Free-Base and Protonated Nicotine in Electronic Cigarette Liquids and Aerosols

Chemical Research in Toxicology

Volumn 28, Issue 8, 2015, Pages 1532-1537

  El Hellani, Ahmad ^a,b   El Hage, Rachel ^a,b   Baalbaki, Rima ^a,b   Salman, Rola ^a,b   Talih, Soha ^a,b   Shihadeh, Alan ^a,b   Saliba, Najat A ^a,b  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; NICOTINE; AEROSOL; PROTON; SOLVENT;

AEROSOL; ARTICLE; CONCENTRATION (PARAMETERS); ELECTRONIC CIGARETTE; GAS CHROMATOGRAPHY; LIQUID; PH; PROTON TRANSPORT; SOLVENT EXTRACTION; CHEMICAL ANALYSIS; CHEMISTRY;

NICOTIANA TABACUM;

AEROSOLS; CHEMISTRY TECHNIQUES, ANALYTICAL; ELECTRONIC CIGARETTES; HYDROGEN-ION CONCENTRATION; NICOTINE; PROTONS; SOLVENTS;

EID: 84939237430     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.5b00107     Document Type: Article

References (30)

1. Ayers, J. W., Ribisl, K. M., and Brownstein, J. S. (2011) Tracking the Rise in Popularity of Electronic Nicotine Delivery Systems (Electronic Cigarettes) Using Search Query Surveillance Am. J. Prev. Med. 40, 448-453 10.1016/j.amepre.2010.12.007
2. Adkison, S. E., O'Connor, R. J., Bansal-Travers, M., Hyland, A., Borland, R., Yong, H.-H., Cummings, K. M., McNeill, A., Thrasher, J. F., Hammond, D., and Fong, G. T. (2013) Electronic Nicotine Delivery Systems Am. J. Prev. Med. 44, 207-215 10.1016/j.amepre.2012.10.018
3. Cahn, Z. and Siegel, M. (2011) Electronic cigarettes as a harm reduction strategy for tobacco control: A step forward or a repeat of past mistakes? J. Public Health Policy 32, 16-31 10.1057/jphp.2010.41
4. Grana, R. A. and Ling, P. M. (2014) Smoking Revolution Am. J. Prev. Med. 46, 395-403 10.1016/j.amepre.2013.12.010
5. Farsalinos, K., Romagna, G., Tsiapras, D., Kyrzopoulos, S., Spyrou, A., and Voudris, V. (2013) Impact of Flavour Variability on Electronic Cigarette Use Experience: An Internet Survey Int. J. Environ. Res. Public Health 10, 7272-7282 10.3390/ijerph10127272
6. Williams, M., Villarreal, A., Bozhilov, K., Lin, S., and Talbot, P. (2013) Metal and Silicate Particles Including Nanoparticles Are Present in Electronic Cigarette Cartomizer Fluid and Aerosol PLoS One 8, e57987 10.1371/journal.pone.0057987
7. Perfetti, T. A. (1983) Structural Study of Nicotine Salts Beitr. Tabakforsch. Int. 12, 43-56 10.2478/cttr-2013-0524
8. Lee, J.-M., Jang, G.-C., Lee, J.-T., Park, J.-W., Kim, D.-Y., Kim, H.-K., Hwang, K.-J., and Min, Y.-K. (2006) Changes in Unprotonated Nicotine Concentration in Cigarette Mainstream Smoke with Three Machine-Smoking Conditions J. Kor. Soc. Tob. Sci. 28, 136-143
9. Graton, J., Berthelot, M., Gal, J.-F., Girard, S., Laurence, C., Lebreton, J., Le Questel, J.-Y., Maria, P.-C., and Nauš, P. (2002) Site of Protonation of Nicotine and Nornicotine in the Gas Phase: Pyridine or Pyrrolidine Nitrogen? J. Am. Chem. Soc. 124, 10552-10562 10.1021/ja017770a
10. Reininghaus, W. (1994) Bioavailability of Nicotine, Philip Morris Research Center USA, Richmond, VA.
11. Goniewicz, M. L., Hajek, P., and McRobbie, H. (2014) Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: regulatory implications Addiction 109, 500-507 10.1111/add.12410
12. Trehy, M. L., Ye, W., Hadwiger, M. E., Moore, T. W., Allgire, J. F., Woodruff, J. T., Ahadi, S. S., Black, J. C., and Westenberger, B. J. (2011) Analysis of Electronic Cigarette Cartridges, Refill Solutions, and Smoke for Nicotine and Nicotine Related Impurities J. Liq. Chromatogr. Relat. Technol. 34, 1442-1458 10.1080/10826076.2011.572213
13. Etter, J.-F., Zäther, E., and Svensson, S. (2013) Analysis of refill liquids for electronic cigarettes Addiction 108, 1671-1679 10.1111/add.12235
