Dental demineralization and caries in patients with head and neck cancer

Oral Oncology

Volumn 51, Issue 9, 2015, Pages 824-831

  Deng, Jie ^a   Jackson, Leanne ^b   Epstein, Joel B ^c   Migliorati, Cesar A ^d   Murphy, Barbara A ^b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Decay; Dental caries; Dental demineralization; Head and neck cancer; Prevention; Radiation caries; Radiation therapy; Review

Indexed keywords

ARTICLE; BODY IMAGE; CANCER PATIENT; CANCER RADIOTHERAPY; CLINICAL ASSESSMENT; DENTAL CARIES; DENTAL HEALTH; ENAMEL; FUNCTIONS OF THE MOUTH, JAWS AND TEETH; HEAD AND NECK CANCER; HUMAN; HYPOSALIVATION; PANORAMIC RADIOGRAPHY; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SALIVA; SOCIAL STATUS; TOOTH DISEASE; XEROSTOMIA; ADVERSE EFFECTS; CHEMICALLY INDUCED; CHEMORADIOTHERAPY; COMPLICATION; HEAD AND NECK NEOPLASMS; RADIATION INJURY; RISK FACTOR;

CHEMORADIOTHERAPY; DENTAL CARIES; HEAD AND NECK NEOPLASMS; HUMANS; QUALITY OF LIFE; RADIATION INJURIES; RISK FACTORS; TOOTH DEMINERALIZATION; XEROSTOMIA;

EID: 84938971773     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2015.06.009     Document Type: Review

References (120)

1. S.S. Lin, S.T. Massa, and M.A. Varvares Improved overall survival and mortality in head and neck cancer with adjuvant concurrent chemoradiotherapy in national databases Head Neck 2014 2014 Sept 16
2. B.A. Murphy, J. Gilbert, A. Cmelak, and S.H. Ridner Symptom control issues and supportive care of patients with head and neck cancers Clin Adv Hematol Oncol 5 10 2007 807 822
3. B.A. Murphy, J. Gilbert, and S.H. Ridner Systemic and global toxicities of head and neck treatment Expert Rev Anticanc 7 7 2007 1043 1053
4. B.A. Murphy Clinical and economic consequences of mucositis induced by chemotherapy and/or radiation therapy J Support Oncol 5 9 Suppl 4 2007 13 21
5. B.A. Murphy, S. Ridner, N. Wells, and M. Dietrich Quality of life research in head and neck cancer: a review of the current state of the science Crit Rev Oncol Hematol 62 3 2007 251 267
6. A.K. Chaturvedi, E.A. Engels, W.F. Anderson, and M.L. Gillison Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States J Clin Oncol 26 4 2008 612 619
7. A.J. Cmelak, S. Li, M.A. Goldwasser, B. Murphy, M. Cannon, H. Pinto, and et al. Phase II trial of chemoradiation for organ preservation in resectable stage III or IV squamous cell carcinomas of the larynx or oropharynx: results of Eastern Cooperative Oncology Group Study E2399 J Clin Oncol 25 25 2007 3971 3977
8. The Oral Cancer Foundation. HPV Connection, the human papilloma virus, 2012. < http://oralcancerfoundation.org/hpv/index.htm > [accessed 7.15.12].
9. Swierzewski SJ. Head and neck cancer overview, 2014. < http://www.healthcommunities.com/head-and-neck-cancer/overview-of-head-and-neck-cancer.shtml > [accessed 1.8.15].
10. National institute of dental and craniofacial research, national institutes of health. Oral complications of cancer treatment: what the dental team can do, 2009. Access method: < http://www.nidcr.nih.gov/oralhealth/Topics/CancerTreatment/OralComplicationsCancerOral.htm#top > [accessed 11.8.14].
