메뉴 건너뛰기




Volumn 75, Issue 11, 2015, Pages 2349-2362

Vimentin-ERK signaling uncouples slug gene regulatory function

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR SLUG; VIMENTIN; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 1; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

EID: 84939423713     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-2842     Document Type: Article
Times cited : (104)

References (39)
  • 1
    • 84866327767 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition by transforming growth factor beta
    • Moustakas A, Heldin CH. Induction of epithelial-mesenchymal transition by transforming growth factor beta. Semin Cancer Biol 2012; 22: 446-54.
    • (2012) Semin Cancer Biol , vol.22 , pp. 446-454
    • Moustakas, A.1    Heldin, C.H.2
  • 2
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 2013; 13: 97-110.
    • (2013) Nat Rev Cancer , vol.13 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 5
    • 84901787644 scopus 로고    scopus 로고
    • Oncogenic roles of EMT-inducing transcription factors
    • Puisieux A, Brabletz T, Caramel J. Oncogenic roles of EMT-inducing transcription factors. Nat Cell Biol 2014; 16: 488-94.
    • (2014) Nat Cell Biol , vol.16 , pp. 488-494
    • Puisieux, A.1    Brabletz, T.2    Caramel, J.3
  • 6
    • 79952654970 scopus 로고    scopus 로고
    • Molecular stratification of triple-negative breast cancers
    • Perou CM Molecular stratification of triple-negative breast cancers. Oncologist 2010; 15(SUPPL. 5): 39-48.
    • (2010) Oncologist , vol.15 , pp. 39-48
    • Perou, C.M.1
  • 7
    • 84862526929 scopus 로고    scopus 로고
    • The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    • Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 2012; 486: 395-9.
    • (2012) Nature , vol.486 , pp. 395-399
    • Shah, S.P.1    Roth, A.2    Goya, R.3    Oloumi, A.4    Ha, G.5    Zhao, Y.6
  • 8
    • 80052267874 scopus 로고    scopus 로고
    • Vimentin in cancer and Its potential as a molecular target for cancer therapy
    • Satelli A, Li S. Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell Mol Life Sci 2011; 68: 3033-46.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 3033-3046
    • Satelli, A.1    Li, S.2
  • 10
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-15.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 12
    • 77953484480 scopus 로고    scopus 로고
    • Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition
    • Mendez MG, Kojima S, Goldman RD. Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J 2010; 24: 1838-51.
    • (2010) FASEB J , vol.24 , pp. 1838-1851
    • Mendez, M.G.1    Kojima, S.2    Goldman, R.D.3
  • 13
    • 79953060389 scopus 로고    scopus 로고
    • Vimentin regulates EMT induction by slug and oncogenic H-ras and migration by governing axl expression in breast cancer
    • Vuoriluoto K, Haugen H, Kiviluoto S, Mpindi JP, Nevo J, Gjerdrum C, et al. Vimentin regulates EMT induction by slug and oncogenic H-ras and migration by governing axl expression in breast cancer. Oncogene 2011; 30: 1436-48.
    • (2011) Oncogene , vol.30 , pp. 1436-1448
    • Vuoriluoto, K.1    Haugen, H.2    Kiviluoto, S.3    Mpindi, J.P.4    Nevo, J.5    Gjerdrum, C.6
  • 14
    • 84878615544 scopus 로고    scopus 로고
    • The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis
    • Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, et al. The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol 2013; 15: 677-87.
    • (2013) Nat Cell Biol , vol.15 , pp. 677-687
    • Zhang, K.1    Corsa, C.A.2    Ponik, S.M.3    Prior, J.L.4    Piwnica-Worms, D.5    Eliceiri, K.W.6
  • 15
    • 77950353276 scopus 로고    scopus 로고
    • ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events
    • Shin S, Dimitri CA, Yoon SO, Dowdle W, Blenis J. ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell 2010; 38: 114-27.
