Brain connectomics predict response to treatment in social anxiety disorder

Molecular Psychiatry

Volumn 21, Issue 5, 2016, Pages 680-685

  Whitfield Gabrieli, S ^a,b   Ghosh, S S ^a,c   Nieto Castanon, A ^a,b,d   Saygin, Z ^b   Doehrmann, O ^a   Chai, X J ^a,b   Reynolds, G O ^a   Hofmann, S G ^d   Pollack, M H ^e   Gabrieli, J D E ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOSTON UNIVERSITY   (United States)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ADULT; ARTICLE; CLINICAL ARTICLE; COGNITIVE BEHAVIORAL THERAPY; CONNECTOME; FEMALE; HUMAN; INFERIOR LONGITUDINAL FASCICULUS; MALE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SOCIAL PHOBIA; TREATMENT RESPONSE; ADOLESCENT; BRAIN; COGNITIVE THERAPY; MIDDLE AGED; NERVE TRACT; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHOBIA, SOCIAL; PROCEDURES; PROGNOSIS; REST; STATISTICAL MODEL; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; BRAIN; COGNITIVE THERAPY; CONNECTOME; FEMALE; HUMANS; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEURAL PATHWAYS; PHOBIA, SOCIAL; PROGNOSIS; REST; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84938820272     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2015.109     Document Type: Article

References (52)

1. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005; 62: 593-602
2. Katzelnick DJ, Kobak KA, DeLeire T, Henk HJ, Greist JH, Davidson JR et al. Impact of generalized social anxiety disorder in managed care. Am J Psychiatry 2001; 158: 1999-2007
3. Magee WJ, Eaton WW, Wittchen HU, McGonagle KA, Kessler RC. Agoraphobia, simple phobia, and social phobia in the National Comorbidity Survey. Arch Gen Psychiatry 1996; 53: 159-168
4. Stein MB, Kean YM. Disability and quality of life in social phobia: epidemiologic findings. Am J Psychiatry 2000; 157: 1606-1613
5. Schneier FR, Johnson J, Hornig CD, Liebowitz MR, Weissman MM. Social phobia. Comorbidity and morbidity in an epidemiologic sample. Arch Gen Psychiatry 1992; 49: 282-288
6. Heimberg RG, Liebowitz MR, Hope DA, Schneier FR, Holt CS, Welkowitz LA et al. Cognitive behavioral group therapy vs phenelzine therapy for social phobia: 12-week outcome. Arch Gen Psychiatry 1998; 55: 1133-1141
7. Davidson JRT, Foa EB, Huppert JD, Keefe FJ, Franklin ME, Compton JS et al. Fluoxetine, comprehensive cognitive behavioral therapy, and placeboin generalized social phobia. Arch Gen Psychiatry 2004; 61: 1005-1013
8. Blanco C, Heimberg RG, Schneier FR, Fresco DM, Chen H, Turk CL et al. A placebocontrolled trial of phenelzine, cognitive behavioral group therapy, and their combination for social anxiety disorder. Arch Gen Psychiatry 2010; 67: 286-295
9. Biswal B, Yetkin FZ, Haughton VM, Hyde JS. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 1995; 34: 537-541
10. Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA 2005; 102: 9673-9678
11. Liao W, Chen H, Feng Y, Mantini D, Gentili C, Pan Z et al. Selective aberrant functional connectivity of resting state networks in social anxiety disorder. Neuroimage 2010; 52: 1549-1558
12. Hahn A, Stein P, Windischberger C, Weissenbacher A, Spindelegger C, Moser E et al. Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder. Neuroimage 2011; 56: 881-889
13. Arnold Anteraper S, Triantafyllou C, Sawyer AT, Hofmann SG, Gabrieli JD, Whitfield-Gabrieli S. Hyper-connectivity of subcortical resting-state networks in social anxiety disorder. Brain Connect 2014; 4: 81-90
14. Liao W, Xu Q, Mantini D, Ding J, Machado-de-Sousa JP, Hallak JEC et al. Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder. Brain Res 2011; 1388: 167-177
15. Phan KL, Orlichenko A, Boyd E, Angstadt M, Coccaro EF, Liberzon I et al. Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder. Biol Psychiatry 2009; 66: 691-694
16. Baur V, Hänggi J, Rufer M, Delsignore A, Jäncke L, Herwig U et al. White matter alterations in social anxiety disorder. J Psychiatr Res 2011; 45: 1366-1372
17. Klumpp H, Keutmann MK, Fitzgerald DA, Shankman SA, Phan KL. Resting state amygdala-prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder. Biol Mood Anxiety Disord 2014; 4: 14
18. Vul E, Harris C, Winkielman P, Pashler H. Puzzlingly high correlations in fMRI studies of emotion, personality, and social cognition. Perspect Psychol Sci 2009; 4: 274-290
19. Baur V, Brühl AB, Herwig U, Eberle T, Rufer M, Delsignore A et al. Evidence of frontotemporal structural hypoconnectivity in social anxiety disorder: a quantitative fiber tractography study. Hum Brain Mapp 2013; 34: 437-446
20. Hofmann SG, Otto MW. Cognitive-behavior therapy of social anxiety disorder: Evidence-based and disorder specific treatment techniques. Routledge/Taylor and Francis: New York, NY, 2008
21. Heimberg RG, Horner KJ, Juster HR, Safren SA, Brown EJ, Schneier FR et al. Psychometric properties of the Liebowitz Social Anxiety Scale. Psychol Med 1999; 29: 199-212
22. Freitas-Ferrari MC, Hallak JEC, Trzesniak C, Filho AS, Machado-de-Sousa JP, Chagas MHN et al. Neuroimaging in social anxiety disorder: a systematic review of the literature. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34: 565-580
23. Doehrmann O, Ghosh SS, Polli FE, Reynolds GO, Horn F, Keshavan A et al. Predicting treatment response in social anxiety disorder from functional magnetic resonance imaging. JAMA Psychiatry 2013; 70: 87-97
24. Catani M, Jones DK, Donato R, Ffytche DH. Occipito-Temporal connections in the human brain. Brain 2003; 126: 2093-2107
25. Theil H. Economic forecasts and policy. 2nd ed. North-Holland Publishing Company: Amsterdam, 1961
26. American National Adult Reading Test (ANART). In: Encyclopedia of Clinical Neuropsychology. Springer: New York, 2011 p 131-131
27. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSMIV Axis I Disorders, Research Version, Patient Edition With Psychotic Screen (SCID-I/P W/PSY SCREEN). Biometrics Research, New York State Psychiatric Institute: New York, 1997
