Cost-effectiveness of Interferon-free therapy for Hepatitis C in Germany - an application of the efficiency frontier approach

BMC Infectious Diseases

Volumn 15, Issue 1, 2015, Pages

  Gissel, Christian ^a   Götz, Georg ^a   Mahlich, Jörg ^b,c   Repp, Holger ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b Janssen Pharmaceutical KK   (Japan)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Cost effectiveness; Efficiency frontier; Germany; Hepatitis C; Interferon free therapy; Simeprevir; Sofosbuvir

Indexed keywords

BOCEPREVIR; PEGINTERFERON; RIBAVIRIN; SIMEPREVIR; SOFOSBUVIR; ALPHA INTERFERON; ANTIVIRUS AGENT; N-(3-AMINO-1-(CYCLOBUTYLMETHYL)-2,3-DIOXOPROPYL)-3-(2-((((1,1-DIMETHYLETHYL)AMINO)CARBONYL)AMINO)-3,3-DIMETHYL-1-OXOBUTYL)-6,6-DIMETHYL-3-AZABICYCLO(3.1.0)HEXAN-2-CARBOXAMIDE; PROLINE;

ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; COST BENEFIT ANALYSIS; COST CONTROL; COST EFFECTIVENESS ANALYSIS; DISEASE COURSE; DRUG COST; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; GERMANY; HEPATITIS C; HUMAN; NONHUMAN; SENSITIVITY ANALYSIS; ANALOGS AND DERIVATIVES; CHRONIC HEPATITIS C; COMBINATION DRUG THERAPY; DISEASE EXACERBATION; ECONOMICS; FEMALE; GENETICS; GENOTYPE; HEPACIVIRUS; LIVER CIRRHOSIS; MALE; TREATMENT OUTCOME;

ANTIVIRAL AGENTS; COST-BENEFIT ANALYSIS; DISEASE PROGRESSION; DRUG COSTS; DRUG THERAPY, COMBINATION; FEMALE; GENOTYPE; GERMANY; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; LIVER CIRRHOSIS; MALE; PROLINE; RIBAVIRIN; SIMEPREVIR; SOFOSBUVIR; TREATMENT OUTCOME;

EID: 84938936013     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/s12879-015-1048-z     Document Type: Article

References (36)

