEINS, HDL; LIVING DONORS; RENAL INSUFFICIENCY, CHRONIC; RISK ASSESSMENT;

EID: 84939570364     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2015.04.046     Document Type: Article

References (46)

1. M.B. Allen, P.L. Abt, and P.P. Reese What are the harms of refusing to allow living kidney donation? An expanded view of risks and benefits Am J Transplant 14 3 2014 531 537
2. H.N. Ibrahim, R. Foley, L. Tan, and et al. Long-term consequences of kidney donation N Engl J Med 360 5 2009 459 469
3. K.L. Lentine, M.A. Schnitzler, H. Xiao, and et al. Racial variation in medical outcomes among living kidney donors N Engl J Med 363 8 2010 724 732
4. A. Reeves-Daniel, J. DePalma, A. Bleyer, and et al. The APOL1 gene and allograft survival after kidney transplantation Am J Transplant 11 5 2011 1025 1030
5. J. Gill, J. Dong, C. Rose, O. Johnston, D. Landsberg, and J. Gill The effect of race and income on living kidney donation in the United States J Am Soc Nephrol 24 11 2013 1872 1879
6. A.D. Muzaale, A.B. Massie, M.C. Wang, and et al. Risk of end-stage renal disease following live kidney donation JAMA 311 6 2014 579 586
7. A. Choi, R. Rodriguez, P. Bacchetti, D. Bertenthal, G. Hernandez, and A. O'Hare White/black racial differences in risk of end-stage renal disease and death Am J Med 122 7 2009 672 678
8. M. Grams, E. Chow, D. Segev, and J. Coresh Lifetime incidence of CKD stages 3-5 in the United States Am J Kidney Dis 62 2 2013 245 252
9. M. Lipkowitz, B. Freedman, C. Langefeld, and et al. Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans Kidney Int 83 1 2013 114 120
10. W. McClellan, D. Warnock, L. McClure, and et al. Racial differences in the prevalence of chronic kidney disease among participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort Study J Am Soc Nephrol 17 6 2006 1710 1715
11. A.J. Collins, R.N. Foley, B. Chavers, and et al. US Renal Data System 2013 annual data report Am J Kidney Dis 63 1 suppl 1 2014 e1 e420
12. W. Kao, M. Klag, L. Meoni, and et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans Nat Genet 40 10 2008 1185 1192
13. J. Kopp, M. Smith, G. Nelson, and et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis Nat Genet 40 10 2008 1175 1184
14. G. Genovese, D. Friedman, M. Ross, and et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans Science 329 5993 2010 841 845
15. S. Tzur, S. Rosset, R. Shemer, and et al. Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene Hum Genet 128 3 2010 345 350
16. B. Freedman, C. Langefeld, J. Turner, and et al. Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease Kidney Int 82 7 2012 805 811
17. N.D. Palmer, and B.I. Freedman APOL1 and progression of nondiabetic nephropathy J Am Soc Nephrol 24 9 2013 1344 1346
18. A. Parsa, W. Kao, D. Xie, and et al. APOL1 risk variants, race, and progression of chronic kidney disease N Engl J Med 369 23 2013 2183 2196
19. M. Foster, J. Coresh, M. Fornage, and et al. APOL1 variants associate with increased risk of CKD among African Americans J Am Soc Nephrol 24 9 2013 1484 1491
20. D. Friedman, J. Kozlitina, G. Genovese, P. Jog, and M. Pollak Population-based risk assessment of APOL1 on renal disease J Am Soc Nephrol 22 11 2011 2098 2105
21. J. Kopp, G. Nelson, K. Sampath, and et al. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy J Am Soc Nephrol 22 11 2011 2129 2137
22. B.I. Freedman, C.D. Langefeld, K.K. Andringa, and et al. End-stage renal disease in African Americans with lupus nephritis is associated with APOL1 Arthritis Rheum 66 2 2014 390 396
23. T. Kofman, C. Narjoz, Q. Raimbourg, and et al. Collapsing glomerulopathy associated lupus in a black female with homozygous APOL1 mutation Lupus 21 13 2012 1459 1462
