The HIV care continuum: Changes over time in retention in care and viral suppression

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Yehia, Baligh R ^a,b,c   Stephens Shields, Alisa J ^c   Fleishman, John A ^d   Berry, Stephen A ^e   Agwu, Allison L ^e,o   Metlay, Joshua P ^f   Moore, Richard D ^e,o   Mathews, W Christopher ^g,w   Nijhawan, Ank ^h   Rutstein, Richard ⁱ   Gaur, Aditya H ^j,t   Gebo, Kelly A ^e,o   Edelstein, Howard ^k   Corales, Roberto ^l   Jacobson, Jeffrey ^m   Allen, Sara ^m   Boswell, Stephen ⁿ   Beil, Robert ^p   Chu, Carolyn ^p   Hanau, Lawrence ^q   Korthuis, P Todd ^r   Akbar, Muhammad ^s   Armas Kolostroubis, Laura ^s   Sharp, Victoria ^u   Arpadi, Stephen ^u   Somboonwit, Charurut ^v   Cohn, Jonathan ^x   Hellinger, Fred ^d   Fraser, Irene ^d   Mills, Robert ^y   Malitz, Faye ^y   Keruly, Jeanne ^o   Voss, Cindy ^o   Balding, Nikki ^o   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d AGENCY FOR HEALTHCARE RESEARCH AND QUALITY   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^h UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

ⁱ CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^j ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^k ALAMEDA COUNTY MEDICAL CENTER   (United States)

^l Children's Hospital of Philadelphia ^*  (United States)

^m DREXEL UNIVERSITY   (United States)

ⁿ FENWAY INSTITUTE   (United States)

^o JOHNS HOPKINS UNIVERSITY   (United States)

^p Montefiore Medical Group Bronx East   (United States)

^q MONTEFIORE MEDICAL CENTER   (United States)

^r OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^s PARKLAND HEALTH AND HOSPITAL SYSTEM   (United States)

^t UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^u ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^v Tampa General Healthcare   (United States)

^w UNIVERSITY OF CALIFORNIA   (United States)

^x WAYNE STATE UNIVERSITY   (United States)

^y HEALTH RESOURCES AND SERVICES ADMINISTRATION   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; FEMALE; HEALTH CARE DELIVERY; HIV CARE CONTINUUM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION CONTROL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PATIENT CARE; PATIENT COMPLIANCE; UNITED STATES; VIRUS INHIBITION; ADOLESCENT; CD4 LYMPHOCYTE COUNT; FOLLOW UP; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; INSURANCE; VIROLOGY; VIRUS LOAD; YOUNG ADULT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADOLESCENT; ADULT; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; CONTINUITY OF PATIENT CARE; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INSURANCE COVERAGE; LOST TO FOLLOW-UP; MALE; MIDDLE AGED; UNITED STATES; VIRAL LOAD; YOUNG ADULT;

EID: 84939182606     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129376     Document Type: Article

References (30)