11. C. Robinson, R.C. Shore, S.J. Brookes, S. Strafford, S.R. Wood, and J. Kirkham The chemistry of enamel caries Crit Rev Oral Biol Med 11 4 2000 481 495
12. L.J. Walsh Contemporary technologies for remineralisation therapies: a review International Dentistry SA 11 6 2009 6 16
13. J.D. Da Silva, D.A. Mitchell, and L. Mitchell Oxford American Handbook of Clinical Dentistry (Oxford American Handbooks of Medicine) 2007 Oxford University Press New York
14. J.D. Featherstone Dental caries: a dynamic disease process Aust Dent J 53 3 2008 Sep 286 291
15. J.B. Epstein, and C. Scully The role of saliva in oral health and the causes and effects of xerostomia J Can Dent Assoc 58 3 1992 217 221
16. M.E. Brosky The role of saliva in oral health: strategies for prevention and management of xerostomia J Support Oncol 5 5 2007 215 225
17. J.B. Epstein, J. Thariat, R.J. Bensadoun, A. Barasch, B.A. Murphy, L. Kolnick, and et al. Oral complications of cancer and cancer therapy: from cancer treatment to survivorship CA Cancer J Clin 62 6 2012 400 422
18. A.R. Hand Salivary glands A. Nanci, Ten Cate's oral histology: development, structure and function 2008 Mosby Elsevier Montreal 290 291
19. I.D. Mandel The role of saliva in maintaining oral homeostasis J Am Dent Assoc 119 2 1989 298 304
20. C. Liena-Puy The role of saliva in maintaining oral health and as an aid to diagnosis Med Oral Patol Oral Cir Bucal 11 5 2006 E449 E455
21. L.K. McCaul Oral and dental management for head and neck cancer patients treated by chemotherapy and radiotherapy Dent Update 39 2 2012 135 138 40
22. L. Kolnick, J. Deng, J.B. Epstein, C.A. Migliorati, J. Rezk, M.S. Dietrich, and et al. Associations of oral health items of the Vanderbilt Head and Neck Symptom Survey with a dental health assessment Oral Oncol 50 2 2014 135 140
23. G.G. Duncan, J.B. Epstein, D. Tu, S. El Sayed, A. Bezjak, J. Ottaway, and et al. Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis Head Neck 27 5 2005 421 428
24. B.S. Henson, M.R. Inglehart, A. Eisbruch, and J.A. Ship Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy Oral Oncol 37 1 2001 84 93
25. A. Lin, H.M. Kim, J.E. Terrell, L.A. Dawson, J.A. Ship, and A. Eisbruch Quality of life after parotid-sparing IMRT for head-and-neck cancer: a prospective longitudinal study Int J Radiat Oncol Biol Phys 57 1 2003 61 70
26. I. Backstrom, U. Funegard, I. Andersson, L. Franzen, and I. Johansson Dietary intake in head and neck irradiated patients with permanent dry mouth symptoms Eur J Cancer B Oral Oncol 31B 4 1995 253 257
27. N.L. Rhodus, K. Moller, S. Colby, and J. Bereuter Articulatory speech performance in patients with salivary gland dysfunction: a pilot study Quintessence Int 26 11 1995 805 810
28. J.A. Logemann, C.H. Smith, B.R. Pauloski, A.W. Rademaker, C.L. Lazarus, L.A. Colangelo, and et al. Effects of xerostomia on perception and performance of swallow function Head Neck 23 4 2001 317 321
29. S. Hamlet, J. Faull, B. Klein, A. Aref, J. Fontanesi, R. Stachler, and et al. Mastication and swallowing in patients with postirradiation xerostomia Int J Radiat Oncol Biol Phys 37 4 1997 789 796
30. H. Flink Studies on the prevalence of reduced salivary flow rate in relation to general health and dental caries, and effect of iron supplementation Swed Dent J Suppl 192 2007 3 50 2p
31. S. Furness, G. Bryan, R. McMillan, and H.V. Worthington Interventions for the management of dry mouth: non-pharmacological interventions Cochrane Database Syst Rev 2013 8CD009603
