Hydrogen sulphide and mild hypothermia activate the CREB signaling pathway and prevent ischemia-reperfusion injury

BMC Anesthesiology

Volumn 15, Issue 1, 2015, Pages

  Dai, Hai bin ^a   Ji, Xiangjun ^a   Zhu, Si hai ^a   Hu, Yi min ^a   Zhang, Li dong ^a   Miao, Xiao lei ^a   Ma, Ru Meng ^b   Duan, Man lin ^a   Li, Wei yan ^a  

^a NANJING UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Brain ischemia; Cyclic AMP response element binding protein; Hydrogen sulphide; Hypothermia; N methyl D aspartate receptor; Reperfusion injury

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYDROGEN SULFIDE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREB SIGNALING PATHWAY; CYTOLOGY; DRUG TISSUE LEVEL; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; INDUCED HYPOTHERMIA; MALE; MILD HYPOTHERMIA; NEUROPROTECTION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TRANSIENT ISCHEMIC ATTACK; TREATMENT OUTCOME; UPREGULATION; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; BRAIN INJURIES; BRAIN ISCHEMIA; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BRAIN INJURIES; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HYDROGEN SULFIDE; HYPOTHERMIA, INDUCED; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84939457708     PISSN: None     EISSN: 14712253     Source Type: Journal    
DOI: 10.1186/s12871-015-0097-6     Document Type: Article

References (19)

1. Carden DL, Granger DN. Pathophysiology of ischaemia-reperfusion injury. J Pathol. 2000;190(3):255-66.
2. Barone FC, Feuerstein GZ. Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab. 1999;19(8):819-34.
3. Liu Y, Wong TP, Aarts M, Rooyakkers A, Liu L, Lai TW, et al. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci. 2007;27(11):2846-57.
4. Hetman M, Kharebava G. Survival signaling pathways activated by NMDA receptors. Curr Top Med Chem. 2006;6(8):787-99.
5. Valera E, Sánchez-Martín FJ, Ferrer-Montiel AV, Messeguer A, Merino JM. NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway. Neurochem Int. 2008;53(5):148-54.
6. Hardingham GE, Fukunaga Y, Bading H. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci. 2002;5(5):405-14.
7. Papadia S, Hardingham GE. The dichotomy of NMDA receptor signaling. Neuroscientist. 2007;13(6):572-9.
8. Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996;16(3):1066-71.
9. Szabo C. Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov. 2007;6(11):917-35.
10. Kimura H. Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. Biochem Biophys Res Commun. 2000;267(1):129-33.
11. Duan M, Li D, Xu J. Mechanisms of selective head cooling for resuscitating damaged neurons during post-ischemic reperfusion. Chin Med J (Engl). 2002;115(1):94-8.
12. Pulsinelli WA, Buchan AM. The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation. Stroke. 1988;19(7):913-4.
13. Pulsinelli WA, Brierley JB. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke. 1979;10(3):267-72.
14. Tan BH, Wong PT, Bian JS. Hydrogen sulfide: a novel signaling molecule in the central nervous system. Neurochem Int. 2010;56(1):3-10.
15. Lonze BE, Ginty DD. Function and regulation of CREB family transcription factors in the nervous system. Neuron. 2002;35(4):605-23.
16. Zhou X, Chen Z, Yun W, Wang H. NMDA receptor activity determines neuronal fate: location or number? Rev Neurosci. 2015;26(1):39-47.
17. Markarian GZ, Lee JH, Stein DJ, Hong SC. Mild hypothermia: therapeutic window after experimental cerebral ischemia. Neurosurgery. 1996;38(3):542-50. discussion 551.
18. Erecinska M, Thoresen M, Silver IA. Effects of hypothermia on energy metabolism in Mammalian central nervous system. J Cereb Blood Flow Metab. 2003;23(5):513-30.
19. Zhao H, Steinberg GK, Sapolsky RM. General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage. J Cereb Blood Flow Metab. 2007;27(12):1879-94.