1. Razavi H, Waked I, Sarrazin C, Myers RP, Idilman R, Calinas F, et al. The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm. J Viral Hepat. 2014;21 Suppl 1:34-59.
2. Cornberg M, Razavi HA, Alberti A, Bernasconi E, Buti M, Cooper C, et al. A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel. Liver Int. 2011;31 Suppl 2:30-60.
3. Deuffic-Burban S, Schwarzinger M, Obach D, Mallet V, Pol S, Pageaux GP, et al. Should we await IFN-free regimens to treat HCV genotype 1 treatment-naive patients? A cost-effectiveness analysis (ANRS 95141). J Hepatol. 2014;61:7-14.
4. Reau NS, Jensen DM. Sticker shock and the price of new therapies for hepatitis C: Is it worth it? Hepatology. 2014;59:1246-9.
5. Huckans M, Fuller B, Wheaton V, Jaehnert S, Ellis C, Kolessar M, et al. A longitudinal study evaluating the effects of interferon-alpha therapy on cognitive and psychiatric function in adults with chronic hepatitis C. J Psychosom Res. 2015;78:184-92.
6. Sarrazin C, Berg T, Buggisch P, Dollinger M, Hinrichsen H, Hüppe D, et al. Aktuelle Empfehlung der DGVS und des bng zur Therapie der chronischen Hepatitis C. 09.06.2014. German Society for Gastroenterology, Digestive and Metabolic Diseases. 2014. http://www.dgvs.de/fileadmin/user_upload/Leitlinien/Empfehlung-Therapie-HepatitisC-DGVS-bng-09.06.2014.pdf. Accessed 16 Mar 2015.
7. Schwabe U, Paffrath D. Arzneiverordnungs-Report 2014: Aktuelle Daten, Kosten, Trends und Kommentare. Berlin: Springer; 2014.
8. Gerber A, Stock S, Dintsios CM. Reflections on the changing face of German pharmaceutical policy: how far is Germany from value-based pricing? Pharmacoeconomics. 2011;29:549-53.
9. Henschke C, Sundmacher L, Busse R. Structural changes in the German pharmaceutical market: price setting mechanisms based on the early benefit evaluation. Health Policy. 2013;109:263-9.
10. Ruof J, Schwartz FW, Schulenburg JM, Dintsios CM. Early benefit assessment (EBA) in Germany: analysing decisions 18 months after introducing the new AMNOG legislation. Eur J Health Econ. 2014;15:577-89.
11. Ivandic V. Requirements for benefit assessment in Germany and England - overview and comparison. Health Econ Rev. 2014;4:12.
12. Institute for Quality and Efficiency in Health Care. General methods for the assessment of the relation of benefits to costs. Version 1.0. 2009. https://www.iqwig.de/download/General_Methods_for_the_Assessment_of_the_Relation_of_Benefits_to_Costs.pdf. Accessed 16 Mar 2015.
13. Caro JJ, Nord E, Siebert U, McGuire A, McGregor M, Henry D, et al. The efficiency frontier approach to economic evaluation of health-care interventions. Health Econ. 2010;19:1117-27.
14. Sculpher M, Claxton K. Sins of omission and obfuscation: IQWIG's guidelines on economic evaluation methods. Health Econ. 2010;19:1132-6.
15. Brouwer WB, Rutten FF. The efficiency frontier approach to economic evaluation: will it help German policy making? Health Econ. 2010;19:1128-31.
16. Danner M, Hummel JM, Volz F, van Manen JG, Wiegard B, Dintsios CM, et al. Integrating patients' views into health technology assessment: Analytic hierarchy process (AHP) as a method to elicit patient preferences. Int J Technol Assess Health Care. 2011;4:369-75.
17. Institute for Quality and Efficiency in Health Care. Choice-based Conjoint Analysis - pilot project to identify, weight, and prioritize multiple attributes in the indication "hepatitis C". Version 1.1. 2014. https://www.iqwig.de/download/GA10-03_Executive-summary-of-working-paper-1.1_Conjoint-Analysis.pdf. Accessed 16 Mar 2015.
18. Institute for Quality and Efficiency in Health Care. Analytic Hierarchy Process (AHP) - pilot project to elicit patient preferences in the indication "depression". Version 1.0. 2013. https://www.iqwig.de/download/Executive-summary-of-working-paper_Analytic-Hierarchy-Process-pilot-project.pdf. Accessed 16 Mar 2015.
19. Westerhout K, Treur M, Mehnert A, Pascoe K, Ladha I, Belsey J. Cost utility analysis of simeprevir used with peginterferon + ribavirin (SMV/PR) in the management of genotype 1 (G1) and 4 (G4) hepatitis C virus (HCV) infection; from the perspective of the UK National Health Service (NHS). Value Health. 2014;17:A679.
