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Volumn 6, Issue JUL, 2015, Pages

The use of phage FCL-2 as an alternative to chemotherapy against columnaris disease in aquaculture

Author keywords

Aquaculture; Disease; Fish; Flavobacterium columnare; Phage therapy

Indexed keywords

BACTERIAL PROTEIN; DNA METHYLTRANSFERASE; PROTEINASE; SINGLE STRANDED DNA BINDING PROTEIN; TOBRAMYCIN;

EID: 84938923733     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2015.00829     Document Type: Article
Times cited : (62)

References (48)
  • 2
    • 0004078614 scopus 로고
    • Interscience Publishers, Inc., New York, N.Y
    • Adams, M.H. (1959). Bacteriophages. Interscience Publishers, Inc., New York, N.Y.
    • (1959) Bacteriophages
    • Adams, M.H.1
  • 4
    • 0031804082 scopus 로고    scopus 로고
    • Use of lytic bacteriophage for control of experimental Escherichia coli septicemia and meningitis in chickens and calves
    • Barrow, P., Lovell, M., and Berchieri, A., Jr (1998). Use of lytic bacteriophage for control of experimental Escherichia coli septicemia and meningitis in chickens and calves. Clin. Diagn. Lab. Immunol. 5, 294-298.
    • (1998) Clin. Diagn. Lab. Immunol , vol.5 , pp. 294-298
    • Barrow, P.1    Lovell, M.2    Berchieri, A.3
  • 5
    • 0025823162 scopus 로고
    • The activity in the chicken alimentary tract of bacteriophages lytic for Salmonella typhimurium
    • Berchieri, A., Jr, Lovell, M. A., and Barrow, P. A. (1991). The activity in the chicken alimentary tract of bacteriophages lytic for Salmonella typhimurium. Res. Microbiol. 142, 541-549. doi:10.1016/0923-2508(91)90187-F.
    • (1991) Res. Microbiol , vol.142 , pp. 541-549
    • Berchieri, A.1    Lovell, M.A.2    Barrow, P.A.3
  • 6
    • 0030634820 scopus 로고    scopus 로고
    • Immunization with bacterial antigens: Flavobacterium and Flexibacter infections
    • Bernardet, J. F. (1997). Immunization with bacterial antigens: Flavobacterium and Flexibacter infections. Dev. Biol. Stand. 90, 179-188.
    • (1997) Dev. Biol. Stand , vol.90 , pp. 179-188
    • Bernardet, J.F.1
  • 9
    • 84880042496 scopus 로고    scopus 로고
    • Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health
    • Cabello, F. C., Godfrey, H. P., Tomova, A., Ivanova, L., Dölz, H., Millanao, A., and Buschmann, A. H. (2013). Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health. Environ. Microbiol. 15, 1917-1942. doi:10.1111/1462-2920.12134.
    • (2013) Environ. Microbiol , vol.15 , pp. 1917-1942
    • Cabello, F.C.1    Godfrey, H.P.2    Tomova, A.3    Ivanova, L.4    Dölz, H.5    Millanao, A.6    Buschmann, A.H.7
  • 10
    • 0033256572 scopus 로고    scopus 로고
    • Phage therapy: past history and future prospect
    • 47, 267-274
    • Carlton, R. M. (1999). Phage therapy: past history and future prospects. 47, 267-274. Arch. Immunol. Ther. Exp. 47, 267-274.
    • (1999) Arch. Immunol. Ther. Exp , vol.47 , pp. 267-274
    • Carlton, R.M.1
  • 11
    • 84893769951 scopus 로고    scopus 로고
    • Genomic structure of bacteriophage 6H and its distribution as prophage in Flavobacterium psychrophilum strains
    • Castillo, D., Espejo, R., and Middelboe, M. (2013). Genomic structure of bacteriophage 6H and its distribution as prophage in Flavobacterium psychrophilum strains. FEMS Microbiol. Lett. 351, 51-58. doi:10.1111/1574-6968.12342.
    • (2013) FEMS Microbiol. Lett , vol.351 , pp. 51-58
    • Castillo, D.1    Espejo, R.2    Middelboe, M.3
  • 12
    • 84856981130 scopus 로고    scopus 로고
    • Diversity of Flavobacterium psychrophilum and the potential use of its phages for protection against bacterial cold water disease in salmonids
    • Castillo, D., Higuera, G., Villa, M., Middelboe, M., Dalsgaard, I., Madsen, L., and Espejo, R. T. (2012). Diversity of Flavobacterium psychrophilum and the potential use of its phages for protection against bacterial cold water disease in salmonids. J. Fish Dis. 35, 193-201. doi:10.1111/j.1365-2761.2011.01336.x.