28. DiNardo PA, Brown TA, Barlow DH. Anxiety Disorders Interview Schedule for DSMIV: Lifetime Version (ADIS-IV-L). Psychological Corp: San Antonio, TX, 1994
29. Turner SM, Beidel DC, Dancu CV, Stanley M.A. An empirically derived inventory to measure social fears and anxiety: The Social Phobia and Anxiety Inventory. Psycholgical Assessment 1989; 1: 35
30. Spielberger CD. STAI manual for the State-Trait anxiety inventory. Self-Evaluation Questionnaire. Consulting Psychologists Press: Palo Alto, CA, 1983
31. Rodrigues H, Figueira I, Lopes A, Gonçalves R, Mendlowicz MV, Coutinho ESF et al. Does D-cycloserine enhance exposure therapy for anxiety disorders in humans?. A meta-Analysis. PLoS One 2014; 9: e93519
32. Hofmann SG, Smits JAJ, Rosenfield D, Simon N, Otto MW, Meuret AE et al. DCycloserine as an augmentation strategy with cognitive-behavioral therapy for social anxiety disorder. Am J Psychiatry 2013; 170: 751-758
33. Whitfield-Gabrieli S, Nieto-Castanon A. Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connect 2012; 2: 125-141
34. Yendiki A, Panneck P, Srinivasan P, Stevens A, Zöllei L, Augustinack J et al. Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomy. Front Neuroinform 2011; 5: 23
35. Shehzad Z, Kelly AMC, Reiss PT, Gee DG, Gotimer K, Uddin LQ et al. The resting brain: unconstrained yet reliable. Cereb Cortex 2009; 19: 2209-2229
36. Gabrieli JDE, Ghosh SS, Whitfield-Gabrieli S. Prediction as a Humanitarian and Pragmatic Contribution from Human Cognitive Neuroscience. Neuron 2015; 85: 11-26
37. Fu CHY, Steiner H, Costafreda SG. Predictive neural biomarkers of clinical response in depression: a meta-Analysis of functional and structural neuroimaging studies of pharmacological and psychological therapies. Neurobiol Dis 2013; 52: 75-83
38. Chen C-H, Ridler K, Suckling J, Williams S, Fu CHY, Merlo-Pich E et al. Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment. Biol Psychiatry 2007; 62: 407-414
39. Siegle GJ, Carter CS, Thase ME. Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapy. Am J Psychiatry 2006; 163: 735-738
40. Kumari V, Peters ER, Fannon D, Antonova E, Premkumar P, Anilkumar AP et al. Dorsolateral prefrontal cortex activity predicts responsiveness to cognitive- behavioral therapy in schizophrenia. Biol Psychiatry 2009; 66: 594-602
41. Fullana MA, Cardoner N, Alonso P, Subirà M, López-Solà C, Pujol J et al. Brain regions related to fear extinction in obsessive-compulsive disorder and its relation to exposure therapy outcome: a morphometric study. Psychol Med 2014; 44: 845-856
42. Whalen PJ, Johnstone T, Somerville LH, Nitschke JB, Polis S, Alexander AL et al. A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder. Biol Psychiatry 2008; 63: 858-863
43. Noël X, Sferrazza R, Van Der Linden M Contribution of frontal cerebral blood flow measured by 99mTc-Bicisate SPECT and executive function deficits to predicting treatment outcome in alcohol-dependent . Alcohol [Internet] 2002. Available from: http://alcalc.oxfordjournals.org/content/37/4/347.short
44. Molfese VJ, Molfese DL, Modgline AA. Newborn and preschool predictors of second-grade reading scores: an evaluation of categorical and continuous scores. J Learn Disabil 2001; 34: 545-554
45. Gruber E, DiClemente RJ, Anderson MM, Lodico M. Early drinking onset and its association with alcohol use and problem behavior in late adolescence. Prev Med 1996; 25: 293-300
46. Grant BF, Dawson DA. Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse 1997; 9: 103-110
47. Yokum S, Ng J, Stice E. Attentional bias to food images associated with elevated weight and future weight gain: an fMRI study. Obesity 2011; 19: 1775-1783
48. McGrath CL, Kelley ME, Holtzheimer PE, Dunlop BW, Craighead WE, Franco AR et al. Toward a neuroimaging treatment selection biomarker for major depressive disorder. JAMA Psychiatry 2013; 70: 821-829
49. Paulus MP, Tapert SF, Schuckit M.A. Neural activation patterns of methamphetaminedependent subjects during decision making predict relapse. Arch Gen Psychiatry 2005; 62: 761-768
50. Lueken U, Straube B, Konrad C, Witchen HU, Strohle A, Wittmann A et al. Neural substrates of treatment response to cognitive-behavioral therapy in panic disorder with agoraphobia. Am J Psychiatry 2013; 170: 1345-1355
51. Ball TM, Stein MB, Paulus MP. Toward the application of functional neuroimaging to individualized treatment for anxiety and depression. Depress Anxiety 2014; 31: 920-933
52. Hoeft F, McCandliss BD, Black JM, Gantman A, Zakerani N, Hulme C et al. Neural systems predicting long-Term outcome in dyslexia. Proc Natl Acad Sci USA 2011; 108: 361-366