메뉴 건너뛰기




Volumn 16, Issue 4, 2015, Pages 323-330

Secukinumab: A Review in Moderate to Severe Plaque Psoriasis

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; PLACEBO; SECUKINUMAB; DERMATOLOGICAL AGENT; IL17A PROTEIN, HUMAN; MONOCLONAL ANTIBODY;

EID: 84938824470     PISSN: 11750561     EISSN: 11791888     Source Type: Journal    
DOI: 10.1007/s40257-015-0143-7     Document Type: Article
Times cited : (45)

References (39)
  • 1
    • 84902177664 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in chronic plaque psoriasis and psoriatic arthritis therapy
    • Gisondi P, Dalle Vedove C, Girolomoni G. Efficacy and safety of secukinumab in chronic plaque psoriasis and psoriatic arthritis therapy. Dermatol Ther. 2014;4(1):1–9.
    • (2014) Dermatol Ther , vol.4 , Issue.1 , pp. 1-9
    • Gisondi, P.1    Dalle Vedove, C.2    Girolomoni, G.3
  • 2
    • 84938079964 scopus 로고    scopus 로고
    • The role of interleukin-17A in psoriatic disease
    • COI: 1:CAS:528:DC%2BC2cXpsVGrsL4%3D, PID: 2489002
    • Adami S, Cavani A, Rossi F, et al. The role of interleukin-17A in psoriatic disease. BioDrugs. 2014;28(6):487–97.
    • (2014) BioDrugs , vol.28 , Issue.6 , pp. 487-497
    • Adami, S.1    Cavani, A.2    Rossi, F.3
  • 3
    • 70249137988 scopus 로고    scopus 로고
    • European S3-guidelines on the systemic treatment of psoriasis vulgaris
    • PID: 1971219
    • Pathirana D, Ormerod AD, Saiag P, et al. European S3-guidelines on the systemic treatment of psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2009;23(Suppl. 2):1–70.
    • (2009) J Eur Acad Dermatol Venereol , vol.23 , pp. 1-70
    • Pathirana, D.1    Ormerod, A.D.2    Saiag, P.3
  • 4
    • 85081873309 scopus 로고    scopus 로고
    • Novartis Europharm Limited. Cosentyx™ (secukinumab subcutaneous injection): EU summary of product characteristics. 2015. Accessed 18 Jun 2015
    • Novartis Europharm Limited. Cosentyx™ (secukinumab subcutaneous injection): EU summary of product characteristics. 2015. http://www.ema.europa.eu. Accessed 18 Jun 2015.
  • 5
    • 84903307484 scopus 로고    scopus 로고
    • Interleukin 17A: toward a new understanding of psoriasis pathogenesis
    • COI: 1:CAS:528:DC%2BC2cXksFWltL8%3D, PID: 2465582
    • Lynde CW, Poulin Y, Vender R, et al. Interleukin 17A: toward a new understanding of psoriasis pathogenesis. J Am Acad Dermatol. 2014;71(1):141–50.
    • (2014) J Am Acad Dermatol , vol.71 , Issue.1 , pp. 141-150
    • Lynde, C.W.1    Poulin, Y.2    Vender, R.3
  • 6
    • 85081882322 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation. Cosentyx™ (secukinumab subcutaneous injection): US prescribing information. 2015. Accessed 18 Jun 2015
    • Novartis Pharmaceuticals Corporation. Cosentyx™ (secukinumab subcutaneous injection): US prescribing information. 2015. http://www.pharma.us.novartis.com. Accessed 18 Jun 2015.
  • 7
    • 85081875520 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation. Advisory Committee briefing materials: secukinumab. 2014. Accessed 18 Jun 2015
    • Novartis Pharmaceuticals Corporation. Advisory Committee briefing materials: secukinumab. 2014. www.fda.gov. Accessed 18 Jun 2015.
  • 9
    • 84977753069 scopus 로고    scopus 로고
    • Secukinumab reverses disease-defining psoriasis histopathology while retaining full T-cell activation potential [abstract no. P43]
    • Krueger J, Wharton K, Fuentes-Duculan J, et al. Secukinumab reverses disease-defining psoriasis histopathology while retaining full T-cell activation potential [abstract no. P43]. Br J Dermatol. 2014;171:e140.
    • (2014) Br J Dermatol , vol.171 , pp. e140
    • Krueger, J.1    Wharton, K.2    Fuentes-Duculan, J.3
  • 10
    • 84931566876 scopus 로고    scopus 로고
    • Evidence that a neutrophil-keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis
    • PID: 2582836
    • Reich K, Papp KA, Matheson RT, et al. Evidence that a neutrophil-keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis. Exp Dermatol. 2015. doi:10.1111/exd.12710.
