Diversity of multi-drug resistant Acinetobacter baumannii population in a major hospital in Kuwait

Frontiers in Microbiology

Volumn 6, Issue JUL, 2015, Pages

  Vali, Leila ^a   Dashti, Khadija ^a   Opazo Capurro, Andrés F ^b   Dashti, Ali A ^a   Al Obaid, Khaled ^c   Evans, Benjamin A ^d  

^a KUWAIT UNIVERSITY   (Kuwait)

^b UNIVERSITY OF CONCEPCIÓN   (Chile)

^c AL AMIRI HOSPITAL   (Kuwait)

^d ANGLIA RUSKIN UNIVERSITY   (United Kingdom)

Author keywords

Acinetobacter baumannii; MLST PFGE OXA PER 1

Indexed keywords

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; MICROBIAL DIVERSITY; MULTILOCUS SEQUENCE TYPING; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; PULSED FIELD GEL ELECTROPHORESIS; SEQUENCE ANALYSIS;

ACINETOBACTER BAUMANNII;

EID: 84938889279     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2015.00743     Document Type: Article

References (40)

1. Al-Sweih, N. A., Al-Hubail, M., and Rotimi, V. O. (2012). Three distinct clones of carbapenem-resistant Acinetobacter baumannii with high diversity of carbapenemases isolated from patients in two hospitals in Kuwait. J. Infect. Public Health 5, 102-108. doi: 10.1016/j.jiph.2011.11.004
2. Aly, M., Tayeb, H. T., Al Johani, S. M., Alyamani, E. J., Aldughaishem, F., Alabdulkarim, I., et al. (2014). Genetic diversity of OXA-51-like genes among multidrug-resistant Acinetobacter baumannii in Riyadh, Saudi Arabia. Eur. J. Clin. Microbiol. Infect. Dis. 33, 1223-1228. doi: 10.1007/s10096-014-2068-0
3. Bakour, S., Alsharapy, S. A., Touati, A., and Rolain, J. M. (2014). Characterization of Acinetobacter baumannii clinical isolates carrying bla(OXA-23) carbapenemase and 16S rRNA methylase armA genes in Yemen. Microb. Drug Resist. 20, 604-609. doi: 10.1089/mdr.2014.0018
4. Bartual, S. G., Seifert, H., Hippler, C., Luzon, M. A., Wisplinghoff, H., and Rodríguez-Valera, F. (2005). Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii. J. Clin. Microbiol. 43, 4382-4390. doi: 10.1128/JCM.43.9.4382-4390.2005
5. Bonnin, R. A., Rotimi, V. O., Al Hubail, M., Gasiorowski, E., Al Sweih, N., Nordmann, P., et al. (2013). Wide dissemination of GES-type Carbapenemases in Acinetobacter baumannii isolates in Kuwait. Antimicrob. Agents Chemother. 57, 183-188. doi: 10.1128/AAC.01384-12
6. Clinical and Laboratory Standards Institute [CLSI]. (2012). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-First Informational Supplement. (2012). Document M100-S21. Wayne, PA: CLSI.
7. Corbella, X., Montero, A., Pujol, M., Dominguez, M. A., Ayats, J., Argerich, M. J., et al. (2000). Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multi resistant Acinetobacter baumannii. J. Clin. Microbiol. 38, 4086-4095.
8. Da Silva, G. J., Van Der Reijden, T., Domingues, S., Mendonça, N., Petersen, K., and Dijkshoorn, L. (2014). Characterization of a novel international clonal complex (CC32) of Acinetobacter baumannii with epidemic potential. Epidemiol. Infect. 142, 1554-1558. doi: 10.1017/S0950268813002288
9. Diancourt, L., Passet, V., Nemec, A., Dijkshoorn, L., and Brisse, S. (2010). The population structure of Acinetobacter baumannii: expanding multiresistant clones from an ancestral susceptible genetic pool. PLoS ONE 5:e10034. doi: 10.1371/journal.pone.0010034
10. European Committee on Antimicrobial Susceptibility Testing [EUCAST]. (2014). European Committee on Antimicrobial Susceptibility Testing Version 4.0, 2014. Available at: http://www.eucast.org/clinicalbreakpoints
11. Evans, B. A., and Amyes, S. G. B. (2014). OXA b-Lactamases. Clin. Microbiol. Rev. 27, 241-263. doi: 10.1128/CMR.00117-13
12. Giannouli, M., Antunes, L. C., Marchetti, V., Triassi, M., Visca, P., and Zarril, R. (2013). Virulence-related traits of epidemic Acinetobacter baumannii strains belonging to the international clonal lineages I-III and to the emerging genotypes ST25 and ST78. BMC Infect. Dis. 13:282. doi: 10.1186/1471-2334-13-282
