Direct injection LC-MS-MS analysis of opiates, methamphetamine, buprenorphine, methadone and their metabolites in oral fluid from substitution therapy patients

Journal of Analytical Toxicology

Volumn 39, Issue 6, 2015, Pages 472-480

  Liu, Hsiu Chuan ^a   Lee, Hsi Tzu ^a   Hsu, Ya Ching ^b   Huang, Mei Han ^b   Liu, Ray H ^c   Chen, Tai Jui ^d   Lin, Dong Liang ^a  

^a MINISTRY OF JUSTICE   (Taiwan)

^b FOOYIN UNIVERSITY   (Taiwan)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d E DA HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; ACETYLCODEINE; AMPHETAMINE; BUPRENORPHINE; CODEINE; METHADONE; METHAMPHETAMINE; MORPHINE; MORPHINE 6 ACETATE; NORBUPRENORPHINE; CENTRAL STIMULANT AGENT; NARCOTIC AGENT; OPIATE;

ARTICLE; BODY FLUID; CENTRIFUGATION; CONTROLLED STUDY; ELECTROSPRAY; HUMAN; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MASS FRAGMENTOGRAPHY; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; MOUTH; ORAL FLUID; REFERENCE VALUE; REVERSED PHASE LIQUID CHROMATOGRAPHY; STANDARD; SUBSTITUTION THERAPY; SUPERNATANT; TANDEM MASS SPECTROMETRY; VALIDATION STUDY; CHEMISTRY; COMPARATIVE STUDY; OPIATE SUBSTITUTION TREATMENT; PROCEDURES; SALIVA; SUBSTANCE ABUSE; TAIWAN;

CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; HUMANS; NARCOTICS; OPIATE ALKALOIDS; OPIATE SUBSTITUTION TREATMENT; SALIVA; SUBSTANCE ABUSE DETECTION; TAIWAN; TANDEM MASS SPECTROMETRY;

EID: 84939561246     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/jat/bkv041     Document Type: Article

References (28)