32. S.F. Cassolato, and R.S. Turnbull Xerostomia: clinical aspects and treatment Gerodontology 20 2 2003 64 77
33. L. Franzen, U. Funegard, T. Ericson, and R. Henriksson Parotid gland function during and following radiotherapy of malignancies in the head and neck. A consecutive study of salivary flow and patient discomfort Eur J Cancer 28 2-3 1992 457 462
34. K.S. Chao, N. Majhail, C.J. Huang, J.R. Simpson, C.A. Perez, B. Haughey, and et al. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques Radiother Oncol 61 3 2001 275 280
35. M.E. Daly, Y. Lieskovsky, T. Pawlicki, J. Yau, H. Pinto, M. Kaplan, and et al. Evaluation of patterns of failure and subjective salivary function in patients treated with intensity modulated radiotherapy for head and neck squamous cell carcinoma Head Neck 29 3 2007 211 220
36. K. Saarilahti, M. Kouri, J. Collan, A. Kangasmaki, T. Atula, H. Joensuu, and et al. Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head and neck cancer Radiother Oncol 78 3 2006 270 275
37. E. Cooperstein, J. Gilbert, J.B. Epstein, M.S. Dietrich, S.M. Bond, S.H. Ridner, and et al. Vanderbilt Head and Neck Symptom Survey version 2.0: report of the development and initial testing of a subscale for assessment of oral health Head Neck 34 6 2012 797 804
38. N. Jha, H. Seikaly, J. Harris, D. Williams, R. Liu, T. McGaw, and et al. Prevention of radiation induced xerostomia by surgical transfer of submandibular salivary gland into the submental space Radiother Oncol 66 3 2003 283 289
39. A.D. Sasse, L.G. Clark, E.C. Sasse, and O.A. Clark Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis Int J Radiat Oncol Biol Phys 64 3 2006 784 791
40. S. Furness, H.V. Worthington, G. Bryan, S. Birchenough, and R. McMillan Interventions for the management of dry mouth: topical therapies Cochrane Database Syst Rev 12 2011 Cd008934
41. L. Hae-Soon, C. Kyung-Yi, K. Ae-Ok, K. Mi-Ran, K. Youn-Shin, K. Mi-Sun, and et al. Cariogenic activity in saliva of Korean head and neck cancer patients Int J Oral Biol 39 2 2014 57 63
42. T. de Siqueira Mellara, R.G. Palma-Dibb, H.F. de Oliveira, F.W. Garcia Paula-Silva, P. Nelson-Filho, R.A. da Silva, and et al. The effect of radiation therapy on the mechanical and morphological properties of the enamel and dentin of deciduous teeth - an in vitro study Radiat Oncol 9 2014 30 Jan 22
43. L.M. Gonçalves, R.G. Palma-Dibb, F.W. Paula-Silva, H.F. Oliveira, P. Nelson-Filho, L.A. Silva, and et al. Radiation therapy alters microhardness and microstructure of enamel and dentin of permanent human teeth J Dent 42 8 2014 986 992
44. A.M. Kielbassa, W. Hinkelbein, E. Hellwig, and H. Meyer-Lückel Radiation-related damage to dentition Lancet Oncol 7 4 2006 326 335
45. R. Reed, C. Xu, Y. Liu, J.P. Gorski, Y. Wang, and M.P. Walker Radiotherapy effect on nano-mechanical properties and chemical composition of enamel and dentine Arch Oral Biol 60 5 2015 690 697
46. M.T. Brennan, F.K. Spijkervet, and L.S. Elting Systematic reviews and guidelines for oral complications of cancer therapies: current challenges and future opportunities Support Care Cancer 18 8 2010 977 978
47. C.H. Hong, J.J. Napeñas, B.D. Hodgson, M.A. Stokman, V. Mathers-Stauffer, L.S. Elting, and et al. A systematic review of dental disease in patients undergoing cancer therapy Support Care Cancer 18 8 2010 1007 1021
48. National Cancer Institute, National Institutes of Health. Oral complications of chemotherapy and head/neck radiation (PDQ®). 2014. Access method: http://www.cancer.gov/cancertopics/pdq/supportivecare/oralcomplications/HealthProfessional/page1 [accessed 11.8.14].
