Factors associated with medication regimen complexity in older people: A cross-sectional population-based study

European Journal of Clinical Pharmacology

Volumn 71, Issue 9, 2015, Pages 1099-1108

  Wimmer, Barbara Caecilia ^a   Johnell, Kristina ^b   Fastbom, Johan ^b   Wiese, Michael David ^c   Bell, J Simon ^a,c  

^a MONASH UNIVERSITY   (Australia)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Aged; Inappropriate prescribing; Medication regimen complexity; Polypharmacy; Population based study

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ASSESSMENT TOOL; COMORBIDITY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICATION REGIMEN COMPLEXITY; MEDICATION REGIMEN COMPLEXITY INDEX; MEDICATION THERAPY MANAGEMENT; MINI MENTAL STATE EXAMINATION; PAIN; POPULATION RESEARCH; PRIORITY JOURNAL; VERY ELDERLY; AGE; MEDICATION COMPLIANCE; MIDDLE AGED; POLYPHARMACY; STATISTICS AND NUMERICAL DATA;

AGE FACTORS; AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; POLYPHARMACY;

EID: 84938978331     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-015-1883-2     Document Type: Article

References (48)

1. Hajjar ER, Cafiero AC, Hanlon JT (2007) Polypharmacy in elderly patients. Am J Geriatr Pharmacother 5:345-351
2. Mansur N, Weiss A, Beloosesky Y (2012) Looking beyond polypharmacy: quantification of medication regimen complexity in the elderly. Am J Geriatr Pharmacother 10:223-229
3. de Vries ST, Keers JC, Visser R, de Zeeuw D, Haaijer-Ruskamp FM, Voorham J, Denig P (2014) Medication beliefs, treatment complexity, and non-adherence to different drug classes in patients with type 2 diabetes. J Psychosom Res 76:134-138
4. Dierich MT, Mueller C, Westra BL (2011) Medication regimens in older home care patients. J Gerontol Nurs 37:45-55
5. Willson MN, Greer CL, Weeks DL (2014) Medication regimen complexity and hospital readmission for an adverse drug event. Ann Pharmacother 48:26-32
6. Wimmer BC, Dent E, Bell JS, Wiese M, Johnell K, Chapman I, Visvanathan R (2014) Medication regimen complexity and unplanned hospital readmissions in older people. Ann Pharmacother 48:1120-1128
7. Fröhlich SE, Zaccolo AV, da Silva SLC, Mengue SS (2010) Association between drug prescribing and quality of life in primary care. Pharm World Sci 32:744-751
8. Wimmer BC, Dent E, Visvanathan R, Wiese M, Johnell K, Chapman I, Bell JS (2014) Polypharmacy and medication regimen complexity as factors associated with hospital discharge destination among older people: a prospective cohort study. Drugs Aging 31:623-630
9. George J, Phun YT, Bailey MJ, Kong DC, Stewart K (2004) Development and validation of the medication regimen complexity index. Ann Pharmacother 38:1369-1376
10. Paquin AM, Zimmerman KM, Kostas TR, Pelletier L, Hwang A, Simone M, Skarf LM, Rudolph JL (2013) Complexity perplexity: a systematic review to describe the measurement of medication regimen complexity. Expert Opin Drug Saf 12:829-840
11. Rettig SM, Wood Y, Hirsch JD (2013) Medication regimen complexity in patients with uncontrolled hypertension and/or diabetes. J Am Pharm Assoc 53:427-431
12. Correr CJ, Melchiors AC, Fernandez-Llimos F, Pontarolo R (2011) Effects of a pharmacotherapy follow-up in community pharmacies on type 2 diabetes patients in Brazil. Int J Clin Pharm 33:273-280
13. Stange D, Kriston L, Von-Wolff A, Baehr M, Dartsch DC (2013) Reducing cardiovascular medication complexity in a German university hospital: effects of a structured pharmaceutical management intervention on adherence. J Manag Care Pharm 19:396-407
14. Linnebur SA, Vande Griend JP, Metz KR, Hosokawa PW, Hirsch JD, Libby AM (2014) Patient-level medication regimen complexity in older adults with depression. Clin Ther 36(1538-1546):e1531
15. Hirsch JD, Metz KR, Hosokawa PW, Libby AM (2014) Validation of a patient-level Medication Regimen Complexity Index as a possible tool to identify patients for medication therapy management intervention. Pharmacotherapy 34:826-835
16. Cardone KE, Manley HJ, Grabe DW, Meola S, Hoy CD, Bailie GR (2011) Quantifying home medication regimen changes and quality of life in patients receiving nocturnal home hemodialysis. Hemodial Int 15:234-242
17. Elliott RA, O'Callaghan C, Paul E, George J (2013) Impact of an intervention to reduce medication regimen complexity for older hospital inpatients. Int J Clin Pharm 35:217-724
18. Stange D, Kriston L, von Wolff A, Baehr M, Dartsch DC (2012) Medication complexity, prescription behaviour and patient adherence at the interface between ambulatory and stationary medical care. Eur J Clin Pharmacol 69:573-580
19. Advinha AM, de Oliveira-Martins S, Mateus V, Pajote SG, Lopes MJ (2014) Medication regimen complexity in institutionalized elderly people in an aging society. Int J Clin Pharm 36:750-756
20. Libby AM, Fish DN, Hosokawa PW, Linnebur SA, Metz KR, Nair KV, Saseen JJ, Vande Griend JP, Vu SP, Hirsch JD (2013) Patient-level medication regimen complexity across populations with chronic disease. Clin Ther 35(385-398):e381
21. McDonald MV, Peng TR, Sridharan S, Foust JB, Kogan P, Pezzin LE, Feldman PH (2013) Automating the medication regimen complexity index. J Am Med Inform Assoc 20:499-505
