Perspectives for Regenerative Medicine in the Treatment of Inflammatory Bowel Diseases

Digestion

Volumn 92, Issue 2, 2015, Pages 73-77

  Okamoto, Ryuichi ^a   Watanabe, Mamoru ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Cell transplantation; Inflammatory bowel disease; Intestinal stem cells; Regenerative medicine

Indexed keywords

CYTOLOGY; EVOLUTION; EX VIVO STUDY; GASTROINTESTINAL TRACT; HEALING; HUMAN; INFLAMMATORY BOWEL DISEASE; INTESTINAL STEM CELL; INTESTINE INJURY; INTESTINE MUCOSA; MEDICAL INFORMATION; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; REGENERATIVE MEDICINE; REVIEW; STEM CELL TRANSPLANTATION; ADULT STEM CELL; CELL CULTURE; CELL CULTURE TECHNIQUE; INFLAMMATORY BOWEL DISEASES; INTESTINE; PATHOPHYSIOLOGY; PROCEDURES; TRANSPLANTATION; TRENDS; WOUND HEALING;

ADULT STEM CELLS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; GASTROINTESTINAL TRACT; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; INTESTINES; REGENERATIVE MEDICINE; WOUND HEALING;

EID: 84939524213     PISSN: 00122823     EISSN: 14219867     Source Type: Journal    
DOI: 10.1159/000438663     Document Type: Review

References (21)

1. Sheehan D, Moran C, Shanahan F: The microbiota in inflammatory bowel disease. J Gastroenterol 2015; 50: 495-507.
2. Goldsmith JR, Sartor RB: The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications. J Gastroenterol 2014; 49: 785-798.
3. Okamoto R, Watanabe M: Molecular and clinical basis for the regeneration of human gastrointestinal epithelia. J Gastroenterol 2004; 39: 1-6.
4. Neurath MF, Travis SP: Mucosal healing in inflammatory bowel diseases: A systematic review. Gut 2012; 61: 1619-1635.
5. Potten CS, Kovacs L, Hamilton E: Continuous labelling studies on mouse skin and intestine. Cell Tissue Kinet 1974; 7: 271-283.
6. Barker N, van de Wetering M, Clevers H: The intestinal stem cell. Genes Dev 2008; 22: 1856-1864.
7. Potten CS, Booth C, Tudor GL, Booth D, Brady G, Hurley P, et al: Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation 2003; 71: 28-41.
8. Kayahara T, Sawada M, Takaishi S, Fukui H, Seno H, Fukuzawa H, et al: Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine. FEBS Lett 2003; 535: 131-135.
9. Kaneko Y, Sakakibara S, Imai T, Suzuki A, Nakamura Y, Sawamoto K, et al: Musashi1: An evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev Neurosci 2000; 22: 139-153.
10. Murayama M, Okamoto R, Tsuchiya K, Akiyama J, Nakamura T, Sakamoto N, et al: Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. J Gastroenterol 2009; 44: 173-182.
11. Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, et al: Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007; 449: 1003-1007.
12. Ootani A, Li X, Sangiorgi E, Ho QT, Ueno H, Toda S, et al: Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med 2009; 15: 701-706.
13. Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, et al: Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009; 459: 262-265.
14. Sato T, Clevers H: Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 2013; 340: 1190-1194.
15. Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, et al: Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 2011; 469: 415-418.
16. Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, et al: Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nat Med 2012; 18: 618-623.
17. Fordham RP, Yui S, Hannan NR, Soendergaard C, Madgwick A, Schweiger PJ, et al: Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell 2013; 13: 734-744.
18. Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, et al: Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev 2014; 28: 1752-1757.
19. Frøslie KF, Jahnsen J, Moum BA, Vatn MH; IBSEN Group: Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology 2007; 133: 412-422.
20. Nagaishi K, Arimura Y, Fujimiya M: Stem cell therapy for inflammatory bowel disease. J Gastroenterol 2015; 50: 280-286.
21. Takebe T, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, et al: Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 2013; 499: 481-484.