13. Gundi, V. A. K. B., Dijkshoorn, L., Burignat, S., Raoult, D., and La Scola, B. (2009). Validation of partial rpoB gene sequence analysis for the identification of clinically important and emerging Acinetobacter species. Microbiology 155, 2333-2341. doi: 10.1099/mic.0.026054-0
14. Hamouda, A., Evans, B. A., Towner, K. J., and Amyes, S. G. B. (2010). Characterization of epidemiologically unrelated Acinetobacter baumannii isolates from four continents by use of multilocus sequence typing, pulsed-field gel electrophoresis, and sequence-based typing of bla (OXA-51-like) genes. J. Clin. Microbiol. 48, 2476-2483. doi: 10.1128/JCM.02431-09
15. Heritier, C., Poirel, L., Fournier, P. E., Claverie, J. M., Raoult, D., and Nordmann, P. (2005). Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii. Antimicrob. Agents Chemother. 49, 4174-4179. doi: 10.1128/AAC.49.10.4174-4179.2005
16. Higgins, P. G., Lehmann, M., Wisplinghoff, H., and Seifert, H. (2010). gyrB multiplex PCR to differentiate between Acinetobacter calcoaceticus and Acinetobacter genomic species 3. J. Clin. Microbiol. 48, 4592-4594. doi: 10.1128/JCM.01765-10
17. Higgins, P. G., Wisplinghoff, H., Krut, O., and Seifert, H. (2007). A PCR-based method to differentiate between Acinetobacter baumannii and Acinetobacter genomic species 13TU. Clin. Microbiol. Infect. 13, 1199-1201. doi: 10.1111/j.1469-0691.2007.01819.x
18. Hindler, J. A., and Humphries, R. M. (2013). Colistin MIC variability by method for contemporary clinical isolates of multidrug-resistant Gram-negative bacilli. J. Clin. Microbiol. 51, 1678-1684. doi: 10.1128/JCM.03385-12
19. Luo, T. L., Rickard, A. H., Srinivasan, U., Kaye, K. S., and Foxman, B. (2015). Association of blaOXA-23 and bap with the persistence of Acinetobacter baumannii within a major healthcare system. Front. Microbiol. 6:182. doi: 10.3389/fmicb.2015.00182
20. Magiorakos, A. P., Srinivasan, A., Carey, R. B., Carmeli, Y., Falagas, M. E., Giske, C. G., et al. (2012). Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin. Microbiol. Infect. 18, 268-281. doi: 10.1111/j.1469-0691.2011.03570.x
21. McCracken, M., Mataseje, L. F., Loo, V., Walkty, A., Adam, H. J., Hoban, D. J., et al. (2011). Characterization of Acinetobacter baumannii and meropenem-resistant Pseudomonas aeruginosa in Canada: results of the CANWARD 2007-2009 study. Diagn. Microbiol. Infect. Dis. 69, 335-341. doi: 10.1016/j.diagmicrobio.2010.10.030
22. Mezzatesta, M. L., Caio, C., Gona, F., Cormaci, R., Salerno, I., Zingali, T., et al. (2014). Carbapenem and multidrug resistance in Gram-negative bacteria in a single centre in Italy: considerations on in vitro assay of active drugs. Int. J. Antimicrob. Agents 44, 112-116. doi: 10.1016/j.ijantimicag.2014.04.014
23. Miranda, G., Kelly, C., Soloranzano, F., Leanos, B., Coria, R., and Patterson, F. E. (1996). Use of pulsed-field gel electrophoresis typing to study an outbreak of infection due to Serratia marcescens in a neonatal intensive care unit. J. Clin. Microbiol. 34, 3138-3141.
24. Mugnier, P. D., Poirel, L., Naas, T., and Nordmann, P. (2010). Worldwide dissemination of the blaOxA-23 carbapenemase gene of Acinetobacter baumannii. Emerg. Infect. Dis. 16, 35-40. doi: 10.3201/eid1601.090852
25. Nemec, A., Krízová, L., Maixnerová, M., Diancourt, L., van der Reijden, T. J. K., Brisse, S., et al. (2008). Emergence of carbapenem resistance in Acinetobacter baumannii in the Czech Republic is associated with the spread of multidrug-resistant strains of European clone II. J. Antimicrob. Chemother. 62, 484-489. doi: 10.1093/jac/dkn205
