Indirect tumor cell death after high-dose hypofractionated irradiation: Implications for stereotactic body radiation therapy and stereotactic radiation surgery

International Journal of Radiation Oncology Biology Physics

Volumn 93, Issue 1, 2015, Pages 166-172

  Song, Chang W ^a,b   Lee, Yoon Jin ^b   Griffin, Robert J ^c   Park, Inhwan ^a   Koonce, Nathan A ^c   Hui, Susanta ^a   Kim, Mi Sook ^b   Dusenbery, Kathryn E ^a   Sperduto, Paul W ^d   Cho, L Chinsoo ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONIC ANHYDRASE; CELL DEATH; DETERIORATION; MAMMALS; RADIATION EFFECTS; RADIOTHERAPY; SURGERY; TUMORS;

ALPHA ACTIVITIES; BIOLOGICAL MECHANISMS; HYPOFRACTIONATED; IMMUNOHISTOCHEMICAL METHODS; METHODS AND MATERIALS; MICROENVIRONMENTS; SINGLE FRACTIONS; STEREOTACTIC BODY RADIATION THERAPY;

IRRADIATION;

CARBONATE DEHYDRATASE IX; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN; CARBONATE DEHYDRATASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD VESSEL INJURY; CELL COUNT; CELL DEATH; CELL FRACTIONATION; CELL SURVIVAL; CONFERENCE PAPER; CONTROLLED STUDY; DETERIORATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; FIBROSARCOMA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE FRACTIONATION; RADIOTHERAPY EQUIPMENT; STEREOTACTIC BODY RADIATION THERAPY; STEREOTACTIC RADIOSURGERY; SURVIVAL RATE; TUMOR CELL; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; C3H MOUSE; CELL HYPOXIA; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROCEDURES; RADIATION RESPONSE; RADIOSURGERY; TIME; VASCULARIZATION;

ANIMALS; CARBONIC ANHYDRASES; CELL DEATH; CELL HYPOXIA; CELL SURVIVAL; DOSE FRACTIONATION; FIBROSARCOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, INBRED C3H; RADIOSURGERY; TIME FACTORS; TUMOR MICROENVIRONMENT;

EID: 84939437067     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2015.05.016     Document Type: Conference Paper

References (35)