20. Kuwabara H, Westerhout K, Treur M, Cerri K, Mahlich J, Yatsuhashi H. Cost-effectiveness analysis of simeprevir in combination with peginterferon and ribavirin for treatment-naïve chronic hepatitis C genotype 1 patients in Japan. J Med Econ. 2015;12:1-36.
21. Hartwell D, Jones J, Baxter L, Shepherd J. Peginterferon alfa and ribavirin for chronic hepatitis C in patients eligible for shortened treatment, re-treatment or in HCV/HIV co-infection: a systematic review and economic evaluation. Health Technol Assess. 2011;15:1-210.
22. Shepherd J, Jones J, Hartwell D, Davidson P, Price A, Waugh N. Interferon alpha (pegylated and non-pegylated) and ribavirin for the treatment of mild chronic hepatitis C: a systematic review and economic evaluation. Health Technol Assess. 2007;11:1-205.
23. Lawitz E, Sulkowski MS, Ghalib R, Rodriguez-Torres M, Younossi ZM, Corregidor A, et al. Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study. Lancet. 2014;384:1756-65.
24. Lalezari JP, Nelson DR, Hyland RH, Lin M, Rossi SJ, Symonds WT, et al. Once Daily Sofosbuvir Plus Ribavirin for 12 and 24 Weeks in Treatment-Naive Patients with HCV Infection: the QUANTUM Study. J Hepatol. 2013;58:S346.
25. Stahmeyer JT, Schauer S, Rossol S, Wedemeyer HH, Wirth D, Bianic F, et al. Cost-effectiveness of Triple Therapy with Telaprevir for Chronic Hepatitis C Virus Patients in Germany. J Health Econ Outcomes Res. 2013;1:239-53.
26. Wasem J, Sroczynski G, Aidelsburger P, Buchberger B, Hessel F, Conrads-Frank A, et al. Health economics of chronic infectious diseases: the example of hepatitis C. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2006;49:57-63.
27. Siebert U, Sroczynski G, German Hepatitis C Model (GEHMO) Group, HTA Expert Panel on Hepatitis C. Antiviral. combination therapy with interferon/peginterferon plus ribavirin for patients with chronic hepatitis C in Germany: a health technology assessment commissioned by the German Agency for Health Technology Assessment. German Med Sci. 2003;1:Doc07, 1-18.
28. Siebert U, Sroczynski G, Aidelsburger P, Rossol S, Wasem J, Manns MP, et al. Clinical effectiveness and cost effectiveness of tailoring chronic hepatitis C treatment with peginterferon alpha-2b plus ribavirin to HCV genotype and early viral response: a decision analysis based on German guidelines. Pharmacoeconomics. 2009;27:341-54.
29. Stahmeyer JT, Rossol S, Bert F, Antoni C, Demir M, Hinrichsen H, et al. Cost of treating hepatitis C in Germany: a retrospective multicenter analysis. Eur J Gastroenterol Hepatol. 2014;26:1278-85.
30. Younossi ZM, Singer ME, Mir HM, Henry L, Hunt S. Impact of interferon free regimens on clinical and cost outcomes for chronic hepatitis C genotype 1 patients. J Hepatol. 2014;60:530-7.
31. Hagan LM, Sulkowski MS, Schinazi RF. Cost analysis of sofosbuvir/ribavirin versus sofosbuvir/simeprevir for genotype 1 hepatitis C virus in interferon-ineligible/intolerant individuals. Hepatology. 2014;60:37-45.
32. Wright M, Grieve R, Roberts J, Main J, Thomas HC. Health benefits of antiviral therapy for mild chronic hepatitis C: randomised controlled trial and economic evaluation. Health Technol Assess. 2006;10:1-113.
33. Fattovich G, Giustina G, Degos F, Tremolada F, Diodati G, Almasio P, et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology. 1997;112:463-72.
34. Cardoso AC, Moucari R, Figueiredo-Mendes C, Ripault MP, Giuily N, Castelnau C, et al. Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: incidence and survival in hepatitis C patients with advanced fibrosis. J Hepatol. 2010;52:652-7.
35. Siebert U, Sroczynski G, Rossol S, Wasem J, Ravens-Sieberer U, Kurth BM, et al. Cost effectiveness of peginterferon alpha-2b plus ribavirin versus interferon alpha-2b plus ribavirin for initial treatment of chronic hepatitis C. Gut. 2003;52:425-32.
36. Clinical Effectiveness Unit Royal College of Surgeons of England. UK & Ireland liver transplant audit, 2003. London: Royal College of Surgeans; 2003.