메뉴 건너뛰기




Volumn 11, Issue 4, 2015, Pages 838-850

Immunogenicity of GX301 cancer vaccine: Four (telomerase peptides) are better than one

Author keywords

Cancer vaccines; Cytokine intracellular staining; Elispot; GX301; Immunogenicity; Telomerase

Indexed keywords

CANCER VACCINE; FLUORESCEIN ISOTHIOCYANATE; GAMMA INTERFERON; GX301 VACCINE; HLA A2 ANTIGEN; HLA ANTIGEN CLASS 1; MONOCLONAL ANTIBODY; TELOMERASE; UNCLASSIFIED DRUG; PEPTIDE;

EID: 84938952627     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.1080/21645515.2015.1012032     Document Type: Article
Times cited : (28)

References (42)
  • 1
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • PMID:1708110
    • Blackburn EH. Structure and function of telomeres. Nature 1991; 350:569-73; PMID:1708110; http://dx. doi. org/10. 1038/350569a0
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 2
    • 0028297039 scopus 로고
    • Mammalian telomere dynamics: Healing, fragmentation shortening and stabilization
    • PMID:8032197
    • Greider CW. Mammalian telomere dynamics: healing, fragmentation shortening and stabilization. Curr Opin Genet Dev 1994; 4:203-11; PMID:8032197; http:// dx. doi. org/10. 1016/S0959-437X(05)80046-2
    • (1994) Curr Opin Genet Dev , vol.4 , pp. 203-211
    • Greider, C.W.1
  • 3
    • 0032522443 scopus 로고    scopus 로고
    • The telomerase reverse transcriptase: Components and regulation
    • PMID:9553037
    • Nugent CI, Lundblad V. The telomerase reverse transcriptase: components and regulation. Genes Dev 1998; 12:1073-185; PMID:9553037; http://dx. doi. org/10. 1101/gad. 12. 8. 1073
    • (1998) Genes Dev , vol.12 , pp. 1073-1185
    • Nugent, C.I.1    Lundblad, V.2
  • 7
    • 0033945105 scopus 로고    scopus 로고
    • Telomeres, telomerase and cancer: An up-date
    • PMID:10963374
    • Dhaene K, Van Marck E, Parwaresch R. Telomeres, telomerase and cancer: an up-date. Virchows Arch 2000; 437:1-16; PMID:10963374; http://dx. doi. org/ 10. 1007/s004280000189
    • (2000) Virchows Arch , vol.437 , pp. 1-16
    • Dhaene, K.1    Van Marck, E.2    Parwaresch, R.3
  • 8
    • 0033151591 scopus 로고    scopus 로고
    • The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes
    • PMID:10403642
    • Vonderheide RH, Hahn WC, Schultze JL, Nadler LM. The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. Immunity 1999; 10:673-79; PMID:10403642; http://dx. doi. org/10. 1016/S1074- 7613(00)80066-7
    • (1999) Immunity , vol.10 , pp. 673-679
    • Vonderheide, R.H.1    Hahn, W.C.2    Schultze, J.L.3    Nadler, L.M.4
  • 9
    • 0034712848 scopus 로고    scopus 로고
    • Cytotoxic T cell immunity against telomerase reverse transcriptase in humans
    • PMID:10759561
    • Minev B, Hipp J, Firat H, Schmidt JD, Langlade- Demoyen P, Zanetti M. Cytotoxic T cell immunity against telomerase reverse transcriptase in humans. Proc Natl Acad Sci 2000; 97:4796-801; PMID:10759561; http://dx. doi. org/10. 1073/ pnas. 070560797
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 4796-4801
    • Minev, B.1    Hipp, J.2    Firat, H.3    Schmidt, J.D.4    Langlade-Demoyen, P.5    Zanetti, M.6
  • 11
    • 51349104272 scopus 로고    scopus 로고
    • Telomerase as a universal tumor antigen for cancer vaccines
    • PMID:18767939
    • Beatty GL, Vonderheide RH. Telomerase as a universal tumor antigen for cancer vaccines. Expert Rev Vaccines 2008; 7:881-87; PMID:18767939; http://dx. doi. org/ 10. 1586/14760584. 7. 7. 881
    • (2008) Expert Rev Vaccines , vol.7 , pp. 881-887
    • Beatty, G.L.1    Vonderheide, R.H.2
  • 12
    • 80455140226 scopus 로고    scopus 로고
    • Telomerase peptide vaccination in NSCLC: A phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial
    • Brunsvig PF, Kyte JA, Kersten C, Sundstrøm S, Møller M, Nyakas M, Hansen GL, Gaudernack G, Aamdal S. Telomerase peptide vaccination in NSCLC: a phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial. Clin Cancer Res 2011; 17:6847-57
    • (2011) Clin Cancer Res , vol.17 , pp. 6847-6857
    • Brunsvig, P.F.1    Kyte, J.A.2    Kersten, C.3    Sundstrøm, S.4    Møller, M.5    Nyakas, M.6    Hansen, G.L.7    Gaudernack, G.8    Aamdal, S.9
  • 14
    • 79955630363 scopus 로고    scopus 로고
    • Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients
    • PMID:21189474
    • Rittig SM, Haentschel M, Weimer KJ, Heine A, Muller MR, Brugger W, Horger MS, Maksimovic O, Stenzl A, Hoerr I, et al. Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients. Mol Ther 2011; 19:990-99; PMID:21189474; http://dx. doi. org/10. 1038/ mt. 2010. 289
    • (2011) Mol Ther , vol.19 , pp. 990-999
    • Rittig, S.M.1    Haentschel, M.2    Weimer, K.J.3    Heine, A.4    Muller, M.R.5    Brugger, W.6    Horger, M.S.7    Maksimovic, O.8    Stenzl, A.9    Hoerr, I.10
  • 16
    • 34047143340 scopus 로고    scopus 로고
    • Telomerase immunity from bench to bedside: Round one
    • PMID:17324292
    • Cortez-Gonzalez X, Zanetti M. Telomerase immunity from bench to bedside: round one. J Transl Med 2007; 5:12; PMID:17324292; http://dx. doi. org/10. 1186/ 1479-5876-5-12
    • (2007) J Transl Med , vol.5 , pp. 12
    • Cortez-Gonzalez, X.1    Zanetti, M.2
  • 18
    • 3242690518 scopus 로고    scopus 로고
    • hTERT:540-548 peptide induces peptide- reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase
    • PMID:15269141
    • Parkhurst MR, Riley JP, Igarashi T, Li Y, Robbins PF, Rosenberg SA. hTERT:540-548 peptide induces peptide- reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase. Clin Cancer Res 2004; 10:4688-98; PMID:15269141; http:// dx. doi. org/10. 1158/1078-0432. CCR-04-0325
    • (2004) Clin Cancer Res , vol.10 , pp. 4688-4698
    • Parkhurst, M.R.1    Riley, J.P.2    Igarashi, T.3    Li, Y.4    Robbins, P.F.5    Rosenberg, S.A.6
  • 19
    • 0038066552 scopus 로고    scopus 로고
    • Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNAtransfected dendritic cells
    • PMID:12727829
    • Su Z, Dannull J, Heiser A, Yancey D, Pruitt S, Madden J, Coleman D, Niedzwiecki D, Gilboa E, Vieweg J. Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNAtransfected dendritic cells. Cancer Res 2003; 63:2127- 33; PMID:12727829
    • (2003) Cancer Res , vol.63 , pp. 2127-2133
    • Su, Z.1    Dannull, J.2    Heiser, A.3    Yancey, D.4    Pruitt, S.5    Madden, J.6    Coleman, D.7    Niedzwiecki, D.8    Gilboa, E.9    Vieweg, J.10
  • 21
    • 0034812048 scopus 로고    scopus 로고
    • Lack of tumor recognition by hTERT peptide 540- 548-specific CD8(+) T cells from melanoma patients reveals inefficient antigen processing
    • PMID:11536162
    • Ayyoub M, Migliaccio M, Guillaume P, Liénard D, Cerottini JC, Romero P, Lévy F, Speiser DE, Valmori D. Lack of tumor recognition by hTERT peptide 540- 548-specific CD8(+) T cells from melanoma patients reveals inefficient antigen processing. Eur J Immunol. 2001; 31:2642-51; PMID:11536162; http://dx. doi. org/10. 1002/1521-4141(200109)31:9%3c2642::AIDIMMU2642% 3e3. 0. CO;2-6
    • (2001) Eur J Immunol. , vol.31 , pp. 2642-2651
    • Ayyoub, M.1    Migliaccio, M.2    Guillaume, P.3    Liénard, D.4    Cerottini, J.C.5    Romero, P.6    Lévy, F.7    Speiser, D.E.8    Valmori, D.9
  • 24
    • 0036569585 scopus 로고    scopus 로고
    • Identification of HLA DR7-restricted epitopes from human telomerase reverse transcriptase recognized by CD4+ T-Helper cells
    • PMID:11980655
