-
1
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
1:CAS:528:DyaK2sXlsFKksLY%3D 9196156
-
Burris HA III, Moore MJ, Andersen J et al (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15:2403-2413
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris, H.A.1
Moore, M.J.2
Andersen, J.3
-
2
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
1:CAS:528:DC%2BC3MXlvF2jsrw%3D 21561347
-
Conroy T, Desseigne F, Ychou M et al (2011) FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. New Engl J Med 364:1817-1825
-
(2011)
New Engl J Med
, vol.364
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
-
3
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
-
Von Hoff DD, Ervin T, Arena FP et al (2013) Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. New Engl J Med 369:1691-1703
-
(2013)
New Engl J Med
, vol.369
, pp. 1691-1703
-
-
Von Hoff, D.D.1
Ervin, T.2
Arena, F.P.3
-
4
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
1:CAS:528:DC%2BD2sXmvVWmsr0%3D 17452677
-
Moore MJ, Goldstein D, Hamm J et al (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25:1960-1966
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
5
-
-
84856741290
-
A multicenter analysis of GTX chemotherapy in patients with locally advanced and metastatic pancreatic adenocarcinoma
-
10.1007/s00280-011-1704-y 3265723 1:CAS:528:DC%2BC38XhsVOktLo%3D 21800112
-
De Jesus-Acosta A, Oliver GR, Blackford A, Kinsman K, Flores EI, Wilfong LS, Zheng L, Donehower RC, Cosgrove D, Laheru D, Le DT, Chung K, Diaz LA Jr (2012) A multicenter analysis of GTX chemotherapy in patients with locally advanced and metastatic pancreatic adenocarcinoma. Cancer Chemother Pharmacol 69(2):415-424. doi: 10.1007/s00280-011-1704-y
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, Issue.2
, pp. 415-424
-
-
De Jesus-Acosta, A.1
Oliver, G.R.2
Blackford, A.3
Kinsman, K.4
Flores, E.I.5
Wilfong, L.S.6
Zheng, L.7
Donehower, R.C.8
Cosgrove, D.9
Laheru, D.10
Le, D.T.11
Chung, K.12
Diaz, L.A.13
-
6
-
-
68949127264
-
Sensitivity to first-line chemotherapy for metastatic breast cancer in BRCA1 and BRCA2 mutation carriers
-
19564533
-
Kriege M, Seynaeve C, Meijers-Heijboer H et al (2009) Sensitivity to first-line chemotherapy for metastatic breast cancer in BRCA1 and BRCA2 mutation carriers. J Clin Oncol 27:3764-3771
-
(2009)
J Clin Oncol
, vol.27
, pp. 3764-3771
-
-
Kriege, M.1
Seynaeve, C.2
Meijers-Heijboer, H.3
-
7
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
1:CAS:528:DC%2BD1MXosVKrtrw%3D 19553641
-
Fong PC, Boss DS, Yap TA et al (2009) Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. New Engl J Med 361:123-134
-
(2009)
New Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
-
8
-
-
0038075462
-
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors
-
1:CAS:528:DC%2BD3sXjtlamtLo%3D 12692539
-
Taniguchi T, Tischkowitz M, Ameziane N et al (2003) Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med 9:568-574
-
(2003)
Nat Med
, vol.9
, pp. 568-574
-
-
Taniguchi, T.1
Tischkowitz, M.2
Ameziane, N.3
-
9
-
-
70149107010
-
Prolonged survival in a patient with BRCA2 associated metastatic pancreatic cancer after exposure to camptothecin: A case report and review of literature
-
1:CAS:528:DC%2BD1MXotFCgtrw%3D 19433978
-
James E, Waldron-Lynch MG, Saif MW (2009) Prolonged survival in a patient with BRCA2 associated metastatic pancreatic cancer after exposure to camptothecin: a case report and review of literature. Anticancer Drugs 20:634-638
-
(2009)
Anticancer Drugs
, vol.20
, pp. 634-638
-
-
James, E.1
Waldron-Lynch, M.G.2
Saif, M.W.3
-
10
-
-
45749088199
-
Response to a third-line mitomycin C (MMC)-based chemotherapy in a patient with metastatic pancreatic adenocarcinoma carrying germline BRCA2 mutation
-
18469443
-