    • (2010) Mol Cell , vol.38 , pp. 114-127
    • Shin, S.1    Dimitri, C.A.2    Yoon, S.O.3    Dowdle, W.4    Blenis, J.5
  • 16
    • 84879856767 scopus 로고    scopus 로고
    • ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines
    • Radtke S, Milanovic M, Rosse C, DeRycker M, Lachmann S, Hibbert A, et al. ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines. J Cell Sci 2013; 126: 2381-91.
    • (2013) J Cell Sci , vol.126 , pp. 2381-2391
    • Radtke, S.1    Milanovic, M.2    Rosse, C.3    DeRycker, M.4    Lachmann, S.5    Hibbert, A.6
  • 17
    • 84861206864 scopus 로고    scopus 로고
    • ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-beta2
    • von Thun A, Birtwistle M, Kalna G, Grindlay J, Strachan D, Kolch W, et al. ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-beta2. J Cell Sci 2012; 125: 1465-77.
    • (2012) J Cell Sci , vol.125 , pp. 1465-1477
    • Von Thun, A.1    Birtwistle, M.2    Kalna, G.3    Grindlay, J.4    Strachan, D.5    Kolch, W.6
  • 18
    • 84857223882 scopus 로고    scopus 로고
    • Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1
    • Botta GP, Reginato MJ, Reichert M, Rustgi AK, Lelkes PI. Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1. Mol Cancer Res 2012; 10: 183-96.
    • (2012) Mol Cancer Res , vol.10 , pp. 183-196
    • Botta, G.P.1    Reginato, M.J.2    Reichert, M.3    Rustgi, A.K.4    Lelkes, P.I.5
  • 19
    • 34249682108 scopus 로고    scopus 로고
    • Novel functions of vimentin in cell adhesion, migration, and signaling
    • Ivaska J, Pallari HM, Nevo J, Eriksson JE. Novel functions of vimentin in cell adhesion, migration, and signaling. Exp Cell Res 2007; 313: 2050-62.
    • (2007) Exp Cell Res , vol.313 , pp. 2050-2062
    • Ivaska, J.1    Pallari, H.M.2    Nevo, J.3    Eriksson, J.E.4
  • 20
    • 33751116969 scopus 로고    scopus 로고
    • Vimentin binding to phosphorylated ERK sterically hinders enzymatic dephosphorylation of the kinase
    • Perlson E, Michaelevski I, Kowalsman N, Ben-Yaakov K, Shaked M, Seger R, et al. Vimentin binding to phosphorylated ERK sterically hinders enzymatic dephosphorylation of the kinase. J Mol Biol 2006; 364: 938-44.
    • (2006) J Mol Biol , vol.364 , pp. 938-944
    • Perlson, E.1    Michaelevski, I.2    Kowalsman, N.3    Ben-Yaakov, K.4    Shaked, M.5    Seger, R.6
  • 21
    • 84866325625 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity
    • Nieto MA, Cano A. The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity. Semin Cancer Biol 2012; 22: 361-8.
    • (2012) Semin Cancer Biol , vol.22 , pp. 361-368
    • Nieto, M.A.1    Cano, A.2
  • 22
    • 84855358964 scopus 로고    scopus 로고
    • Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation
    • Zhang K, Rodriguez-Aznar E, Yabuta N, Owen RJ, Mingot JM, Nojima H, et al. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J 2012; 31: 29-43.
    • (2012) EMBO J , vol.31 , pp. 29-43
    • Zhang, K.1    Rodriguez-Aznar, E.2    Yabuta, N.3    Owen, R.J.4    Mingot, J.M.5    Nojima, H.6
  • 23
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, et al. Dual regulation of snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 2004; 6: 931-40.
    • (2004) Nat Cell Biol , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6
  • 24
    • 84860465552 scopus 로고    scopus 로고
    • Characterization of the SNAG and SLUG domains of Snail2 in the repression of E-cadherin and EMT induction: Modulation by serine 4 phosphorylation
    • Molina-Ortiz P, Villarejo A, MacPherson M, Santos V, Montes A, Souchelnytskyi S, et al. Characterization of the SNAG and SLUG domains of Snail2 in the repression of E-cadherin and EMT induction: modulation by serine 4 phosphorylation. PLoS One 2012; 7: e36132.