    • (2012) J. Fish Dis , vol.35 , pp. 193-201
    • Castillo, D.1    Higuera, G.2    Villa, M.3    Middelboe, M.4    Dalsgaard, I.5    Madsen, L.6    Espejo, R.T.7
  • 13
    • 84876677026 scopus 로고    scopus 로고
    • Columnaris disease in fish: a review with emphasis on bacterium-host interactions
    • 44:27
    • Declercq, A. M., Haesebrouck, F., Van den Broeck, W., Bossier, P., and Decostere, A. (2013). Columnaris disease in fish: a review with emphasis on bacterium-host interactions. 44:27. Vet. Res. 44, 27. doi:10.1186/1297-9716-44-27.
    • (2013) Vet. Res , vol.44 , pp. 27
    • Declercq, A.M.1    Haesebrouck, F.2    Van den Broeck, W.3    Bossier, P.4    Decostere, A.5
  • 14
    • 0031059942 scopus 로고    scopus 로고
    • Shieh medium supplemented with tobramycin for selective isolation of Flavobacterium columnare (Flexibacter columnaris) from diseased fish
    • Decostere, A., Haesebrouck, F., and Devriese, L. A. (1997). Shieh medium supplemented with tobramycin for selective isolation of Flavobacterium columnare (Flexibacter columnaris) from diseased fish. J. Clin. Microbiol. 35, 322-324.
    • (1997) J. Clin. Microbiol , vol.35 , pp. 322-324
    • Decostere, A.1    Haesebrouck, F.2    Devriese, L.A.3
  • 15
    • 84876839596 scopus 로고    scopus 로고
    • Aquaculture can promote the presence and spread of antibiotic-resistant Enterococci in marine sediments
    • Di Cesare, A., Luna, G. M., Vignaroli, C., Pasquaroli, S., Tota, S., Paroncini, P., and Biavasco, F. (2013). Aquaculture can promote the presence and spread of antibiotic-resistant Enterococci in marine sediments. PLoS ONE 8, e62838. doi:10.1371/journal.pone.0062838.
    • (2013) PLoS ONE , vol.8
    • Di Cesare, A.1    Luna, G.M.2    Vignaroli, C.3    Pasquaroli, S.4    Tota, S.5    Paroncini, P.6    Biavasco, F.7
  • 16
    • 77950112266 scopus 로고    scopus 로고
    • Phage choice, isolation, and preparation for phage therapy
    • Gill, J. J., and Hyman, P. (2010). Phage choice, isolation, and preparation for phage therapy. Curr. Pharm. Biotechnol. 11, 2-14.
    • (2010) Curr. Pharm. Biotechnol , vol.11 , pp. 2-14
    • Gill, J.J.1    Hyman, P.2
  • 17
    • 84874940969 scopus 로고    scopus 로고
    • Recently discovered Vibrio anguillarum phages can protect against experimentally induced vibriosis in Atlantic salmon, Salmo salar
    • Higuera, G., Bastías, R., Tsertsvadze, G., Romero, J., and Espejo, R. T. (2013). Recently discovered Vibrio anguillarum phages can protect against experimentally induced vibriosis in Atlantic salmon, Salmo salar. Aquaculture 392-395, 128-133. doi:10.1016/j.aquaculture.2013.02.013.
    • (2013) Aquaculture , vol.392-395 , pp. 128-133
    • Higuera, G.1    Bastías, R.2    Tsertsvadze, G.3    Romero, J.4    Espejo, R.T.5
  • 18
    • 84890899357 scopus 로고    scopus 로고
    • Preserving antibiotics, rationally
    • Hollis, A., and Ahmed, Z. (2013). Preserving antibiotics, rationally. New Engl. J. Med. 369, 2474-2476. doi:10.1056/NEJMp1311479.