26. Opazo, A., Sonnevend, A., Lopes, B., Hamouda, A., Ghazawi, A., Pal, T., et al. (2012). Plasmid-encoded PER-7 β-lactamase responsible for ceftazidime resistance in Acinetobacter baumannii isolated in the United Arab Emirates. J. Antimicrob. Chemother. 67, 1619-1622. doi: 10.1093/jac/dks087
27. Opazo, A., Vali, L., Al Obaid, K., Dashti, A. A., and Amyes, S. G. (2014). Novel genetic structure harbouring blaPER-1 in ceftazidime-resistant Acinetobacter baumannii isolated from Kuwait. Int. J. Antimicrob. Agents 43, 383-384. doi: 10.1016/j.ijantimicag.2014.01.001
28. Peleg, A. Y., Seifert, H., and Paterson, D. L. (2008). Acinetobacter baumannii: emergence of a successful pathogen. Clin. Microbiol. Rev. 21, 538-582. doi: 10.1128/cmr.00058-07
29. Poirel, L., Bonnin, R. A., and Nordmann, P. (2011). Genetic basis of antibiotic resistance in pathogenic Acinetobacter species. IUBMB Life 63, 1061-1067. doi: 10.1002/iub.532
30. Poirel, L., and Nordmann, P. (2006). Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin. Microbiol. Infect. 12, 826-836. doi: 10.1111/j.1469-0691.2006.01456.x
31. Potron, A., Poirel, L., and Nordmann, P. (2015). Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: mechanisms and epidemiology. Int. J. Antimicrob. Agents 45, 568-585. doi: 10.1016/j.ijantimicag.2015.03.001
32. Ruiz, M., Marti, S., Fernandez-Cuenca, F., Pascual, A., and Vila, J. (2007). Prevalence of IS(Aba1) in epidemiologically unrelated Acinetobacter baumannii clinical isolates. FEMS Microbiol. Lett. 274, 63-66. doi: 10.1111/j.1574-6968.2007.00828.x
33. Talbot, G. H., Bradley, J., Edwards, J. E. Jr., Gilbert, D., Scheld, M., and Bartlett, J. G. (2006). Bad bugs need drugs: an update on the development pipeline from the antimicrobial availability task force of the infectious diseases society of America. Clin. Infect. Dis. 42, 657-668. doi: 10.1086/499819
34. Towner, K. J., Levi, K., Vlassiadi, M., and ARPAC Steering Group. (2008). Genetic diversity of carbapenem resistant Acinetobacter baumannii in Europe. Clin. Microbiol. Infect. 14, 161-167. doi: 10.1111/j.1469-0691.2007.01911.x
35. Turton, J. F., Kaufmann, M. E., Gill, M. J., Pike, R., Scott, P. T., Fishbain, J., et al. (2006). Comparison of Acinetobacter baumannii isolates from the United Kingdom and the United States that were associated with repatriated casualties of the Iraq conflict. J. Clin. Microbiol. 44, 2630-2634. doi: 10.1128/JCM.00547-06
36. Villalón, P., Valdezate, S., Medina-Pascual, M. J., Rubio, V., Vindel, A., and Saez-Nieto, J. A. (2011). Clonal diversity of nosocomial epidemic Acinetobacter baumannii strains isolated in Spain. J. Clin. Microbiol. 49, 875-882. doi: 10.1128/JCM.01026-10
37. Woodford, N., Ellington, M. J., Coelho, J. M., Turton, J. F., Ward, M. E., Brown, S., et al. (2006). Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int. J. Antimicrob. Agents 27, 351-353. doi: 10.1016/j.ijantimicag.2006.01.004
38. Wright, M. S., Haft, D. H., Harkins, D. M., Perez, F., Hujer, K. M., Bajaksouzian, S., et al. (2014). New insights into dissemination and variation of the health care-associated pathogen Acinetobacter baumannii from genomic analysis. MBio 5, e00963-e001013. doi: 10.1128/mBio.00963-13
39. Zander, E., Higgins, P. G., Fernández-González, A., and Seifert, H. (2013). Detection of intrinsic blaOXA-51-like by multiplex PCR on its own is not reliable for the identification of Acinetobacter baumannii. Int. J. Med. Microbiol. 303, 88-89. doi: 10.1016/j.ijmm.2012.12.007
40. Zowawi, H. M., Sartor, A. L., Sidjabat, H. E., Balkhy, H. H., Walsh, T. R., Al Johani, S. M., et al. (2015). Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolates in the Gulf Cooperation Council States: dominance of OXA-23-type producers. J. Clin. Microbiol. 53, 896-903. doi: 10.1128/JCM.02784-14