    • (2012) PLoS One , vol.7
    • Molina-Ortiz, P.1    Villarejo, A.2    MacPherson, M.3    Santos, V.4    Montes, A.5    Souchelnytskyi, S.6
  • 25
    • 84867371728 scopus 로고    scopus 로고
    • Canonical wnt signaling regulates slug activity and links epithelial-mesenchymal transition with epigenetic breast cancer 1, early onset (BRCA1) repression
    • Wu ZQ, Li XY, Hu CY, Ford M, Kleer CG, Weiss SJ. Canonical wnt signaling regulates slug activity and links epithelial-mesenchymal transition with epigenetic breast cancer 1, early onset (BRCA1) repression. Proc Natl Acad Sci U S A 2012; 109: 16654-9.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 16654-16659
    • Wu, Z.Q.1    Li, X.Y.2    Hu, C.Y.3    Ford, M.4    Kleer, C.G.5    Weiss, S.J.6
  • 26
    • 84902528711 scopus 로고    scopus 로고
    • GSK3beta controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of slug
    • Kao SH, Wang WL, Chen CY, Chang YL, Wu YY, Wang YT, et al. GSK3beta controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of slug. Oncogene 2014; 33: 3172-82.
    • (2014) Oncogene , vol.33 , pp. 3172-3182
    • Kao, S.H.1    Wang, W.L.2    Chen, C.Y.3    Chang, Y.L.4    Wu, Y.Y.5    Wang, Y.T.6
  • 27
    • 84864408466 scopus 로고    scopus 로고
    • Functional regulation of slug/Snail2 is dependent on GSK-3beta-mediated phosphorylation
    • Kim JY, Kim YM, Yang CH, Cho SK, Lee JW, Cho M. Functional regulation of slug/Snail2 is dependent on GSK-3beta-mediated phosphorylation. FEBS J 2012; 279: 2929-39.
    • (2012) FEBS J , vol.279 , pp. 2929-2939
    • Kim, J.Y.1    Kim, Y.M.2    Yang, C.H.3    Cho, S.K.4    Lee, J.W.5    Cho, M.6
  • 28
    • 73649124286 scopus 로고    scopus 로고
    • Extracellular signalregulated kinase signaling pathway regulates breast cancer cell migration by maintaining slug expression
    • Chen H, Zhu G, Li Y, Padia RN, Dong Z, Pan ZK, et al. Extracellular signalregulated kinase signaling pathway regulates breast cancer cell migration by maintaining slug expression. Cancer Res 2009; 69: 9228-35.
    • (2009) Cancer Res , vol.69 , pp. 9228-9235
    • Chen, H.1    Zhu, G.2    Li, Y.3    Padia, R.N.4    Dong, Z.5    Pan, Z.K.6
  • 29
    • 79960423794 scopus 로고    scopus 로고
    • Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas
    • Geradts J, de Herreros AG, Su Z, Burchette J, Broadwater G, Bachelder RE. Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas. Hum Pathol 2011; 42: 1125-31.
    • (2011) Hum Pathol , vol.42 , pp. 1125-1131
    • Geradts, J.1    De Herreros, A.G.2    Su, Z.3    Burchette, J.4    Broadwater, G.5    Bachelder, R.E.6
  • 30
    • 84874668049 scopus 로고    scopus 로고
    • Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: Association with anaggressive tumour phenotype
    • Karihtala P, Auvinen P, Kauppila S, Haapasaari KM, Jukkola-Vuorinen A, Soini Y. Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with anaggressive tumour phenotype. Breast Cancer Res Treat 2013; 138: 81-90.