Chalasani P, Kurtin S, Dragovich T (2008) Response to a third-line mitomycin C (MMC)-based chemotherapy in a patient with metastatic pancreatic adenocarcinoma carrying germline BRCA2 mutation. JOP 9:305-308
-
(2008)
JOP
, vol.9
, pp. 305-308
-
-
Chalasani, P.1
Kurtin, S.2
Dragovich, T.3
-
11
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
1:CAS:528:DC%2BD2MXjtFOmsrY%3D 15829966
-
Bryant HE, Schultz N, Thomas HD et al (2005) Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434:913-917
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
-
12
-
-
27144532118
-
In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor
-
16243825
-
van der Heijden MS, Brody JR, Dezentje DA et al (2005) In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor. Clin Cancer Res 11:7508-7515
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7508-7515
-
-
Van Der Heijden, M.S.1
Brody, J.R.2
Dezentje, D.A.3
-
13
-
-
69349092943
-
Analysis of the gene coding for the BRCA2-interacting protein PALB2 in familial and sporadic pancreatic cancer
-
3914669 19635604
-
Tischkowitz MD, Sabbaghian N, Hamel N et al (2009) Analysis of the gene coding for the BRCA2-interacting protein PALB2 in familial and sporadic pancreatic cancer. Gastroenterology 137:1183-1186
-
(2009)
Gastroenterology
, vol.137
, pp. 1183-1186
-
-
Tischkowitz, M.D.1
Sabbaghian, N.2
Hamel, N.3
-
14
-
-
53749102277
-
Germline BRCA1 mutations predispose to pancreatic adenocarcinoma
-
1:CAS:528:DC%2BD1cXht1art7nM 18762988
-
Al-Sukhni W, Rothenmund H, Borgida AE et al (2008) Germline BRCA1 mutations predispose to pancreatic adenocarcinoma. Hum Genet 124:271-278
-
(2008)
Hum Genet
, vol.124
, pp. 271-278
-
-
Al-Sukhni, W.1
Rothenmund, H.2
Borgida, A.E.3
-
15
-
-
33846625493
-
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
-
2871593 1:CAS:528:DC%2BD2sXpvFeqsw%3D%3D 17200668
-
Rahman N, Seal S, Thompson D et al (2007) PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat Genet 39:165-167
-
(2007)
Nat Genet
, vol.39
, pp. 165-167
-
-
Rahman, N.1
Seal, S.2
Thompson, D.3
-
16
-
-
12544255089
-
Germ line Fanconi anemia complementation group C mutations and pancreatic cancer
-
1:CAS:528:DC%2BD2MXns1Krsg%3D%3D 15695377
-
Couch FJ, Johnson MR, Rabe K et al (2005) Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. Cancer Res 65:383-386
-
(2005)
Cancer Res
, vol.65
, pp. 383-386
-
-
Couch, F.J.1
Johnson, M.R.2
Rabe, K.3
-
18
-
-
33847762750
-
The prevalence of BRCA2 mutations in familial pancreatic cancer
-
1:CAS:528:DC%2BD2sXhs1ylsLY%3D
-
Couch FJ, Johnson MR, Rabe KG et al (2007) The prevalence of BRCA2 mutations in familial pancreatic cancer. Cancer Epidemiol Biomark Prev 16:342-346
-
(2007)
Cancer Epidemiol Biomark Prev
, vol.16
, pp. 342-346
-
-
Couch, F.J.1
Johnson, M.R.2
Rabe, K.G.3
-
19
-
-
0037087536
-
Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: Analysis of 10,000 individuals
-
1:CAS:528:DC%2BD38XivFeisbY%3D 11896095
-
Frank TS, Deffenbaugh AM, Reid JE et al (2002) Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J Clin Oncol 20:1480-1490
-
(2002)
J Clin Oncol
, vol.20
, pp. 1480-1490
-
-
Frank, T.S.1
Deffenbaugh, A.M.2
Reid, J.E.3
-
20
-
-
0033523268
-
Cancer risks in BRCA2 mutation carriers
-
Breast Cancer Linkage C
-
Breast Cancer Linkage C (1999) Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst 91:1310-1316
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1310-1316
-
-
-
21
-
-
12644253827
-
Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
-
1:CAS:528:DyaK28Xntl2mt74%3D 8968085
-
Goggins M, Schutte M, Lu J et al (1996) Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 56:5360-5364
-
(1996)
Cancer Res
, vol.56
, pp. 5360-5364
-
-
Goggins, M.1
Schutte, M.2
Lu, J.3
-
22
-
-
18444362122
-
Biallelic inactivation of BRCA2 in Fanconi anemia
-
1:CAS:528:DC%2BD38XlslWrs7k%3D 12065746
-
Howlett NG, Taniguchi T, Olson S et al (2002) Biallelic inactivation of BRCA2 in Fanconi anemia. Science 297:606-609