1. Y. Nagata Stereotactic body radiation therapy for early stage lung cancer Cancer Res Treat 45 2013 155 161
2. R. Timmerman, R. Paulus, J. Galvin, and et al. Stereo-tactic body radiotherapy to treat medically inoperable early stage lung cancer patients J Am Med Assoc 303 2010 1070 1076
3. L.C. Cho, V. Fonteyne, W. DeNeve, S.S. Lo, and R.D. Timmerman Stereotactic body radiotherapy S.H. Levitt, Technical Basis of Radiation Therapy: Practical Clinical Application 2012 Springer Publishing Co New York 363 400
4. P.W. Sperduto A Review of stereotactic radiosurgery in the management of brain metastases Technol Cancer Res Treat 2 2003 105 110
5. M. Staehler, M. Bader, J. Cascuscelli, and et al. Single-fraction radiosurgery for the treatment of renal tumors J Urol 193 2015 771 775
6. C.W. Song, L.C. Cho, J. Yuan, and et al. Radiobiology of stereotactic body radiation therapy/stereotactic radiosurgery and the linear-quadratic mode Int J Radiat Oncol Biol Phys 87 2013 18 19
7. C.W. Song, I. Park, L.C. Cho, and et al. Is there indirect cell death involved in response of tumor to SRS and SBRT? Int J Radiat Oncol Biol Phys 89 2014 924 925
8. P.W. Sperduto, C.W. Song, J. Kirkpatrick, and et al. A hypothesis on indirect cell death in the radiosurgery era Int J Radiat Oncol Biol Phys 91 2015 11 13
9. J.M. Brown, D.J. Brenner, and D.J. Carlson Dose escalation, not "new biology" can account for the efficacy of stereotactic body radiation therapy with non-small cell lung cancer Int J Radiat Oncol Biol Phys 85 2013 1159 1160
10. J.M. Brown, D.J. Carlson, and D.J. Brenner The tumor radiobiology of SRS and SBRT: Are more than the 5Rs involved? Int J Radiat Oncol Biol Phys 88 2014 254 262
11. C.W. Song, H.J. Park, R.J. Griffin, and S.H. Levitt Radiobiology of stereotactic radiosurgery and stereotactic body radiation therapy S.H. Levitt, Technical Basis of Radiation Therapy: Practical Clinical Application 2012 Springer Publishing Co New York 51 61
12. H.J. Park, R.J. Griffin, S. Hui, and et al. Radiation-induced vascular damage in tumors: Implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS) Radiat Res 177 2012 311 327
13. C.W. Song, M.S. Kim, L.C. Cho, and et al. Radiobiological basis of SBRT and SRS Int J Clin Oncol 19 2014 570 578
14. C.W. Song, and S.H. Levitt Effect of X irradiation on vascularity of normal tissues and experimental tumor Radiology 94 1970 445 447
15. C.W. Song, and S.H. Levitt Vascular changes in Walker 256 carcinoma of rats following X irradiation Radiology 100 1971 397 407
16. C.W. Song, T. Payne, and S.H. Levitt Vascularity and blood flow in X-irradiated Walker carcinoma 256 of rats Radiology 104 1972 693 697
17. H.H. Wong, C.W. Song, and S.H. Levitt Early changes in the functional vasculature of Walker carcinoma 256 following irradiation Radiology 108 1973 429 434
18. C.W. Song, J.H. Sung, J.J. Clement, and et al. Vascular changes in neuroblastoma of mice following X-irradiation Cancer Res 34 1974 2344 2350
19. J.J. Clement, N. Tanaka, and C.W. Song Tumor reoxygenation and postirradiation vascular changes Radiology 127 1978 799 803
20. J.J. Clement, C.W. Song, and S.H. Levitt Changes in functional vascularity and cell number following X-irradiation of a murine carcinoma Int J Radiat Oncol Biol Phys 1 1976 671 678
21. M. Garcia-Barrps, F. Paris, C. Cordon-Cardo, and et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis Science 3000 2003 1155 1159
22. W. Cramer Experimental Observation on the therapeutic action of radium Tenth Scientic Report, Imperial Cancer Research Fund, London 1932 pp.95-123
23. I. Lasnitzki Quantitative analysis of the direct and indirect action of X radiation on malignant cells Br J Radiol 20 1947 240 247
24. G. Szeifert, N. Massager, D. DeVriendt, and et al. Observation of intracranial neoplasm treated with gamma knife radiosurgery Neuosurg 5 suppl 2002 623 626
25. J. Denekamp Vascular endothelium as the vulnerable element in tumours Acta Radiol Oncol 23 1984 217 225
26. R.J. Griffin, K. Okajima, A. Ogawa, and et al. Radiosensitization of two murine tumours with mild temperature hyperthermia and carbogen breathing Int J Radiat Oncol Biol Phys 75 1999 1299 1306
27. R. Azim, P. Alaei, E. Spezi, and et al. Characterization of an orthovoltage biological irradiator used for radiobiological research J Radiat Res 56 2015 485 492
28. R.P. Dings, M. Loren, H. Heum, and et al. Scheduling of radiation with angiogenesis inhibitors anginex and Vastin improves therapeutic outcome via vessel normalization Clin Cancer Res 1 2007 3395 3402
29. D. Cao, M. Hou, Y.S. Guan, and et al. Expression of HIF-1alpha and VEGF in colorectal cancer: Association with clinical outcomes and prognostic implications BMC Cancer 9 2009 432
30. U.D. Monte Does the cell number 109 still really fit one gram of tumor tissue? Cell Cycle 8 2009 505 506
31. J.T. Leith, S. Cook, P. Choughle, and et al. Intrinsic and extrinsic characteristics of human tumors relevant to radiosurgery: Comparative cellular radiosensitivity and hypoxic percentages Acta Neurochir Suppl 62 1994 18 27
32. J.F. Fowler, A.T. Wolfgang, J.D. Fenwick, and et al. A challenge to traditional radiation oncology Int J Radiat Oncol Biol Phys 60 2004 1241 1256
33. W.H. McBride, and D. Schaue In situ tumor ablation with radiation therapy: Its effect on the tumor microenvironment and anti-tumor immunity Y. Keisari, Tumor Ablation 2012 Spinger Publishing Co New York 109 119
34. Y. Lee, S.L. Auh, Y. Wang, and et al. Therapeutic effects of ablative radiation on local tumor require CD8 T cells: Changing strategies for cancer treatment Blood 114 2009 589 595
35. S. Matsumura, B. Wang, N. Kawashima, and et al. Radiation induced CXCL16 release by breast cancer cells attracts effector T cells J Immunol 181 2008 3009 3107