    • (2015) Exp Dermatol
    • Reich, K.1    Papp, K.A.2    Matheson, R.T.3
  • 11
    • 85081883087 scopus 로고    scopus 로고
    • Secukinumab, a novel anti-IL-17A antibody, can be quantified in skin after a single dose by dermal open flow microperfusion (dOFM) [abstract]
    • Bruin G, Dragatin C, Aigner B, et al. Secukinumab, a novel anti-IL-17A antibody, can be quantified in skin after a single dose by dermal open flow microperfusion (dOFM) [abstract]. J Dtsch Dermatol Ges. 2014;12(Suppl 1):15.
    • (2014) J Dtsch Dermatol Ges , vol.12 , pp. 15
    • Bruin, G.1    Dragatin, C.2    Aigner, B.3
  • 12
    • 85081879011 scopus 로고    scopus 로고
    • Secukinumab reduces hsCRP levels in subjects with moderate-to-severe plaque psoriasis and concomitant psoriatic arthritis: a sub-analysis from the phase 3 ERASURE study [abstract no. AB0738]
    • Gottlieb A, Sigurgeirsson B, Blauvelt A, et al. Secukinumab reduces hsCRP levels in subjects with moderate-to-severe plaque psoriasis and concomitant psoriatic arthritis: a sub-analysis from the phase 3 ERASURE study [abstract no. AB0738]. Ann Rheum Dis. 2014;73(Suppl 2):1047.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1047
    • Gottlieb, A.1    Sigurgeirsson, B.2    Blauvelt, A.3
  • 13
    • 84938854624 scopus 로고    scopus 로고
    • Secukinumab reduces C-reactive protein levels in patients with moderate to severe plaque psoriasis: result of a regimen-finding study [abstract no. P6395]
    • Strober B, Guettner A, Sigurgeirrson B, et al. Secukinumab reduces C-reactive protein levels in patients with moderate to severe plaque psoriasis: result of a regimen-finding study [abstract no. P6395]. J Am Acad Dermatol. 2013;68(4 Suppl 1):AB212.
    • (2013) J Am Acad Dermatol , vol.68 , pp. AB212
    • Strober, B.1    Guettner, A.2    Sigurgeirrson, B.3
  • 14
    • 85043416219 scopus 로고    scopus 로고
    • Secukinumab treatment shows a neutral effect on the lipid profile of patients with moderate to severe plaque psoriasis: results from a randomized, double-blind, placebo-controlled, phase II study [abstract no. P6871]
    • Mrowietz U, Qureshi A, Escrig C. Secukinumab treatment shows a neutral effect on the lipid profile of patients with moderate to severe plaque psoriasis: results from a randomized, double-blind, placebo-controlled, phase II study [abstract no. P6871]. J Am Acad Dermatol. 2013;68(4 Suppl 1):AB212.
    • (2013) J Am Acad Dermatol , vol.68 , pp. AB212
    • Mrowietz, U.1    Qureshi, A.2    Escrig, C.3
  • 15
    • 84867247301 scopus 로고    scopus 로고
    • Treatment with the interleukin-17A-blocking antibody secukinumab does not interfere with the efficacy of influenza and meningococcal vaccinations in healthy subjects: results of an open-label, parallel-group, randomized single-center study
    • COI: 1:CAS:528:DC%2BC38XhsFSmsbbK, PID: 2287560
    • Chioato A, Noseda E, Stevens M, et al. Treatment with the interleukin-17A-blocking antibody secukinumab does not interfere with the efficacy of influenza and meningococcal vaccinations in healthy subjects: results of an open-label, parallel-group, randomized single-center study. Clin Vaccine Immunol. 2012;19(10):1597–602.
    • (2012) Clin Vaccine Immunol , vol.19 , Issue.10 , pp. 1597-1602
    • Chioato, A.1    Noseda, E.2    Stevens, M.3
  • 16
    • 85081880709 scopus 로고    scopus 로고
    • US FDA. Dermatologic and Ophthalmic Drugs Advisory Committee Meeting background package for BLA 125504 Cosentyx (secukinumab). 2014. Accessed 18 Jun 2015
    • US FDA. Dermatologic and Ophthalmic Drugs Advisory Committee Meeting background package for BLA 125504 Cosentyx (secukinumab). 2014. http://www.fda.gov. Accessed 18 Jun 2015.
  • 17
    • 84873168729 scopus 로고    scopus 로고
    • Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study
    • COI: 1:CAS:528:DC%2BC3sXhvV2nsbc%3D, PID: 2336296
    • Rich P, Sigurgeirsson B, Thaci D, et al. Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study. Br J Dermatol. 2013;168(2):402–11.
