Anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm

Natural Product Research

Volumn 30, Issue 16, 2016, Pages 1830-1833

  Selim, Samy ^a,c   Al Jaouni, Soad ^b  

^a JOUF UNIVERSITY   (Saudi Arabia)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^c Suez Canal University   (Egypt)

Author keywords

anti angiogenic; Anti inflammatory; antioxidant; C. speciosus; diosgenin

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ASCORBIC ACID; BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIOSGENIN; LIPOXYGENASE; METHOTREXATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; ANGIOGENESIS INHIBITOR; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; LIPOPOLYSACCHARIDE; PLANT EXTRACT; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CHEILOCOSTUS SPECIOSUS; CONTROLLED STUDY; ENZYME ACTIVATION; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; IC50; IN VITRO STUDY; MACROPHAGE CULTURE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; APOPTOSIS; CELL PROLIFERATION; CHEMISTRY; COSTUS; DRUG EFFECTS; ISOLATION AND PURIFICATION; MEDICINAL PLANT; RAW 264.7 CELL LINE;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CELL PROLIFERATION; COSTUS; DIOSGENIN; LIPOPOLYSACCHARIDES; MICE; PLANT EXTRACTS; PLANTS, MEDICINAL; RAW 264.7 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84939172590     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2015.1065493     Document Type: Article

References (9)

1. R.Gupta 2010. Medicinal and aromatic plants. New Delhi:CBS. 234–499.
2. S.Hirai, T.Uemura, N.Mizoguchi, J.Y.Lee, K.Taketani, Y.Nakano, S.Hoshino, N.Tsuge, T.Narukami, R.Yu,. 2010. Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages. Mol Nutr Food Res. 54:797–804.
3. J.Jagadeesan, N.Nandakumar, T.Rengarajan, M.P.Balasubramanian. 2012. Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma. J Environ Pathol Toxicol Oncol. 31:121–129.10.1615/JEnvironPatholToxicolOncol.v31.i2
4. S.Jagtap, R.Satpute 2014. Phytochemical screening and antioxidant activity of rhizome extracts of Costus speciosus (Koen.) J.E. Smith J Acad Ind Res. 3:40–47.
5. B.Liagre, P.Vergne-Salle, C.Corbiere, J.L.Charissoux, J.L.Beneytout. 2004. Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synovyocytes, with cyclohexogenase -2 overexpression. Arthritis Res Ther. 6:R373–383.10.1186/ar1199
6. K.A.Mackenzie, A.P.Miller, B.D.Hock, J.Gardner, J.W.Simcock, J.A.Roake, G.U.Dachs, B.A.Robinson, M.J.Currie. 2011. Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients. Mol Aspects Med. 32:71–87.
7. M.Murakawa, K.Yamaoka, Y.Tanaka, Y.Fukuda. 2006. Involvement of tumor necrosis factor (TNF)-α in phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice. Biochem Pharmacol. 71:1331–1336.10.1016/j.bcp.2006.01.005
8. K.Patel, M.Gadewar, V.Tahilyani, D.K.Patel. 2012. A review on pharmacological and analytical aspects of diosgenin:a concise report. Nat Prod Bioprospect. 2:46–52.10.1007/s13659-012-0014-3
9. M.A.Vijayalakshmi, N.C.Sarada. 2008. Screening of Costus speciosus extracts for antioxidant activity. Fitoterapia. 79:197–198.10.1016/j.fitote.2007.11.014