Safety & pK of IV loading dose of lacosamide in the ICU

Epilepsy and Behavior

Volumn 49, Issue , 2015, Pages 340-342

  Ramsay, R Eugene ^a   Sabharwal, Vivek ^a   Khan, Fawad ^a   Dave, Hina ^a   Kafai, Cyrus ^a   Shumate, Rachel ^a   Irland, Megan ^a  

^a OCHSNER MEDICAL CENTER   (United States)

Author keywords

IV dosing; Lacosamide; Loading dose; Safety; Status epilepticus

Indexed keywords

HARKOSERIDE; ACETAMIDE DERIVATIVE; ANTICONVULSIVE AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; DRUG BLOOD LEVEL; DRUG SAFETY; EPILEPTIC STATE; HUMAN; INTENSIVE CARE UNIT; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; DRUG EFFECTS; DRUG RESISTANT EPILEPSY; ELECTROENCEPHALOGRAPHY; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIDDLE AGED; RETROSPECTIVE STUDY; STATUS EPILEPTICUS; VERY ELDERLY; YOUNG ADULT;

ACETAMIDES; ADMINISTRATION, INTRAVENOUS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; DRUG RESISTANT EPILEPSY; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; STATUS EPILEPTICUS; YOUNG ADULT;

EID: 84938995715     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2015.06.032     Document Type: Article

References (21)

1. Bialer M., Johannessen S.I., Kupferberg H.J., Levy R.H., Perucca E., Tomson T. Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res 2004, 61:1-48.
2. Doty P., Rudd G.D., Stoehr T., Thomas D. Lacosamide. Neurotherapeutics 2007, 4:1458.
3. Kellinghaus C., Berning S., Immisch I., Larch J., Rosenow F., Rossetti A.O., et al. Intravenous lacosamide for treatment of status epilepticus. Acta Neurol Scand 2011, 123:137-141.
4. Errington A.C., Coyne L., Stohr T., Selve N., Lees G. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008, 73(1):157-169.
5. Chung S., Sperling M.R., Biton V., Krauss G., Hebert D., Rudd G.D., et al. Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial. Epilepsia 2010, 51:958-967.
6. Horstmann R., Bonn R., Cawello W., Doty P., Rudd G.D. Basic clinical pharmacological investigations of the new antiepileptic drug SPM 927. Epilepsia 2002, 43:188. [Abstract].
7. Thomas D., Scharfenecker U., Nickel B., Doty P., Cawello W., Horstmann R. Low potential for drug-drug interaction of lacosamide. Epilepsia 2006, 47:200.
8. Biton V., Rosenfeld W.E., Whitesides J., Fountain N.B., Vaiciene N., Rudd G.D. Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures. Epilepsia 2008, 49:418-424.
9. Fountain N.B., et al. Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide-naive patients with partial-onset seizures. Epilepsia 2013, 54(1):58-65.
10. Beyreuther B.K., Freitag J., Heers C., Krebsfaenger N., Scharfenecker U., Stohr T. Lacosamide: a review of preclinical properties. CNS Drug Rev 2007, 13:21-42.
11. Kellinghaus C., Berning S., Besselmann M. Intravenous lacosamide as successful treatment for nonconvulsive status epilepticus after failure of first-line therapy. Epilepsy Behav 2009, 14:429-431.
12. Degiorgio C.M. Atrial flutter/atrial fibrillation associated with lacosamide for partial seizures. Epilepsy Behav 2010, 18:322-324.
13. Shaibani A., et al. Lacosamide in painful diabetic neuropathy: an 18-week double-blind placebo-controlled trial. J Pain 2009, 10(8):818-828.
14. Wymer J.P., Simpson J., Sen D., Bongardt S. Efficacy and safety of lacosamide in diabetic neuropathic pain: an 18-week double-blind placebo-controlled trial of fixed-dose regimens. Clin J Pain 2009, 25:376-385.
15. Nizam A., et al. Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy. Epilepsia 2011, 52(10):e153-e155.
16. Ben-Menachem E., Biton V., Jatuzis D., Abou-Khalil B., Doty P., Rudd G.D. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia 2007, 48:1308-1317.
17. Höfler j., Unterberger I., Dobesberger J., Kuchukhidze G., Walser G., Trinka E. Intravenous lacosamide in status epilepticus and seizure clusters. Epilepsia 2011, 52(10):e148-e152.
18. Tiltz C., Resch R., Hofer T., Eggers C. Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. Epilepsia 2010, 51:316-317.
19. Rantsch K., Walter U., Wittstock M., Benecke R., Rosche J. Efficacy of intravenous lacosamide in refractory nonconvulsive status epilepticus and simple partial status epilepticus. Seizure 2011, 20(7):529-532.
20. Höfler J., Trinka E. Lacosamide as a new treatment option in status epilepticus. Epilepsia 2013, 54(3):393-404.
21. Krauss G., Ben-Menacheem E., Mameniskiene R., Vaiciene-Magistris N., Brock M., Whitesides J.G., et al. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures. Epilepsia 2010, 51:951-957.