    • (2013) New Engl. J. Med , vol.369 , pp. 2474-2476
    • Hollis, A.1    Ahmed, Z.2
  • 19
    • 35948993040 scopus 로고    scopus 로고
    • Large variabilities in host strain susceptibility and phage host range govern interactions between lytic marine phages and their Flavobacterium hosts
    • Holmfeldt, K., Middelboe, M., Nybroe, O., and Riemann, L. (2007). Large variabilities in host strain susceptibility and phage host range govern interactions between lytic marine phages and their Flavobacterium hosts. Appl. Environ. Mi crobiol. 73, 6730-6739. doi:10.1128/AEM.01399-07.
    • (2007) Appl. Environ. Mi crobiol , vol.73 , pp. 6730-6739
    • Holmfeldt, K.1    Middelboe, M.2    Nybroe, O.3    Riemann, L.4
  • 20
    • 84874530236 scopus 로고    scopus 로고
    • The Pacific Ocean Virome (POV): a marine viral metagenomic dataset and associated protein clusters for quantitative viral ecology
    • Hurwitz, B. L., and Sullivan, M. B. (2013). The Pacific Ocean Virome (POV): a marine viral metagenomic dataset and associated protein clusters for quantitative viral ecology. PLoS ONE 8, e57355. doi:10.1371/journal.pone.0057355.
    • (2013) PLoS ONE , vol.8
    • Hurwitz, B.L.1    Sullivan, M.B.2
  • 21
    • 62749126646 scopus 로고    scopus 로고
    • Evaluation of bacteriophages for prevention and treatment of diarrhea due to experimental enterotoxigenic Escherichia coli O149 infection of pigs
    • Jamalludeen, N., Johnson, R. P., Shewen, P. E., and Gyles, C. L. (2009). Evaluation of bacteriophages for prevention and treatment of diarrhea due to experimental enterotoxigenic Escherichia coli O149 infection of pigs. Vet. Microbiol. 136, 135-141. doi:10.1016/j.vetmic.2008.10.021.
    • (2009) Vet. Microbiol , vol.136 , pp. 135-141
    • Jamalludeen, N.1    Johnson, R.P.2    Shewen, P.E.3    Gyles, C.L.4
  • 23
    • 84890905184 scopus 로고    scopus 로고
    • Novel bacteriophage therapy for controlling metallo-beta-lactamase producing Pseudomonas aeruginosa infection in catfish
    • Khairnar, K., Raut, M. P., Chandekar, R. H., Sanmukh, S. G., and Paunikar, W. N. (2013). Novel bacteriophage therapy for controlling metallo-beta-lactamase producing Pseudomonas aeruginosa infection in catfish. BMC Vet. Res. 9, 264. doi:10.1186/1746-6148-9-264.
    • (2013) BMC Vet. Res , vol.9 , pp. 264
    • Khairnar, K.1    Raut, M.P.2    Chandekar, R.H.3    Sanmukh, S.G.4    Paunikar, W.N.5
  • 24
    • 84920286959 scopus 로고    scopus 로고
    • Biological control of Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) using aeromonas phage PAS-1
    • Kim, J. H., Choresca, C. H., Shin, S. P., Han, J. E., Jun, J. W., and Park, S. C. (2015). Biological control of Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) using aeromonas phage PAS-1. Transbound Emerg. Dis. 62, 81-86. doi:10.1111/tbed.12088.
    • (2015) Transbound Emerg. Dis , vol.62 , pp. 81-86
    • Kim, J.H.1    Choresca, C.H.2    Shin, S.P.3    Han, J.E.4    Jun, J.W.5    Park, S.C.6
  • 25
    • 84927693101 scopus 로고    scopus 로고
    • Bacteria-phage coevolution as a driver of ecological and evolutionary processes in microbial communities
    • Koskella, B., and Brockhurst, M. A. (2014). Bacteria-phage coevolution as a driver of ecological and evolutionary processes in microbial communities. FEMS Microbiol. Rev. 38, 916-931. doi:10.1111/1574-6976.12072.
    • (2014) FEMS Microbiol. Rev , vol.38 , pp. 916-931
    • Koskella, B.1    Brockhurst, M.A.2
  • 26
    • 84864016762 scopus 로고    scopus 로고
    • Environment may be the source of Flavobacterium columnare outbreaks at fish farms
    • Kunttu, H. M. T., Sundberg, L.-R., Pulkkinen, K., and Valtonen, E. T. (2012). Environment may be the source of Flavobacterium columnare outbreaks at fish farms. Environ. Microbiol. Rep. 4, 398-402. doi:10.1111/j.1758-2229.2012.00342.x.
