Prevention and treatment effect of total flavonoids in Stellera chamaejasme L. on nonalcoholic fatty liver in rats

Lipids in Health and Disease

Volumn 14, Issue 1, 2015, Pages 1-9

  Wang, Yu ^a   Li, Jian Yun ^b   Han, Min ^a   Wang, Wen Long ^a   Li, Yun Zhang ^a  

^a INNER MONGOLIA AGRICULTURAL UNIVERSITY   (China)

^b Inner Mongolia Center for Endemic Disease Control and Research   (China)

Author keywords

Blood lipid; Blood lipid index; Gene expression; Liver index; Nonalcoholic Fatty Liver; Rats; Stellera chamaejasme L.; Total flavonoids

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CARNITINE PALMITOYLTRANSFERASE I; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; FATTY ACID SYNTHASE; FLAVONOID; LEPTIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRIACYLGLYCEROL; LIPID; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME ASSAY; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GENE EXPRESSION; LIVER PROTECTION; LOW DRUG DOSE; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; STELLERA CHAMAEJASME; THYMELAEACEAE; WEIGHT CHANGE; ANIMAL; BLOOD; BODY WEIGHT; CHEMISTRY; DRUG EFFECTS; LIVER; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; PATHOLOGY; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS; STELLERA CHAMAEJASME;

ANIMALS; BODY WEIGHT; FLAVONOIDS; LIPIDS; LIVER; MALE; NON-ALCOHOLIC FATTY LIVER DISEASE; PLANT EXTRACTS; RATS, WISTAR; THYMELAEACEAE;

EID: 84938781181     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/s12944-015-0082-6     Document Type: Article

References (26)

1. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002;346:1221-31.
2. Ji G, Zhao X, Leng L, Liu P, Jiang Z. Comparison of dietary control and atorvastatin on high fat diet induced hepatic steatosis and hyperlipidemia in rats. Lipids Health Dis. 2011;10:23-33.
3. Li J, Yang J, Cui W, Chen X, Chen G, Wen X, et al. Analysis of therapeutic effect of ilex hainanensis merr. extract on nonalcoholic fatty liver disease through urine metabolite profiling by ultraperformance Liquid chromatography/ quadrupole time of flight mass spectrometry. Evidence-Based Complementary Alternative Med. 2013;2013:1-12.
4. Clark JM. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol. 2006;40(Suppl1):S5-10.
5. Fan JG, Farrell GC. Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol. 2009;50:204-10.
6. Gao Y, Song L, Jiang M, Ge G, Jia Y. Effects of traditional Chinese medicine on endotoxin and its receptors in rats with non-alcoholic steatohepatitis. Inflammation. 2008;31:121-32.
7. Liu W, Wang C. Research on chemical constituents, bioactivity and application of Stellera chamaejasme. Xian Dai Yao Wu Yu Lin Chuang. 2010;25(1):26-30.
8. Zhao M, Gao X, Wang J, He X, Han B. A review of the most economically important poisonous plants to the livestock industry on temperate grasslands of China. J Appl Toxicol. 2013;33(1):9-17.
9. Anonymous. Langdu. Quan Guo Zhong Cao Yao Hui Bian. Beijing: People's Health Publishing House; 1975. p. 717.
10. Liu G, Fu Y, Hou F, Wan L, Wan S, Li M. Chemical constituents of Stellera chamaejasme L. Zhong guo Zhong Yao Za Zhi. 1995;20(12):738-40. 763.
11. Feng B, Pei Y, Hua M. Chemical constituents of Stellera chamaejasme L. J Asian Nat Prod Res. 2002;4(4):259-63.
12. Wang M, Jia ZP, Ma J, Wang B. The antitumor effects of total-flavonoid from Stellera chamaejasme L. Zhongguo Zhong Yao Za Zhi. 2005;30(8):603-6.
13. Wu X, Han M, Liu X, Zhang R, Wang Y. Comparison on the three methods of extracting total flavone from Stellera chamaejasme. Animal Husbandry Feed Sci. 2009;30(1):39-40.
14. Liu W. Study on blood-fat-lowering effects of phytosterol esters in hyperlipidemia rats. Zhejiang: Zhejiang university master's degree thesis; 2007. p. 13-5.
15. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37(8):911-7.
16. Janes RG, Prosser M. Influence of high fat diets on alloxan diabetes. Am J Physiol. 1947;151:581-7.
17. Li H, Wang L. A proton nuclear magnetic resonance metabonomics approach for biomarker discovery in nonalcoholic fatty liver disease. J Proteome Res. 2011;10(6):2797-806.
18. Milagro FI, Campión J, Martínez JA. Weight gain induced by high-fat feeding involves increased liver oxidative stress. Obesity (Silver Spring). 2006;14:1118-23.
19. Zhang R. Extraction of the active components from Stellera Chamaejrime L. and its effects on immune functions of mice. In: Inner mongolia agricultural university master's degree thesis. 2009. p. 1-10.
20. Chen M. Studies of acarocidal activity and mechanism of the extraction of Stellera Chamaejrime L. Shan-dong: Shan-dong agricultural university master's degree thesis; 2009. p. 1-21.
21. Hu C. Protective effects of total fiavonoids litsea careana an alcoholic fatty liver in rats and the potential mechanism. Anhui: Doctoral dissertation of medical university Of Anhui; 2011. p. 1-25.
22. Bettzieche A, Brandsch C, Hirche F, Eder K, Stangl GI. L-cysteine down-regulates SREBP-1c-regulated lipogenic enzymes expression via glutathione in HepG2 cells. Ann Nutr Metab. 2008;52:196-203.
23. Foretz M, Guichard C, Ferré P, Foufelle F. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci U S A. 1999;96:12737-42.
24. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1997;89:331-40.
25. Ae Wha H, Woo Kyoung K. The effect of fucoxanthin rich power on the lipid metabolism in rats with a high fat diet. Nutr Res Pract. 2013;7(4):287-93.
26. Woo MN, Jeon SM, Shin YC, Lee MK, Kang MA, Choi MS. Anti-obese property of fucoxanthin is partly mediated by altering lipid-regulating enzymes and uncoupling proteins of visceral adipose tissue in mice. Mol Nutr Food Res. 2009;53:1603-11.