49. W. Siala, W. Mnejja, F. Elloumi, A. Ghorbel, J. Mnif, M. Frikha, and et al. Late toxicities after conventional radiotherapy for nasopharyngeal carcinoma: incidence and risk factors J Radiother 2014 Article ID 268340 2014 8 pages
50. D. Elkassas, and A. Arafa Remineralizing efficacy of different calcium-phosphate and fluoride based delivery vehicles on artificial caries like enamel lesions J Dent 42 4 2014 466 474
51. B. Thompson, P. Cooney, H. Lawrence, V. Ravaghi, and C. Quinonez Cost as a barrier to accessing dental care: findings from a Canadian population-based study J Public Health Dent 74 3 2014 210 218
52. D. Kandelman, S. Arpin, R.J. Baez, P.C. Baehni, and P.E. Petersen Oral health care systems in developing and developed countries Periodontol 60 1 2000 98 109
53. American Psychological Association, Task Force on Socioeconomic Status. Report of the APA Task Force on socioeconomic status. Washington, DC: American Psychological Association; 2007.
54. S.T. Reisine, and W. Psoter Socioeconomic status and selected behavioral determinants as risk factors for dental caries J Dent Educ 65 10 2001 1009 1016
55. K. Tanaka, Y. Miyake, S. Sasaki, and Y. Hirota Socioeconomic status and risk of dental caries in Japanese preschool children: the Osaka Maternal and child health study J Public Health Dent 73 3 2013 217 223
56. M. Tickle, M. Williams, T. Jenner, and A. Blinkhorn The effects of socioeconomic status and dental attendance on dental caries' experience, and treatment patterns in 5-year-old children Br Dent J 186 3 1999 135 137
57. World Health Organization. Oral health surveys: basic methods. Geneva: WHO; 1987.
58. National institute of dental and craniofacial research, national institutes of health. Dental caries (tooth decay) in adults (age 20 to 64), 2014. Access method: < http://www.nidcr.nih.gov/DataStatistics/FindDataByTopic/DentalCaries/DentalCariesAdults20to64.htm > [accessed 12.15.14].
59. M. Michelet Caries and periodontal disease in cancer survivors Evid Based Dent 13 3 2012 70 73
60. F. Schwendicke, C.E. Dorfer, P. Schlattmann, L.F. Page, W.M. Thomson, and S. Paris Socioeconomic inequality and caries: a systematic review and meta-analysis J Dent Res 94 1 2015 10 18 Ebub 2014 Nov 15
61. A.I. Ismail, W. Sohn, M. Tellez, A. Amaya, A. Sen, H. Hasson, and et al. The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries Community Dent Oral Epidemiol 35 3 2007 170 178
62. J.E. Iranzo-Cortes, J.M. Montiel-Company, and J.M. Almerich-Silla Caries diagnosis: agreement between WHO and ICDAS II criteria in epidemiological surveys Community Dent Health 30 2 2013 108 111
63. J. Clara, D. Bourgeois, and M. Muller-Bolla DMF from WHO basic methods to ICDAS II advanced methods: a systematic review of literature Odontostomatol Trop 35 139 2012 5 11
64. B. Nyvad, V. Machiulskiene, and V. Baelum Reliability of a new caries diagnostic system differentiating between active and inactive caries lesions Caries Res 33 4 1999 252 260
65. B. Nyvad, V. Machiulskiene, and V. Baelum Construct and predictive validity of clinical caries diagnostic criteria assessing lesion activity J Dent Res 82 2 2003 117 122
66. S. Shankar, N. Naveen, M. Kruthika, S. Vinay, and H. Shaikh Comparison of def index with Nyvad's new caries diagnostic criteria among three to six years old children in a school at Bangalore city Indian J Dent Res 23 2 2012 135 139
67. A. Mehta Comprehensive review of caries assessment systems developed over the last decade RSBO 9 3 2012 316 321