14. Cheah, N. P., Chong, N. W. L., Tan, J., Morsed, F. A., and Yee, S. K. (2014) Electronic nicotine delivery systems: regulatory and safety challenges: Singapore perspective Tobacco Control 23, 119-125 10.1136/tobaccocontrol-2012-050483
15. Hutzler, C., Paschke, M., Kruschinski, S., Henkler, F., Hahn, J., and Luch, A. (2014) Chemical hazards present in liquids and vapors of electronic cigarettes Arch. Toxicol. 88, 1295-1308 10.1007/s00204-014-1294-7
16. Caldwell, B., Sumner, W., and Crane, J. (2012) A Systematic Review of Nicotine by Inhalation: Is There a Role for the Inhaled Route? Nicotine Tob. Res. 14, 1127-1139 10.1093/ntr/nts009
17. Lisko, J. G., Tran, H., Stanfill, S. B., Blount, B. C., and Watson, C. H. (2015) Chemical composition and evaluation of nicotine, tobacco alkaloids, pH, and selected flavors in E-cigarette cartridges and refill solutions. Nicotine Tob. Res., in press. DOI: 10.1093/ntr/ntu279.
18. Pankow, J. F. (2001) A Consideration of the Role of Gas/Particle Partitioning in the Deposition of Nicotine and Other Tobacco Smoke Compounds in the Respiratory Tract Chem. Res. Toxicol. 14, 1465-1481 10.1021/tx0100901
19. Marche, C., Ferronato, C., De Hemptinne, J.-C., and Jose, J. (2006) Apparatus for the Determination of Water Solubility in Hydrocarbon: Toluene and Alkylcyclohexanes (C6 to C8) from 30 to 180 °C J. Chem. Eng. Data 51, 355-359 10.1021/je0502041
20. García, M. A., Lucas, A. d., Valverde, J. L., and Rodríguez, J. F. (2000) Liquid-Liquid Equilibria of Nicotine + Water + Toluene at Various Temperatures J. Chem. Eng. Data 45, 540-543 10.1021/je990257g
21. How Do I Choose an E-liquid Strength?, http://www.vapertrain.com/page/hdics (accessed on May 21, 2015).
22. Jha, A. How Do I Choose Nicotine Level/Strength?, http://www.180smoke.com/blogs/e-cigarette-faq/9244123-how-do-i-choose-nicotine-level-strength# (accessed on May 21, 2015).
23. An Explanation of Nicotine Measurements, http://www.whitecloudelectroniccigarettes.com/blog/nicotine-measurements/ (accessed on May21, 2015).
24. Leo, A., Hansch, C., and Elkins, D. (1971) Partition coefficients and their uses Chem. Rev. 71, 525-616 10.1021/cr60274a001
25. Shihadeh, A. and Azar, S. (2006) A Closed-Loop Control "Playback" Smoking Machine for Generating Mainstream Smoke Aerosols J. Aerosol Med. 19, 137-147 10.1089/jam.2006.19.137
26. Talih, S., Balhas, Z., Eissenberg, T., Salman, R., Karaoghlanian, N., El Hellani, A., Baalbaki, R., Saliba, N., and Shihadeh, A. (2015) Effects of User Puff Topography, Device Voltage, and Liquid Nicotine Concentration on Electronic Cigarette Nicotine Yield: Measurements and Model Predictions Nicotine Tob. Res. 17, 150-157 10.1093/ntr/ntu174
27. Hua, M., Yip, H., and Talbot, P. (2013) Mining data on usage of electronic nicotine delivery systems (ENDS) from YouTube videos Tobacco Control 22, 103-106 10.1136/tobaccocontrol-2011-050226
28. Farsalinos, K., Romagna, G., Tsiapras, D., Kyrzopoulos, S., and Voudris, V. (2013) Evaluation of Electronic Cigarette Use (Vaping) Topography and Estimation of Liquid Consumption: Implications for Research Protocol Standards Definition and for Public Health Authorities' Regulation Int. J. Environ. Res. Public Health 10, 2500-2514 10.3390/ijerph10062500
29. Spindle, T. R., Breland, A. B., Karaoghlanian, N. V., Shihadeh, A. L., and Eissenberg, T. (2015) Preliminary Results of an Examination of Electronic Cigarette User Puff Topography: The Effect of a Mouthpiece-Based Topography Measurement Device on Plasma Nicotine and Subjective Effects Nicotine Tob. Res. 17, 142-149 10.1093/ntr/ntu186
30. Stepanov, I. and Fujioka, N. (2015) Bringing attention to e-cigarette pH as an important element for research and regulation. Tobacco Control, in press. DOI: 24, 413 10.1136/tobaccocontrol-2014-051540.