Cutting edge: Redox signaling hypersensitivity distinguishes human germinal center B cells

Journal of Immunology

Volumn 195, Issue 4, 2015, Pages 1364-1367

  Polikowsky, Hannah G ^a,b   Wogsland, Cara E ^a   Diggins, Kirsten E ^b   Huse, Kanutte ^c,d   Irish, Jonathan M ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OSLO   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; CD20 ANTIGEN; CD22 ANTIGEN; CD27 ANTIGEN; CD3 ANTIGEN; CD38 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; HLA DR ANTIGEN; HYDROGEN PEROXIDE; IMMUNOGLOBULIN D; PHOSPHOLIPASE C GAMMA; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; LYMPHOCYTE ANTIGEN RECEPTOR; PTPN6 PROTEIN, HUMAN;

ARTICLE; B LYMPHOCYTE; CELL INTERACTION; CELL MATURATION; CELL POPULATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOMETRY; FLOW CYTOMETRY; GERMINAL CENTER; HUMAN; HUMAN CELL; HYPERSENSITIVITY; INTRACELLULAR SIGNALING; MASS CYTOMETRY; MEMORY CELL; OXIDATION REDUCTION REACTION; PLASMABLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; PALATINE TONSIL; PHENOTYPE; SIGNAL TRANSDUCTION;

B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; CELL DIFFERENTIATION; GENE EXPRESSION; GERMINAL CENTER; HUMANS; HYDROGEN PEROXIDE; IMMUNOPHENOTYPING; OXIDATION-REDUCTION; PALATINE TONSIL; PHENOTYPE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION;

EID: 84938911679     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500904     Document Type: Article

References (19)

1. Reth, M. 2002. Hydrogen peroxide as second messenger in lymphocyte activation. Nat. Immunol. 3: 1129-1134.
2. Nathan, C., and A. Cunningham-Bussel. 2013. Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat. Rev. Immunol. 13: 349-361.
3. Maecker, H. T., J. P. McCoy, and R. Nussenblatt. 2012. Standardizing immunophenotyping for the Human Immunology Project. Nat. Rev. Immunol. 12: 191-200.
4. Victora, G. D., T. A. Schwickert, D. R. Fooksman, A. O. Kamphorst, M. Meyer-Hermann, M. L. Dustin, and M. C. Nussenzweig. 2010. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 143: 592-605.
5. Gitlin, A. D., Z. Shulman, and M. C. Nussenzweig. 2014. Clonal selection in the germinal centre by regulated proliferation and hypermutation. Nature 509: 637-640.
6. Shulman, Z., A. D. Gitlin, J. S. Weinstein, B. Lainez, E. Esplugues, R. A. Flavell, J. E. Craft, and M. C. Nussenzweig. 2014. Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science 345: 1058-1062.
7. Klein, U., Y. Tu, G. A. Stolovitzky, J. L. Keller, J. Haddad, Jr., V. Miljkovic, G. Cattoretti, A. Califano, and R. Dalla-Favera. 2003. Transcriptional analysis of the B cell germinal center reaction. Proc. Natl. Acad. Sci. USA 100: 2639-2644.
8. Khalil, A. M., J. C. Cambier, and M. J. Shlomchik. 2012. B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science 336: 1178-1181.
9. Singh, D. K., D. Kumar, Z. Siddiqui, S. K. Basu, V. Kumar, and K. V. S. Rao. 2005. The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell 121: 281-293.
10. Woo, H. A., S. H. Yim, D. H. Shin, D. Kang, D. Y. Yu, and S. G. Rhee. 2010. Inactivation of peroxiredoxin I by phosphorylation allows localized H2O2 accumulation for cell signaling. Cell 140: 517-528.
11. Irish, J. M., J. H. Myklebust, A. A. Alizadeh, R. Houot, J. P. Sharman, D. K. Czerwinski, G. P. Nolan, and R. Levy. 2010. B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression. Proc. Natl. Acad. Sci. USA 107: 12747-12754.
12. Amir, A. D., K. L. Davis, M. D. Tadmor, E. F. Simonds, J. H. Levine, S. C. Bendall, D. K. Shenfeld, S. Krishnaswamy, G. P. Nolan, and D. Pe'er. 2013. viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat. Biotechnol. 31: 545-552.
13. Becher, B., A. Schlitzer, J. Chen, F. Mair, H. R. Sumatoh, K. W. W. Teng, D. Low, C. Ruedl, P. Riccardi-Castagnoli, M. Poidinger, et al. 2014. High-dimensional analysis of the murine myeloid cell system. Nat. Immunol. 15: 1181-1189.
14. Bendall, S. C., K. L. Davis, A. D. Amir, M. D. Tadmor, E. F. Simonds, T. J. Chen, D. K. Shenfeld, G. P. Nolan, and D. Pe'er. 2014. Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Cell 157: 714-725.
15. Irish, J. M., D. K. Czerwinski, G. P. Nolan, and R. Levy. 2006. Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry. J. Immunol. 177: 1581-1589.
16. Jackson, S. M., P. C. Wilson, J. A. James, and J. D. Capra. 2008. Human B cell subsets. Adv. Immunol. 98: 151-224.
17. Kraus, M., M. B. Alimzhanov, N. Rajewsky, and K. Rajewsky. 2004. Survival of resting mature B lymphocytes depends on BCR signaling via the Iga/b heterodimer. Cell 117: 787-800.
18. Irish, J. M., D. K. Czerwinski, G. P. Nolan, and R. Levy. 2006. Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells. Blood 108: 3135-3142.
19. Mueller, J., M. Matloubian, and J. Zikherman. 2015. Cutting edge: an in vivo reporter reveals active B cell receptor signaling in the germinal center. J. Immunol. 194: 2993-2997.