68. S. Banava, M. Fattah, Kharrazifard. Mj, T. Safaie, S. Askarzadeh, M. Safaie Yazdi, and et al. Clinical comparison of dental caries by DMFT and ICDAS systems JIDA 24 2 2012 176 183
69. N.B. Pitts, K.R. Ekstrand Icdas Foundation International Caries Detection and Assessment System (ICDAS) and its International Caries Classification and Management System (ICCMS) - methods for staging of the caries process and enabling dentists to manage caries Community Dent Oral Epidemiol 41 1 2013 e41 e52
70. M.M. Braga, F.M. Mendes, and K.R. Ekstrand Detection activity assessment and diagnosis of dental caries lesions Dent Clin North Am 54 3 2010 479 493
71. T. Chng GLUT2 and TAS1R2 genotype and risk of dental caries 2012 University of Toronto Toronto, Ontario Canada
72. R.G. de Amorim, M.J. Figueiredo, S.C. Leal, J. Mulder, and J.E. Frencken Caries experience in a child population in a deprived area of Brazil, using ICDAS II Clin Oral Investig 16 2 2012 513 520
73. M.C. Gonzalez, J.A. Ruiz, M.C. Fajardo, A.D. Gomez, C.S. Moreno, M.J. Ochoa, and et al. Comparison of the def index with Nyvad's caries diagnostic criteria in 3- and 4-year-old Colombian children Pediatr Dent 25 2 2003 132 136
74. L.K. Jackson, J.B. Epstein, C.A. Migliorati, J. Rezk, W.H. Shintaku, M.E. Noujeim, and et al. Development of tools for the oral health and panoramic radiograph evaluation of head and neck cancer patients: a methodologic study Spec Care Dentist 7 2015 1 8
75. K.R. Ekstrand, S. Martignon, D.J. Ricketts, and V. Qvist Detection and activity assessment of primary coronal caries lesions: a methodologic study Oper Dent 32 3 2007 225 235
76. A.G. Farman Panoramic Corporation Panoramic radiology: seminars on maxillofacial imaging and interpretation 2007 Springer Berlin; New York
77. M.A. Moll, M. Seuthe, C. von See, A. Zapf, E. Hornecker, R.F. Mausberg, and et al. Comparison of clinical and dental panoramic findings: a practice-based crossover study BMC Oral Health 13 2013 48
78. J.W. Choi Assessment of panoramic radiography as a national oral examination tool: review of the literature Imaging Sci Dent 41 1 2011 1 6
79. P. Tantradi, V. Sreenivasan, and H. Kadaganche Role of bitewing in enhancing the assessment of DMFS index in a group of Indian adolescents Indian J Dent Res 21 2 2010 266 269
80. K. Kamburoglu, E. Kolsuz, S. Murat, S. Yuksel, and T. Ozen Proximal caries detection accuracy using intraoral bitewing radiography, extraoral bitewing radiography and panoramic radiography Dentomaxillofac Radiol 41 6 2012 450 459
81. S. Manjunath, R.T. Ragavendra, S.K. Setty, and K. Jayalakshmi Photography in clinical dentistry-a review Int J Dent Clin 3 2 2011 40 43
82. D.T. Kopycka-Kedzierawski, and R.J. Billings Comparative effectiveness study to assess two examination modalities used to detect dental caries in preschool urban children Telemed J E Health 19 11 2013 834 840
83. U. Boye, I.A. Pretty, M. Tickle, and T. Walsh Comparison of caries detection methods using varying numbers of intra-oral digital photographs with visual examination for epidemiology in children BMC Oral Health 13 2013 6
84. M. Sharland Improving your image. then and now. Digital photography in dentistry Dent Update 40 4 2013 333 334 6
85. Institute of Medicine. Advancing oral health in America. Washington, DC: National Academy of Sciences; 2011.
86. Healthy People 2020, Office of Disease Prevention and Health Promotion, U.S. Department of Health and Human Services. Oral Health: overview, 2009. Access method: < http://www.healthypeople.gov/2020/topics-objectives/topic/oral-health > [accessed 11.2.14].