    • (2013) Breast Cancer Res Treat , vol.138 , pp. 81-90
    • Karihtala, P.1    Auvinen, P.2    Kauppila, S.3    Haapasaari, K.M.4    Jukkola-Vuorinen, A.5    Soini, Y.6
  • 31
    • 84862857118 scopus 로고    scopus 로고
    • High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients
    • Bartholomeusz C, Gonzalez-Angulo AM, Liu P, Hayashi N, Lluch A, Ferrer-Lozano J, et al. High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients. Oncologist 2012; 17: 766-74.
    • (2012) Oncologist , vol.17 , pp. 766-774
    • Bartholomeusz, C.1    Gonzalez-Angulo, A.M.2    Liu, P.3    Hayashi, N.4    Lluch, A.5    Ferrer-Lozano, J.6
  • 32
    • 41549160315 scopus 로고    scopus 로고
    • Phosphatase-mediated crosstalk betweenMAPK signaling pathways inthe regulation of cell survival
    • Junttila MR, Li SP, Westermarck J. Phosphatase-mediated crosstalk betweenMAPK signaling pathways inthe regulation of cell survival. FASEB J 2008; 22: 954-65.
    • (2008) FASEB J , vol.22 , pp. 954-965
    • Junttila, M.R.1    Li, S.P.2    Westermarck, J.3
  • 33
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003; 3: 11-22.
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 34
    • 79952975186 scopus 로고    scopus 로고
    • New druggable targets in the ras pathway?
    • Matallanas D, Crespo P. New druggable targets in the ras pathway? Curr Opin Mol Ther 2010; 12: 674-83.
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 674-683
    • Matallanas, D.1    Crespo, P.2
  • 35
    • 79952093753 scopus 로고    scopus 로고
    • Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization
    • Slorach EM, Chou J, Werb Z. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes Dev 2011; 25: 471-84.
    • (2011) Genes Dev , vol.25 , pp. 471-484
    • Slorach, E.M.1    Chou, J.2    Werb, Z.3
  • 36
    • 0038450250 scopus 로고    scopus 로고
    • Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor
    • Dominguez D, Montserrat-Sentis B, Virgos-Soler A, Guaita S, Grueso J, Porta M, et al. Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor. Mol Cell Biol 2003; 23: 5078-89.
    • (2003) Mol Cell Biol , vol.23 , pp. 5078-5089
    • Dominguez, D.1    Montserrat-Sentis, B.2    Virgos-Soler, A.3    Guaita, S.4    Grueso, J.5    Porta, M.6
  • 37
    • 75649122615 scopus 로고    scopus 로고
    • Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail 1 function: Potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A
    • MacPherson MR, Molina P, Souchelnytskyi S, Wernstedt C, Martin-Perez J, Portillo F, et al. Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail 1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. Mol Biol Cell 2010; 21: 244-53.
    • (2010) Mol Biol Cell , vol.21 , pp. 244-253
    • MacPherson, M.R.1    Molina, P.2    Souchelnytskyi, S.3    Wernstedt, C.4    Martin-Perez, J.5    Portillo, F.6
  • 38
    • 27844444696 scopus 로고    scopus 로고
    • PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility
    • Ivaska J, Vuoriluoto K, Huovinen T, Izawa I, Inagaki M, Parker PJ. PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J 2005; 24: 3834-45.
    • (2005) EMBO J , vol.24 , pp. 3834-3845
    • Ivaska, J.1    Vuoriluoto, K.2    Huovinen, T.3    Izawa, I.4    Inagaki, M.5    Parker, P.J.6
  • 39
    • 84871998076 scopus 로고    scopus 로고
    • An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies axl as a therapeutic target for overcoming EGFR inhibitor resistance
    • Byers LA, Diao L, Wang J, Saintigny P, Girard L, Peyton M, et al. An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res 2013; 19: 279-90.
    • (2013) Clin Cancer Res , vol.19 , pp. 279-290
    • Byers, L.A.1    Diao, L.2    Wang, J.3    Saintigny, P.4    Girard, L.5    Peyton, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.