    • (2012) Environ. Microbiol. Rep , vol.4 , pp. 398-402
    • Kunttu, H.M.T.1    Sundberg, L.-R.2    Pulkkinen, K.3    Valtonen, E.T.4
  • 27
    • 67649380353 scopus 로고    scopus 로고
    • Saprophytism of a fish pathogen as a transmission strategy
    • Kunttu, H. M. T., Valtonen, E. T., Jokinen, E. I., and Suomalainen, L.-R. (2009). Saprophytism of a fish pathogen as a transmission strategy. Epidemics 1, 96-100. doi:10.1016/j.epidem.2009.04.003.
    • (2009) Epidemics , vol.1 , pp. 96-100
    • Kunttu, H.M.T.1    Valtonen, E.T.2    Jokinen, E.I.3    Suomalainen, L.-R.4
  • 28
    • 84871769684 scopus 로고    scopus 로고
    • Phage-driven loss of virulence in a fish pathogenic bacterium
    • Laanto, E., Bamford, J. K. H., Laakso, J., and Sundberg, L.-R. (2012). Phage-driven loss of virulence in a fish pathogenic bacterium. PLoS ONE 7, e53157. doi:10.1371/journal.pone.0053157.
    • (2012) PLoS ONE , vol.7
    • Laanto, E.1    Bamford, J.K.H.2    Laakso, J.3    Sundberg, L.-R.4
  • 29
    • 83155161223 scopus 로고    scopus 로고
    • Phage specificity of the freshwater fish pathogen Flavobacterium columnare
    • Laanto, E., Sundberg, L.-R., and Bamford, J. K. H. (2011). Phage specificity of the freshwater fish pathogen Flavobacterium columnare. Appl. Environ. Microbiol. 77, 7868-7872. doi:10.1128/AEM.05574-11.
    • (2011) Appl. Environ. Microbiol , vol.77 , pp. 7868-7872
    • Laanto, E.1    Sundberg, L.-R.2    Bamford, J.K.H.3
  • 30
    • 1842455969 scopus 로고    scopus 로고
    • Population and evolutionary dynamics of phage therapy
    • Levin, B. R., and Bull, J. J. (2004). Population and evolutionary dynamics of phage therapy. Nature Rev. Microbiol. 2, 166-173. doi:10.1038/nrmicro822.
    • (2004) Nature Rev. Microbiol , vol.2 , pp. 166-173
    • Levin, B.R.1    Bull, J.J.2
  • 31
    • 0036156073 scopus 로고    scopus 로고
    • Bacteriophage therapy of infectious diseases in aquaculture
    • Nakai, T., and Park, S. C. (2002). Bacteriophage therapy of infectious diseases in aquaculture. Res. Microbiol.153, 13-18.
    • (2002) Res. Microbiol , vol.153 , pp. 13-18
    • Nakai, T.1    Park, S.C.2
  • 32
    • 84896305356 scopus 로고    scopus 로고
    • Phage therapy: Should bacterial resistance to phages be a concern, even in the long run?
    • Örmälä, A.-M., and Jalasvuori, M. (2013). Phage therapy: Should bacterial resistance to phages be a concern, even in the long run? Bacteriophage 3, e24219. doi:10.4161/bact.24219.
    • (2013) Bacteriophage , vol.3
    • Örmälä, A.-M.1    Jalasvuori, M.2
  • 33
    • 0037460403 scopus 로고    scopus 로고
    • Bacteriophage control of Pseudomonas plecoglossicida infection in ayu Plecoglossus altivelis
    • Park, S. C., and Nakai, T. (2003). Bacteriophage control of Pseudomonas plecoglossicida infection in ayu Plecoglossus altivelis. Dis. Aquat. Org. 53, 33-39.
    • (2003) Dis. Aquat. Org , vol.53 , pp. 33-39
    • Park, S.C.1    Nakai, T.2
  • 34
    • 84864869422 scopus 로고    scopus 로고
    • Isolation and efficacy evaluation of virulent bacteriophages specific to fish pathogenic bacterium, Flavobacterium columnare
    • Prasad, Y., and Kumar, A. D. (2012). Isolation and efficacy evaluation of virulent bacteriophages specific to fish pathogenic bacterium, Flavobacterium columnare. J. Appl. Anim. Res. 38, 169-172. doi:10.1080/09712119.2010.10539505.