1. Rodger AJ, Lodwick R, Schechter M, Deeks S, Amin J, Gilson R, et al. Mortality in well controlled HIV in the continuous antiretroviral therapy arms of the SMART and ESPRIT trials compared with the general population. AIDS. 2013 Mar 27; 27(6):973-979. doi: 10.1097/QAD.0b013e32835cae9c PMID: 23698063
2. Arribas JR, Eron J. Advances in antiretroviral therapy. Curr Opin HIV AIDS. Jul 2013; 8(4):341-349. doi: 10.1097/COH.0b013e328361fabd PMID: 23666392
3. Cohen CJ, Meyers JL, Davis KL. Association between daily antiretroviral pill burden and treatment adherence, hospitalisation risk, and other healthcare utilisation and costs in a US medicaid population with HIV. BMJ Open. 2013; 3(8).
4. Berry SA, Fleishman JA, Moore RD, Gebo KA. Trends in reasons for hospitalization in a multisite United States cohort of persons living with HIV, 2001-2008. J Acquir Immune Defic Syndr. 2012 April 1; 59(4):368-375. doi: 10.1097/QAI.0b013e318246b862 PMID: 22240460
5. Bangsberg DR, Ragland K, Monk A, Deeks SG. A single tablet regimen is associated with higher adherence and viral suppression than multiple tablet regimens in HIV+ homeless and marginally housed people. AIDS. 2010 Nov 27; 24(18):2835-2840. doi: 10.1097/QAD.0b013e328340a209 PMID: 21045636
6. Yehia BR, Fleishman JA, Hicks PL, Ridore M, Moore RD, Gebo KA. Inpatient health services utilization among HIV-infected adult patients in care 2002-2007. J Acquir Immune Defic Syndr. 2010 Mar; 53(3):397-404. doi: 10.1097/QAI.0b013e3181bcdc16 PMID: 19841589
7. Althoff KN, Buchacz K, Hall HI, Zhang J, Hanna DB, Rebeiro P, et al. U.S. trends in antiretroviral therapy use, HIV RNA plasma viral loads, and CD4 T-lymphocyte cell counts among HIV-infected persons, 2000 to 2008. Ann Intern Med. 2012 Sep 4; 157(5):325-335. PMID: 22944874
8. Vital signs: HIV prevention through care and treatment-United States. Morb Mortal Wkly Rep. 2011 Dec 2; 60(47):1618-1623. PMID: 22129997
9. Fleishman JA, Yehia BR, Moore RD, Korthuis PT, Gebo KA. Establishment, retention, and loss to follow-up in outpatient HIV care. J Acquir Immune Defic Syndr. 2012 Jul 1; 60(3):249-259. doi: 10.1097/QAI.0b013e318258c696 PMID: 22531758
10. Mugavero MJ, Amico KR, Horn T, Thompson MA. The state of engagement in HIV care in the United States: from cascade to continuum to control. Clin Infect Dis. 2013; 57(8):1164-1171. doi: 10.1093/cid/cit420 PMID: 23797289
11. Eberhart MG, Yehia BR, Hillier A, Voytek CD, Blank MB, Frank I, et al. Behind the cascade: analyzing spatial patterns along the HIV care continuum. J Acquir Immune Defic Syndr. 2013 Nov 1; 64 Suppl 1: S42-51. doi: 10.1097/QAI.0b013e3182a90112 PMID: 24126447
12. Wiewel EW, Braunstein SL, Xia Q, Shepard CW, Torian LV. Monitoring Outcomes for Newly Diagnosed and Prevalent HIV Cases Using a Care Continuum Created With New York City Surveillance Data. J Acquir Immune Defic Syndr. 2015 Feb 1; 68(2):217-226. doi: 10.1097/QAI.0000000000000424 PMID: 25394192
13. Horberg M, Hurly L, Klein D, Towner W, Kadlecik P, Finnegan C, et al. The HIV Care Cascade ("Cascade") Measured Over Multiple Time Periods Varies by Time Period and Method. Paper presented at: 20th International AIDS Conference 2014; Melbourne, Australia.
14. Mugavero MJ, Amico KR, Westfall AO, Crane HM, Zinski A, Willig JH, et al. Early retention in HIV care and viral load suppression: implications for a test and treat approach to HIV prevention. J Acquir Immune Defic Syndr. 2012 Jan 1; 59(1):86-93. doi: 10.1097/QAI.0b013e318236f7d2 PMID: 21937921
15. Yehia BR, Gebo KA, Hicks PB, Korthuis PT, Moore RD, Ridore M, et al. Structures of care in the clinics of the HIV Research Network. AIDS Patient Care STDs. 2008; 22(12):1007-1013. doi: 10.1089/apc.2008.0093 PMID: 19072107
16. The White House Office of National AIDS Policy. The National HIV/AIDS Strategy of the United States. 2010.
17. Viera AJ, Garrett JM. Understanding interobserver agreement: the kappa statistic. Fam Med. 2005 May; 37(5):360-363. PMID: 15883903
18. Kleinman LC, Norton EC. What's the Risk? A simple approach for estimating adjusted risk measures from nonlinear models including logistic regression. Health Serv Res. Feb 2009; 44(1):288-302. doi: 10.1111/j.1475-6773.2008.00900.x PMID: 18793213
19. Ulett KB, Willig JH, Lin HY, Routman JS, Abroms S, Allison J, et al. The therapeutic implications of timely linkage and early retention in HIV care. AIDS Patient Care STDs. 2009 Jan; 23(1):41-49. doi: 10.1089/apc.2008.0132 PMID: 19055408
20. Andersen RM. Revisiting the behavioral model and access to medical care: does it matter? J Health Soc Behav. 1995 Mar; 36(1):1-10. PMID: 7738325
21. Yehia BR, Schranz AJ, Momplaisir F, Keller SC, Gross R, Frank I, et al. Outcomes of HIV-Infected Patients Receiving Care at Multiple Clinics. AIDS Behavior. 2014 Aug; 18(8):1511-22. PMID: 24077931
22. Lorig KR, Ritter P, Stewart AL, et al. Chronic disease self-management program: 2-year health status and health care utilization outcomes. Medical Care. 2001 Nov; 39(11):1217-1223. PMID: 11606875
23. Chodosh J, Morton SC, Mojica W, Maglione M, Suttorp MJ, Hilton L, et al. Meta-analysis: chronic disease self-management programs for older adults. Ann Intern Med. 2005 Sep 20; 143(6):427-438. PMID: 16172441
24. Bodenheimer T, Lorig K, Holman H, Grumbach K. Patient self-management of chronic disease in primary care. JAMA. 2002 Nov 20; 288(19):2469-2475. PMID: 12435261
25. Department of Health and Human Services. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Available: http://www.aidsinfo.nih.gov.
26. Holtzman CW, Shea JA, Glanz K, Jacobs LM, Gross R, Hines J, et al. Mapping Patient-Identified Barriers and Facilitators to Retention in HIV Care and Antiretroviral Therapy Adherence to Anderson's Behavioral Model. AIDS Care. 2015 27(7):817-28. doi: 10.1080/09540121.2015.1009362 PMID: 25671515
27. Mugavero MJ, Westfall AO, Zinski A, Davila J, Drainoni ML, Gardner LI, et al. Measuring retention in HIV care: the elusive gold standard. J Acquir Immune Defic Syndr. 2012 Dec 15; 61(5):574-580. doi: 10.1097/QAI.0b013e318273762f PMID: 23011397
28. Yehia BR, Fleishman JA, Metlay JP, Korthuis PT, Agwu AL, Berry SA, et al. Comparing different measures of retention in outpatient HIV care. AIDS. 2012 Jun 1; 26(9):1131-1139. doi: 10.1097/QAD.0b013e3283528afa PMID: 22382143
29. Yehia B, Frank I. Battling AIDS in America: an evaluation of the National HIV/AIDS Strategy. Am J Public Health. 2011 Sep; 101(9):e4-8. doi: 10.2105/AJPH.2011.300259 PMID: 21778507
30. Mahle Gray K, Tang T, Shouse L, Li J, Mermin J, Hall HI. Using the HIV surveillance system to monitor the National HIV/AIDS Strategy. Am J Public Health. 2013 Jan; 103(1):141-147. doi: 10.2105/AJPH.2012.300859 PMID: 23153150