Latitude, sun exposure and vitamin D supplementation: Associations with quality of life and disease outcomes in a large international cohort of people with multiple sclerosis

BMC Neurology

Volumn 15, Issue 1, 2015, Pages 1-

  Jelinek, George A ^a   Marck, Claudia H ^a   Weiland, Tracey J ^a,b   Pereira, Naresh ^c   van der Meer, Dania M ^b   Hadgkiss, Emily J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c BOX HILL HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

VITAMIN D; VITAMIN;

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GEOGRAPHIC DISTRIBUTION; HUMAN; LATITUDE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; PHYSICAL DISABILITY; PREDICTION; QUALITY OF LIFE; RELAPSE; SELF REPORT; SUN EXPOSURE; VITAMIN SUPPLEMENTATION; CROSS-SECTIONAL STUDY; DAILY LIFE ACTIVITY; DIETARY SUPPLEMENT; GEOGRAPHY; HEALTH STATUS; MIDDLE AGED; PATHOPHYSIOLOGY; PROTECTION; RECURRENT DISEASE; RISK FACTOR; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL; SUNLIGHT;

ACTIVITIES OF DAILY LIVING; ADULT; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DIETARY SUPPLEMENTS; FEMALE; GEOGRAPHY; HEALTH STATUS; HUMANS; LIFE STYLE; LINEAR MODELS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; PROTECTIVE FACTORS; QUALITY OF LIFE; RECURRENCE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SUNLIGHT; VITAMIN D; VITAMINS;

EID: 84939431402     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/s12883-015-0394-1     Document Type: Article

References (26)

1. Ascherio A. Environmental factors in multiple sclerosis. Expert Rev Neurother. 2013;13(12 Suppl):3-9. doi: 10.1586/14737175.2013.865866 .
2. Ascherio A, Munger K. Epidemiology of multiple sclerosis: from risk factors to prevention. Semin Neurol. 2008;28(1):17-28. doi: 10.1055/s-2007-1019126 .
3. Poser CM. The multiple sclerosis trait and the development of multiple sclerosis: Genetic vulnerability and environmental effect. Clin Neurol Neurosurg. 2006.
4. Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011;476(7359):214-9. doi: 10.1038/nature10251 .
5. Simpson Jr S, Blizzard L, Otahal P, Van der Mei I, Taylor B. Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis. J Neurol Neurosurg Psychiatry. 2011;82(10):1132-41. doi: 10.1136/jnnp.2011.240432 .
6. Acheson ED, Bachrach CA, Wright FM. Some comments on the relationship of the distribution of multiple sclerosis to latitude, solar radiation, and other variables. Acta Psychiatr Scand Suppl. 1960;35(147):132-47.
7. Salzer J, Bistrom M, Sundstrom P. Vitamin D and multiple sclerosis: where do we go from here? Expert Rev Neurother. 2014;14(1):9-18. doi: 10.1586/14737175.2014.864952 .
8. Pierrot-Deseilligny C, Rivaud-Pechoux S, Clerson P, de Paz R, Souberbielle JC. Relationship between 25-OH-D serum level and relapse rate in multiple sclerosis patients before and after vitamin D supplementation. Ther Adv Neurol Disord. 2012;5(4):187-98. doi: 10.1177/1756285612447090 .
9. Hutchinson M. If I, had CIS with MRI diagnostic of MS, I would take vitamin D 10,000IU daily: Commentary. Mult Scler. 2013;19(2):143-4. doi: 10.1177/1352458513475916 .
10. Pierrot-Deseilligny C, Souberbielle JC. Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis. Ther Adv Neurol Disord. 2013;6(2):81-116. doi: 10.1177/1756285612473513 .
11. Hadgkiss EJ, Jelinek GA, Weiland TJ, Pereira NG, Marck CH, van der Meer DM. Methodology of an international study of people with multiple sclerosis recruited through web 2.0 platforms: demographics, lifestyle, and disease characteristics. Neurol Res Int. 2013;2013:580596.
12. Hohol MJ, Orav EJ, Weiner HL. Disease steps in multiple sclerosis: a simple approach to evaluate disease progression. Neurology. 1995;45(2):251-5.
13. Vickrey BG, Hays RD, Harooni R, Myers LW, Ellison GW. A health-related quality of life measure for multiple sclerosis. Qual Life Res. 1995;4(3):187-206.
14. Kappos L, Gold R, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, et al. Quality of life outcomes with BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: the DEFINE study. Mult Scler. 2014;20(2):243-52. doi: 10.1177/1352458513507817 .
15. Norman GR, Sloan JA, Wyrwich KW. Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care. 2003;41(5):582-92. doi: 10.1097/01.MLR.0000062554.74615.4C .
16. McLeod JG, Hammond SR, Hallpike JF. Epidemiology of multiple sclerosis in Australia. With NSW and SA survey results. Med J Aust. 1994;160(3):117-22.
17. van der Mei IA, Ponsonby AL, Dwyer T, Blizzard L, Simmons R, Taylor BV, et al. Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. BMJ. 2003;327(7410):316.
18. Spelman T, Gray O, Trojano M. Seasonal variation of relapse rate in multiple sclerosis is latitude dependent. Anal Neurol. 2014 Oct. doi: 10.1002/ana.24287 [Epub ahead of print].
19. Jin Y, de Pedro-Cuesta J, Soderstrom M, Stawiarz L, Link H. Seasonal patterns in optic neuritis and multiple sclerosis: a meta-analysis. J Neurol Sci. 2000;181(1-2):56-64.
20. Derakhshandi H, Etemadifar M, Feizi A, Abtahi SH, Minagar A, Abtahi MA, et al. Preventive effect of vitamin D3 supplementation on conversion of optic neuritis to clinically definite multiple sclerosis: a double blind, randomized, placebo-controlled pilot clinical trial. Acta Neurol Belg. 2013;113(3):257-63. doi: 10.1007/s13760-012-0166-2 .
21. Soilu-Hanninen M, Aivo J, Lindstrom BM, Elovaara I, Sumelahti ML, Farkkila M, et al. A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon beta-1b in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2012;83(5):565-71. doi: 10.1136/jnnp-2011-301876 .
22. Hart PH, Gorman S. Exposure to UV Wavelengths in Sunlight Suppresses Immunity. To What Extent is UV-induced Vitamin D3 the Mediator Responsible? Clin Biochem Rev. 2013;34(1):3-13.
23. Lucas RM, Ponsonby AL, Dear K, Valery PC, Pender MP, Taylor BV, et al. Sun exposure and vitamin D are independent risk factors for CNS demyelination. Neurology. 2011;76(6):540-8. doi: 10.1212/WNL.0b013e31820af93d .
24. Hoffmann MR, Senior PA, Mager DR. Vitamin D Supplementation and Health-Related Quality of Life: A Systematic Review of the Literature. J Acad Nutr Diet. 2015. doi: 10.1016/j.jand.2014.10.023.
25. Jelinek GA, Hadgkiss EJ, Weiland TJ, Pereira NG, Marck CH, van der Meer DM. Association of fish consumption and Omega 3 supplementation with quality of life, disability and disease activity in an international cohort of people with multiple sclerosis. Int J Neurosci. 2013;123(11):792-800. doi: 10.3109/00207454.2013.803104 .
26. Marck CH, Hadgkiss E, Weiland TJ, van der Meer DM, Pereira N, Jelinek GA. Physical activity and associated levels of disability and quality of life in people with multiple sclerosis: a large international survey. BMC neurology. 2014; in press.