    • (2012) J. Appl. Anim. Res , vol.38 , pp. 169-172
    • Prasad, Y.1    Kumar, A.D.2
  • 35
    • 76249124758 scopus 로고    scopus 로고
    • Intensive fish farming and the evolution of pathogen virulence: the case of columnaris disease in Finland
    • Pulkkinen, K., Suomalainen, L.-R., Read, A. F., Ebert, D., Rintamäki, P., and Valtonen, E. T. (2010). Intensive fish farming and the evolution of pathogen virulence: the case of columnaris disease in Finland. Proc. Biol. Sci. 277, 593-600. doi:10.1098/rspb.2009.1659.
    • (2010) Proc. Biol. Sci , vol.277 , pp. 593-600
    • Pulkkinen, K.1    Suomalainen, L.-R.2    Read, A.F.3    Ebert, D.4    Rintamäki, P.5    Valtonen, E.T.6
  • 36
    • 84884286187 scopus 로고    scopus 로고
    • Revenge of the phages: defeating bacterial defences
    • Samson, J. E., Magadán, A. H., Sabri, M., and Moineau, S. (2013). Revenge of the phages: defeating bacterial defences. Nature Rev. Microbiol. 11, 675-687. doi:10.1038/nrmicro3096.
    • (2013) Nature Rev. Microbiol , vol.11 , pp. 675-687
    • Samson, J.E.1    Magadán, A.H.2    Sabri, M.3    Moineau, S.4
  • 37
    • 0034066697 scopus 로고    scopus 로고
    • Four different genes responsible for nonimmune immunoglobulin-binding activities within a single strain of Escherichia coli
    • Sandt, C. H., and Hill, C. W. (2000). Four different genes responsible for nonimmune immunoglobulin-binding activities within a single strain of Escherichia coli. Infect. Immun. 68, 2205-2214. doi:10.1128/IAI.68.4.2205-2214.2000.
    • (2000) Infect. Immun , vol.68 , pp. 2205-2214
    • Sandt, C.H.1    Hill, C.W.2
  • 38
    • 0026045287 scopus 로고
    • An improved method for the small scale preparation of bacteriophage DNA based on phage precipitation by zinc chloride
    • Santos, M. A. (1991). An improved method for the small scale preparation of bacteriophage DNA based on phage precipitation by zinc chloride. Nucl. Acids Res. 19, 5442-5442. doi:10.1093/nar/19.19.5442.
    • (1991) Nucl. Acids Res , vol.19 , pp. 5442-5442
    • Santos, M.A.1
  • 39
    • 77749320333 scopus 로고    scopus 로고
    • Susceptibility of Escherichia coli isolated from uteri of postpartum dairy cows to antibiotic and environmental bacteriophages. Part II: In vitro antimicrobial activity evaluation of a bacteriophage cocktail and several antibiotics
    • Santos, T. M. A., Gilbert, R. O., Caixeta, L. S., Machado, V. S., Teixeira, L. M., and Bicalho, R. C. (2010). Susceptibility of Escherichia coli isolated from uteri of postpartum dairy cows to antibiotic and environmental bacteriophages. Part II: In vitro antimicrobial activity evaluation of a bacteriophage cocktail and several antibiotics. J. Dairy Sci. 93, 105-114. doi:10.3168/jds.2009-2299.
    • (2010) J. Dairy Sci , vol.93 , pp. 105-114
    • Santos, T.M.A.1    Gilbert, R.O.2    Caixeta, L.S.3    Machado, V.S.4    Teixeira, L.M.5    Bicalho, R.C.6
  • 40
    • 84899704528 scopus 로고    scopus 로고
    • Exploring the risks of phage application in the environment
    • Meaden, S., and Koskella, B. (2013). Exploring the risks of phage application in the environment. Front. Microbiol. 4, 358. doi:10.3389/fmicb.2013.00358.
    • (2013) Front. Microbiol , vol.4 , pp. 358
    • Meaden, S.1    Koskella, B.2
  • 41
    • 0020956015 scopus 로고
    • Effectiveness of phages in treating experimental Escherichia coli diarrhoea in calves, piglets and lambs
    • Smith, H. W., and Huggins, M. B. (1983). Effectiveness of phages in treating experimental Escherichia coli diarrhoea in calves, piglets and lambs. Microbiology (Reading, Engl.) 129, 2659-2675. doi:10.1099/00221287-129-8-2659.