22. Clay PG (2014) Medication Regimen Complexity Indices (MRCI): a tool to focus MTM efforts? J Am Pharm Assoc 54:664
23. Lagergren M, Fratiglioni L, Hallberg IR, Berglund J, Elmstahl S, Hagberg B, Holst G, Rennemark M, Sjolund BM, Thorslund M, Wiberg I, Winblad B, Wimo A (2004) A longitudinal study integrating population, care and social services data. The Swedish National study on Aging and Care (SNAC). Aging Clin Exp Res 16:158-168
24. Stockholm Gerontology Research Center, Aging Research Center Karolinska Institutet. SNAC-K The Swedish National Study on Aging and Care in Kungsholmen; Stockholm Gerontology Research Center in collaboration with Aging Research Center Karolinska Institutet http://www.snac-k.se/index.htm. Acessed 19 February 2015
25. Haasum Y, Fastbom J, Fratiglioni L, Kareholt I, Johnell K (2011) Pain treatment in elderly persons with and without dementia: a population-based study of institutionalized and home-dwelling elderly. Drugs Aging 28:283-293
26. Haasum Y, Fastbom J, Fratiglioni L, Johnell K (2012) Undertreatment of osteoporosis in persons with dementia? A population-based study. Osteoporos Int 23:1061-1068
27. Australian pharmaceutical formulary and handbook APF 22 ed. Chris Pirie CES, Biotext Pty Ltd, ACT, editor: Pharmaceutical Society of Australia 2012
28. British Medical Association and the Royal Pharmaceutical Society of Great Britain. British National Formulary. 61st ed. UK: BMJ Publishing Group 2011
29. The electronic Medicines Compendium (eMC). Available at: http://www.medicines.org.uk/emc/. Accessed 04 April, 2014
30. Johnell K, Fastbom J (2011) Antiepileptic drug use in community-dwelling and institutionalized elderly: a nationwide study of over 1 300 000 older people. Eur J Clin Pharmacol 67:1069-1075
31. Klarin I, Fastbom J, Wimo A (2006) The use of angiotensin-converting enzyme inhibitors and other drugs with cardiovascular effects by non-demented and demented elderly with a clinical diagnosis of heart failure. A population-based study of the very old. Eur J Clin Pharmacol 62:555-562
32. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198
33. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW (1963) Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA 185:914-919
34. Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373-383
35. Klarin I, Wimo A, Fastbom J (2005) The association of inappropriate drug use with hospitalisation and mortality. Drugs Aging 22:69-82
36. Koenker R, Hallok KF (2001) Quantile regresssion. J Econ Perspect 15:143-156
37. Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B (2012) Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet 380:37-43
38. Payne R, Avery A, Duerden M, Saunders C, Simpson C, Abel G (2014) Prevalence of polypharmacy in a Scottish primary care population. Eur J Clin Pharmacol 70:575-581
39. Kutner JS, Blatchford PJ, Taylor DH Jr, Ritchie CS, Bull JH, Fairclough DL, Hanson LC, LeBlanc TW, Samsa GP, Wolf S, Aziz NM, Currow DC, Ferrell B, Wagner-Johnston N, Zafar SY, Cleary JF, Dev S, Goode PS, Kamal AH, Kassner C, Kvale EA, McCallum JG, Ogunseitan AB, Pantilat SZ, Portenoy RK, Prince-Paul M, Sloan JA, Swetz KM, Von Gunten CF, Abernethy AP (2015) Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial. JAMA Intern Med 175:691-700
40. Holmes HM, Min LC, Yee M, Varadhan R, Basran J, Dale W, Boyd CM (2013) Rationalizing prescribing for older patients with multimorbidity: considering time to benefit. Drugs Aging 30:655-666
41. Vik SA, Maxwell CJ, Hogan DB (2004) Measurement, correlates, and health outcomes of medication adherence among seniors. Ann Pharmacother 38:303-312
42. Lee DSH, de Rekeneire N, Hanlon JT, Gill TM, Bauer DC, Meibohm B, Harris TB, Jeffery SM (2012) Cognitive impairment and medication complexity in community-living older adults: The Health, Aging and Body Composition Study. J Pharm Technol 28:156-162
43. Abdulla A, Adams N, Bone M, Elliott AM, Gaffin J, Jones D, Knaggs R, Martin D, Sampson L, Schofield P, British Geriatric S (2013) Guidance on the management of pain in older people. Age Ageing 42(Suppl 1):i1-i57
44. Tan ECK, Jokanovic N, Koponen M, Thomas D, Hilmer SN, JS B (2015) Prevalence of analgesic use and pain in people with and without dementia or cognitive impairment in aged care facilities: a systematic review and meta-analysis. Curr Clin Pharmacol [in press]
45. Auret K, Schug SA (2005) Underutilisation of opioids in elderly patients with chronic pain. Drugs Aging 22:641-654
46. Kuijpers MA, Van Marum RJ, Egberts AC, Jansen PA (2007) Relationship between polypharmacy and underprescribing. Br J Clin Pharmacol 65:130-133
47. Hovstadius B, Hovstadius K, Petersson G (2010) Increasing polypharmacy - an individual-based study of the Swedish population 2005-2008. BMC Clin Pharmacol 10:16. doi: 10.1186/1472-6904-10-16. 10: 16
48. Haider SI, Johnell K, Weitoft GR, Thorslund M, Fastbom J (2009) The Influence of educational level on polypharmacy and inappropriate drug use: a register-based study of more than 600,000 older people. J Am Geriatr Soc 57:62-69