    • (2013) Br J Dermatol , vol.168 , Issue.2 , pp. 402-411
    • Rich, P.1    Sigurgeirsson, B.2    Thaci, D.3
  • 18
    • 84873124241 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study
    • COI: 1:CAS:528:DC%2BC3sXhvV2nt74%3D, PID: 2310610
    • Papp KA, Langley RG, Sigurgeirsson B, et al. Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study. Br J Dermatol. 2013;168(2):412–21.
    • (2013) Br J Dermatol , vol.168 , Issue.2 , pp. 412-421
    • Papp, K.A.1    Langley, R.G.2    Sigurgeirsson, B.3
  • 19
    • 84904545875 scopus 로고    scopus 로고
    • Secukinumab in plaque psoriasis—results of two phase 3 trials
    • PID: 2500739
    • Langley RG, Elewski BE, Lebwohl M, et al. Secukinumab in plaque psoriasis—results of two phase 3 trials. N Engl J Med. 2014;371(4):326–38.
    • (2014) N Engl J Med , vol.371 , Issue.4 , pp. 326-338
    • Langley, R.G.1    Elewski, B.E.2    Lebwohl, M.3
  • 20
    • 84922933349 scopus 로고    scopus 로고
    • Secukinumab administration by pre-filled syringe: efficacy, safety and usability results from a randomized controlled trial in psoriasis (FEATURE)
    • PID: 2513241
    • Blauvelt A, Prinz JC, Gottlieb AB, et al. Secukinumab administration by pre-filled syringe: efficacy, safety and usability results from a randomized controlled trial in psoriasis (FEATURE). Br J Dermatol. 2014;172(2):484–93.
    • (2014) Br J Dermatol , vol.172 , Issue.2 , pp. 484-493
    • Blauvelt, A.1    Prinz, J.C.2    Gottlieb, A.B.3
  • 21
    • 84929629144 scopus 로고    scopus 로고
    • Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: a randomized, controlled trial (JUNCTURE)
    • PID: 2524391
    • Paul C, Lacour JP, Tedremets L, et al. Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: a randomized, controlled trial (JUNCTURE). J Eur Acad Dermatol Venereol. 2014;29(6):1082–90.
    • (2014) J Eur Acad Dermatol Venereol , vol.29 , Issue.6 , pp. 1082-1090
    • Paul, C.1    Lacour, J.P.2    Tedremets, L.3
  • 22
    • 84939463415 scopus 로고    scopus 로고
    • Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial
    • Thaci D, Blauvelt A, Reich K, et al. Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial. J Am Acad Dermatol. 2015. doi:10.1016/j.jaad.2015.05.013.
    • (2015) J Am Acad Dermatol
    • Thaci, D.1    Blauvelt, A.2    Reich, K.3
  • 23
    • 85081878494 scopus 로고    scopus 로고
    • Secukinumab efficacy and safety in subjects with moderate to severe palmoplantar psoriasis in a phase 3b study (GESTURE) [abstract no. FC24-07]
    • Gottlieb A, Sullivan J, van Doorn M, et al. Secukinumab efficacy and safety in subjects with moderate to severe palmoplantar psoriasis in a phase 3b study (GESTURE) [abstract no. FC24-07]. In: 23rd World Congress of Dermatology. 2015.
    • (2015) 23rd World Congress of Dermatology
    • Gottlieb, A.1    Sullivan, J.2    van Doorn, M.3
  • 24
    • 84938820972 scopus 로고    scopus 로고
    • Secukinumab is effective in subjects with nail psoriasis: 16 week results from the TRANSFIGURE study [abstract]
    • Reich K, Sullivan J, Arenberger P, et al. Secukinumab is effective in subjects with nail psoriasis: 16 week results from the TRANSFIGURE study [abstract]. In: 23rd World Congress of Dermatology. 2015.
    • (2015) 23rd World Congress of Dermatology
    • Reich, K.1    Sullivan, J.2    Arenberger, P.3
  • 25
    • 85081881511 scopus 로고    scopus 로고
    • Secukinumab efficacy in relationship with response to previous biologic psoriasis therapy: a subanalysis from the ERASURE Study [abstract no. P8011]
    • Papp K, Karpov A, Papavassilis C, et al. Secukinumab efficacy in relationship with response to previous biologic psoriasis therapy: a subanalysis from the ERASURE Study [abstract no. P8011]. J Am Acad Dermatol. 2014;70(5 Suppl 1):AB186.