87. S.E. Udeabor, M. Rana, G. Wegener, N.C. Gellrich, and A.M. Eckardt Squamous cell carcinoma of the oral cavity and the oropharynx in patients less than 40 years of age: a 20-year analysis Head Neck Oncol 4 2012 28
88. E. Benson, R. Li, D. Eisele, and C. Fakhry The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas Oral Oncol 50 6 2014 565 574
89. H. Bronheim, J.J. Strain, and H.F. Biller Psychiatric aspects of head and neck surgery. Part II: Body image and psychiatric intervention Gen Hosp Psychiatry 13 4 1991 225 232
90. B.A. Rhoten, J. Deng, M.S. Dietrich, B. Murphy, and S.H. Ridner Body image and depressive symptoms in patients with head and neck cancer: an important relationship Support Care Cancer 22 11 2014 3053 3060
91. J. Cunha-Cruz, P.P. Hujoel, and P. Nadanovsky Secular trends in socio-economic disparities in edentulism: USA, 1972-2001 J Dent Res 86 2 2007 131 136
92. R.D. Marinelli, L.M. Sreebny, and S. Kamen Perception of dental needs by the well elderly Spec Care Dentist 2 4 1982 161 164
93. G.D. Slade Derivation and validation of a short-form oral health impact profile Community Dent Oral Epidemiol 25 4 1997 284 290
94. H.P. Lawrence, W.M. Thomson, J.M. Broadbent, and R. Poulton Oral health-related quality of life in a birth cohort of 32-year olds Community Dent Oral Epidemiol 36 4 2008 305 316
95. U. Stenman, M. Ahlqwist, C. Bjorkelund, and M. Hakeberg Oral health-related quality of life-associations with oral health and conditions in Swedish 70-year-old individuals Gerodontology 29 2 2012 e440 e446
96. National institute of dental and craniofacial research, national institutes of health. Oral complications of cancer treatment: what the oncology team can do, 2009. Access method: < http://www.nidcr.nih.gov/oralhealth/topics/cancertreatment/oralcomplicationscanceroncology.htm > [accessed 11.2.14]
97. R.J. Weyant, S.L. Tracy, T.T. Anselmo, E.D. Beltran-Aguilar, K.J. Donly, W.A. Frese, and et al. Topical fluoride for caries prevention: executive summary of the updated clinical recommendations and supporting systematic review J Am Dent Assoc 144 11 2013 1279 1291
98. J.B. Epstein, B.C. McBride, P. Stevenson-Moore, H. Merilees, and J. Spinelli The efficacy of chlorhexidine gel in reduction of Streptococcus mutans and Lactobacillus species in patients treated with radiation therapy Oral Surg Oral Med Oral Pathol 71 2 1991 172 178
99. J.B. Epstein, R. Loh, P. Stevenson-Moore, B.C. McBride, and J. Spinelli Chlorhexidine rinse in prevention of dental caries in patients following radiation therapy Oral Surg Oral Med Oral Pathol Oral Radiol Endod 68 4 1989 401 405
100. M. Gorsky, J.B. Epstein, J. Parry, M.S. Epstein, N.D. Le, and S. Silverman Jr. The efficacy of pilocarpine and bethanechol upon saliva production in cancer patients with hyposalivation following radiation therapy Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97 2 2004 190 195
101. N. Chainani-Wu, M. Gorsky, P. Mayer, A. Bostrom, J.B. Epstein, and S. Silverman Jr. Assessment of the use of sialogogues in the clinical management of patients with xerostomia Spec Care Dentist 26 4 2006 164 170
102. P. Han, P. Suarez-Durall, and R. Mulligan Dry mouth: a critical topic for older adult patients J Prosthodont Res 59 1 2015 6 19 Epub 2014 Dec 9
103. J. Saleh, M.A. Figueiredo, K. Cherubini, and F.G. Salum Salivary hypofunction: an update on aetiology, diagnosis and therapeutics Arch Oral Biol 60 2 2015 242 255 Epub 2014 Nov 4