-
(2002)
Science
, vol.297
, pp. 606-609
-
-
Howlett, N.G.1
Taniguchi, T.2
Olson, S.3
-
23
-
-
84908365902
-
Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers
-
1:CAS:528:DC%2BC2cXht1GksL3N 25072261
-
Golan T, Kanji ZS, Epelbaum R et al (2014) Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers. Br J Cancer 111:1132-1138
-
(2014)
Br J Cancer
, vol.111
, pp. 1132-1138
-
-
Golan, T.1
Kanji, Z.S.2
Epelbaum, R.3
-
24
-
-
79961228580
-
Complete remission, in BRCA2 mutation carrier with metastatic pancreatic adenocarcinoma, treated with cisplatin based therapy
-
1:CAS:528:DC%2BC38XhsVaqsb0%3D 21613821
-
Sonnenblick A, Kadouri L, Appelbaum L et al (2011) Complete remission, in BRCA2 mutation carrier with metastatic pancreatic adenocarcinoma, treated with cisplatin based therapy. Cancer Biol Ther 12:165-168
-
(2011)
Cancer Biol Ther
, vol.12
, pp. 165-168
-
-
Sonnenblick, A.1
Kadouri, L.2
Appelbaum, L.3
-
25
-
-
0037403380
-
Improved survival in women with BRCA-associated ovarian carcinoma
-
1:CAS:528:DC%2BD3sXjvVSjs70%3D 12712470
-
Cass I, Baldwin RL, Varkey T, Moslehi R, Narod SA, Karlan BY (2003) Improved survival in women with BRCA-associated ovarian carcinoma. Cancer 97:2187-2195
-
(2003)
Cancer
, vol.97
, pp. 2187-2195
-
-
Cass, I.1
Baldwin, R.L.2
Varkey, T.3
Moslehi, R.4
Narod, S.A.5
Karlan, B.Y.6
-
26
-
-
84856158117
-
Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer
-
3727895 1:CAS:528:DC%2BC38Xhs1Srsrw%3D 22274685
-
Bolton KL, Chenevix-Trench G, Goh C et al (2012) Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA 307:382-390
-
(2012)
JAMA
, vol.307
, pp. 382-390
-
-
Bolton, K.L.1
Chenevix-Trench, G.2
Goh, C.3
-
27
-
-
84864026311
-
BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: A report from the Australian Ovarian Cancer Study Group
-
3413277 1:CAS:528:DC%2BC38Xht1ygsr%2FN 22711857
-
Alsop K, Fereday S, Meldrum C et al (2012) BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group. J Clin Oncol 30:2654-2663
-
(2012)
J Clin Oncol
, vol.30
, pp. 2654-2663
-
-
Alsop, K.1
Fereday, S.2
Meldrum, C.3
-
28
-
-
75749143502
-
Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy
-
1:CAS:528:DC%2BC3cXivFart74%3D 20008645
-
Byrski T, Gronwald J, Huzarski T et al (2010) Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol 28:375-379
-
(2010)
J Clin Oncol
, vol.28
, pp. 375-379
-
-
Byrski, T.1
Gronwald, J.2
Huzarski, T.3
-
29
-
-
84929992639
-
Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients
-
1:CAS:528:DC%2BC2cXhtl2htL3L 25129345
-
Byrski T, Huzarski T, Dent R et al (2014) Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat 147:401-405
-
(2014)
Breast Cancer Res Treat
, vol.147
, pp. 401-405
-
-
Byrski, T.1
Huzarski, T.2
Dent, R.3
-
30
-
-
77950974130
-
Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors
-
1:CAS:528:DC%2BC3cXkslSmu7c%3D 20371688
-
Mukhopadhyay A, Elattar A, Cerbinskaite A et al (2010) Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. Clin Cancer Res 16:2344-2351
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2344-2351
-
-
Mukhopadhyay, A.1
Elattar, A.2
Cerbinskaite, A.3
-
31
-
-
0033635935
-
Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer
-
1:STN:280:DC%2BD3M7lt12rtw%3D%3D 11142479
-
Heinemann V, Wilke H, Mergenthaler HG et al (2000) Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer. Ann Oncol 11:1399-1403
-
(2000)
Ann Oncol
, vol.11
, pp. 1399-1403
-
-
Heinemann, V.1
Wilke, H.2
Mergenthaler, H.G.3
-
32
-
-
20644464360
-
Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial
-
1:CAS:528:DC%2BD2MXlsVyhsrg%3D 15908661
-
Louvet C, Labianca R, Hammel P et al (2005) Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol 23:3509-3516
-
(2005)
J Clin Oncol
, vol.23
, pp. 3509-3516
-
-
Louvet, C.1
Labianca, R.2
Hammel, P.3
|