    • (2014) J Am Acad Dermatol , vol.70 , pp. AB186
    • Papp, K.1    Karpov, A.2    Papavassilis, C.3
  • 26
    • 85081873945 scopus 로고    scopus 로고
    • Secukinumab efficacy in subjects with moderate-to-severe plaque psoriasis and concomitant psoriatic arthritis: a subanalysis of the ERASURE study [abstract no. P8033]
    • Blauvelt A, Gottlieb A, Sigurgeirsson B, et al. Secukinumab efficacy in subjects with moderate-to-severe plaque psoriasis and concomitant psoriatic arthritis: a subanalysis of the ERASURE study [abstract no. P8033]. J Am Acad Dermatol. 2014;70(5 Suppl 1):AB2.
    • (2014) J Am Acad Dermatol. , vol.70 , pp. AB2
    • Blauvelt, A.1    Gottlieb, A.2    Sigurgeirsson, B.3
  • 27
    • 85081878411 scopus 로고    scopus 로고
    • Philipp S, Papavassilis C, Notter M, et al. Secukinumab effect on functional ability in subjects with moderate to severe plaque psoriasis and psoriatic arthritis: a subanalysis from the FIXTURE study [abstract no. P8098]. J Am Acad Dermatol. 2014;70:AB185
    • Philipp S, Papavassilis C, Notter M, et al. Secukinumab effect on functional ability in subjects with moderate to severe plaque psoriasis and psoriatic arthritis: a subanalysis from the FIXTURE study [abstract no. P8098]. J Am Acad Dermatol. 2014;70:AB185.
  • 28
    • 84938894835 scopus 로고    scopus 로고
    • Secukinumab treatment maintains efficacy in moderate to severe plaque psoriasis through second year of treatment: a randomized extension of the ERASURE and FIXTURE studies [abstract]
    • Blauvelt A, Szepietowski J, Sigurgeirrson B, et al. Secukinumab treatment maintains efficacy in moderate to severe plaque psoriasis through second year of treatment: a randomized extension of the ERASURE and FIXTURE studies [abstract]. In: 73rd annual meeting of the American Academy of Dermatology. 2015.
    • (2015) 73rd annual meeting of the American Academy of Dermatology
    • Blauvelt, A.1    Szepietowski, J.2    Sigurgeirrson, B.3
  • 29
    • 84937972700 scopus 로고    scopus 로고
    • Mrowietz U, Leonardi CL, Girolomoni G, et al. Secukinumab retreatment-as-needed versus fixed-interval maintenance regimen for moderate to severe plaque psoriasis: A randomized, double-blind, noninferiority trial (SCULPTURE). J Am Acad Dermatol. 2015;73(1):27–36 e1
    • Mrowietz U, Leonardi CL, Girolomoni G, et al. Secukinumab retreatment-as-needed versus fixed-interval maintenance regimen for moderate to severe plaque psoriasis: A randomized, double-blind, noninferiority trial (SCULPTURE). J Am Acad Dermatol. 2015;73(1):27–36 e1.
  • 30
    • 84937984975 scopus 로고    scopus 로고
    • Secukinumab in psoriasis: randomized, controlled phase 3 trial results assessing the potential to improve treatment response in partial responders (STATURE)
    • Thaci D, Humeniuk J, Frambach Y, et al. Secukinumab in psoriasis: randomized, controlled phase 3 trial results assessing the potential to improve treatment response in partial responders (STATURE). Br J Dermatol. 2015. doi:10.1111/bjd.13814.
    • (2015) Br J Dermatol
    • Thaci, D.1    Humeniuk, J.2    Frambach, Y.3
  • 31
    • 84923084142 scopus 로고    scopus 로고
    • Evaluation of infections with secukinumab in a pooled analysis of 10 clinical studies of moderate-to-severe plaque psoriasis [abstract no. 193]
    • Tsai T, Blauvelt A, Karpov A, et al. Evaluation of infections with secukinumab in a pooled analysis of 10 clinical studies of moderate-to-severe plaque psoriasis [abstract no. 193]. J Invest Dermatol. 2014;134:S33.
    • (2014) J Invest Dermatol. , vol.134 , pp. S33
    • Tsai, T.1    Blauvelt, A.2    Karpov, A.3
  • 32
    • 84923108270 scopus 로고    scopus 로고
    • Secukinumab safety in subjects with moderate to severe plaque psoriasis: a pooled analysis of neutropenia from 10 clinical studies [abstract no. P8266]
    • Griffiths C, Guettner A, Prinz J, et al. Secukinumab safety in subjects with moderate to severe plaque psoriasis: a pooled analysis of neutropenia from 10 clinical studies [abstract no. P8266]. J Am Acad Dermatol. 2014;70(5 Suppl 1):AB188.
