A time-course study of long term over-expression of ARR19 in mice

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Qamar, Imteyaz ^a   Ahmad, Mohammad Faiz ^b   Narayanasamy, Arul ^c  

^a GAUTAM BUDDHA UNIVERSITY   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

^c Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CMTM2A PROTEIN, MOUSE; HDAC5 PROTEIN, MOUSE; HISTONE DEACETYLASE; MARVEL DOMAIN CONTAINING PROTEIN; PROGESTERONE; REPRESSOR PROTEIN; TESTOSTERONE;

ADENOVIRIDAE; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; EPIDIDYMIS; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MALE; METABOLISM; MOUSE; PROSTATE; TESTIS;

ADENOVIRIDAE; ANIMALS; CELL DIFFERENTIATION; EPIDIDYMIS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTONE DEACETYLASES; HUMANS; MALE; MARVEL DOMAIN-CONTAINING PROTEINS; MICE; PROGESTERONE; PROSTATE; RECEPTORS, ANDROGEN; REPRESSOR PROTEINS; TESTIS; TESTOSTERONE;

EID: 84939134638     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13014     Document Type: Article

References (20)

1. Clark, B. J. & Cochrum, R. K. The steroidogenic acute regulatory protein as a target of endocrine disruption in male reproduction. Drug Metab Rev. 39, 353-370 (2007).
2. Payne, A. H. & O'Shaughnessy, P. J. Structure, function and regulation of steroidogenic enzymes in The Leydig Cell. In The Leydig Cell. 259-286. Cache River Press. Vienna, H. (1996).
3. Mellon, S. H., Compagnone N. A. & Zhang, P. Orphan receptors, proto-oncogenes and other nuclear factors regulate P450C17 gene transcription. Endocr Rev. 24, 505-5134 (1998).
4. Parker, K. L. & Schimmer, B. P. Steroidogenic factor 1: a key determinant of endocrine development and function. Endocr Rev. 18, 361-377 (1997).
5. Sadovsky, Y. & Dorn, C. Function of steroidogenic factor 1 during development and differentiation of the reproductive system. Rev. Reprod. 5, 136-142 (2000).
6. Zhang, P. & Mellon, S. H. Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: novel mechanisms for orphan nuclear receptor action. Mol. Endocrinol. 11, 891-904 (1997).
7. Wilson, T. E., Mouw, A. R., Weaver, C. A., Milbrandt, J. & Parker, K. L. The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol. Cell. Biol. 13, 861-868 (1993).
8. Stocco, C. O. et al. Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77. J. Biol. Chem. 275, 37202-37211 (2000).
9. Li. et al. Molecular cloning and identification of mouse Cklfsf2a and Cklfsf2b, two homologues of human CKLFSF2. Int. J. Biochem. Cell Biol. 38, 420-429 (2006).
10. Jeong, B. C. et al. Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase. Mol. Endocrinol. 18, 13-25 (2004).
11. Qamar, I., Park, E., Gong, E. Y., Lee, H. J. & Lee, K. ARR19 (androgen receptor corepressor of 19 kDa), an antisteroidogenic factor, is regulated by GATA-1 in testicular Leydig cells. J Biol Chem. 284, 18021-18032 (2009).
12. Qamar, I. et al. Anti-steroidogenic factor ARR19 inhibits testicular steroidogenesis through the suppression of Nur77 transactivation. J Biol Chem. 285, 22360-22369 (2010).
13. Ge, R. S. et al. In search of rat stem Leydig cells: identification, isolation, and lineage-specific development. Proc. Natl. Acad. Sci. USA. 103, 2719-2724 (2006).
14. Moraga, P. F., Llanos, M. N. & Ronco, A. M. Arachidonic acid release from rat Leydig cells depends on the presence of luteinizing hormone/human chorionic gonadotrophin receptors. J. Endocrinol. 154, 201-209 (1997).
15. Song, K. H. et al. The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation. Mol. Endocrinol. 18, 1929-1940 (2004).
16. Kim, J. Y. et al. rphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding. Mol. Endocrinol. 18, 2880-2894 (2004).
17. Hong, C. Y. et al. Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha. Mol. Cell. Biol. 24, 2593-2604 (2004).
18. Koskimies, P., Spiess, A. N., Lahti, P., Huhtaniemi, I. & Ivell, R. The mouse relaxin-like factor gene and its promoter are located within the 3' region of the JAK3 genomic sequence. FEBS Lett. 419, 186-90 (1997).
19. Pusch, W., Balvers, M. & Ivell, R. Molecular cloning and expression of the relaxin-like factor from the mouse testis. Endocrinology. 137, 3009-13 (1996).
20. Büllesbach, E. E. & Schwabe, C. A novel Leydig cell cDNA-derived protein is a relaxin-like factor. J Biol Chem. 270, 16011-5 (1995).