The effect of standard dose multivitamin supplementation on disease progression in HIV-infected adults initiating HAART: A randomized double blind placebo-controlled trial in Uganda

BMC Infectious Diseases

Volumn 15, Issue 1, 2015, Pages

  Guwatudde, David ^a   Wang, Molin ^b   Ezeamama, Amara E ^c   Bagenda, Danstan ^a,b   Kyeyune, Rachel ^a   Wamani, Henry ^a   Manabe, Yukari C ^d   Fawzi, Wafaie W ^b  

^a MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; ANTIRETROVIRUS AGENT; ASCORBIC ACID; CD4 ANTIGEN; HEMOGLOBIN; MULTIVITAMIN; PLACEBO; VITAMIN B COMPLEX; VITAMIN;

ADULT; ANEMIA; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERAMYLASEMIA; INTENTION TO TREAT ANALYSIS; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NAUSEA; PATIENT COMPLIANCE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RECOMMENDED DRUG DOSE; TREATMENT OUTCOME; UGANDA; VITAMIN SUPPLEMENTATION; VOMITING; WEIGHT CHANGE; ADOLESCENT; BODY WEIGHT; DIETARY REFERENCE INTAKE; DIETARY SUPPLEMENT; HIV INFECTIONS; IMMUNOLOGY; KAPLAN MEIER METHOD; MIDDLE AGED; STATISTICAL MODEL; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BODY WEIGHT; CD4 LYMPHOCYTE COUNT; DIETARY SUPPLEMENTS; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; HIV INFECTIONS; HUMANS; KAPLAN-MEIER ESTIMATE; LINEAR MODELS; MALE; MIDDLE AGED; QUALITY OF LIFE; RECOMMENDED DIETARY ALLOWANCES; TREATMENT OUTCOME; UGANDA; VITAMINS; YOUNG ADULT;

EID: 84939492457     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/s12879-015-1082-x     Document Type: Article

References (30)

