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Volumn 4, Issue , 2015, Pages

Phase 2 trial of ixazomib in patients with relapsed multiple myeloma not refractory to bortezomib

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; DEXAMETHASONE; IMMUNOMODULATING AGENT; IXAZOMIB CITRATE; LENALIDOMIDE; M PROTEIN; ANTINEOPLASTIC AGENT; BORON DERIVATIVE; GLYCINE; IXAZOMIB;

EID: 84939494205     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2015.60     Document Type: Article
Times cited : (67)

References (21)
  • 2
    • 72949085546 scopus 로고    scopus 로고
    • Management of newly diagnosed symptomatic multiple myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines
    • Kumar SK, Mikhael JR, Buadi FK, Dingli D, Dispenzieri A, Fonseca R et al. Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines. Mayo Clin Proc 2009; 84: 1095-1110.
    • (2009) Mayo Clin Proc , vol.84 , pp. 1095-1110
    • Kumar, S.K.1    Mikhael, J.R.2    Buadi, F.K.3    Dingli, D.4    Dispenzieri, A.5    Fonseca, R.6
  • 3
    • 0036181371 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor PS-341
    • Adams J. Development of the proteasome inhibitor PS-341. Oncologist 2002; 7: 9-16.
    • (2002) Oncologist , vol.7 , pp. 9-16
    • Adams, J.1
  • 4
    • 0037111832 scopus 로고    scopus 로고
    • Phase i trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
    • Orlowski RZ, Stinchcombe TE, Mitchell BS, Shea TC, Baldwin AS, Stahl S et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002; 20: 4420-4427.
    • (2002) J Clin Oncol , vol.20 , pp. 4420-4427
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3    Shea, T.C.4    Baldwin, A.S.5    Stahl, S.6
  • 5
    • 35148825003 scopus 로고    scopus 로고
    • Extended follow-up of a phase 3 trial in relapsed multiple myeloma: Final time-toevent results of the APEX trial
    • Richardson PG, Sonneveld P, Schuster M, Irwin D, Stadtmauer E, Facon T et al. Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-toevent results of the APEX trial. Blood 2007; 110: 3557-3560.
    • (2007) Blood , vol.110 , pp. 3557-3560
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.3    Irwin, D.4    Stadtmauer, E.5    Facon, T.6
  • 7
    • 84865552564 scopus 로고    scopus 로고
    • An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib
    • Vij R, Siegel DS, Jagannath S, Jakubowiak AJ, Stewart AK, McDonagh K et al. An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib. Br J Haematol 2012; 158: 739-748.
    • (2012) Br J Haematol , vol.158 , pp. 739-748
    • Vij, R.1    Siegel, D.S.2    Jagannath, S.3    Jakubowiak, A.J.4    Stewart, A.K.5    McDonagh, K.6
  • 8
    • 84867295563 scopus 로고    scopus 로고
    • A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
    • Siegel DS, Martin T, Wang M, Vij R, Jakubowiak AJ, Lonial S et al. A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood 2012; 120: 2817-2825.
    • (2012) Blood , vol.120 , pp. 2817-2825
    • Siegel, D.S.1    Martin, T.2    Wang, M.3    Vij, R.4    Jakubowiak, A.J.5    Lonial, S.6
  • 9
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S, Jakubowiak AJ, Jagannath S, Raje NS et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 2010; 116: 679-686.
    • (2010) Blood , vol.116 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3    Jakubowiak, A.J.4    Jagannath, S.5    Raje, N.S.6
  • 10
    • 84860907057 scopus 로고    scopus 로고
    • Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma
    • Kumar S, Flinn I, Richardson PG, Hari P, Callander N, Noga SJ et al. Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma. Blood 2012; 119: 4375-4382.
    • (2012) Blood , vol.119 , pp. 4375-4382
    • Kumar, S.1    Flinn, I.2    Richardson, P.G.3    Hari, P.4    Callander, N.5    Noga, S.J.6
  • 11
    • 84865333050 scopus 로고    scopus 로고
    • A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
    • Jakubowiak AJ, Dytfeld D, Griffith KA, Lebovic D, Vesole DH, Jagannath S et al. A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma. Blood 2012; 120: 1801-1809.
    • (2012) Blood , vol.120 , pp. 1801-1809
    • Jakubowiak, A.J.1    Dytfeld, D.2    Griffith, K.A.3    Lebovic, D.4    Vesole, D.H.5    Jagannath, S.6
  • 12
    • 77954125336 scopus 로고    scopus 로고
    • Peripheral neuropathy during bortezomib treatment of multiple myeloma: A review of recent studies
    • Cavaletti G, Jakubowiak AJ. Peripheral neuropathy during bortezomib treatment of multiple myeloma: a review of recent studies. Leuk Lymphoma 2010; 51: 1178-1187.
    • (2010) Leuk Lymphoma , vol.51 , pp. 1178-1187