104. N.J. Cochrane, F. Cai, N.L. Huq, M.F. Burrow, and E.C. Reynolds New approaches to enhanced remineralization of tooth enamel J Dent Res 89 11 2010 1187 1197
105. J.B. Epstein, E.H. van der Meij, R. Lunn, and P. Stevenson-Moore Effects of compliance with fluoride gel application on caries and caries risk in patients after radiation therapy for head and neck cancer Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82 3 1996 268 275
106. J.B. Epstein, E.H. van der Meij, S.M. Emerton, N.D. Le, and P. Stevenson-Moore Compliance with fluoride gel use in irradiated patients Spec Care Dentist 15 6 1995 218 222
107. M.L. Singh, and A.S. Papas Long-term clinical observation of dental caries in salivary hypofunction patients using a supersaturated calcium-phosphate remineralizing rinse J Clin Dent 20 3 2009 87 92
108. A. Papas, D. Russell, M. Singh, R. Kent, C. Triol, and A. Winston Caries clinical trial of a remineralising toothpaste in radiation patients Gerodontology 25 2 2008 76 88
109. E.C. Reynolds Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions J Dent Res 76 9 1997 1587 1595
110. M.S. Tung, and F.C. Eichmiller Amorphous calcium phosphates for tooth mineralization Compend Contin Educ Dent 25 9 Suppl 1 2004 9 13
111. A. Charig, A. Winston, and M. Flickinger Enamel mineralization by calcium-containing-bicarbonate toothpastes: assessment by various techniques Compend Contin Educ Dent 25 9 Suppl 1 2004 14 24
112. GC America Inc. About MI Paste™ & MI Paste Plus™, 2014. Access method: < http://www.mi-paste.com/about.php > [accessed 12.12.14].
113. M.V. Morgan, G.G. Adams, D.L. Bailey, C.E. Tsao, S.L. Fischman, and E.C. Reynolds The anticariogenic effect of sugar-free gum containing CPP-ACP nanocomplexes on approximal caries determined using digital bitewing radiography Caries Res 42 3 2008 171 184
114. D.L. Bailey, G.G. Adams, C.E. Tsao, A. Hyslop, K. Escobar, D.J. Manton, and et al. Regression of post-orthodontic lesions by a remineralizing cream J Dent Res 88 12 2009 1148 1153
115. M.L. Juárez-López, R.D. Hernández-Palacios, J.C. Hernández-Guerrero, D. Jiménez-Farfán, and N. Molina-Frechero Preventive and remineralization effect over incipient lesions of caries decay by phosphopeptic phosphate of calcium amorfous Rev Invest Clin 66 2 2014 144 151
116. J. Krithikadatta, C. Fredrick, M. Abarajithan, and D. Kandaswamy Remineralisation of occlusal white spot lesion with a combination of 10% CPP-ACP and 0.2% sodium fluoride evaluated using Diagnodent: a pilot study Oral Health Prev Dent 11 2 2013 191 196
117. J.X. Wang, Y. Yan, and X.J. Wang Clinical evaluation of remineralization potential of casein phosphopeptide amorphous calcium phosphate nanocomplexes for enamel decalcification in orthodontics Chin Med J (Engl) 125 22 2012 4018 4021
118. M.A. Robertson, C.H. Kau, J.D. English, R.P. Lee, J. Powers, and J.T. Nguyen MI Paste Plus to prevent demineralization in orthodontic patients: a prospective randomized controlled trial Am J Orthod Dentofacial Orthop 140 5 2011 660 668
119. R. Vashisht, R. Indira, S. Ramachandran, A. Kumar, and M.R. Srinivasan Role of casein phosphopeptide amorphous calcium phosphate in remineralization of white spot lesions and inhibition of Streptococcus mutans? J Conserv Dent 16 4 2013 342 346
120. C.P. Sim, J. Wee, Y. Xu, Y.B. Cheung, Y.L. Soong, and D.J. Manton Anti-caries effect of CPP-ACP in irradiated nasopharyngeal carcinoma patients Clin Oral Investig 2014 [Epub 2014 Sep 27]