Increased calcium in neurons in the cerebral cortex and cerebellum is not associated with cell loss in the mdx mouse model of Duchenne muscular dystrophy

NeuroReport

Volumn 26, Issue 13, 2015, Pages 785-790

  Tuckett, Emma ^a   Gosetti, Troy ^a   Hayes, Alan ^a   Rybalka, Emma ^a   Verghese, Elizabeth ^a  

^a VICTORIA UNIVERSITY   (Australia)

Author keywords

calcium; cerebellum; cerebral cortex; Duchenne muscular dystrophy; hippocampus; mdx mice; neurons

Indexed keywords

ALIZARIN RED S; CALCIUM; EOSIN; HEMATOXYLIN; PHOSPHOTUNGSTIC ACID;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN TISSUE; CELL LOSS; CEREBELLUM; CONTROLLED STUDY; DUCHENNE MUSCULAR DYSTROPHY; FEMALE; GLIOSIS; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE; ANIMAL; C57BL MOUSE; DISEASE MODEL; METABOLISM;

ANIMALS; CALCIUM; CEREBELLUM; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MUSCULAR DYSTROPHY, DUCHENNE; NEURONS;

EID: 84939545716     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0000000000000425     Document Type: Article

References (27)

1. Parker AE, Robb SA, Chambers J, Davidson AC, Evans L, ODowd J, et al. Analysis of an adult Duchenne muscular dystrophy population. QJ Med 2005; 98: 729-736
2. Blake DJ, Weir A, Newey SE, Davies KE. Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol Rev 2002; 82: 291-329
3. De Boulogne GBAD. Studies on pseudohypertrophic musculae paralysis or myosclerotic paralysis. Arch Neurol 1968; 19: 629-636
4. Bresolin N, Castelli E, Comi GP, Feisari G, Bardoni A, Perani D, et al. Cognitive impairment in Duchenne muscular dystrophy. Neuromuscular Disord 1994; 4: 8341-8353
5. Cotton S, Voudouris NJ, Greenwood KM. Intelligence and Duchenne muscular dystrophy: full-scale, verbal, and performance intelligence quotients. Dev Med Child Neurol 2001; 43: 497-501
6. Cotton SM, Voudouris NJ, Greenwood ICM. Association between intellectual functioning and age in children and young adults from a meta-Analysis. Dev Med Child Neurol 2005; 47: 257-265
7. Muntoni F, Meteddu A, Serra G. Passive avoidance behavior deficit in the mdx mouse. Neuromuscul Disrod 1991; 1: 121-123
8. Booth JR, Wood L, Lu D, Houk JC, Bitan T. The role of the basal ganglia and cerebellum in language processing. Brain Res 2007; 1133: 136-144
9. Cyrulnik SE, Fee RJ, de Vivo RJ, Goldstein E, Hinton W. Delayed developmental language milestones in children with Duchenne muscular dystrophy. J Pediatr 2007; 150: 174-178
10. Hinton VJ, de Vivo DC, Nereo NE, Goldstein E, Serra Y. Selective deficits in verbal working memory associated with a known genetic etiology: the neuropsychological profile of Duchenne muscular dystrophy. J Int Neuropsychol Soc 2001; 7: 45-54
11. Kaplan Lc, Osbourne P, Elias E. The diagnosis of muscular dystrophy in patients referred for language delay. J Child Psychol Psychiatry 1986; 27: 545-549
12. Vaillend C, Billard JM, Caroche S. Impaired long-Term spatial and recognition memory and enhanced CA1 hippocampal LTP in the dystrophin-deficient Dmd (mdx) mouse. Neurobiol Dis 2004; 17: 10-20
13. Lidov HGW, Byers TJ, Kunkel LM. The distribution of dystrophin in the murine central nervous system: an immunocytochemical study. Neuroscience 1993; 54: 167-187
14. Mäkinen S, van Groen T, Clarke J, Thornell A, Corbett D, Hiltunen M, et al. Coaccumulation of calcium and beta-Amyloid in the thalamus after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 2008; 28: 263-268
15. Hopf FW, Steinhardt RA. Regulation of intracellular free calcium in normal and dystrophic mouse cerebellar neurons. Brain Res 1992; 578: 49-54
16. Uchino M, Teramoto H, Noae H, Yoshioka K, Miike T, Ando M. Localization and characterization of dystrophin in the central nervous system of controls and patients with Duchenne muscular dystrophy. J Neurol Neurosurg Psychiatry 1994; 57: 426-429
17. Miranda R, Sèbriè C, Degrouard J, Gillet B, Jaillard D, Larroche S, Vaillend C. Reorganization of inhibitory synapses and increased PSD length of perforated excitatory synapses in hippocampal area CA1 of dystrophindeficient mdx mice. Cerebral Cortex 2009; 19: 876-888
18. Sim B, Rae C. The effect of Duchenne muscular dystrophy on Purkinje cell numbers in the mdx mouse. Aust Med Student J 2011; 2: 52-55
19. Bellinger AM, Reiken S, Carlson C, Mongillo M, Liu X, Rothman L, et al. Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med 2009; 15: 325-330
20. Han R, Grounds MD, Bekker AJ. Measurement of sum-membrane [Ca2+] in adult myofibers and cytosolic [Ca2+] in myotubes from normal and mdx mice using the Ca2+ indicator FFP-18. Cell Calcium 2006; 40: 299-307
21. Alderton JM, Steinhardt RA. How calcium influx through calcium leak channels is responsible for the elevated levels of calcium-dependent proteolysis in dystrophic myotubes. Trends Cardiovasc Med 2000; 10: 268-272
22. Blake DJ, Hawkes R, Benson MA, Beesley PW. Different dystrophin-like complexes are expressed in neurons and glia. J Cell Biol 1999; 147: 645-658
23. Haws CM, Lansman JB. Calcium permeable ion channels in cerebellar neurons from mdx mice. Proc Biol Sci 1991; 244: 185-189
24. Dubowitz V, Crome L. The central nervous system in Duchenne muscular dystrophy. Brain 1969; 92: 805-808
25. Itoh K, Jinnai K, Tada K, Hara K, Itoh H, Takahashi K. Multifocal glial nodules in a case of Duchenne muscular dystrophy with severe mental retardation. Neuropathology 1999; 19: 322-327
26. Sbricolli A, Santarelli M, Carretta D, Pinto F, Granato A, Miciacchi P. Archetictural changes in the corticospinal system in the dystrophin defective mdx mouse. Neurosci Lett 1995; 200: 53-56
27. Anderson JL, Head SI, Rae C, Morley JW. Brain function in Duchenne muscular dystrophy. Brain 2002; 125 (Pt 1): 4-13