Safety and immunogenicity of a trivalent recombinant PcpA, PhtD, and PlyD1 pneumococcal protein vaccine in adults, toddlers, and infants: A phase I randomized controlled study

Vaccine

Volumn 33, Issue 36, 2015, Pages 4610-4617

  Brooks, W Abdullah ^a,b   Chang, Lee Jah ^c   Sheng, Xiaohua ^c   Hopfer, Robert ^c   de Bruyn, Guy ^c   Bologa, Monica ^e   Menezes, Josemund ^a   Kirby, Daniel ^c   Da Costa, Xavier ^c   Neveu, David ^c   Gurunathan, Sanjay ^c   Goswami, Doli ^d   Yeasmin, Sultana ^d   Parvin, Nasrin ^d   Moshtaq Ahmed, ^d   Nahar, Kamrun ^d   Rahman, Mohammed Ziaur ^d  

^a INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH   (Bangladesh)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c SANOFI PASTEUR   (France)

^d Sanofi Pasteur   (Canada)

^e Sanofi Pasteur India   (India)

Author keywords

Infants; Phase I clinical trials; Pneumococcal vaccine; Streptococcus pneumoniae; WHO Universal Trial Number U1111 1117 7316

Indexed keywords

BACTERIAL PROTEIN; PCPA PROTEIN; PHTD PROTEIN; PLYD1 PROTEIN; PNEUMOCOCCUS VACCINE; TRIPLE VACCINE; UNCLASSIFIED DRUG; ALUMINUM POTASSIUM SULFATE; ALUMINUM SULFATE; BACTERIAL ANTIGEN; IMMUNOLOGICAL ADJUVANT; PLACEBO; RECOMBINANT VACCINE; SUBUNIT VACCINE;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; CHILD; CONTROLLED STUDY; CRYING; DIARRHEA; DOSE RESPONSE; DROWSINESS; DRUG FATALITY; DRUG HYPERSENSITIVITY; DRUG INDUCED HEADACHE; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FEVER; GASTROENTERITIS; HUMAN; IMMUNOGENICITY; INFANT; INJECTION SITE ERYTHEMA; INJECTION SITE PAIN; INJECTION SITE REACTION; IRRITABILITY; LARYNGOMALACIA; LOSS OF APPETITE; MAJOR CLINICAL STUDY; MALAISE; MALE; MENINGITIS; MYALGIA; PHASE 1 CLINICAL TRIAL; PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE BLIND PROCEDURE; URTICARIA; VACCINATION; VOMITING; ADOLESCENT; BLOOD; CLINICAL TRIAL; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; GENETICS; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY; STREPTOCOCCUS PNEUMONIAE; YOUNG ADULT;

ADJUVANTS, IMMUNOLOGIC; ADOLESCENT; ADULT; ALUM COMPOUNDS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; PLACEBOS; PNEUMOCOCCAL VACCINES; SINGLE-BLIND METHOD; STREPTOCOCCUS PNEUMONIAE; VACCINES, SUBUNIT; VACCINES, SYNTHETIC; YOUNG ADULT;

EID: 84939564719     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.06.078     Document Type: Article

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