1. Liu, R.H.,Goldberger, B.A. (eds) Handbook ofWorkplaceDrug Testing; American Association for Clinical Chemistry Press: Washington, DC, 1995.
2. Ropero-Miller, J.D., Goldberger, B.A., Liu, R.H. (Ed Emeritus) (eds) Handbook of Workplace Drug Testing; 2nd edition. American Association for Clinical Chemistry Press: Washington, DC, 2009.
3. Heltsley, R., Zichterman, A., Black, D.L., Cawthon, B., Robert, T., Moser, F. et al. (2010) Urine drug testing of chronic pain patients. II. Prevalence patterns of prescription opiates and metabolites. Journal of Analytical Toxicology, 34, 32-38.
4. Methadone Maintenance Therapy (MMT) Program: Urine Drug Testing of Patients; British Columbia Medical Association: Victoria, BC, Canada; 2007. http://www.bcguidelines.ca/gpac/ pdf/methadone.pdf.
5. Verstraete, A.G. (2005) Oral fluid testing for driving under the influence of drugs: history, recent progress and remaining challenges. Forensic Science International, 150, 143-150.
6. Toennes, S.W., Kauert, G.F., Steinmeyer, S., Moeller, M.R. (2005) Driving under the influence of drugs-evaluation of analytical data of drugs in oral fluid, serum and urine and correlation with impairment symptoms. Forensic Science International, 152, 149-155.
7. Cone, E.J. (2001) Legal, workplace, and treatment drug testing with alternate biological matrices on a global scale. Forensic Science International, 121, 7-15.
8. Schramm, W., Smith, R.H., Craig, P.A., Kidwell, D.A. (1992) Drugs of abuse in saliva: a review. Journal of Analytical Toxicology, 16, 1-9.
9. Dams, R., Murphy, C.M., Choo, R.E., Lambert, W.E., Leenheer, A.P.D., Huestis, M.A. (2003) LC-atmospheric pressure chemical ionization-MS/MS analysis of multiple illicit drugs, methadone, and their metabolites in oral fluid following protein precipitation. Analytical Chemistry, 75, 798-804.
10. Maure, H.H. (2005) Advances in analytical toxicology: the current role of liquid chromatography-mass spectrometry in drug quantification in blood and oral fluid. Analytical and Bioanalytical Chemistry, 381, 110-118.
11. Sato, M., Hida, M., Nagase, H. (2002) Analysis of dimethylamphetamine and its metabolites in human urine by liquid chromatography- electrospray ionization-mass spectrometry with direct sample injection. Forensic Science International, 128, 146-154.
12. Dams, R., Murphy, C.M., Lambert, W.E., Huestis, M.A. (2003) Urine drug testing for opioids, cocaine, and metabolites by direct injection liquid chromatography/tandem mass spectrometry. Rapid Communication in Mass Spectrometry, 17, 1665-1670.
13. Nordgren, H.K., Beck, O. (2004) Multicomponent screening for drugs of abuse direct analysis of urine by LC-MS-MS. Therapeutic Drug Monitoring, 26, 90-97.
14. Nordgren, H.K., Holmgren, P., Liljeberg, P., Eriksson, N., Beck, O. (2005) Application of direct urine LC-MS-MS analysis for screening of novel substances in drug abusers. Journal of Analytical Toxicology, 29, 234-239.
15. Edinboro, L.E., Backer, R.C., Poklis, A. (2005) Direct analysis of opiates in urine by liquid chromatography-tandem mass spectrometry. Journal of Analytical Toxicology, 29, 704-710.
16. Kollroser, M., Schober, C. (2002) Simultaneous determination of seven tricylic antidepressant drugs in human plasma by direct-injection HPLC-APCI-MS-MS with an ion trap detector. Therapeutic Drug Monitoring, 24, 537-544.
17. Kollroser, M., Schober, C. (2002) Direct-injection high performance liquid chromatography ion trap mass spectrometry for the quantitative determination of olanzapine, clozapine and N-desmethylclozapine in human plasma. Rapid Communication in Mass Spectrometry, 16, 1266-1272.
18. Mortier, K.A., Clauwert, K.M., Lambert, W.E., Bocxlaer, J.F., Eckhout, E.G., Peteghem, C.H. et al. (2001) Pitfalls associated with liquid chromatography/ electrospray tandem mass spectrometry in quantitative bioanalysis of drugs of abuse in saliva. Rapid Communication in Mass Spectrometry, 15, 1773-1775.
19. Mortier, K.A., Maudens, K.E., Labert, W.E., Clauwaert, K.M., Van Boxlaer, J.F., Deforce, D.L. et al. (2002) Simultaneous, quantitative determination of opiates, amphetamines, cocaine and benzoylecgonine in oral fluid by liquid chromatography quadrupole-time-of-flight mass spectrometry. Journal of Chromatography B, 779, 321-330.
20. Wylie, F.M., Torance, H., Anderson, R.A., Oliver, J.S. (2005) Drugs in oral fluid: part I. Validation of an analytical procedure for licit and illicit drugs in oral fluid. Forensic Science International, 150, 191-198.
21. Wood, M., Laloup, M., Ramirez Fernandez, M.M., Jenkins, K.M., Young, M.S., Ramaekers, J.G. et al. (2005) Quantitative analysis of multiple illicit drugs in preserved oral fluid by solid-phase extraction and liquid chromatography-tandem mass spectrometry. Forensic Science International, 150, 227-238.
22. Kintz, P., Villain, M., Concheiro, M., Cirimele, V. (2005) Screening and confirmation method for benzodiazepines and hypnotics in oral fluid by LC-MS/MS. Forensic Science International, 150, 213-220.
23. Oiestad, E.L., Johansen, U., Christophersen, A.S. (2007) Drug screening of preserved oral fluid by liquid chromatography-tandem mass spectrometry. Clinical Chemistry, 53, 300-309.
24. Link, B., Haschke, M.,Wenk, M., Krahenbuhl, S. (2007) Determination of midazolam and its hydroxyl metabolites in human plasma and oral fluid by liquid chromatography/electrospray ionization ion trap tandem mass spectrometry. Rapid Communication in Mass Spectrometry, 21, 1531-1540.
25. Simoes, S.S., Ajenjo, A.C., Franco, J.M., Vieira, D.N., Dias, M.J. (2009) Liquid chromatography/tandem mass spectrometry for the qualitative and quantitative analysis of illicit drugs and medicines in preserved oral fluid. Rapid Communication in Mass Spectrometry, 23, 1451-1460.
26. Hsu, Y.C., Chen, B.G., Yang, S.C., Wang, Y.S., Huang, S.P., Huang, M.H. et al. (2013) Methadone concentrations in blood, plasma, and oral fluid determined by isotope-dilution gas chromatography-mass spectrometry. Analytical and Bioanalytical Chemistry, 405, 3921-3928.
27. Liu, H.C., Lin, D.L., McCurdy, H.H. (2013) Matrix effect in liquid chromatography- tandem mass spectrometry (LC-MS-MS) method of analysis. Forensic Science Review, 25, 65-78.
28. Fucci, N., De Giovanni, N. (2008) Stability of methadone and its main metabolite in oral fluid. Drug Metabolism Letters, 2, 125-129.