24. C.P. Larsen, M.L. Beggs, M. Saeed, and P.D. Walker Apolipoprotein L1 risk variants associate with systemic lupus erythematosus-associated collapsing glomerulopathy J Am Soc Nephrol 24 5 2013 722 725
25. A.E. Ashley-Koch, E.C. Okocha, M.E. Garrett, and et al. MYH9 and APOL1 are both associated with sickle cell disease nephropathy Br J Haematol 155 3 2011 386 394
26. N. Papeta, K. Kiryluk, A. Patel, and et al. APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy J Am Soc Nephrol 22 11 2011 1991 1996
27. S.M. Madhavan, J.F. O'Toole, M. Konieczkowski, S. Ganesan, L.A. Bruggeman, and J.R. Sedor APOL1 localization in normal kidney and nondiabetic kidney disease J Am Soc Nephrol 22 11 2011 2119 2128
28. L. Ma, G.S. Shelness, J.A. Snipes, and et al. Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines J Am Soc Nephrol 26 2 2015 339 348
29. H. Chakkera, A. O'Hare, K. Johansen, and et al. Influence of race on kidney transplant outcomes within and outside the Department of Veterans Affairs J Am Soc Nephrol 16 1 2005 269 277
30. B. Lee, V. Kumar, T. Williams, and et al. The APOL1 genotype of African American kidney transplant recipients does not impact 5-year allograft survival Am J Transplant 12 7 2012 1924 1928
31. E. Gibney, A. King, D. Maluf, A. Garg, and C. Parikh Living kidney donors requiring transplantation: focus on African Americans Transplantation 84 5 2007 647 649
32. L. Akil, and H.A. Ahmad Effects of socioeconomic factors on obesity rates in four southern states and Colorado Ethn Dis 21 1 2011 58 62
33. A.M. Clark, M. DesMeules, W. Luo, A.S. Duncan, and A. Wielgosz Socioeconomic status and cardiovascular disease: risks and implications for care Nat Rev Cardiol 6 11 2009 712 722
34. C.G. Hudson Socioeconomic status and mental illness: tests of the social causation and selection hypotheses Am J Orthopsychiatry 75 1 2005 3 18
35. R.E. Patzer, and W.M. McClellan Influence of race, ethnicity and socioeconomic status on kidney disease Nat Rev Nephrol 8 9 2012 533 541
36. J. Sobal, and A.J. Stunkard Socioeconomic status and obesity: a review of the literature Psychol Bull 105 2 1989 260 275
37. G. Mjoen, S. Hallan, A. Hartmann, and et al. Long-term risks for kidney donors Kidney Int 86 1 2014 162 167
38. N. Boudville, and A.X. Garg End-stage renal disease in living kidney donors Kidney Int 86 1 2014 20 22
39. T. Kofman, V. Audard, C. Narjoz, and et al. APOL1 polymorphisms and development of CKD in an identical twin donor and recipient pair Am J Kidney Dis 63 5 2014 816 819
40. D. Cohen, A. Mittalhenkle, D. Scott, C. Young, and D. Norman African American living-kidney donors should be screened for APOL1 risk alleles Transplantation 92 7 2011 722 725
41. R.C. Green, J.S. Roberts, L.A. Cupples, and et al. Disclosure of APOE genotype for risk of Alzheimer's disease N Engl J Med 361 3 2009 245 254
42. S.B. Haga, M.J. Khoury, and W. Burke Genomic profiling to promote a healthy lifestyle: not ready for prime time Nat Genet 34 4 2003 347 350
43. K. Offit Genomic profiles for disease risk: predictive or premature? JAMA 299 11 2008 1353 1355
44. J. Divers, N.D. Palmer, L. Lu, and et al. Gene-gene interactions in APOL1-associated nephropathy Nephrol Dial Transplant 29 3 2014 587 594
45. R.C. Kalayjian, B. Lau, R.N. Mechekano, and et al. Risk factors for chronic kidney disease in a large cohort of HIV-1 infected individuals initiating antiretroviral therapy in routine care AIDS 26 15 2012 1907 1915
46. B.I. Freedman, and K. Skorecki Gene-gene and gene-environment interactions in apolipoprotein L1 gene-associated nephropathy Clin J Am Soc Nephrol 9 11 2014 2006 2013