Effects of aerosolized adenosine 5'-triphosphate in smokers and patients with COPD

Chest

Volumn 148, Issue 2, 2015, Pages 430-435

  Basoglu, Ozen K ^a   Barnes, Peter J ^b   Kharitonov, Sergei A ^b   Pelleg, Amir ^c  

^a EGE UNIVERSITY   (Turkey)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE;

ADULT; ARTICLE; BORG SCALE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; COUGHING; DYSPNEA; EXHALED BREATH CONDENSATE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; MALE; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE ASSESSMENT; RESPIRATORY TRACT PARAMETERS; SMOKING; THROAT IRRITATION; BREATH ANALYSIS; BRONCHOCONSTRICTION; BRONCHUS; CASE CONTROL STUDY; CHEMICALLY INDUCED; DRUG EFFECTS; INHALATIONAL DRUG ADMINISTRATION; MIDDLE AGED; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX;

ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADMINISTRATION, INHALATION; ADULT; BREATH TESTS; BRONCHI; BRONCHOCONSTRICTION; CASE-CONTROL STUDIES; COUGH; DYSPNEA; FEMALE; HUMANS; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SEVERITY OF ILLNESS INDEX; SMOKING;

EID: 84939223351     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.14-2285     Document Type: Article

References (26)

1. Lazarowski ER, Boucher RC, Harden TK. Mechanisms of release of nucleotides and integration of their action as P2X-and P2Y-receptor activating molecules. Mol Pharmacol. 2003; 64 (4): 785-795.
2. Burnstock G. Purine and pyrimidine receptors. Cell Mol Life Sci. 2007; 64 (12): 1471-1483.
3. Burnstock G, Brouns I, Adriaensen D, Timmermans JP. Purinergic signaling in the airways. Pharmacol Rev. 2012; 64 (4): 834-868.
4. Zimmermann H. Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch Pharmacol. 2000; 362 (4-5): 299-309.
5. Pellegrino R, Wilson O, Jenouri G, Rodarte JR. Lung mechanics during induced bronchoconstriction. J Appl Physiol (1985). 1996; 81 (2): 964-975.
6. Basoglu OK, Pelleg A, Essilfie-Quaye S, Brindicci C, Barnes PJ, Kharitonov SA. Effects of aerosolized adenosine 5 9-triphosphate vs adenosine 5 9-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma. Chest. 2005; 128 (4): 1905-1909.
7. Cushley MJ, Tattersfield AE, Holgate ST. Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol. 1983; 15 (2): 161-165.
8. Cushley MJ, Holgate ST. Adenosineinduced bronchoconstriction in asthma: role of mast cell-mediator release. J Allergy Clin Immunol. 1985; 75 (2): 272-278.
9. Pelleg A, Hurt CM. Mechanism of action of ATP on canine pulmonary vagal C fibre nerve terminals. J Physiol. 1996; 490 (pt 1): 265-275.
10. Pelleg A, Undem BJ. A-317491 inhibits the activation of guinea-pig pulmonary vagal sensory nerve terminals by a, b-methylene-ATP. C lin Immunol. 2005; 115 (suppl 1): S59-S60.
11. Widdicombe JG. Neurophysiology of the cough reflex. E ur Respir J. 1995; 8 (7): 1193-1202.
12. Widdicombe J. Sensory mechanisms. Pulm Pharmacol. 1996; 9 (5-6): 383-387.
13. Mann JS, Holgate ST, Renwick AG, Cushley MJ. Airway effects of purine nucleosides and nucleotides and release with bronchial provocation in asthma. J Appl Physiol (1985). 1986; 61 (5): 1667-1676.
14. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS; GOLD Scientific Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med. 2001; 163 (5): 1256-1276.
15. Rutgers SR, ten Hacken NH, Koeter GH, Postma DS. Borg scores before and after challenge with adenosine 5 9-monophosphate and methacholine in subjects with COPD and asthma. Eur Respir J. 2000; 16 (3): 486-490.
16. Burdon JG, Juniper EF, Killian KJ, Hargreave FE, Campbell EJ. The perception of breathlessness in asthma. Am Rev Respir Dis. 1982; 126 (5): 825-828.
17. Pelleg A, Schulman ES. Adenosine 5 9-triphosphate axis in obstructive airway diseases. Am J Ther. 2002; 9 (5): 454-464.
18. Adriaensen D, Timmermans JP. Purinergic signalling in the lung: important in asthma and COPD? Curr Opin Pharmacol. 2004; 4 (3): 207-214.
19. Idzko M, Hammad H, van Nimwegen M, et al. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med. 2007; 13 (8): 913-919.
20. Jacob F, Pérez Novo C, Bachert C, Van Crombruggen K. Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses. Purinergic Signal. 2013; 9 (3): 285-306.
21. Sprague RS, Ellsworth ML, Stephenson AH, Kleinhenz ME, Lonigro AJ. Deformation-induced ATP release from red blood cells requires CFTR activity. Am J Physiol. 1998; 275 (5 pt 2): H1726-H1732.
22. Ellsworth ML, Forrester T, Ellis CG, Dietrich HH. The erythrocyte as a regulator of vascular tone. Am J Physiol. 1995; 269 (6 pt 2): H2155-H2161.
23. Abdulqawi R, Dockry R, Holt K, et al. Inhibition of ATP-gated P2X3 channels by AF-219: an effective anti-tussive mechanism in chronic cough. Eur Respir J. 2013; 42 (suppl 57): 386s.
24. Oguma T, Ito S, Kondo M, et al. Roles of P2X receptors and Ca 2 1 sensitization in extracellular adenosine triphosphateinduced hyperresponsiveness in airway smooth muscle. Clin Exp Allergy. 2007; 37 (6): 893-900.
25. Xu J, Kussmaul W, Kurnik PB, Al-Ahdav M, Pelleg A. Electrophysiologicalanatomic correlates of ATP-triggered vagal reflex in the dog. V. Role of purinergic receptors. Am J Physiol Regul Integr Comp Physiol. 2005; 288 (3): R651-R655.
26. Katchanov G, Xu J, Schulman ES, Pelleg A. ATP causes neurogenic bronchoconstriction in the dog. Drug Dev Res. 1998; 45 (3-4): 342-349.