1. Beisel WR. In: Gershwin ME, German JB, Keen CL, editors. Nutrition and immunology: principles and practices. Totowa, NJ: Humana Press; 2000. p. 389-403.
2. Coyne-Meyers K, Trombley LE. A review of nutrition in human immunodeficiency virus infection in the era of highly active antiretroviral therapy. Nutr Clin Pract. 2004;19(4):340-55.
3. Beisel WR. Single nutrients and immunity. Am J Clin Nutr. 1982;35(2 Suppl):417-68.
4. Beach RS, Mantero-Atienza E, Shor-Posner G, Javier JJ, Szapocznik J, Morgan R, et al. Specific nutrient abnormalities in asymptomatic HIV-1 infection. AIDS. 1992;6(7):701-8.
5. Baum MK, Shor-Posner G, Lu Y, Rosner B, Sauberlich HE, Fletcher MA, et al. Micronutrients and HIV-1 disease progression. AIDS. 1995;9(9):1051-6.
6. Vorster HH, Kruger A, Margetts BM, Venter CS, Kruger HS, Veldman FJ, et al. The nutritional status of asymptomatic HIV-infected Africans: directions for dietary intervention? Public Health Nutr. 2004;7(8):1055-64.
7. Jiamton S, Pepin J, Suttent R, Filteau S, Mahakkanukrauh B, Hanshaoworakul W, et al. A randomized trial of the impact of multiple micronutrient supplementation on mortality among HIV-infected individuals living in Bangkok. AIDS. 2003;17(17):2461-9.
8. Fawzi WW, Msamanga GI, Spiegelman D, Urassa EJ, McGrath N, Mwakagile D, et al. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet. 1998;351(9114):1477-82.
9. Allard JP, Aghdassi E, Chau J, Tam C, Kovacs CM, Salit IE, et al. Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects. AIDS. 1998;12(13):1653-9.
10. Baum MK, Campa A, Lai S, Sales Martinez S, Tsalaile L, Burns P, et al. Effect of micronutrient supplementation on disease progression in asymptomatic, antiretroviral-naive, HIV-infected adults in Botswana: a randomized clinical trial. JAMA. 2013;310(20):2154-63.
11. Mugusi F, Med M, Hertzmark E, Essex M, Hunter DJ. A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med. 2004;351(1):23-32.
12. Jiang S, He J, Zhao X, Li H. The effect of multiple micronutrient supplementation on mortality and morbidity of HIV-infected adults: a meta-analysis of randomized controlled trials. J Nutr Sci Vitaminol (Tokyo). 2012;58(2):105-12.
13. Giacomet V, Vigano A, Manfredini V, Cerini C, Bedogni G, Mora S, et al. Cholecalciferol supplementation in HIV-infected youth with vitamin D insufficiency: effects on vitamin D status and T-cell phenotype: a randomized controlled trial. HIV Clin Trials. 2013;14(2):51-60.
14. Grigoletti SS, Guindani G, Moraes RS, Ribeiro JP, Sprinz E. Short-term folinic acid supplementation improves vascular reactivity in HIV-infected individuals: a randomized trial. Nutrition. 2013;29(6):886-91.
15. Batterham M, Gold J, Naidoo D, Lux O, Sadler S, Bridle S, et al. A preliminary open label dose comparison using an antioxidant regimen to determine the effect on viral load and oxidative stress in men with HIV/AIDS. Eur J Clin Nutr. 2001;55(2):107-14.
16. De Souza Junior O, Treitinger A, Baggio GL, Michelon C, Verdi JC, Cunha J, et al. alpha-Tocopherol as an antiretroviral therapy supplement for HIV-1-infected patients for increased lymphocyte viability. Clin Chem Lab Med. 2005;43(4):376-82.
17. Kaiser JD, Campa AM, Ondercin JP, Leoung GS, Pless RF, Baum MK. Micronutrient supplementation increases CD4 count in HIV-infected individuals on highly active antiretroviral therapy: a prospective, double-blinded, placebo-controlled trial. J Acquir Immune Defic Syndr. 2006;42(5):523-8.
18. Isanaka S, Mugusi F, Hawkins C, Spiegelman D, Okuma J, Aboud S, et al. Effect of high-dose vs standard-dose multivitamin supplementation at the initiation of HAART on HIV disease progression and mortality in Tanzania: a randomized controlled trial. JAMA. 2012;308(15):1535-44.
19. Guwatudde D, Ezeamama AE, Bagenda D, Kyeyune R, Wabwire-Mangen F, Wamani H, et al. Multivitamin supplementation in HIV infected adults initiating antiretroviral therapy in Uganda: the protocol for a randomized double blinded placebo controlled efficacy trial. BMC Infect Dis. 2012;12:304.
20. Reports-Institute of Medicine. 2015 May 22.
21. Dietary Reference Intakes (DRIs): estimated average requirements. 2015 May 21.
22. Mast TC, Kigozi G, Wabwire-Mangen F, Black R, Sewankambo N, Serwadda D, et al. Measuring quality of life among HIV-infected women using a culturally adapted questionnaire in Rakai district, Uganda. AIDS Care. 2004;16(1):81-94.
23. Fawzi W, Msamanga G, Spiegelman D, Hunter DJ. Studies of vitamins and minerals and HIV transmission and disease progression. J Nutr. 2005;135(4):938-44.
24. Lawn SD, Harries AD, Anglaret X, Myer L, Wood R. Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. AIDS. 2008;22(15):1897-908.
25. Olsen MF, Abdissa A, Kæstel P, Tesfaye M, Yilma D, Girma T, et al. Effects of nutritional supplementation for HIV patients starting antiretroviral treatment: randomised controlled trial in Ethiopia. BMJ. 2014;348:g3187.
26. Koethe JR, Heimburger DC. Nutritional aspects of HIV-associated wasting in sub-Saharan Africa. Am J Clin Nutr. 2010;91(4):1138S-42.
27. Swaminathan S, Padmapriyadarsini C, Sukumar B, Iliayas S, Kumar SR, Triveni C, et al. Nutritional status of persons with HIV infection, persons with HIV infection and tuberculosis, and HIV-negative individuals from southern India. Clin Infect Dis. 2008;46(6):946-9.
28. Swaminathan S, Padmapriyadarsini C, Yoojin L, Sukumar B, Iliayas S, Karthipriya J, et al. Nutritional supplementation in HIV-infected individuals in South India: a prospective interventional study. Clin Infect Dis. 2010;51(1):51-7.
29. Wig N, Bhatt SP, Sakhuja A, Srivastava S, Agarwal S. Dietary adequacy in Asian Indians with HIV. AIDS Care. 2008;20(3):370-5.
30. Executive Board 116. Nutrition and HIV/AIDS: report by the Secretariat. World Health Organization. 2005.