    • (2014) J Am Acad Dermatol , vol.70 , pp. AB188
    • Griffiths, C.1    Guettner, A.2    Prinz, J.3
  • 33
    • 84938864380 scopus 로고    scopus 로고
    • Evaluation of malignancy risk with secukinumab treatment in a pooled analysis of 10 clinical studies of moderate-to-severe plaque psoriasis up to 52 weeks [abstract no. 194]
    • Van De Kerkhof P, Strober B, Karpov A, et al. Evaluation of malignancy risk with secukinumab treatment in a pooled analysis of 10 clinical studies of moderate-to-severe plaque psoriasis up to 52 weeks [abstract no. 194]. J Invest Dermatol. 2014;134:S33.
    • (2014) J Invest Dermatol , vol.134 , pp. S33
    • Van De Kerkhof, P.1    Strober, B.2    Karpov, A.3
  • 34
    • 85081876153 scopus 로고    scopus 로고
    • Incidence of major adverse cardiovascular events with secukinumab: a pooled analysis of data from 10 phase 2 and 3 clinical trials in psoriasis [abstract no. T.106]
    • Craig L, Nehal M, Mark L, et al. Incidence of major adverse cardiovascular events with secukinumab: a pooled analysis of data from 10 phase 2 and 3 clinical trials in psoriasis [abstract no. T.106]. In: Federation of Clinical Immunology Societies Annual Meeting. 2014.
    • (2014) Federation of Clinical Immunology Societies Annual Meeting
    • Craig, L.1    Nehal, M.2    Mark, L.3
  • 35
    • 84923104600 scopus 로고    scopus 로고
    • Secukinumab safety and tolerability in subjects with moderate to severe plaque psoriasis: a pooled subgroup analysis of 10 clinical studies evaluating exacerbation of Crohn’s disease [abstract no. P8233]
    • Ward N, Guettner A, Sands B, et al. Secukinumab safety and tolerability in subjects with moderate to severe plaque psoriasis: a pooled subgroup analysis of 10 clinical studies evaluating exacerbation of Crohn’s disease [abstract no. P8233]. J Am Acad Dermatol. 2014;70(5 Suppl 1):AB188.
    • (2014) J Am Acad Dermatol. , vol.70 , pp. AB188
    • Ward, N.1    Guettner, A.2    Sands, B.3
  • 36
    • 85081881609 scopus 로고    scopus 로고
    • Secukinumab, a novel Anti-IL-17A antibody, exhibits low immunogenicity in clinical trials and human in vitro assays [abstract no. 1320]
    • Reich K, Blauvelt A, Armstrong A, et al. Secukinumab, a novel Anti-IL-17A antibody, exhibits low immunogenicity in clinical trials and human in vitro assays [abstract no. 1320]. In: 73rd annual meeting of the American Academy of Dermatology. 2015.
    • (2015) 73rd annual meeting of the American Academy of Dermatology
    • Reich, K.1    Blauvelt, A.2    Armstrong, A.3
  • 37
    • 84855987158 scopus 로고    scopus 로고
    • Consensus guidelines for the management of plaque psoriasis
    • COI: 1:CAS:528:DC%2BC38Xis1aqs7k%3D, PID: 2225023
    • Hsu S, Papp KA, Lebwohl MG, et al. Consensus guidelines for the management of plaque psoriasis. Arch Dermatol. 2012;148(1):95–102.
    • (2012) Arch Dermatol , vol.148 , Issue.1 , pp. 95-102
    • Hsu, S.1    Papp, K.A.2    Lebwohl, M.G.3
  • 38
    • 78649271458 scopus 로고    scopus 로고
    • Newer trends in the management of psoriasis at difficult to treat locations: scalp, palmoplantar disease and nails
    • PID: 2107930
    • Handa S. Newer trends in the management of psoriasis at difficult to treat locations: scalp, palmoplantar disease and nails. Indian J Dermatol Venereol Leprol. 2010;76(6):634–44.
    • (2010) Indian J Dermatol Venereol Leprol , vol.76 , Issue.6 , pp. 634-644
    • Handa, S.1
  • 39
    • 84923105894 scopus 로고    scopus 로고
    • Secukinumab: first global approval
    • COI: 1:CAS:528:DC%2BC2MXis1agtrc%3D, PID: 2564826
    • Sanford M, McKeage K. Secukinumab: first global approval. Drugs. 2015;75(3):329–38.
    • (2015) Drugs , vol.75 , Issue.3 , pp. 329-338
    • Sanford, M.1    McKeage, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.