PML in patients treated with dimethyl fumarate: To the editor

New England Journal of Medicine

Volumn 373, Issue 6, 2015, Pages 582-584

  Balak, Deepak ^a   Hajdarbegovic, Enes ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; FUMARIC ACID DIMETHYL ESTER; FUMARIC ACID DERIVATIVE; IMMUNOSUPPRESSIVE AGENT;

CASE REPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; DELAYED RELEASE FORMULATION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; LETTER; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; PATIENT MONITORING; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; PSORIASIS; RISK ASSESSMENT; CHEMICALLY INDUCED; FEMALE;

FEMALE; FUMARATES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL;

EID: 84938829741     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1506151     Document Type: Letter

References (5)

1. Nieuwkamp DJ, Murk JL, van Oosten BW, et al. PML in a patient without severe lymphocytopenia receiving dimethyl fumarate. N Engl J Med 2015;372:1474-6.
2. Spencer CM, Crabtree-Hartman EC, Lehmann-Horn K, Cree BA, Zamvil SS. Reduction of CD8(+) T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate. Neurol Neuroimmunol Neuroinflamm 2015;2(3):e76.
3. Philipp S, Kokolakis G, Hund M, et al. Immunological changes in psoriasis patients under long-term treatment with fumaric acid esters: risk of Kaposi sarcoma occurrence? Eur J Dermatol 2013;23:339-43.
4. Gambichler T, Scola N, Rotterdam S, et al. Monitoring peripheral blood CD4(+) intracellular adenosine triphosphate concentration in patients with psoriasis treated with fumaric acid esters. Acta Derm Venereol 2012;92:364-6.
5. Haghikia A, Perrech M, Pula B, et al. Functional energetics of CD4+-cellular immunity in monoclonal antibody-associated progressive multifocal leukoencephalopathy in autoimmune disorders. PLoS One 2011;6(4):e18506.