    • Schroers R, Huang XF, Hammer J, Zhang J, Chen SY. Identification of HLA DR7-restricted epitopes from human telomerase reverse transcriptase recognized by CD4+ T-Helper cells. Cancer Res 2002; 62:2600-05; PMID:11980655
    • (2002) Cancer Res , vol.62 , pp. 2600-2605
    • Schroers, R.1    Huang, X.F.2    Hammer, J.3    Zhang, J.4    Chen, S.Y.5
  • 25
    • 0142157136 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes
    • PMID:14581345
    • Schroers R, Shen L, Rollins L, Rooney CM, Slawin K, Sonderstrup G, Huang XF, Chen SY. Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes. Clin Cancer Res 2003; 9:4743-55; PMID:14581345
    • (2003) Clin Cancer Res , vol.9 , pp. 4743-4755
    • Schroers, R.1    Shen, L.2    Rollins, L.3    Rooney, C.M.4    Slawin, K.5    Sonderstrup, G.6    Huang, X.F.7    Chen, S.Y.8
  • 26
    • 0031782910 scopus 로고    scopus 로고
    • The role of CD4+ T cell responses in antitumor immunity
    • PMID:9794842
    • Pardoll DM, Topalian SL. The role of CD4+ T cell responses in antitumor immunity. Curr Opin Immunol 1998; 10:588-94; PMID:9794842; http://dx. doi. org/ 10. 1016/S0952-7915(98)80228-8
    • (1998) Curr Opin Immunol , vol.10 , pp. 588-594
    • Pardoll, D.M.1    Topalian, S.L.2
  • 27
    • 0031690892 scopus 로고    scopus 로고
    • Expression of HLA class I antigens in transporter associated with antigen processing (TAP)-deficient mutant cell lines
    • PMID:9820600
    • Young NT, Mulder A, Cerundolo V, Claas FH, Welsh KI. Expression of HLA class I antigens in transporter associated with antigen processing (TAP)-deficient mutant cell lines. Tissue Antigens 1998; 52:368-73; PMID:9820600; http://dx. doi. org/10. 1111/j. 1399- 0039. 1998. tb03057. x
    • (1998) Tissue Antigens , vol.52 , pp. 368-373
    • Young, N.T.1    Mulder, A.2    Cerundolo, V.3    Claas, F.H.4    Welsh, K.I.5
  • 29
    • 0029041355 scopus 로고
    • Human T helper cells specific for HIV reverse transcriptase: Possible role in intrastructural help for HIV envelope-specific antibodies
    • PMID:7539750
    • Manca F, Fenoglio D, Valle MT, Li Pira G, Kunkl A, Balderas RS, Baccala RG, Kono DH, Ferraris A, Saverino D, et al. Human T helper cells specific for HIV reverse transcriptase: possible role in intrastructural help for HIV envelope-specific antibodies. Eur J Immunol 1995; 25:1217-23; PMID:7539750; http://dx. doi. org/10. 1002/eji. 1830250513
    • (1995) Eur J Immunol , vol.25 , pp. 1217-1223
    • Manca, F.1    Fenoglio, D.2    Valle, M.T.3    Li Pira, G.4    Kunkl, A.5    Balderas, R.S.6    Baccala, R.G.7    Kono, D.H.8    Ferraris, A.9    Saverino, D.10
  • 30
    • 0036839573 scopus 로고    scopus 로고
    • Clonal deletion of simian virus 40 large T antigen-specific T cells in the transgenic adenocarcinoma of mouse prostate mice: An important role for clonal deletion in shaping the repertoire of T cells specific for antigens overexpressed in solid tumors
    • PMID: 12391185
    • Zheng X, Gao JX, Zhang H, Geiger TL, Liu Y, Zheng P. Clonal deletion of simian virus 40 large T antigen-specific T cells in the transgenic adenocarcinoma of mouse prostate mice: an important role for clonal deletion in shaping the repertoire of T cells specific for antigens overexpressed in solid tumors. J Immunol 2002; 169:4761-69; PMID: 12391185; http://dx. doi. org/10. 4049/jimmunol. 169. 9. 4761
    • (2002) J Immunol , vol.169 , pp. 4761-4769
    • Zheng, X.1    Gao, J.X.2    Zhang, H.3    Geiger, T.L.4    Liu, Y.5    Zheng, P.6
  • 32
    • 0027181070 scopus 로고
    • Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles
    • PMID:8315383
    • Chicz RM, Urban RG, Gorga JC, Vignali DA, Lane WS, Strominger JL. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J Exp Med 1993; 178:27-47; PMID:8315383; http:// dx. doi. org/10. 1084/jem. 178. 1. 27