    • (1983) Microbiology (Reading, Engl.) , vol.129 , pp. 2659-2675
    • Smith, H.W.1    Huggins, M.B.2
  • 42
    • 46949095754 scopus 로고    scopus 로고
    • Isolation and characterization of bacteriophages infecting the fish pathogen Flavobacterium psychrophilum
    • Stenholm, A. R., Dalsgaard, I., and Middelboe, M. (2008). Isolation and characterization of bacteriophages infecting the fish pathogen Flavobacterium psychrophilum. Appl. Environ. Microbiol. 74, 4070-4078. doi:10.1128/AEM.00428-08.
    • (2008) Appl. Environ. Microbiol , vol.74 , pp. 4070-4078
    • Stenholm, A.R.1    Dalsgaard, I.2    Middelboe, M.3
  • 43
    • 33746082120 scopus 로고    scopus 로고
    • Molecular diversity and growth features of Flavobacterium columnare strains isolated in Finland
    • Suomalainen, L.-R., Kunttu, H., Valtonen, E. T., Hirvelä-Koski, V., and Tiirola, M. (2006). Molecular diversity and growth features of Flavobacterium columnare strains isolated in Finland. Dis. Aquat. Org. 70, 55-61. doi:10.3354/dao070055.
    • (2006) Dis. Aquat. Org , vol.70 , pp. 55-61
    • Suomalainen, L.-R.1    Kunttu, H.2    Valtonen, E.T.3    Hirvelä-Koski, V.4    Tiirola, M.5
  • 44
    • 0033597533 scopus 로고    scopus 로고
    • Protective effects of bacteriophage on experimental Lactococcus garvieae infection in yellowtail
    • Nakai, T., Suqimoto, R., Park, K.H., Matsuoka, S., Mori, K., Nishioka, T., and Maruyama, K. (1999). Protective effects of bacteriophage on experimental Lactococcus garvieae infection in yellowtail. Dis. Aquat. Org. 37, 33-41. doi:10.3354/dao037033.
    • (1999) Dis. Aquat. Org , vol.37 , pp. 33-41
    • Nakai, T.1    Suqimoto, R.2    Park, K.H.3    Matsuoka, S.4    Mori, K.5    Nishioka, T.6    Maruyama, K.7
  • 45
    • 13244264968 scopus 로고    scopus 로고
    • Development and evaluation of an experimental model of cutaneous columnaris disease in koi Cyprinus carpio
    • Tripathi, N. K., Latimer, K. S., Gregory, C. R., Ritchie, B. W., Wooley, R. E., and Walker, R. L. (2005). Development and evaluation of an experimental model of cutaneous columnaris disease in koi Cyprinus carpio. J. Vet. Diagn. Invest. 17, 45-54.
    • (2005) J. Vet. Diagn. Invest , vol.17 , pp. 45-54
    • Tripathi, N.K.1    Latimer, K.S.2    Gregory, C.R.3    Ritchie, B.W.4    Wooley, R.E.5    Walker, R.L.6
  • 46
    • 16344389614 scopus 로고    scopus 로고
    • Transmission and detection of Flavobacterium columnare in channel catfish Ictalurus punctatus
    • Welker, T. L., Shoemaker, C. A., and Arias, C. R. (2005). Transmission and detection of Flavobacterium columnare in channel catfish Ictalurus punctatus. Dis. Aquat. Organ. 63, 129-138.
    • (2005) Dis. Aquat. Organ , vol.63 , pp. 129-138
    • Welker, T.L.1    Shoemaker, C.A.2    Arias, C.R.3
  • 48
    • 84908371667 scopus 로고    scopus 로고
    • Association of colony morphotypes with virulence, growth and resistance against protozoan predation in the fish pathogen Flavobacterium columnare
    • Zhang, J., Laakso, J., Mappes, J., Laanto, E., Ketola, T., Bamford, J. K.H., Kunttu, H. and Sundberg, L.-R. (2014). Association of colony morphotypes with virulence, growth and resistance against protozoan predation in the fish pathogen Flavobacterium columnare. FEMS Microbiol. Ecol., 89: 553-562. doi: 10.1111/1574-6941.12356.
    • (2014) FEMS Microbiol. Ecol , vol.89 , pp. 553-562
    • Zhang, J.1    Laakso, J.2    Mappes, J.3    Laanto, E.4    Ketola, T.5    Bamford, J.K.H.6    Kunttu, H.7    Sundberg, L.-R.8


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