Discovery of Tyk2 inhibitors via the virtual site-directed fragment-based drug design

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 18, 2015, Pages 3947-3952

  Jang, Woo Dae ^a   Kim, Jun Tae ^a   Son, Hoon Young ^b   Park, Seung Yeon ^c   Cho, Young Sik ^c   Koo, Tae Sung ^a   Lee, Hyuk ^b   Kang, Nam Sook ^a  

^a Chungnam National University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Keimyung University   (South Korea)

Author keywords

FBDD; Inhibitor; STATs activation; Tyk2; Water ring analysis

Indexed keywords

5 BROMO 3 NITRO 4 (4 (PYRIDIN 3 YLMETHYL)PIPERAZIN 1 YL)PYRIDIN 2 AMINE; ALPHA INTERFERON; BETA INTERFERON; CELL SURFACE RECEPTOR; INTERFERON ALPHA5; JANUS KINASE 1; PROTEIN KINASE INHIBITOR; PROTEIN KINASE TYK2; PROTEIN KINASE TYK2 INHIBITOR; STAT3 PROTEIN; TOFACITINIB; UNCLASSIFIED DRUG; TYK2 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; DOSE RESPONSE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MOLECULAR CONFORMATION; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TYK2 KINASE;

EID: 84939265473     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.07.037     Document Type: Article

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