An Inverse Relationship Between Weight and Free Thyroxine During Early Gestation Among Women Treated for Hypothyroidism

Thyroid

Volumn 25, Issue 8, 2015, Pages 949-953

  Haddow, James E ^a,b,e   Neveux, Louis M ^a,b   Palomaki, Glenn E ^a,b   Lambert Messerlian, Geralyn ^a   Malone, Fergal D ^c,d   D'Alton, Mary E ^c  

^a BROWN UNIVERSITY   (United States)

^b Savjani Institute for Health Research   (United States)

^c University College of Physicians and Surgeons ^*  (United States)

^d ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^e WOMEN AND INFANTS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROXINE;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; BIRTH WEIGHT; BLOOD SAMPLING; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; COVARIANCE; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; FREE THYROXINE INDEX; GESTATIONAL AGE; HUMAN; HYPOTHYROIDISM; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MATERNAL AGE; MATERNAL OBESITY; MULTICENTER STUDY; PREDICTIVE VALUE; PREGNANT WOMAN; PRENATAL CARE; PRIORITY JOURNAL; RISK FACTOR; THYROID FUNCTION TEST; THYROID GLAND; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; BLOOD; PATHOLOGY; PREGNANCY; PREGNANCY COMPLICATION; REFERENCE VALUE; SECOND TRIMESTER PREGNANCY; STATISTICAL MODEL; YOUNG ADULT;

ADULT; BODY WEIGHT; FEMALE; HUMANS; HYPOTHYROIDISM; LINEAR MODELS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY TRIMESTER, FIRST; PREGNANCY TRIMESTER, SECOND; REFERENCE VALUES; THYROID FUNCTION TESTS; THYROID GLAND; THYROTROPIN; THYROXINE; YOUNG ADULT;

EID: 84938903562     PISSN: 10507256     EISSN: 15579077     Source Type: Journal    
DOI: 10.1089/thy.2015.0085     Document Type: Article

References (20)

1. Jonklaas J, Davidson B, Bhagat S, Soldin SJ 2008 Triiodothyronine levels in athyreotic individuals during levothyroxine therapy. JAMA 299:769-777.
2. Gullo D, Latina A, Frasca F, Le Moli R, Pellegriti G, Vigneri R 2011 Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients. PLoS One 6:e22552.
3. Ito M, Miyauchi A, Morita S, Kudo T, Nishihara E, Kihara M, Takamura Y, Ito Y, Kobayashi K, Miya A, Kubota S, Amino N 2012 TSH-suppressive doses of levothyroxine are required to achieve preoperative native serum triiodothyronine levels in patients who have undergone total thyroidectomy. Eur J Endocrinol 167:373-378.
4. Woeber KA 2002 Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. J Endocrinol Invest 25:106-109.
5. Hoermann R, Midgley JE, Larisch R, Dietrich JW 2013 Is pituitary TSH an adequate measure of thyroid hormonecontrolled homoeostasis during thyroxine treatment? Eur J Endocrinol 168:271-280.
6. Slawik M, Klawitter B, Meiser E, Schories M, Zwermann O, Borm K, Peper M, Lubrich B, Hug MJ, Nauck M, Olschewski M, Beuschlein F, Reincke M 2007 Thyroid hormone replacement for central hypothyroidism: a randomized controlled trial comparing two doses of thyroxine (T4) with a combination of T4 and triiodothyronine. J Clin Endocrinol Metab 92:4115-4122.
7. Iverson JF, Mariash CN 2008 Optimal free thyroxine levels for thyroid hormone replacement in hypothyroidism. Endocr Pract 14:550-555.
8. Ojomo KA, Schneider DF, Reiher AE, Lai N, Schaefer S, Chen H, Sippel RS 2013 Using body mass index to predict optimal thyroid dosing after thyroidectomy. J Am Coll Surg 216:454-460.
9. Cleary-Goldman J, Malone FD, Lambert-Messerlian G, Sullivan L, Canick J, Porter TF, Luthy D, Gross S, Bianchi DW, D'Alton ME 2008 Maternal thyroid hypofunction and pregnancy outcome. Obstet Gynecol 112:85-92.
10. Lambert-Messerlian G, McClain M, Haddow JE, Palomaki GE, Canick JA, Cleary-Goldman J, Malone FD, Porter TF, Nyberg DA, Bernstein P, D'Alton ME 2008 First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study. Am J Obstet Gynecol 199:62.e61-66.
11. McClain MR, Lambert-Messerlian G, Haddow JE, Palomaki GE, Canick JA, Cleary-Goldman J, Malone FD, Porter TF, Nyberg DA, Bernstein P, D'Alton ME 2008 Sequential first- and second-trimester TSH, free thyroxine, and thyroid antibody measurements in women with known hypothyroidism: a FaSTER trial study. Am J Obstet Gynecol 199:129 e121-126.
12. Salmon D, Rendell M, Williams J, Smith C, Ross DA, Waud JM, Howard JE 1982 Chemical hyperthyroidism: serum triiodothyronine levels in clinically euthyroid individuals treated with levothyroxine. Arch Intern Med 142: 571-573.
13. Fish LH, Schwartz HL, Cavanaugh J, Steffes MW, Bantle JP, Oppenheimer JH 1987 Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. Role of triiodothyronine in pituitary feedback in humans. N Engl J Med 316:764-770.
14. Biondi B, Wartofsky L 2014 Treatment with thyroid hormone. Endocr Rev 35:433-512.
15. Haddow JE, Craig WY, Palomaki GE, Neveux LM, Lambert-Messerlian G, Canick JA, Malone FD, D'Alton ME 2013 Impact of adjusting for the reciprocal relationship between maternal weight and free thyroxine during early pregnancy. Thyroid 23:225-230.
16. Mannisto T, Surcel HM, Ruokonen A, Vaarasmaki M, Pouta A, Bloigu A, Jarvelin MR, Hartikainen AL, Suvanto E 2011 Early pregnancy reference intervals of thyroid hormone concentrations in a thyroid antibody-negative pregnant population. Thyroid 21:291-298.
17. Mehran L, Amouzegar A, Tohidi M, Moayedi M, Azizi F 2014 Serum free thyroxine concentration is associated with metabolic syndrome in euthyroid subjects. Thyroid 24: 1566-1574.
18. Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, Pessah-Pollack R, Singer PA, Woeber KA; American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults 2012 Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid 22:1200-1235.
19. Biondi B, Wartofsky L 2012 Combination treatment with T4 and T3: toward personalized replacement therapy in hypothyroidism? J Clin Endocrinol Metab 97:2256-2271.
20. Wiersinga WM, Duntas L, Fadeyev V, Nygaard B, Vanderpump MP 2012 2012 ETA Guidelines: the use of LT4 + L-T3 in the treatment of hypothyroidism. Eur Thyroid J 1:55-71.