    • Cavaletti, G.1    Jakubowiak, A.J.2
  • 13
    • 79955461011 scopus 로고    scopus 로고
    • Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: A randomised, phase 3, non-inferiority study
    • Moreau P, Pylypenko H, Grosicki S, Karamanesht I, Leleu X, Grishunina M et al. Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study. Lancet Oncol 2011; 12: 431-440.
    • (2011) Lancet Oncol , vol.12 , pp. 431-440
    • Moreau, P.1    Pylypenko, H.2    Grosicki, S.3    Karamanesht, I.4    Leleu, X.5    Grishunina, M.6
  • 14
    • 78649681350 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly bortezomib in multiple myeloma patients
    • Bringhen S, Larocca A, Rossi D, Cavalli M, Genuardi M, Ria R et al. Efficacy and safety of once-weekly bortezomib in multiple myeloma patients. Blood 2010; 116: 4745-4753.
    • (2010) Blood , vol.116 , pp. 4745-4753
    • Bringhen, S.1    Larocca, A.2    Rossi, D.3    Cavalli, M.4    Genuardi, M.5    Ria, R.6
  • 15
    • 77950238258 scopus 로고    scopus 로고
    • Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer
    • Kupperman E, Lee EC, Cao Y, Bannerman B, Fitzgerald M, Berger A et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res 2010; 70: 1970-1980.
    • (2010) Cancer Res , vol.70 , pp. 1970-1980
    • Kupperman, E.1    Lee, E.C.2    Cao, Y.3    Bannerman, B.4    Fitzgerald, M.5    Berger, A.6
  • 16
    • 80051691845 scopus 로고    scopus 로고
    • In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells
    • Chauhan D, Tian Z, Zhou B, Kuhn D, Orlowski R, Raje N et al. In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells. Clin Cancer Res 2011; 17: 5311-5321.
    • (2011) Clin Cancer Res , vol.17 , pp. 5311-5321
    • Chauhan, D.1    Tian, Z.2    Zhou, B.3    Kuhn, D.4    Orlowski, R.5    Raje, N.6
  • 17
    • 82555189384 scopus 로고    scopus 로고
    • Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies
    • Lee EC, Fitzgerald M, Bannerman B, Donelan J, Bano K, Terkelsen J et al. Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies. Clin Cancer Res 2011; 17: 7313-7323.
    • (2011) Clin Cancer Res , vol.17 , pp. 7313-7323
    • Lee, E.C.1    Fitzgerald, M.2    Bannerman, B.3    Donelan, J.4    Bano, K.5    Terkelsen, J.6
  • 18
    • 84905982938 scopus 로고    scopus 로고
    • Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor ixazomib in relapsed/refractory multiple myeloma
    • Kumar SK, Bensinger WI, Zimmerman TM, Reeder CB, Berenson JR, Berg D et al. Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor ixazomib in relapsed/refractory multiple myeloma. Blood 2014; 124: 1047-1055.
    • (2014) Blood , vol.124 , pp. 1047-1055
    • Kumar, S.K.1    Bensinger, W.I.2    Zimmerman, T.M.3    Reeder, C.B.4    Berenson, J.R.5    Berg, D.6
  • 19
    • 84925230724 scopus 로고    scopus 로고
    • Safety and tolerability of ixazomib, an oral proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma: An open-label phase 1/2 study
    • Kumar SK, Berdeja JG, Niesvizky R, Lonial S, Laubach JP, Hamadani M et al. Safety and tolerability of ixazomib, an oral proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma: an open-label phase 1/2 study. Lancet Oncol 2014; 15: 1503-1512.
    • (2014) Lancet Oncol , vol.15 , pp. 1503-1512
    • Kumar, S.K.1    Berdeja, J.G.2    Niesvizky, R.3    Lonial, S.4    Laubach, J.P.5    Hamadani, M.6
  • 20
    • 84905962613 scopus 로고    scopus 로고
    • Phase 1 study of twice-weekly dosing of investigational oral proteasome inhibitor ixazomib in patients with relapsed and/or refractory multiple myeloma
    • Richardson PG, Baz R, Wang M, Jakubowiak AJ, Laubach JP, Harvey RD et al. Phase 1 study of twice-weekly dosing of investigational oral proteasome inhibitor ixazomib in patients with relapsed and/or refractory multiple myeloma. Blood 2014; 124: 1038-1046.
    • (2014) Blood , vol.124 , pp. 1038-1046
    • Richardson, P.G.1    Baz, R.2    Wang, M.3    Jakubowiak, A.J.4    Laubach, J.P.5    Harvey, R.D.6
  • 21
    • 33644844108 scopus 로고    scopus 로고
    • Extended follow-up of a phase II trial in relapsed, refractory multiple myeloma:: Final time-to-event results from the SUMMIT trial
    • Richardson PG, Barlogie B, Berenson J, Singhal S, Jagannath S, Irwin DH et al. Extended follow-up of a phase II trial in relapsed, refractory multiple myeloma:: final time-to-event results from the SUMMIT trial. Cancer 2006; 106: 1316-1319.
    • (2006) Cancer , vol.106 , pp. 1316-1319
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3    Singhal, S.4    Jagannath, S.5    Irwin, D.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.