    • (1993) J Exp Med , vol.178 , pp. 27-47
    • Chicz, R.M.1    Urban, R.G.2    Gorga, J.C.3    Vignali, D.A.4    Lane, W.S.5    Strominger, J.L.6
  • 33
    • 0034979180 scopus 로고    scopus 로고
    • Self-reactive T cells and degeneracy of T cell recognition: Evolving concepts-from sequence homology to shape mimicry and TCR flexibility
    • PMID:11334484
    • Maverakis E, van den Elzen P, Sercarz EE. Self-reactive T cells and degeneracy of T cell recognition: evolving concepts-from sequence homology to shape mimicry and TCR flexibility. J Autoimmun 2001; 16:201-9; PMID:11334484; http://dx. doi. org/10. 1006/ jaut. 2000. 0493
    • (2001) J Autoimmun , vol.16 , pp. 201-209
    • Maverakis, E.1    van den Elzen, P.2    Sercarz, E.E.3
  • 34
    • 1242270587 scopus 로고    scopus 로고
    • Recognition and function in a degenerate immune system
    • PMID:15036903
    • Sercarz EE, Maverakis E. Recognition and function in a degenerate immune system. Mol Immunol 2004; 40:1003-8; PMID:15036903; http://dx. doi. org/ 10. 1016/j. molimm. 2003. 11. 002
    • (2004) Mol Immunol , vol.40 , pp. 1003-1008
    • Sercarz, E.E.1    Maverakis, E.2
  • 35
    • 84872263479 scopus 로고    scopus 로고
    • Next-generation peptide vaccines for advanced cancer
    • PMID:23107418
    • Yamada A, Sasada T, Noguchi M, Itoh K. Next-generation peptide vaccines for advanced cancer. Cancer Sci 2013; 104:15-21; PMID:23107418; http://dx. doi. org/ 10. 1111/cas. 12050
    • (2013) Cancer Sci , vol.104 , pp. 15-21
    • Yamada, A.1    Sasada, T.2    Noguchi, M.3    Itoh, K.4
  • 36
    • 33646236935 scopus 로고    scopus 로고
    • Immune monitoring of T-cell responses in cancer vaccine development
    • PMID:16609057
    • Keilholz U, Martus P, Scheibenbogen C. Immune monitoring of T-cell responses in cancer vaccine development. Clin Cancer Res 2006; 12:2346s-52s; PMID:16609057; http://dx. doi. org/10. 1158/1078- 0432. CCR-05-2540
    • (2006) Clin Cancer Res , vol.12 , pp. 2346s-2352s
    • Keilholz, U.1    Martus, P.2    Scheibenbogen, C.3
  • 37
    • 0018652557 scopus 로고
    • Monoclonal antibodies for analysis of the HLA system
    • PMID:95015
    • Brodsky FM, Parham P, Barnstable CJ, Crumpton MJ, Bodmer WF. Monoclonal antibodies for analysis of the HLA system. Immunol Rev 1979; 47:3-61; PMID:95015; http://dx. doi. org/10. 1111/j. 1600- 065X. 1979. tb00288. x
    • (1979) Immunol Rev , vol.47 , pp. 3-61
    • Brodsky, F.M.1    Parham, P.2    Barnstable, C.J.3    Crumpton, M.J.4    Bodmer, W.F.5
  • 38
    • 37349020262 scopus 로고    scopus 로고
    • Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI)
    • PMID:17721781
    • Janetzki S, Panageas KS, Ben-Porat L, Boyer J, Britten CM, Clay TM, Kalos M, Maecker HT, Romero P, Yuan J, et al. Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI). Cancer Immunol Immunother 2008; 57:303-15; PMID:17721781; http://dx. doi. org/ 10. 1007/s00262-007-0380-6
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 303-315
    • Janetzki, S.1    Panageas, K.S.2    Ben-Porat, L.3    Boyer, J.4    Britten, C.M.5    Clay, T.M.6    Kalos, M.7    Maecker, H.T.8    Romero, P.9    Yuan, J.10
  • 39
    • 84890046091 scopus 로고    scopus 로고
    • Enumeration and characterization of human memory T cells by enzyme-linked immunospot assays
    • PMID:24319467
    • Calarota S A, Baldanti F. Enumeration and characterization of human memory T cells by enzyme-linked immunospot assays. Clin Dev Immunol 2013; 2013:637649; PMID:24319467; http://dx. doi. org/ 10. 1155/2013/637649
    • (2013) Clin Dev Immunol , vol.2013
    • Calarota, S.A.1    Baldanti, F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.